公开(公告)号：US07226384B2

公开(公告)日：2007-06-05

申请号：US11061106

申请日：2005-02-18

申请人： Eric S. Tryon ,  Joel E. Mowatt ,  James A. Raszkowski ,  Richard L. Wagner

发明人： Eric S. Tryon ,  Joel E. Mowatt ,  James A. Raszkowski ,  Richard L. Wagner

IPC分类号： B60W30/20 ,  F16D3/14

CPC分类号： F16H57/04 ,  B60K17/12 ,  F16D25/0638 ,  F16F15/12353 ,  F16H3/728 ,  Y10T477/26

摘要： The present invention relates to a torsional damper for an electrically-variable transmission. The torsional damper is equipped with a lock-out clutch to directly couple the engine to the input shaft of the transmission. The electric motors provided with the electrically-variable transmission can serve to effectively cancel out engine compression pulses when the springs of the torsional damper are locked out. The present invention also includes damper springs of variable rates to effectively attenuate distinctive or inconsistent torque fluctuations when the engine is operating in displacement-on-demand mode.

摘要翻译： 本发明涉及一种用于电动变速器的扭转阻尼器。 扭转阻尼器装有一个锁定离合器，用于将发动机直接联接到变速器的输入轴上。 设置有电动变速器的电动机可以在扭转阻尼器的弹簧被锁定时有效地抵消发动机压缩脉冲。 本发明还包括具有可变速率的减震弹簧，以便当发动机以逐点放电模式运行时有效地衰减特征或不一致的转矩波动。

公开(公告)号：US06236946B1

公开(公告)日：2001-05-22

申请号：US08764870

申请日：1996-12-13

申请人： Thomas S. Scanlan ,  John D. Baxter ,  Robert J. Fletterick ,  Richard L. Wagner ,  Peter J. Kushner ,  James Apriletti ,  Brian West ,  Andrew K. Shiau

发明人： Thomas S. Scanlan ,  John D. Baxter ,  Robert J. Fletterick ,  Richard L. Wagner ,  Peter J. Kushner ,  James Apriletti ,  Brian West ,  Andrew K. Shiau

IPC分类号： G06F1900

CPC分类号： C07K14/72 ,  C07K2299/00

摘要： The present invention provides new methods, particularly computational methods, and compositions for the generation of nuclear receptor synthetic ligands based on the three dimensional structure of nuclear receptors, particularly the thyroid receptor (herein referred to as “TR”). Also provided are crystals, nuclear receptor synthetic ligands, and related methods.

摘要翻译： 本发明提供了基于核受体，特别是甲状腺受体（本文中称为“TR”）的三维结构产生核受体合成配体的新方法，特别是计算方法和组合物。 还提供了晶体，核受体合成配体和相关方法。

公开(公告)号：US5234278A

公开(公告)日：1993-08-10

申请号：US723985

申请日：1991-07-01

申请人： Arthur Hall, III ,  Richard L. Wagner

发明人： Arthur Hall, III ,  Richard L. Wagner

IPC分类号： B60K17/02 ,  F16D1/072 ,  F16H41/24

CPC分类号： B60K17/02 ,  F16D1/072 ,  F16H41/24 ,  F16D2001/103 ,  Y10T403/58 ,  Y10T403/60 ,  Y10T403/7033

摘要： A drive connection between an engine and transmission has an internally splined flywheel drivingly connected to the engine and an externally splined driven member connected to the transmission and engaging the flywheel spline. A retainer ring includes a tab member which is disposed in a slot in the flywheel to maintain the spline connection. The tab has an area which is deformable after assembly to engage a recess formed in a wall of the slot to resist relative rotation between the retainer ring and the flywheel.

摘要翻译： 发动机和变速器之间的驱动连接具有驱动地连接到发动机的内花键飞轮和连接到变速器并与飞轮花键接合的外花键从动构件。 保持环包括突片构件，其设置在飞轮中的狭槽中以维持花键连接。 突片具有在组装之后可变形以接合形成在槽的壁中的凹部以抵抗保持环和飞轮之间的相对旋转的区域。

公开(公告)号：US06266622B1

公开(公告)日：2001-07-24

申请号：US08980115

申请日：1997-11-26

申请人： Thomas S. Scanlan ,  John D. Baxter ,  Robert J. Fletterick ,  Richard L. Wagner ,  Peter J. Kushner ,  James J. Apriletti ,  Brian L. West ,  Andrew K. Shiau

发明人： Thomas S. Scanlan ,  John D. Baxter ,  Robert J. Fletterick ,  Richard L. Wagner ,  Peter J. Kushner ,  James J. Apriletti ,  Brian L. West ,  Andrew K. Shiau

IPC分类号： G06F1900

CPC分类号： C07K14/723 ,  A61K31/192 ,  A61K31/195 ,  A61K31/198 ,  A61K31/27 ,  C07K14/72 ,  C07K2299/00 ,  G01N33/68 ,  G01N33/78 ,  G01N2333/723 ,  G01N2500/04 ,  G06F19/16

摘要： The present invention provides new methods, particularly computational methods, and compositions for the generation of nuclear receptor synthetic ligands based on the three dimensional structure of nuclear receptors, particularly the thyroid receptor (herein referred to as “TR”). Also provided are crystals, nuclear receptor synthetic ligands, and related methods.

公开(公告)号：US5016694A

公开(公告)日：1991-05-21

申请号：US491265

申请日：1990-03-09

申请人： Richard L. Wagner ,  William C. Weber

发明人： Richard L. Wagner ,  William C. Weber

IPC分类号： A47B87/00 ,  B25B5/10 ,  B25B5/14 ,  B25B5/16 ,  F16B2/06 ,  F16B12/18

CPC分类号： B25B5/163 ,  A47B87/002 ,  B25B5/10 ,  B25B5/142 ,  F16B12/18 ,  F16B2/065

摘要： A clamping assembly with at least two clamping members with inner surfaces facing towards each other and outer surfaces facing away from each other, a bolt passes through holes formed in the clamping members, the bolt including a bolt head and a threaded section, the inner surfaces including means for gripping work surface, such that when the bolt is tightened, work pieces are clamped together.

摘要翻译： 一种具有至少两个夹紧构件的夹持组件，其内表面彼此面对并且彼此背离的外表面，螺栓穿过形成在夹紧构件中的孔，螺栓包括螺栓头和螺纹部分，内表面 包括用于夹紧工作表面的装置，使得当螺栓被紧固时，工件被夹紧在一起。

公开(公告)号：US06965850B2

公开(公告)日：2005-11-15

申请号：US09281717

申请日：1999-03-30

申请人： John D. Baxter ,  Beatrice Darimont ,  Weijun Feng ,  Robert J. Fletterick ,  Peter J. Kushner ,  Richard L. Wagner ,  Brian L. West ,  Keith R. Yamamoto

发明人： John D. Baxter ,  Beatrice Darimont ,  Weijun Feng ,  Robert J. Fletterick ,  Peter J. Kushner ,  Richard L. Wagner ,  Brian L. West ,  Keith R. Yamamoto

IPC分类号： G01N33/53 ,  C07K14/47 ,  C07K14/705 ,  C12N15/09 ,  G01N33/00 ,  G01N33/15 ,  G01N33/50 ,  G01N33/68 ,  G06F17/30 ,  G06F17/50 ,  H01L21/3065 ,  H01L21/314 ,  H01L21/336 ,  G06N7/00 ,  G06G7/58

CPC分类号： H01L21/3065 ,  G01N33/6875 ,  G01N2500/20 ,  H01L21/314 ,  H01L29/6659

摘要： The present invention relates to methods and agonist/antagonist compounds for modulating nuclear receptor coactivator binding. The invention includes a method for identifying residues comprising a coactivator binding site for a nuclear receptor of interest. Also included is a method of identifying agonists and/or antagonists that bind to a coactivator binding site of a nuclear receptor of interest. Agonists and antagonists of coactivator binding to nuclear receptors also are provided. The invention is exemplified by identification and manipulation of the coactivator binding site of the thyroid receptor (TR), and compounds that bind to this sites. The methods can be applied to other nuclear receptors including RAR, RXR, PPAR, VDR, ER, GR, PR, MR, and AR.

摘要翻译： 本发明涉及用于调节核受体共激活因子结合的方法和激动剂/拮抗剂化合物。 本发明包括用于鉴定残留物的方法，所述残基包含感兴趣的核受体的共激活子结合位点。 还包括鉴定结合感兴趣的核受体的共激活子结合位点的激动剂和/或拮抗剂的方法。 共激活剂与核受体结合的激动剂和拮抗剂也被提供。 本发明通过甲状腺受体（TR）的共激活因子结合位点的鉴定和操作以及与该位点结合的化合物来举例说明。 该方法可应用于其他核受体，包括RAR，RXR，PPAR，VDR，ER，GR，PR，MR和AR。

公开(公告)号：US07018318B2

公开(公告)日：2006-03-28

申请号：US10819448

申请日：2004-04-07

申请人： Donald Klemen ,  Richard L. Wagner

发明人： Donald Klemen ,  Richard L. Wagner

IPC分类号： F16H3/62

CPC分类号： F16H3/666 ,  F16H3/663 ,  F16H2200/0056 ,  F16H2200/2007 ,  F16H2200/2023 ,  F16H2200/2097

摘要： A seven-speed transmission includes an input shaft, an output shaft, and three planetary gear sets. An interconnecting member continuously connects members of the second and third planetary gear sets. Six torque-transmitting mechanisms are provided between the planetary gear sets and a transmission housing. The six torque-transmitting mechanisms are engaged in combinations of two to establish seven forward speed ratios and a reverse speed ratio between the input shaft and the output shaft. A unique engagement sequence is provided for the torque-transmitting mechanisms to minimize sun gear loading.

摘要翻译： 七速变速器包括输入轴，输出轴和三个行星齿轮组。 互连构件连续地连接第二和第三行星齿轮组的构件。 在行星齿轮组和变速器壳体之间设有六个扭矩传递机构。 六个扭矩传递机构以两种组合结合，以在输入轴和输出轴之间建立七个前进速度比和倒档速度比。 为扭矩传递机构提供独特的接合顺序，以尽量减少太阳齿轮的负载。