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公开(公告)号：US4371530A
公开(公告)日：1983-02-01
申请号：US279825
申请日：1981-07-02
IPC分类号： C07D295/14 , A61K31/4433 , A61K31/445 , A61K31/535 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P11/08 , A61P43/00 , C07C17/16 , C07C29/147 , C07C67/00 , C07C401/00 , C07C405/00 , C07D267/10 , C07D267/20 , C07D295/116 , C07D295/155 , C07D307/935 , C07D309/12 , C07D311/00 , C07D333/12 , C07D333/16 , C07D333/22 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14
CPC分类号： C07D295/116 , C07C29/147 , C07C405/0041 , C07D267/10 , C07D295/155 , C07D307/935 , C07D309/12 , C07D311/00 , C07D333/12 , C07D333/16 , C07D333/22
摘要： Compounds are described of the formula ##STR1## in which R.sup.1 is unsubstituted or substituted phenylalkyl, thienylalkyl or naphthylalkyl, or cinnamyl;R.sup.2 is a hydrogen atom, methyl or alkyl substituted by alkoxy or --COOH;W is alkylene;X is cis or trans --CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --; andY is a saturated heterocyclic amino group having 5-8 ring members;and their salts and solvates.These compounds inhibit blood platelet aggregation and bronchoconstriction and may be formulated for use as antithrombotic and anti-asthmatic agents.
摘要翻译： 描述了式（1）的化合物，其中R 1是未取代的或取代的苯基烷基，噻吩基烷基或萘基烷基或肉桂基; R2是氢原子，甲基或被烷氧基或-COOH取代的烷基; W是亚烷基; X为顺式或反式-CH = CH-或-CH 2 CH 2 - ; Y是具有5-8个环成员的饱和杂环氨基; 及其盐和溶剂合物。 这些化合物抑制血小板聚集和支气管收缩，并可配制用作抗血栓形成和抗哮喘药。
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公开(公告)号：US4613597A
公开(公告)日：1986-09-23
申请号：US647537
申请日：1984-09-05
IPC分类号： C07C405/00 , C07D295/096 , C07D295/112 , C07D295/155 , C07D333/16 , C07D521/00 , C07F7/18 , A61K31/55 , C07D295/08 , C07D295/10
CPC分类号： C07D295/096 , C07C405/0041 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/112 , C07D295/155 , C07D333/16 , C07F7/1896
摘要： Compounds are described of the formulae (1a) and 1b) ##STR1## in which: R.sup.1 is -H, C.sub.1-6 alkyl or C.sub.7-10 aralkyl,W is C.sub.1-7 alkyleneX is cis or trans --CH.dbd.CH--,Y is a saturated heterocyclic amino group having 5-8 ring members,R.sup.2 is (i) substituted or unsubstituted phenylalkyl, thienylalkyl or naphthylalkyl or (ii) cinnamyl, and Z is --CH.sub.2 OH, --CHO or --CONHR.sup.4 where R.sup.4 is --H or methyl,and their salts and solvates.These compounds inhibit blood platelet aggregation, bronchoconstriction and vasoconstriction, and may be formulated for use as antithrombotic and antiasthmatic agents.
摘要翻译： 化合物由式（1a）和1b）描述：其中：R 1是-H，C 1-6烷基或C 7-10芳烷基，W是C 1-7亚烷基，X是顺式或反式-CH = CH-， Y是具有5-8个环成员的饱和杂环氨基，R2是（i）取代或未取代的苯基烷基，噻吩基烷基或萘基烷基或（ii）肉桂基，Z是-CH 2 OH，-CHO或-CONHR 4，其中R 4是-H或 甲基及其盐和溶剂合物。 这些化合物抑制血小板聚集，支气管收缩和血管收缩，并且可以配制用作抗血栓形成和抗哮喘药。
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3.发明授权
公开(公告)号：US4977163A
公开(公告)日：1990-12-11
申请号：US183293
申请日：1988-04-11
IPC分类号： A61K31/33 , C07C405/00 , C07D295/112 , C07D295/116 , C07D295/14 , C07D295/155 , C07D307/00 , C07D309/12 , C07D333/16 , C07D405/08 , C07D413/08 , C07D413/12
CPC分类号： C07D295/112 , C07C405/0041 , C07D295/116 , C07D295/155 , C07D307/00 , C07D309/12 , C07D333/16
摘要： Compounds are described of the formula ##STR1## in which R.sup.1 is H, C.sub.1-6 alkyl or C.sub.7-10 aralkyl;W is C.sub.1-7 alkylene;X is cis or trans --CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --;n is 1 or 2;Y is a saturated heterocyclic amino group having 5-8 ring members;R.sup.2 is (i) substituted or unsubstituted phenylalkyl, thienylalkyl or naphthylalkyl or (ii) substituted or unsubstituted cinnamyl; and their salts and solvates.These compounds inhibit blood platelet aggregation and bronchoconstriction and may be formulated for use as antithrombotic and antiasthmatic agents.
摘要翻译： 化合物描述为其中R 1是H，C 1-6烷基或C 7-10芳烷基的式“IMAGE”; W是C 1-7亚烷基; X为顺式或反式-CH = CH-或-CH 2 CH 2 - ; n为1或2; Y是具有5-8个环成员的饱和杂环氨基; R2是（i）取代或未取代的苯基烷基，噻吩基烷基或萘基烷基或（ii）取代或未取代的肉桂基; 及其盐和溶剂合物。 这些化合物抑制血小板聚集和支气管收缩，并且可以配制用作抗血栓形成和抗哮喘药。
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4.发明授权
公开(公告)号：US4342756A
公开(公告)日：1982-08-03
申请号：US258721
申请日：1981-04-29
IPC分类号： B29C55/02 , A61K31/38 , A61K31/381 , A61K31/445 , A61K31/535 , A61K31/5375 , A61K31/54 , A61K31/55 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/08 , A61P27/02 , A61P43/00 , B29C49/00 , B29C55/00 , B29C55/18 , B29K67/00 , B29L7/00 , C07C17/16 , C07C29/147 , C07C45/30 , C07C405/00 , C07D267/10 , C07D295/02 , C07D295/096 , C07D295/112 , C07D295/14 , C07D295/155 , C07D307/935 , C07D309/12 , C07D311/00 , C07D333/12 , C07D333/16 , C07D333/22 , C07D333/24 , C07D333/54 , C07D409/02 , C07D413/04 , D01F6/62
CPC分类号： C07D295/096 , C07C17/16 , C07C405/00 , C07C405/0033 , C07C405/0041 , C07C45/30 , C07D267/10 , C07D295/112 , C07D295/155 , C07D307/935 , C07D309/12 , C07D311/00 , C07D333/12 , C07D333/16 , C07D333/22 , C07D333/24 , D01F6/625 , Y10S514/826
摘要： Compounds are described of the formula ##STR1## (and their salts and solvates) in which: X is cis or trans --CH.dbd.CH--;R.sup.1 is C.sub.1-7 alkyl terminated by --COOR.sup.3 where R.sup.3 is H, C.sub.1-6 alkyl or C.sub.7-10 aralkyl;Y is a saturated heterocyclic amino group having 5-8 ring members; andR.sup.2 is C.sub.2-4 alkanoyl, C.sub.3-6 alkenyl (optionally substituted), C.sub.1-12 alkyl, or substituted or unsubstituted phenylalkyl, biphenylalkyl or naphthylalkyl.These compounds inhibit blood platelet aggregation and bronchoconstriction and may be formulated for use as antithrombotic and anti-asthmatic agents.
摘要翻译： 化合物描述为式（1）（及其盐和溶剂合物），其中：X为顺式或反式-CH = CH-; R1是被-COOR3封端的C1-7烷基，其中R3是H，C1-6烷基或C7-10芳烷基; Y是具有5-8个环成员的饱和杂环氨基; 并且R 2是C 2-4的烷酰基，C 3-6烯基（任选取代的），C 1-12烷基或取代或未取代的苯基烷基，联苯基烷基或萘基烷基。 这些化合物抑制血小板聚集和支气管收缩，并可配制用作抗血栓形成和抗哮喘药。
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公开(公告)号：US4482549A
公开(公告)日：1984-11-13
申请号：US578014
申请日：1984-02-08
申请人： Eric W. Collington , Peter Hallett , Christopher J. Wallis , Norman F. Hayes , John Bradshaw , Malcolm Carter , Alan Wadsworth
发明人： Eric W. Collington , Peter Hallett , Christopher J. Wallis , Norman F. Hayes , John Bradshaw , Malcolm Carter , Alan Wadsworth
IPC分类号： C07D401/08 , C07C45/63 , C07D213/65 , C07D213/70 , C07D295/155 , C07D307/33 , C07D309/12 , C07D311/00 , C07D333/16 , A61K31/55 , A61K31/535 , C07D295/14
CPC分类号： C07D213/70 , C07C45/63 , C07D213/65 , C07D295/155 , C07D307/33 , C07D309/12 , C07D311/00 , C07D333/16
摘要： Compounds are described of the formula ##STR1## in which --COR.sup.1 is a complex ester or thioester group,W is alkylene,X is cis or trans --CH.dbd.CH or --CH.sub.2 CH.sub.2 --,n is 1 or 2,Y is a saturated heterocyclic amino group having 5-8 ring members, andR.sup.2 is unsubstituted or substituted phenylalkyl, thienzlalkyl, naphthylalkyl or cinnamyl, and their salts and solvates.These compounds inhibit blood platelet aggregation and bronchoconstriction and may be formulated for use as antithrombotic and antiasthmatic agents.
摘要翻译： 化合物描述为其中-COR 1是络合酯或硫酯基团的式“IMAGE”，W是亚烷基，X是顺式或反式-CH = CH或-CH 2 CH 2 - ，n是1或2，Y是饱和杂环 具有5-8个环成员的氨基，R2是未取代的或取代的苯基烷基，硫烷基烷基，萘基烷基或肉桂基，及其盐和溶剂合物。 这些化合物抑制血小板聚集和支气管收缩，并且可以配制用作抗血栓形成和抗哮喘药。
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公开(公告)号：US4410521A
公开(公告)日：1983-10-18
申请号：US418975
申请日：1982-09-16
申请人： Eric W. Collington , Peter Hallett , Christopher J. Wallis , Norman F. Hayes , John Bradshaw , Malcolm Carter
发明人： Eric W. Collington , Peter Hallett , Christopher J. Wallis , Norman F. Hayes , John Bradshaw , Malcolm Carter
IPC分类号： C07C45/63 , C07D213/65 , C07D213/70 , C07D295/155 , C07D307/33 , C07D309/12 , C07D311/00 , C07D333/16 , A61K31/55 , A61K31/535 , C07D295/14
CPC分类号： C07D213/70 , C07C45/63 , C07D213/65 , C07D295/155 , C07D307/33 , C07D309/12 , C07D311/00 , C07D333/16 , Y10S514/826
摘要： Compounds are described of the formula ##STR1## in which --COR.sup.1 is a complex ester or thioester group,W is alkylene,X is cis or trans --CH.dbd.CH or --CH.sub.2 CH.sub.2 --,n is 1 or 2,Y is a saturated heterocyclic amino group having 5-8 ring members, andR.sup.2 is unsubstituted or substituted phenylalkyl, thienylalkyl, naphthylalkyl or cinnamyl,and their salts and solvates.These compounds inhibit blood platelet aggregation and bronchoconstruction and may be formulated for use as antithrombotic and antiasthmatic agents.
摘要翻译： 化合物描述为其中-COR 1是络合酯或硫酯基团的式“IMAGE”，W是亚烷基，X是顺式或反式-CH = CH或-CH 2 CH 2 - ，n是1或2，Y是饱和杂环 具有5-8个环成员的氨基，R2是未取代的或取代的苯基烷基，噻吩基烷基，萘基烷基或肉桂基，以及它们的盐和溶剂合物。 这些化合物抑制血小板聚集和支气管扩张，并且可以配制用作抗血栓形成和抗哮喘药。
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公开(公告)号：US4438112A
公开(公告)日：1984-03-20
申请号：US419521
申请日：1982-09-17
IPC分类号： C07D295/08 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P7/02 , A61P11/08 , A61P43/00 , C07C29/147 , C07C405/00 , C07D295/10 , C07D295/112 , C07D295/116 , C07D295/14 , C07D295/155 , C07D307/42 , C07D307/935 , C07D309/12 , C07D311/00 , C07D333/08 , C07D333/12 , C07D333/16 , C07D333/22 , C07D333/28 , A61K31/53 , A61K31/54
CPC分类号： C07D295/112 , C07C29/147 , C07C317/00 , C07C405/0041 , C07D295/116 , C07D295/155 , C07D307/42 , C07D307/935 , C07D309/12 , C07D311/00 , C07D333/08 , C07D333/12 , C07D333/16 , C07D333/22 , C07D333/28 , Y10S514/826
摘要： Prostanoids are described of the formulae ##STR1## (and the salts thereof) in which: X is cis or trans --CH.dbd.CH-- or CH.sub.2 CH.sub.2 --;R.sup.1 is C.sub.1-7 alkyl terminated by --COOR.sup.10 where R.sup.10 is H, C.sub.1-6 alkyl or aralkyl;Y is a saturated heterocyclic amino group; andR.sup.4 is aralkyl (in which the aryl portion is substituted by alkylthio, alkylsulphinyl, alkylsulphonyl, alkanoylamino, aroylamino, phenalkyl, aminosulphonyl, alkanoylaminosulphonyl, phenylsulphonyl, nitro, tetrazolyl, substituted phenyl or thienyl).These compounds inhibit blood platelet aggregation and have bronchodilatory action, and may be formulated for use as anti-asthmatics and antithrombotic agents.
摘要翻译： 前列腺素被描述为其中：X是顺式或反式-CH = CH-或CH 2 CH 2 - 的式“（其盐） R1是被-COOR10封端的C1-7烷基，其中R10是H，C1-6烷基或芳烷基; Y是饱和杂环氨基; 烷基磺酰基，烷酰基氨基，芳酰基氨基，苯基烷基，氨基磺酰基，烷酰基氨基磺酰基，苯基磺酰基，硝基，四唑基，取代的苯基或噻吩基）取代的芳烷基（其中芳基部分被烷硫基，烷酰基氨基， 这些化合物抑制血小板聚集并具有支气管扩张作用，并可配制用作抗哮喘和抗血栓形成剂。
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8.发明授权
公开(公告)号：US4327092A
公开(公告)日：1982-04-27
申请号：US258737
申请日：1981-04-29
IPC分类号： B29C55/02 , A61K31/38 , A61K31/381 , A61K31/445 , A61K31/535 , A61K31/5375 , A61K31/54 , A61K31/55 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/08 , A61P27/02 , A61P43/00 , B29C49/00 , B29C55/00 , B29C55/18 , B29K67/00 , B29L7/00 , C07C17/16 , C07C29/147 , C07C45/30 , C07C405/00 , C07D267/10 , C07D295/02 , C07D295/096 , C07D295/112 , C07D295/14 , C07D295/155 , C07D307/935 , C07D309/12 , C07D311/00 , C07D333/12 , C07D333/16 , C07D333/22 , C07D333/24 , C07D333/54 , C07D409/02 , C07D413/04 , D01F6/62 , C07D413/12 , C07D417/12
CPC分类号： C07D295/096 , C07C17/16 , C07C405/00 , C07C405/0033 , C07C405/0041 , C07C45/30 , C07D267/10 , C07D295/112 , C07D295/155 , C07D307/935 , C07D309/12 , C07D311/00 , C07D333/12 , C07D333/16 , C07D333/22 , C07D333/24 , D01F6/625 , Y10S514/826
摘要： Compounds are described of the formula ##STR1## (and their salts and solvates) in which: X is cis or trans --CH.dbd.CH--;R.sup.1 is C.sub.1-7 alkyl terminated by --COOR.sup.3 where R.sup.3 is H, C.sub.1-6 alkyl or C.sub.7-10 aralkyl;Y is a saturated heterocyclic amino group having 5-8 ring members; andR.sup.2 is substituted or unsubstituted thienylalkyl or furanylalkyl.These compounds inhibit blood platelet aggregation and bronchoconstriction and may be formulated for use as antithrombotic and anti-asthmatic agents.
摘要翻译： 化合物描述为式（1）（及其盐和溶剂合物），其中：X为顺式或反式-CH = CH-; R1是被-COOR3封端的C1-7烷基，其中R3是H，C1-6烷基或C7-10芳烷基; Y是具有5-8个环成员的饱和杂环氨基; 并且R 2是取代或未取代的噻吩基烷基或呋喃基烷基。 这些化合物抑制血小板聚集和支气管收缩，并可配制用作抗血栓形成和抗哮喘药。
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公开(公告)号：US5164503A
公开(公告)日：1992-11-17
申请号：US698895
申请日：1991-05-13
申请人： Ian Waterhouse , David R. Marshall , Eric W. Collington , Christopher J. Wallis , Peter Hallett
发明人： Ian Waterhouse , David R. Marshall , Eric W. Collington , Christopher J. Wallis , Peter Hallett
IPC分类号： C07D295/08 , A61K31/44 , A61K31/535 , A61K31/5375 , A61P7/02 , A61P11/00 , C07D295/096 , C07D295/112 , C07D295/116 , C07D295/155 , C07D309/12 , C07D311/00 , C07D333/16 , C07D333/26
CPC分类号： C07D295/096 , C07D295/112 , C07D295/116 , C07D295/155 , C07D311/00
摘要： A process is described for the preparation of compounds of the formula ##STR1## in which W is C.sub.1-7 alkyleneX is cis or trans --CH.dbd.CH-- or --CH.sub.2 Ch.sub.2 --Y is a saturated heterocyclic amino group, andR.sup.2 is substituted or unsubstituted phenyl-, thienyl- or naphthyl-alkyl, or cinnamyl,and their salts and solvates.The process comprises hydrolysing a corresponding ester, amide, nitrile or ortho-ester. The starting materials are preferably prepared by reducing the corresponding cyclopentanone and hydrolysis can take place simultaneously with reduction.
摘要翻译： 描述了制备式“IMAGE”的化合物的方法，其中W为C 1-7亚烷基X为顺式或反式-CH = CH-或-CH 2 CH 2 - Y为饱和杂环氨基，R 2为取代或 未取代的苯基 - ，噻吩基或萘基 - 烷基或肉桂基，及其盐和溶剂合物。 该方法包括水解相应的酯，酰胺，腈或原酸酯。 原料优选通过还原相应的环戊酮制备，水解可以同时还原而进行。
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公开(公告)号：US4530925A
公开(公告)日：1985-07-23
申请号：US589303
申请日：1984-03-14
IPC分类号： C07D295/08 , A61K31/445 , A61K31/535 , A61K31/5375 , A61P9/00 , A61P11/00 , A61P43/00 , C07D295/096 , C07D295/10 , C07D295/112 , C07D295/116 , C07D295/155 , C07D305/06 , C07D307/935 , C07D317/24 , C07D333/16 , C07D493/08 , C07F9/6561 , A61K31/54 , C07D295/14
CPC分类号： C07D295/096 , C07D295/112 , C07D295/116 , C07D295/155 , C07D305/06 , C07D307/935 , C07D317/24 , C07D333/16 , C07D493/08 , C07F9/6561
摘要： Compounds are described of the formulae (1a) and (1b) ##STR1## in which: --COR.sup.1 is an ester group,n is 1 or 2,W is C.sub.1-7 alkylene,X is cis or trans --CH.dbd.CH or --CH.sub.2 CH.sub.2 --,Y is a saturated heterocyclic amino group,R.sup.2 is substituted or unsubstituted phenylalkyl, thienylalkyl or naphthylalkyl or cinnamyl, andR.sup.3 is --H or C.sub.1-5 alkanoyl, including their salts.These compounds inhibit blood platelet aggregation and bronchoconstriction and may be formulated for use as antithrombotic or antiasthmatic agents.
摘要翻译： 化合物描述于式（1a）和（1b）中：其中：-COR1为酯基，n为1或2，W为C1-7亚烷基，X为 顺式或反式-CH = CH或-CH 2 CH 2 - ，Y是饱和杂环氨基，R 2是取代或未取代的苯基烷基，噻吩基烷基或萘基烷基或肉桂基，R 3是-H或C 1-5烷酰基，包括它们的盐。 这些化合物抑制血小板聚集和支气管收缩，并且可以配制用作抗血栓形成剂或止喘剂。
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