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公开(公告)号：US5852294A
公开(公告)日：1998-12-22
申请号：US887730
申请日：1997-07-03
CPC分类号： H01J49/063 , H01J49/068 , H01J49/4255
摘要： A miniature multipole rod assembly which can be operated as an ion guide or a mass analyzer is constructed by bonding individual rods directly to plates which are separated by ceramic insulators. The multipole rod assemblies are constructed by using a fixture which locates and orients all elements during the process or bonding the rods to the disks.
摘要翻译： 可以通过将单独的杆直接粘接到由陶瓷绝缘体分离的板上而构成可以作为离子导向器或质量分析器操作的微型多极杆组件。 多极杆组件通过使用夹具来构造，所述夹具在工艺过程中定位和定向所有元件，或者将棒粘合到盘上。
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公开(公告)号：US06600155B1
公开(公告)日：2003-07-29
申请号：US09807796
申请日：2001-09-06
IPC分类号： H01J4916
CPC分类号： H01J49/40 , B82Y15/00 , B82Y30/00 , H01J49/0068
摘要： A Time-Of-Flight mass spectrometer (1) is configured with a pulsing region (10) and electronic controls to cause the directing of ions to a surface (12) in the Time-Of-Flight pulsing region (10). The population of ions resulting from the collecting of said ions on or near said surface (12) is subsequently accelerated into the Time-Of-Flight tube (17) for mass to charge analysis. Ions produced away from said surface (12) can be directed to the surface (12) with high or low surface collisional energies. Higher energy ion collisions with the surface (12) can result in Surface Induced Dissociation fragmentation and the resulting ion fragment population can be mass analyzed. Mass analysis can be performed prior to directing the ions to the surface allowing MS/MS Time-Of-Flight mass analysis with SID. Ion to surface low energy collisions or soft landings resulting in little or no ion fragmentation provide a means for spatially focusing ions on or near the surface prior to accelerating the surface collected ions into the Time-Of-Flight tube.
摘要翻译： 飞行时间质谱仪（1）配置有脉冲区域（10）和电子控制器以引导离子到飞行时间脉动区域（10）中的表面（12）。 随后将所述离子收集在所述表面（12）上或其附近产生的离子群随后被加速到飞行时间管（17）中以进行大量电荷分析。 离开所述表面（12）产生的离子可以以高或低的表面碰撞能量被引导到表面（12）。 与表面（12）的高能离子碰撞可导致表面诱导解离破碎，并且可以质量分析得到的离子片段。 在将离子引导到表面之前可以进行质量分析，允许使用SID进行MS / MS飞行时间质量分析。 离子到表面的低能量碰撞或软着陆导致很少或没有离子碎裂提供了在将表面收集的离子加速到飞行时间管之前将离子空间聚焦在表面上或附近的手段。
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公开(公告)号：US06573494B1
公开(公告)日：2003-06-03
申请号：US10022116
申请日：2001-12-04
IPC分类号： H01J4910
CPC分类号： H01J49/167 , H01J49/107 , H01J49/165
摘要： A single or multiple layer curved Electrospray sample introduction means has been configured in an Atmospheric Pressure Ion (API) source interfaced to a mass analyzer. Sample solutions introduced through curved or bent sample introduction Electrospray (ES) probes configured in an API source are sprayed from the ES probe tip at an angle which differs from centerline of the ES probe body. Single or multiple curved ES probes can be configured in an Atmospheric Pressure Ion source interfaced to mass analyzers. Curved ES probes can also be configured in an API source which includes Atmospheric Pressure Chemical ionization.
摘要翻译： 单个或多层弯曲的电喷雾样品引入装置已经配置在与质量分析仪接口的大气压离子（API）源中。 通过弯曲或弯曲样品引入引入的样品溶液以API源形式配置的电喷雾（ES）探针以不同于ES探针体中心线的角度从ES探针尖端喷射。 单个或多个弯曲的ES探头可以在与大量分析仪接口的大气压离子源中配置。 弯曲的ES探头也可以在包含大气压化学电离的API源中配置。
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公开(公告)号：US06326616B1
公开(公告)日：2001-12-04
申请号：US09173195
申请日：1998-10-15
IPC分类号： H01J4910
CPC分类号： H01J49/167 , H01J49/107 , H01J49/165
摘要： A single or multiple layer curved Electrospray sample introduction means has been configured in an Atmospheric Pressure Ion (API) source interfaced to a mass analyzer. Sample solutions introduced through curved or bent sample introduction Electrospray (ES) probes configured in an API source are sprayed from the ES probe tip at an angle which differs from centerline of the ES probe body. Single or multiple curved ES probes can be configured in an Atmospheric Pressure Ion source interfaced to mass analyzers. Curved ES probes can also be configured in an API source which includes Atmospheric Pressure Chemical ionization.
摘要翻译： 单个或多层弯曲的电喷雾样品引入装置已经配置在与质量分析仪接口的大气压离子（API）源中。 通过弯曲或弯曲样品引入引入的样品溶液以API源形式配置的电喷雾（ES）探针以不同于ES探针体中心线的角度从ES探针尖端喷射。 单个或多个弯曲的ES探头可以在与大量分析仪接口的大气压离子源中配置。 弯曲的ES探头也可以在包含大气压化学电离的API源中配置。
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公开(公告)号：US06593568B1
公开(公告)日：2003-07-15
申请号：US09324401
申请日：1999-06-02
IPC分类号： B01D5944
CPC分类号： H01J49/0477 , H01J49/0404 , H01J49/044
摘要： An Atmospheric Pressure Ion (API) source is configured for Electrospray (ES) and Atmospheric Pressure Chemical Ionization (APCI) operating modes. The API source includes a multipurpose heater assembly mounted in the API source chamber. The multipurpose heater supplies heat to the API chamber endplate, bath gas and entrance end of the capillary orifice into vacuum as well as supplying electrical connections to the API source elements. An additional heater is configured at the exit end of the capillary orifice into vacuum. With this configuration, the bath gas, endplate and capillary entrance temperature can be set independent of gas flow rate. The capillary exit and entrance temperatures can be set independently as well. The multipurpose endplate heater combined with the capillary exit heater allows the optimization of API source performance over a wide range of operating conditions and analytical applications.
摘要翻译： 大气压离子（API）源被配置用于电喷雾（ES）和大气压化学电离（APCI）操作模式。 API源包括安装在API源室中的多用途加热器组件。 多功能加热器将API室端板，浴室气体和毛细孔入口端的热量提供到真空中，并向API源元件提供电气连接。 另外的加热器配置在毛细管孔的出口端进入真空。 通过这种配置，浴气，终板和毛细管入口温度可独立于气体流量设定。 毛细管出口和入口温度也可以独立设置。 多用途终板加热器与毛细管出口加热器相结合，可以在广泛的操作条件和分析应用中优化API源性能。
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公开(公告)号：US06541768B2
公开(公告)日：2003-04-01
申请号：US09813396
申请日：2001-03-21
IPC分类号： B01D5944
CPC分类号： H01J49/107 , H01J49/0009 , H01J49/0431 , H01J49/165
摘要： Multiple sample introduction means have been configured in Atmospheric Pressure Ion sources which are interfaced to mass analyzers. Different samples can be introduced through multiple Electrospray (ES) or Atmospheric Pressure Chemical Ionization (APCI) probes individually or simultaneously and ionized. The gas phase ion mixture resulting from individual solutions sprayed from multiple ES or APCI probe inputs is mass analyzed. In this manner a calibration solution can be introduced through one ES or APCI probe while one or more sample solutions are spray from additional probes. Simultaneous spraying of calibration and sample solutions, results in an acquired mass spectrum containing peaks of ions with known molecular weights as well as sample related peaks. The calibration peaks can be used as an internal calibration standard during data analysis. Acquisition of mass spectra containing internal calibration peaks can be achieved by spraying different solutions simultaneously from multiple inlet probes without having to mix calibration and sample solutions in the liquid phase. Arrangements of ES and APCI probes can be configured in one API source chamber and the solution flow through any combination of ES or APCI probes can be switched on or off during an analytical run. A single mass analyzer can serve as a detector for multiple separation systems each delivering sample solution through separate ES or APCI inlet probes into an atmospheric pressure ion source.
摘要翻译： 在大气压离子源中配置了多个样品引入装置，它们与大量分析仪接口。 可以通过多个电喷雾（ES）或大气压化学电离（APCI）探针单独或同时引入不同的样品并进行电离。 对从多个ES或APCI探针输入喷射的各溶液产生的气相离子混合物进行质量分析。 以这种方式，可以通过一个ES或APCI探针引入校准溶液，同时从另外的探针喷射一种或多种样品溶液。 同时喷射校准和样品溶液，得到包含已知分子量的离子峰以及样品相关峰的获得质谱。 在数据分析期间，校准峰可用作内部校准标准。 通过从多个入口探针同时喷射不同的溶液而无需在液相中混合校准和样品溶液，可以获得含有内部校准峰的质谱。 可以在一个API源室中配置ES和APCI探针的安排，并且可以在分析运行期间打开或关闭通过ES或APCI探针的任意组合的溶液流。 单个质量分析仪可用作多个分离系统的检测器，每个分离系统将样品溶液通过单独的ES或APCI入口探针输送到大气压离子源。
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公开(公告)号：US06337480B1
公开(公告)日：2002-01-08
申请号：US09632572
申请日：2000-08-04
申请人： Bruce A. Andrien, Jr. , Craig M. Whitehouse , Michael A. Sansone , Denise M. Sauro , Glenn P. Whitehouse
发明人： Bruce A. Andrien, Jr. , Craig M. Whitehouse , Michael A. Sansone , Denise M. Sauro , Glenn P. Whitehouse
IPC分类号： H01J4904
CPC分类号： H01J49/167
摘要： An Electrospray probe which includes a replaceable or disposable micron size diameter Electrospray tip used for low flow rate Electrospray has been developed. The Electrospray probe assembly combines the use of a low pressure gas and electric fields to initiate and sustain the Electrospray process at low liquid flow rates. The operational flow rates of this probe range from below 25 nL/min to over 1 &mgr;L/min, with total sample volume loaded ranging from less than 1 &mgr;L to over 20 &mgr;L. The Electrospray probe assembly includes axial and radial adjustment of the Electrospray tip position relative to the sampling orifice into vacuum and that tip position can be locked in place. The replaceable microtip can be safely removed from the Electrospray (ES) chamber without turning off high voltage within the ES chamber. Telescoping support ways have been included to prevent ES tip damage by guiding the Electrospray probe tip during removal from and insertion into the ES chamber. The replaceable microtip is held in a fixed position during operation with a collet assembly which also provides electrical contact with coated microtips. The replaceable microtip ES probe assembly is compatible with microtips that are metal or coated or uncoated glass materials. For uncoated glass microtips the ES probe assembly accommodates a wire electrical contact which is installed in the replaceable microtip bore.
摘要翻译： 已经开发了一种电喷探针，其包括用于低流速电喷雾的可替换或一次性微米尺寸直径的电喷雾尖端。 电喷雾探针组件结合了低压气体和电场的使用，以低液体流速启动和维持电喷雾过程。 该探头的操作流量范围从低于25 nL / min到超过1μL/ min，总样品体积加载范围从小于1μL到20μL。 电喷雾探针组件包括相对于采样孔将电喷雾头部位置轴向和径向调节成真空并且尖端位置可以锁定就位。 可以从电喷雾（ES）室中安全地移除可更换的微尖端，而不会关闭ES室内的高压。 通过引导电喷雾探针尖端从ES腔中取出并插入ES腔，已经包括伸缩支撑方式来防止ES尖端损伤。 在使用夹套组件的操作期间，可替换的微尖头保持在固定位置，其还提供与涂覆的微尖端的电接触。 可替换的微尖头ES探针组件与金属或涂层或未涂覆的玻璃材料的微尖头兼容。 对于未涂覆的玻璃微尖头，ES探头组件可容纳安装在可更换微型钻孔中的电线触点。
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公开(公告)号：US06207954B1
公开(公告)日：2001-03-27
申请号：US09151501
申请日：1998-09-11
IPC分类号： B01D5944
CPC分类号： H01J49/107 , H01J49/0009 , H01J49/0431 , H01J49/165
摘要： Multiple sample introduction means have been configured in Atmospheric Pressure Ion sources which are interfaced to mass analyzers. Different samples can be introduced through multiple Electrospray (ES) or Atmospheric Pressure Chemical Ionization (APCI) probes individually or simultaneously and ionized. The gas phase ion mixture resulting from individual solutions sprayed from multiple ES or APCI probe inputs is mass analyzed. In this manner a calibration solution can be introduced through one ES or APCI probe while one or more sample solutions are spray from additional probes. Simultaneous spraying of calibration and sample solutions, results in an acquired mass spectrum containing peaks of ions with known molecular weights as well as sample related peaks. The calibration peaks can be used as an internal calibration standard during data analysis. Acquisition of mass spectra containing internal calibration peaks can be achieved by spraying different solutions simultaneously from multiple inlet probes without having to mix calibration and sample solutions in the liquid phase. Arrangements of ES and APCI probes can be configured in one API source chamber and the solution flow through any combination of ES or APCI probes can be switched on or off during an analytical run. A single mass analyzer can serve as a detector for multiple separation systems each delivering sample solution through separate ES or APCI inlet probes into an atmospheric pressure ion source.
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公开(公告)号：US6127680A
公开(公告)日：2000-10-03
申请号：US41715
申请日：1998-03-13
申请人： Bruce A. Andrien, Jr. , Craig M. Whitehouse , Michael A. Sansone , Denise M. Sauro , Glenn P. Whitehouse
发明人： Bruce A. Andrien, Jr. , Craig M. Whitehouse , Michael A. Sansone , Denise M. Sauro , Glenn P. Whitehouse
CPC分类号： H01J49/167
摘要： An Electrospray probe which includes a replaceable or disposable micron size diameter Electrospray tip used for low flow rate Electrospray has been developed. The Electrospray probe assembly combines the use of a low pressure gas and electric fields to initiate and sustain the Electrospray process at low liquid flow rates. The operational flow rates of this probe range from below 25 nL/min to over 1 .mu.L/min, with total sample volume loaded ranging from less than 1 .mu.L to over 20 .mu.L. The Electrospray probe assembly includes axial and radial adjustment of the Electrospray tip position relative to the sampling orifice into vacuum and that tip position can be locked in place. The replaceable microtip can be safely removed from the Electrospray (ES) chamber without turning off high voltage within the ES chamber. Telescoping support ways have been included to prevent ES tip damage by guiding the Electrospray probe tip during removal from and insertion into the ES chamber. The replaceable microtip is held in a fixed position during operation with a collet assembly which also provides electrical contact with coated microtips. The replaceable microtip ES probe assembly is compatible with microtips that are metal or coated or uncoated glass materials. For uncoated glass microtips the ES probe assembly accommodates a wire electrical contact which is installed in the replaceable microtip bore.
摘要翻译： 已经开发了一种电喷探针，其包括用于低流速电喷雾的可替换或一次性微米尺寸直径的电喷雾尖端。 电喷雾探针组件结合了低压气体和电场的使用，以低液体流速启动和维持电喷雾过程。 该探头的操作流量范围从低于25 nL / min到超过1μL/ min，总样品体积负载范围从小于1μL至超过20μL。电喷探针组件包括轴向和径向调整 相对于采样孔的电喷雾尖端位置变为真空，并且尖端位置可以锁定到位。 可以从电喷雾（ES）室中安全地移除可更换的微尖端，而不会关闭ES室内的高压。 通过引导电喷雾探针尖端从ES腔中取出并插入ES腔，已经包括伸缩支撑方式来防止ES尖端损伤。 在使用夹套组件的操作期间，可替换的微尖头保持在固定位置，其还提供与涂覆的微尖端的电接触。 可替换的微尖头ES探针组件与金属或涂层或未涂覆的玻璃材料的微尖头兼容。 对于未涂覆的玻璃微尖头，ES探头组件可容纳安装在可更换微型钻孔中的电线触点。
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公开(公告)号：US4981469A
公开(公告)日：1991-01-01
申请号：US182968
申请日：1988-04-18
IPC分类号： A61M39/14
CPC分类号： A61M39/14 , A61M2039/1027 , A61M2039/1072 , A61M2039/1077 , Y10S604/905
摘要： An assembly for connection to at least one medicant supply tube, includes (a) a septum assembly including a distal end cap having opposite first and second ends, an outer peripheral wall extending between the first and second ends and a bore extending therethrough from the first end to the second end; a septum cap including a puncture sealing section positioned over the first end and a securing section integrally formed with the puncture sealing section and positioned in fluid sealing contact with the peripheral wall adjacent the first end so as to secure the septum cap to the distal end cap; and a proximal connector connected with the distal end cap in covering relation to the septum cap, the proximal connector including a bore extending therethrough and a connection at one end thereof; and (b) an external adapter fitting having a septum piercing tube for piercing the puncture sealing section when the external adapter fitting is connected with the proximal connector, and a luer lock connection cooperating with the connection of the proximal connector for connecting the external adapter fitting to the proximal connector.
摘要翻译： 一种用于连接到至少一个药剂供应管的组件，包括（a）隔膜组件，其包括具有相对的第一和第二端的远端帽，在第一和第二端之间延伸的外周壁和从第一和第二端延伸穿过的孔 结束到第二端 隔膜帽，其包括设置在第一端上的穿刺密封部分和固定部分，该固定部分与穿刺密封部分一体地形成并且与邻近第一端部的周壁流体密封接触，以将隔膜帽固定到远端帽 ; 以及近端连接器，其与所述远端帽连接，以与所述隔膜盖相关联，所述近端连接器包括延伸穿过其中的孔和在其一端的连接; 以及（b）外部适配器配件，其具有用于在外部适配器配件与近侧连接器连接时刺穿穿刺密封部分的隔膜穿刺管，以及与近端连接器的连接配合的路厄锁定连接器，用于连接外部适配器接头 到近端连接器。
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