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公开(公告)号：US20130139899A1
公开(公告)日：2013-06-06
申请号：US13643426
申请日：2010-04-26
Applicant: Jean-Christophe Galas , Emmanuel Roy , Teodor Veres
Inventor： Jean-Christophe Galas , Emmanuel Roy , Teodor Veres
IPC: F17D1/00
CPC classification number: F17D1/00 , B01L3/502738 , B01L2400/0661 , F16K99/0026 , F16K99/0059 , Y10T137/0379 , Y10T137/7737
Abstract: A microfluidic valve operable to semi-permanently close a channel of a microfluidic device defined between a thermoplastic elastomer (TPE) film and a substrate operates employs a surface contact bond between the TPE and a wall of the channel. Thermomechanical release of the valve, tristate functionality, and repeated semi-permanent closure and release are demonstrated.
Abstract translation: 用于半永久封闭限定在热塑性弹性体（TPE）膜和基板之间的微流体装置的通道的微流体阀操作使用TPE与通道的壁之间的表面接触键。 证明阀的热机械释放，三态功能和重复的半永久性闭合和释放。
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公开(公告)号：US20110085949A1
公开(公告)日：2011-04-14
申请号：US12588236
申请日：2009-10-08
Applicant: Emmanuel Roy , Teodor Veres
Inventor： Emmanuel Roy , Teodor Veres
CPC classification number: B01L3/502707 , B01L3/5027 , B01L2200/12 , B01L2300/0887 , B01L2300/12 , B01L2300/123 , B29C41/045 , B29C59/02 , B29C65/02 , B29C71/02 , B29K2019/00 , B29K2995/0026 , B29K2995/0046 , B29K2995/0056 , B29K2995/007 , B29L2009/00 , B32B3/30 , B32B7/02 , B32B25/04 , B32B25/14 , B32B27/28 , B32B27/302 , B32B2270/00 , B32B2274/00 , B32B2307/306 , B32B2307/536 , B32B2307/546 , C08J5/18 , C08J2309/06 , C08J2323/04 , C08J2323/20 , C08J2325/08 , C08J2353/00 , Y10T428/24802
Abstract: A composition made of at least 60 wt. % of a thermoplastic elastomer resin and additives that are solid at least from 0-50° C., that has a Shore A hardness that is less than about 50 bears a patterned surface, the pattern comprising at least one microfluidic channel having a cross-sectional dimension smaller than 100 microns is a substrate for forming a microfluidic device. The chief advantages of such compositions are: its ability to bond in a sealing manner to smooth surfaces of many different compositions, its ease of manufacture and microstructure patterning, and its general impermeability to liquids.
Abstract translation: 由至少60重量％ ％的热塑性弹性体树脂和至少0-50℃固体的添加剂，其具有小于约50的肖氏A硬度带有图案化表面，该图案包括至少一个具有交联的微流体通道， 小于100微米的截面尺寸是用于形成微流体装置的衬底。 这种组合物的主要优点是：其以密封方式粘合到许多不同组合物的光滑表面，其易于制造和微结构图案化以及其对液体的一般不渗透性的能力。
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3.发明授权3D microfluidic devices based on open-through thermoplastic elastomer membranes 有权基于开放式热塑性弹性体膜的3D微流体装置公开(公告)号：US09498914B2
公开(公告)日：2016-11-22
申请号：US13985317
申请日：2011-02-15
Applicant: Daniel Brassard , Emmanuel Roy , Kebin Li , Teodor Veres
Inventor： Daniel Brassard , Emmanuel Roy , Kebin Li , Teodor Veres
CPC classification number: B29C51/00 , B29C43/021 , B29C43/04 , B33Y80/00
Abstract: The invention provides a new process for patterning TPE membranes for use in the design and fabrication of 3D microfluidic devices. The process involves patterning a TPE material without permitting the highest features of the mold to come into contact with the counter-plate, whereby adhesion between the TPE and the mold or counter-plate during demolding results directly in removal of the excess layer from the TPE membrane to produce well formed micrometric-sized open-through holes in the TPE membrane. The process permits rapid, reliable and efficient patterning of densely packed and arbitrarily placed micrometric open-through holes and channels of high aspect-ratio and any shape or wall profile in thin TPE membranes.
Abstract translation: 本发明提供了用于图案化TPE膜的新工艺，用于设计和制造3D微流体装置。 该方法包括图案化TPE材料，而不允许模具的最高特征与反向板接触，由此在脱模期间TPE与模具或反向板之间的粘附直接导致从TPE中去除多余的层 膜以在TPE膜中产生良好形成的微米尺寸的开孔。 该方法允许在薄的TPE膜中快速，可靠和有效地构图密集包装和任意放置的微孔开孔和高纵横比以及任何形状或壁形的通道。
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公开(公告)号：US09238346B2
公开(公告)日：2016-01-19
申请号：US12588236
申请日：2009-10-08
Applicant: Emmanuel Roy , Teodor Veres
Inventor： Emmanuel Roy , Teodor Veres
CPC classification number: B01L3/502707 , B01L3/5027 , B01L2200/12 , B01L2300/0887 , B01L2300/12 , B01L2300/123 , B29C41/045 , B29C59/02 , B29C65/02 , B29C71/02 , B29K2019/00 , B29K2995/0026 , B29K2995/0046 , B29K2995/0056 , B29K2995/007 , B29L2009/00 , B32B3/30 , B32B7/02 , B32B25/04 , B32B25/14 , B32B27/28 , B32B27/302 , B32B2270/00 , B32B2274/00 , B32B2307/306 , B32B2307/536 , B32B2307/546 , C08J5/18 , C08J2309/06 , C08J2323/04 , C08J2323/20 , C08J2325/08 , C08J2353/00 , Y10T428/24802
Abstract: A composition made of at least 60 wt. % of a thermoplastic elastomer resin and additives that are solid at least from 0-50° C., that has a Shore A hardness that is less than about 50 bears a patterned surface, the pattern comprising at least one microfluidic channel having a cross-sectional dimension smaller than 100 microns is a substrate for forming a microfluidic device. The chief advantages of such compositions are: its ability to bond in a sealing manner to smooth surfaces of many different compositions, its ease of manufacture and microstructure patterning, and its general impermeability to liquids.
Abstract translation: 由至少60重量％ ％的热塑性弹性体树脂和至少0-50℃固体的添加剂，其具有小于约50的肖氏A硬度带有图案化表面，该图案包括至少一个具有交联的微流体通道， 小于100微米的截面尺寸是用于形成微流体装置的衬底。 这种组合物的主要优点是：其以密封方式粘合到许多不同组合物的光滑表面，其易于制造和微结构图案化以及其对液体的一般不渗透性的能力。
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公开(公告)号：US09435490B2
公开(公告)日：2016-09-06
申请号：US13643426
申请日：2010-04-26
Applicant: Jean-Christophe Galas , Emmanuel Roy , Teodor Veres
Inventor： Jean-Christophe Galas , Emmanuel Roy , Teodor Veres
CPC classification number: F17D1/00 , B01L3/502738 , B01L2400/0661 , F16K99/0026 , F16K99/0059 , Y10T137/0379 , Y10T137/7737
Abstract: A microfluidic valve operable to semi-permanently close a channel of a microfluidic device defined between a thermoplastic elastomer (TPE) film and a substrate operates employs a surface contact bond between the TPE and a wall of the channel. Thermomechanical release of the valve, tristate functionality, and repeated semi-permanent closure and release are demonstrated.
Abstract translation: 用于半永久封闭限定在热塑性弹性体（TPE）膜和基板之间的微流体装置的通道的微流体阀操作使用TPE与通道的壁之间的表面接触键。 证明阀的热机械释放，三态功能和重复的半永久性闭合和释放。
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Patent Agency Ranking
6.发明授权Centrifugal microfluidic system for nucleic acid sample preparation, amplification, and detection 有权用于核酸样品制备，扩增和检测的离心微流体系统公开(公告)号：US08303911B2
公开(公告)日：2012-11-06
申请号：US12904794
申请日：2010-10-14
Applicant: Jonathan P. Siegrist , Robert A. Gorkin, III , Regis Peytavi , Marc Madou , Horacio Kido , Mary Amasia , Emmanuel Roy , Teodor Veres
Inventor： Jonathan P. Siegrist , Robert A. Gorkin, III , Regis Peytavi , Marc Madou , Horacio Kido , Mary Amasia , Emmanuel Roy , Teodor Veres
CPC classification number: B01L3/5027 , B01L7/52 , B01L2200/0621 , B01L2200/0647 , B01L2200/10 , B01L2300/0806 , B01L2300/087 , B01L2300/1822 , B01L2400/0406 , B01L2400/0409 , B01L2400/043 , G01N35/00069
Abstract: A microfluidic system for processing a sample includes a microfluidic CD in the form a rotatable disc, the disc containing a plurality of separate lysis chambers therein. A magnetic lysis blade and lysis beads are disposed in each of the lysis chambers and a plurality of stationary magnets are disposed adjacent to and separate from the microfluidic CD. The stationary magnets are configured to magnetically interact with each of the magnetic lysis blades upon rotation of the microfluidic CD. Each lysis chamber may have its own separate sample inlet port or, alternatively, the lysis chambers may be connected to one another with a single inlet port coupled to one of the lysis chambers. Downstream processing may include nucleic acid amplification using thermoelectric heating as well as detection using a nucleic acid microarray.
Abstract translation: 用于处理样品的微流体系统包括可旋转盘形式的微流体CD，所述盘在其中包含多个分离的裂解室。 在每个裂解室中设置磁性裂解刀片和溶解珠，并且多个静止磁体被布置成与微流体CD相邻并分离。 固定磁体配置为在微流体CD旋转时与每个磁性裂解叶片磁性相互作用。 每个裂解室可以具有其自己的单独的样品入口端口，或者可选地，裂解室可以通过与一个裂解室连接的单个入口相互连接。 下游处理可以包括使用热电加热的核酸扩增以及使用核酸微阵列的检测。
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公开(公告)号：US20140134631A1
公开(公告)日：2014-05-15
申请号：US14128079
申请日：2012-03-22
Applicant: Liviu Clime , Maxence Mounier , Emmanuel Roy , Teodor Veres
Inventor： Liviu Clime , Maxence Mounier , Emmanuel Roy , Teodor Veres
IPC: C12Q1/68
CPC classification number: C12Q1/686 , B01L3/502746 , B01L2200/0605 , B01L2300/0803 , B01L2300/0867 , B01L2300/0883 , B01L2400/0406 , B01L2400/0409 , B01L2400/084 , G01N35/00009
Abstract: A centrifugal microfluidic device is provided having a microfluidic circuit, a fluid reservoir for providing fluid in the microfluidic circuit, a hydrodynamic resistance element in fluid communication with the reservoir for controlling rate of flow of a fluid out of the reservoir, and a siphoned chamber in fluid communication with the hydrodynamic resistance element and the microfluidic circuit for receiving fluid from the hydrodynamic resistance element and for delaying and metering of the fluid into the microfluidic circuit. The microfluidic device is useful for performing a biological assay. Operation of the device is completely independent on the liquid-solid contact angle and wetting properties of the liquids on the solid material of the platform, and the device does not need a carefully controlled rotation protocol.
Abstract translation: 提供了具有微流体回路的离心微流体装置，用于在微流体回路中提供流体的流体储存器，与储存器流体连通的流体动力阻力元件，用于控制流体从储存器流出的速率，以及虹吸室 与流体动力阻力元件和用于从流体动力学阻力元件接收流体并用于将流体延迟和计量到微流体回路中的微流体回路的流体连通。 微流体装置可用于进行生物测定。 该装置的操作完全独立于平台的固体材料上的液体 - 液体接触角和润湿性能，并且该装置不需要仔细控制的旋转方案。
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8.发明申请3D Microfluidic Devices Based on Open-Through Thermoplastic Elastomer Membranes 有权基于开放式热塑性弹性体膜的3D微流体装置公开(公告)号：US20130317130A1
公开(公告)日：2013-11-28
申请号：US13985317
申请日：2011-02-15
Applicant: Daniel Brassard , Emmanuel Roy , Kebin Li , Teodor Veres
Inventor： Daniel Brassard , Emmanuel Roy , Kebin Li , Teodor Veres
IPC: B29C51/00
CPC classification number: B29C51/00 , B29C43/021 , B29C43/04 , B33Y80/00
Abstract: The invention provides a new process for patterning TPE membranes for use in the design and fabrication of 3D microfluidic devices. The process involves patterning a TPE material without permitting the highest features of the mold to come into contact with the counter-plate, whereby adhesion between the TPE and the mold or counter-plate during demolding results directly in removal of the excess layer from the TPE membrane to produce well formed micrometric-sized open-through holes in the TPE membrane. The process permits rapid, reliable and efficient patterning of densely packed and arbitrarily placed micrometric open-through holes and channels of high aspect-ratio and any shape or wall profile in thin TPE membranes.
Abstract translation: 本发明提供了用于图案化TPE膜的新工艺，用于设计和制造3D微流体装置。 该方法包括图案化TPE材料，而不允许模具的最高特征与反向板接触，由此在脱模期间TPE与模具或反向板之间的粘附直接导致从TPE中去除多余的层 膜以在TPE膜中产生良好形成的微米尺寸的开孔。 该方法允许在薄的TPE膜中快速，可靠和有效地构图密集包装和任意放置的微孔开孔和高纵横比以及任何形状或壁形的通道。
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9.发明申请CENTRIFUGAL MICROFLUIDIC SYSTEM FOR NUCLEIC ACID SAMPLE PREPARATION, AMPLIFICATION, AND DETECTION 有权用于核酸样品制备，放大和检测的离心微流控系统公开(公告)号：US20110111987A1
公开(公告)日：2011-05-12
申请号：US12904794
申请日：2010-10-14
Applicant: Jonathan Siegrist , Robert A. Gorkin, III , Regis Peytavi , Marc Madou , Horacio Kido , Mary Amasia , Emmanuel Roy , Teodor Veres
Inventor： Jonathan Siegrist , Robert A. Gorkin, III , Regis Peytavi , Marc Madou , Horacio Kido , Mary Amasia , Emmanuel Roy , Teodor Veres
CPC classification number: B01L3/5027 , B01L7/52 , B01L2200/0621 , B01L2200/0647 , B01L2200/10 , B01L2300/0806 , B01L2300/087 , B01L2300/1822 , B01L2400/0406 , B01L2400/0409 , B01L2400/043 , G01N35/00069
Abstract: A microfluidic system for processing a sample includes a microfluidic CD in the form a rotatable disc, the disc containing a plurality of separate lysis chambers therein. A magnetic lysis blade and lysis beads are disposed in each of the lysis chambers and a plurality of stationary magnets are disposed adjacent to and separate from the microfluidic CD. The stationary magnets are configured to magnetically interact with each of the magnetic lysis blades upon rotation of the microfluidic CD. Each lysis chamber may have its own separate sample inlet port or, alternatively, the lysis chambers may be connected to one another with a single inlet port coupled to one of the lysis chambers. Downstream processing may include nucleic acid amplification using thermoelectric heating as well as detection using a nucleic acid microarray.
Abstract translation: 用于处理样品的微流体系统包括可旋转盘形式的微流体CD，所述盘在其中包含多个分离的裂解室。 在每个裂解室中设置磁性裂解刀片和溶解珠，并且多个静止磁体被布置成与微流体CD相邻并分离。 固定磁体配置为在微流体CD旋转时与每个磁性裂解叶片磁性相互作用。 每个裂解室可以具有其自己的单独的样品入口端口，或者可选地，裂解室可以通过与一个裂解室连接的单个入口相互连接。 下游处理可以包括使用热电加热的核酸扩增以及使用核酸微阵列的检测。
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10.发明申请Microdevice for a Fluorescence-based Assay, and a Method for Making the Microdevice 有权用于基于荧光的测定的微型设备以及制造微型设备的方法公开(公告)号：US20080124246A1
公开(公告)日：2008-05-29
申请号：US11563011
申请日：2006-11-23
Applicant: Gerardo A. Diaz-Quijada , Teodor Veres
Inventor： Gerardo A. Diaz-Quijada , Teodor Veres
IPC: G01N21/64
CPC classification number: G01N21/6452 , Y10T156/10
Abstract: Glass as a substrate for fluorescence-based assays is expensive. Disclosed is a poly(cyclic olefin) alternative to glass that is of comparable sensitivity. More specifically, disclosed is a method of making a microdevice for the immobilization of biomolecules for the purpose of carrying out a fluorescence-based assay, said method comprising providing a substrate comprising a poly(cyclic olefin); protecting the substrate from ultraviolet (UV) light; and subjecting a surface of said UV-protected substrate to ozone oxidation to activate said surface; wherein a content of intrinsic fluorophores on the surface of the substrate remains substantially unchanged after the ozone oxidation. Also disclosed is a microdevice for the immobilization of biomolecules for the purpose of carrying out a fluorescence-based assay, said microdevice comprising a body comprising a poly(cyclic olefin), said body having an ozone-activated surface substantially free of intrinsic fluorophores; wherein said activated surface is substantially free of intrinsic fluorescence during a fluorescence-based assay of said biomolecules bound to said activated surface.
Abstract translation: 玻璃作为荧光基分析的底物是昂贵的。 公开了具有相当灵敏度的玻璃的聚（环烯烃）替代物。 更具体地，公开了制备用于固定生物分子的微型装置以进行基于荧光的测定的方法，所述方法包括提供包含聚（环状烯烃）的基材; 保护基材免受紫外线（UV）光的影响; 并使所述受UV保护的基板的表面经受臭氧氧化以激活所述表面; 其中在臭氧氧化之后，基材表面上的固有荧光团的含量基本上保持不变。 还公开了用于固定生物分子以用于进行基于荧光的测定的微装置，所述微装置包括包含聚（环烯烃）的主体，所述主体具有基本上不含固有荧光团的臭氧活化表面; 其中所述活化表面在与所述活化表面结合的所述生物分子的基于荧光的测定中基本上不含固有荧光。
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