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1.发明授权Poxvirus-canine distemper virus (CDV) recombinants and compositions and methods employing the recombinants 失效疱疹病毒 - 犬瘟热病毒（CDV）重组体和使用重组体的组合物和方法
公开(公告)号：US5756102A
公开(公告)日：1998-05-26
申请号：US224657
申请日：1994-04-06
申请人： Enzo Paoletti , James Tartaglia , Jill Taylor
发明人： Enzo Paoletti , James Tartaglia , Jill Taylor
IPC分类号： C12N15/09 , A61K39/175 , A61K39/275 , A61K39/285 , A61P31/12 , C07K14/11 , C07K14/115 , C07K14/12 , C07K14/125 , C07K14/13 , C07K14/145 , C12N7/01 , C12N7/04 , C12N15/863 , C12P21/02
CPC分类号： C12N15/86 , C07K14/005 , C12N2710/24043 , C12N2710/24143 , C12N2760/16122 , C12N2760/18122 , C12N2760/18422 , C12N2760/18722 , C12N2760/20122
摘要： Attenuated recombinant viruses containing DNA coding for a canine distemper virus antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The DNA can code for at least one of: canine distemper virus fusion protein and canine distemper virus hemagglutinin glycoprotein. The recombinant viruses and gene products therefrom are useful for eliciting protection against canine distemper virus.
摘要翻译： 含有编码犬瘟热病毒抗原的DNA的减毒重组病毒以及使用该病毒的方法和组合物被公开并要求保护。 重组病毒可以是NYVAC或ALVAC重组病毒。 DNA可编码以下至少一种：犬瘟热病毒融合蛋白和犬瘟热病毒血凝素糖蛋白。 重组病毒及其基因产物可用于引发针对犬瘟热病毒的保护。
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公开(公告)号：US5494807A
公开(公告)日：1996-02-27
申请号：US105483
申请日：1993-08-12
申请人： Enzo Paoletti , Marion E. Perkus , Jill Taylor , James Tartaglia , Elizabeth K. Norton , Michel Riviere , Charles de Taisne , Keith J. Limbach , Gerard P. Johnson , Steven E. Pincus , William I. Cox , Jean-Christophe F. Audonnet , Russell R. Gettig
发明人： Enzo Paoletti , Marion E. Perkus , Jill Taylor , James Tartaglia , Elizabeth K. Norton , Michel Riviere , Charles de Taisne , Keith J. Limbach , Gerard P. Johnson , Steven E. Pincus , William I. Cox , Jean-Christophe F. Audonnet , Russell R. Gettig
IPC分类号： A61K39/12 , A61K39/00 , A61K39/08 , A61K39/15 , A61K39/165 , A61K39/17 , A61K39/175 , A61K39/205 , A61K39/21 , A61K39/23 , A61K39/245 , A61K39/275 , A61K39/285 , A61K39/29 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , C07H21/04 , C07K1/00 , C07K14/015 , C07K14/02 , C07K14/03 , C07K14/035 , C07K14/045 , C07K14/05 , C07K14/06 , C07K14/065 , C07K14/07 , C07K14/11 , C07K14/12 , C07K14/125 , C07K14/145 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/175 , C07K14/18 , C07K14/33 , C12N7/00 , C12N7/01 , C12N7/04 , C12N7/08 , C12N15/00 , C12N15/09 , C12N15/86 , C12N15/863 , C12P21/06 , C12R1/93 , A61K39/295 , C12N15/63
CPC分类号： C12N15/86 , C07K14/005 , C07K14/33 , A61K2039/5254 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2710/16122 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12122 , C12N2760/16122 , C12N2760/18122 , C12N2760/18422 , C12N2760/18722 , C12N2760/20122 , C12N2770/24122 , C12N2770/24322 , Y10S530/826
摘要： What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
摘要翻译： 描述的是具有增强的安全性的修饰载体，例如重组痘病毒，特别是重组痘苗病毒。 修饰的重组病毒具有在其中灭活的非必需病毒编码的遗传功能，使得病毒具有减毒毒力。 在一个实施方案中，通过删除编码毒力因子的开放阅读框来使遗传功能失活。 在另一个实施方案中，通过插入失活编码毒力因子的开放阅读框来使遗传功能失活。 还描述了含有在其中灭活的非必需病毒编码的遗传功能的修饰的重组病毒的疫苗，使得疫苗与已知重组病毒疫苗相比具有提高的安全性水平。
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公开(公告)号：US5891442A
公开(公告)日：1999-04-06
申请号：US480697
申请日：1995-06-07
申请人： Enzo Paoletti , Jill Taylor , Russell Gettig
发明人： Enzo Paoletti , Jill Taylor , Russell Gettig
IPC分类号： A61K39/285 , A61K39/00 , A61P31/12 , C07K14/08 , C12N15/863 , C12P21/02 , C12R1/92 , A61K39/12 , C07H21/02 , C12N15/00 , C12P21/06
CPC分类号： C12N7/00 , C07K14/005 , C12N15/86 , A61K2039/525 , A61K39/00 , C12N2710/10222 , C12N2710/24043 , C12N2720/10022
摘要： What is described is a recombinant poxvirus, such as fowlpox virus, containing foreign DNA from infectious bursal disease virus. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine.
摘要翻译： 描述的是重组痘病毒，如禽痘病毒，含有传染性法氏囊病病毒的外来DNA。 还描述了含有用于在接种疫苗的宿主动物中诱导免疫应答的重组痘病毒的疫苗。
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公开(公告)号：US5766599A
公开(公告)日：1998-06-16
申请号：US458101
申请日：1995-06-01
申请人： Enzo Paoletti , Marion E. Perkus , Jill Taylor , James Tartaglia , Elizabeth K. Norton , Michel Riviere , Charles de Taisne , Keith J. Limbach , Gerard P. Johnson , Steven E. Pincus , William I. Cox , Jean-Christophe Francis Audonnet , Russell Robert Gettig
发明人： Enzo Paoletti , Marion E. Perkus , Jill Taylor , James Tartaglia , Elizabeth K. Norton , Michel Riviere , Charles de Taisne , Keith J. Limbach , Gerard P. Johnson , Steven E. Pincus , William I. Cox , Jean-Christophe Francis Audonnet , Russell Robert Gettig
IPC分类号： A61K39/12 , A61K39/00 , A61K39/08 , A61K39/15 , A61K39/165 , A61K39/17 , A61K39/175 , A61K39/205 , A61K39/21 , A61K39/23 , A61K39/245 , A61K39/275 , A61K39/285 , A61K39/29 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , C07H21/04 , C07K1/00 , C07K14/015 , C07K14/02 , C07K14/03 , C07K14/035 , C07K14/045 , C07K14/05 , C07K14/06 , C07K14/065 , C07K14/07 , C07K14/11 , C07K14/12 , C07K14/125 , C07K14/145 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/175 , C07K14/18 , C07K14/33 , C12N7/00 , C12N7/01 , C12N7/04 , C12N7/08 , C12N15/00 , C12N15/09 , C12N15/86 , C12N15/863 , C12P21/06 , C12R1/93
CPC分类号： C12N15/86 , C07K14/005 , C07K14/33 , A61K2039/5254 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2710/16122 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12122 , C12N2760/16122 , C12N2760/18122 , C12N2760/18422 , C12N2760/18722 , C12N2760/20122 , C12N2770/24122 , C12N2770/24322 , Y10S530/826
摘要： What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
摘要翻译： 描述的是具有增强的安全性的修饰载体，例如重组痘病毒，特别是重组痘苗病毒。 修饰的重组病毒具有在其中灭活的非必需病毒编码的遗传功能，使得病毒具有减毒毒力。 在一个实施方案中，通过删除编码毒力因子的开放阅读框来使遗传功能失活。 在另一个实施方案中，通过插入失活编码毒力因子的开放阅读框来使遗传功能失活。 还描述了含有在其中灭活的非必需病毒编码的遗传功能的修饰的重组病毒的疫苗，使得疫苗与已知重组病毒疫苗相比具有提高的安全性水平。
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公开(公告)号：US5762938A
公开(公告)日：1998-06-09
申请号：US709209
申请日：1996-08-21
申请人： Enzo Paoletti , Marion E. Perkus , Jill Taylor , James Tartaglia , Elizabeth K. Norton , Michel Riviere , Charles de Taisne , Keith J. Limbach , Gerard P. Johnson , Steven E. Pincus , William I. Cox , Jean-Christophe Francis Audonnet , Russell Robert Gettig
发明人： Enzo Paoletti , Marion E. Perkus , Jill Taylor , James Tartaglia , Elizabeth K. Norton , Michel Riviere , Charles de Taisne , Keith J. Limbach , Gerard P. Johnson , Steven E. Pincus , William I. Cox , Jean-Christophe Francis Audonnet , Russell Robert Gettig
IPC分类号： A61K39/12 , A61K39/00 , A61K39/08 , A61K39/15 , A61K39/165 , A61K39/17 , A61K39/175 , A61K39/205 , A61K39/21 , A61K39/23 , A61K39/245 , A61K39/275 , A61K39/285 , A61K39/29 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , C07H21/04 , C07K1/00 , C07K14/015 , C07K14/02 , C07K14/03 , C07K14/035 , C07K14/045 , C07K14/05 , C07K14/06 , C07K14/065 , C07K14/07 , C07K14/11 , C07K14/12 , C07K14/125 , C07K14/145 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/175 , C07K14/18 , C07K14/33 , C12N7/00 , C12N7/01 , C12N7/04 , C12N7/08 , C12N15/00 , C12N15/09 , C12N15/86 , C12N15/863 , C12P21/06 , C12R1/93
CPC分类号： C12N15/86 , C07K14/005 , C07K14/33 , A61K2039/5254 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2710/16122 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12122 , C12N2760/16122 , C12N2760/18122 , C12N2760/18422 , C12N2760/18722 , C12N2760/20122 , C12N2770/24122 , C12N2770/24322 , Y10S530/826
摘要： What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
摘要翻译： 描述的是具有增强的安全性的修饰载体，例如重组痘病毒，特别是重组痘苗病毒。 修饰的重组病毒具有在其中灭活的非必需病毒编码的遗传功能，使得病毒具有减毒毒力。 在一个实施方案中，通过删除编码毒力因子的开放阅读框来使遗传功能失活。 在另一个实施方案中，通过插入失活编码毒力因子的开放阅读框来使遗传功能失活。 还描述了含有在其中灭活的非必需病毒编码的遗传功能的修饰的重组病毒的疫苗，使得疫苗与已知重组病毒疫苗相比具有提高的安全性水平。
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公开(公告)号：US5759552A
公开(公告)日：1998-06-02
申请号：US207792
申请日：1994-03-07
申请人： Enzo Paoletti , Jill Taylor , James Tartaglia , Louis Ross
发明人： Enzo Paoletti , Jill Taylor , James Tartaglia , Louis Ross
IPC分类号： A61K39/255 , A61K39/275 , A61K39/295 , C12N7/01 , C12N15/86
CPC分类号： A61K39/255 , A61K39/12 , C12N7/00 , A61K2039/5256 , C12N2710/16334 , C12N2710/24143 , C12N2710/24161
摘要： What is described is a recombinant poxvirus, such as vaccinia virus or fowlpox virus, containing foreign DNA from Marek's disease virus. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine.
摘要翻译： 描述的是重组痘病毒，如痘苗病毒或禽痘病毒，含有马立克氏病病毒的外来DNA。 还描述了含有用于在接种疫苗的宿主动物中诱导免疫应答的重组痘病毒的疫苗。
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7.发明授权Poxvirus—canine dispemper virus (CDV) or measles virus recombinants and compositions and methods employing the recombinants 有权疱疹病毒 - 犬瘟热病毒（CDV）或麻疹病毒重组体以及使用重组体的组合物和方法公开(公告)号：US06309647B1
公开(公告)日：2001-10-30
申请号：US09354138
申请日：1999-07-15
申请人： Enzo Paoletti , James Tartaglia , Jill Taylor , Russell Gettig
发明人： Enzo Paoletti , James Tartaglia , Jill Taylor , Russell Gettig
IPC分类号： A61K39275
CPC分类号： C12N15/86 , A61K39/00 , A61K2039/525 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C07K14/33 , C07K2319/00 , C12N2710/16122 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12022 , C12N2760/16122 , C12N2760/18122 , C12N2760/18422 , C12N2760/18722 , C12N2760/20122 , C12N2770/24022 , C12N2770/24122
摘要： Attenuated recombinant viruses containing DNA coding for a canine distemper virus antigen or measles M or N antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The DNA can code for at least one of: canine distemper virus fusion protein, canine distemper virus hemagglutinin glycoprotein, canine distemper nucleocaspid protein, canine distemper matrix protein, measles virus nucleocaspid protein, and measles virus matrix protein. The recombinant viruses and gene products therefrom are useful for eliciting protection against canine distemper virus and/or measles virus, and, the gene products and antibodies elicited thereby are useful in assays. Additionally, DNA from the recombinants is used for probes or for generating PCR primers.
摘要翻译： 包含编码犬瘟热病毒抗原或麻疹M或N抗原的DNA的减毒重组病毒以及使用病毒的方法和组合物被公开和要求保护。 重组病毒可以是NYVAC或ALVAC重组病毒。 DNA可以编码以下至少一种：犬瘟热病毒融合蛋白，犬瘟热病毒血凝素糖蛋白，犬瘟热核心蛋白蛋白，犬瘟热蛋白基因蛋白，麻疹病毒核壳蛋白和麻疹病毒基质蛋白。 重组病毒及其基因产物可用于引发针对犬瘟热病毒和/或麻疹病毒的保护，由此引发的基因产物和抗体可用于测定。 此外，来自重组体的DNA用于探针或产生PCR引物。
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公开(公告)号：US5759553A
公开(公告)日：1998-06-02
申请号：US475063
申请日：1995-06-07
申请人： Enzo Paoletti , Jill Taylor , James Tartaglia , Louis Ross
发明人： Enzo Paoletti , Jill Taylor , James Tartaglia , Louis Ross
IPC分类号： A61K39/255 , A61K39/275 , A61K39/295 , C12N7/01 , C12N15/86
CPC分类号： A61K39/255 , A61K39/12 , C12N7/00 , A61K2039/5256 , C12N2710/16334 , C12N2710/24143 , C12N2710/24161
摘要： What is described is a recombinant poxvirus, such as vaccinia virus or fowlpox virus, containing foreign DNA from Marek's disease virus. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine.
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公开(公告)号：US5503834A
公开(公告)日：1996-04-02
申请号：US73962
申请日：1993-06-08
申请人： Enzo Paoletti , Jill Taylor
发明人： Enzo Paoletti , Jill Taylor
IPC分类号： A61K39/00 , C07K14/015 , C07K14/02 , C07K14/03 , C07K14/035 , C07K14/045 , C07K14/05 , C07K14/06 , C07K14/065 , C07K14/07 , C07K14/11 , C07K14/12 , C07K14/125 , C07K14/145 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/175 , C07K14/18 , C07K14/33 , C12N15/863 , A61K39/165 , A61K39/175 , A61K39/285 , C12N7/01
CPC分类号： C12N15/86 , C07K14/005 , C07K14/33 , A61K2039/525 , A61K2039/5254 , A61K2039/53 , A61K39/00 , C07K2319/00 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12022 , C12N2760/16122 , C12N2760/18122 , C12N2760/18722 , C12N2760/20022 , C12N2770/24022 , C12N2770/24122
摘要： What is described is a recombinant poxvirus, such as vaccinia virus or canarypox virus, containing foreign DNA from Morbillivirus. In one embodiment, the foreign DNA is expressed in a host by the production of a measles virus glycoprotein. In another embodiment, the foreign DNA is expressed in a host by the production of at least two measles virus glycoproteins. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine. By the present invention, cross-protection of dogs against canine distemper is obtained by inoculating the dog with the recombinant poxvirus.
摘要翻译： 描述的是重组痘病毒，例如痘苗病毒或金丝雀痘病毒，含有来自莫尔病毒的外来DNA。 在一个实施方案中，外源DNA通过产生麻疹病毒糖蛋白在宿主中表达。 在另一个实施方案中，外源DNA通过产生至少两种麻疹病毒糖蛋白在宿主中表达。 还描述了含有用于在接种疫苗的宿主动物中诱导免疫应答的重组痘病毒的疫苗。 通过本发明，通过用重组痘病毒接种狗获得狗对犬瘟热的交叉保护。
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10.发明授权Poxvirus-rabies recombinants and compositions and methods employing the recombinants 有权痘病毒狂犬病重组体，以及采用重组体的组合物和方法公开(公告)号：US07144578B2
公开(公告)日：2006-12-05
申请号：US09951061
申请日：2001-09-13
申请人： Enzo Paoletti , James Tartaglia , Jill Taylor , Russell Gettig
发明人： Enzo Paoletti , James Tartaglia , Jill Taylor , Russell Gettig
IPC分类号： A61K39/275 , A61K39/285 , C12N7/01 , C12N15/863 , C12N15/47
CPC分类号： C12N15/86 , A61K39/00 , A61K2039/525 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C07K14/33 , C07K2319/00 , C12N2710/16122 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12022 , C12N2760/16122 , C12N2760/18122 , C12N2760/18422 , C12N2760/18722 , C12N2760/20122 , C12N2770/24022 , C12N2770/24122
摘要： Recombinant viruses containing DNA coding for a rabies virus antigen, such as rabies virus G are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The recombinant viruses and gene products therefrom are useful for eliciting an immunological against rabies virus, and, the gene products and antibodies elicited thereby are useful in assays.
摘要翻译： 含有编码狂犬病病毒抗原的DNA的狂犬病病毒G的重组病毒被公开并要求保护。 重组病毒可以是NYVAC或ALVAC重组病毒。 重组病毒及其基因产物可用于引发针对狂犬病病毒的免疫学，并且由此引发的基因产物和抗体可用于测定。
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