-
公开(公告)号：US20120093850A1
公开(公告)日：2012-04-19
申请号：US13234077
申请日：2011-09-15
申请人： Fabio BAGNOLI , Massimiliano Biagini , Luigi Fiaschi , Guido Grandi , Ravi Pratap Narayan Mishra , Nathalie Norais , Maria Scarselli
发明人： Fabio BAGNOLI , Massimiliano Biagini , Luigi Fiaschi , Guido Grandi , Ravi Pratap Narayan Mishra , Nathalie Norais , Maria Scarselli
IPC分类号： A61K39/085 , C12N9/52 , C12N9/02 , C12N9/16 , A61P31/04 , C12N9/20 , C12N9/14 , A61K39/385 , C12N15/31 , A61P37/04 , C07K14/31 , C12N9/10
CPC分类号： A61K39/085 , A61K39/00 , C07K14/31 , C07K2319/00
摘要： Staphylococcus aureus Hla polypeptides having various deletions, insertions, and/or mutations which are useful for immunisation are provided herein. Also provided herein are Hla heptamers which are non-haemolytic. Additionally, an effective Staphylococcus aureus vaccine may require several antigenic components, and so various combinations of S. aureus antigens, including Hla polypeptides having deletions, insertions, and/or mutations, are identified for use in immunisation. These polypeptides may optionally be used in combination with S. aureus saccharides.
摘要翻译： 具有可用于免疫的各种缺失，插入和/或突变的金黄色葡萄球菌Hla多肽在本文中提供。 本文还提供了非溶血性的Hla七聚体。 此外，有效的金黄色葡萄球菌疫苗可能需要几种抗原成分，因此确定金黄色葡萄球菌抗原（包括具有缺失，插入和/或突变的Hla多肽）的各种组合用于免疫。 这些多肽可以任选地与金黄色葡萄球菌组合使用。
-
公开(公告)号：US08679505B2
公开(公告)日：2014-03-25
申请号：US13264369
申请日：2010-04-14
申请人： Fabio Bagnoli , Massimiliano Biagini , Luigi Fiaschi , Guido Grandi , Ravi Pratap Narayan Mishra , Nathalie Norais , Maria Scarselli
发明人： Fabio Bagnoli , Massimiliano Biagini , Luigi Fiaschi , Guido Grandi , Ravi Pratap Narayan Mishra , Nathalie Norais , Maria Scarselli
IPC分类号： A61K39/085 , C07K14/31 , C07H21/00
CPC分类号： A61K39/085 , A61K39/00 , C07K14/31 , C07K2319/00
摘要： An effective Staphylococcus aureus vaccine may require several antigenic components, and so various combinations of S. aureus antigens are identified for use in immunization. These polypeptides may optionally be used in combination with S. aureus saccharides.
摘要翻译： 有效的金黄色葡萄球菌疫苗可能需要几种抗原成分，因此鉴定出金黄色葡萄球菌抗原的各种组合用于免疫。 这些多肽可以任选地与金黄色葡萄球菌组合使用。
-
公开(公告)号：US20120107340A1
公开(公告)日：2012-05-03
申请号：US13264369
申请日：2010-04-14
申请人： Fabio Bagnoli , Massimilliano Biagini , Luigi Fiaschi , Guido Grandi , Ravi Pratap Narayan Mishra , Nathalie Norais , Maria Scarselli
发明人： Fabio Bagnoli , Massimilliano Biagini , Luigi Fiaschi , Guido Grandi , Ravi Pratap Narayan Mishra , Nathalie Norais , Maria Scarselli
IPC分类号： A61K39/085 , A61P31/04 , C07H21/00 , A61P37/04 , A61K39/385 , C07K14/31
CPC分类号： A61K39/085 , A61K39/00 , C07K14/31 , C07K2319/00
摘要： An effective Staphylococcus aureus vaccine may require several antigenic components, and so various combinations of S. aureus antigens are identified for use in immunisation. These polypeptides may optionally be used in combination with S. aureus saccharides.
摘要翻译： 有效的金黄色葡萄球菌疫苗可能需要几种抗原成分，因此鉴定出金黄色葡萄球菌抗原的各种组合用于免疫。 这些多肽可以任选地与金黄色葡萄球菌组合使用。
-
公开(公告)号：US20100015168A1
公开(公告)日：2010-01-21
申请号：US12303999
申请日：2007-06-11
申请人： Domenico Maione , Guido Grandi , Nathalie Norais
发明人： Domenico Maione , Guido Grandi , Nathalie Norais
CPC分类号： A61K39/092 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/315 , G01N33/56944 , G01N2469/20
摘要： The invention relates to immunogenic polypeptides derived from epitopes in a Streptococcus agalactiae (“GBS”) protein GBS 80 and their use as prophylactic, diagnostic and therapeutic compositions. The invention also provides nucleic acids encoding the immunogenic polypeptides. Also provided are vectors useful for making such immunogenic polypeptides and host cells transformed with such vectors. In particular, the invention relates to a group immunogenic polypeptides derived from GBS 80. The compositions may include one or more of the immunogenic polypeptides either alone or with other antigenic components. For example, the immunogenic polypeptides may be combined with other GBS antigens to provide therapeutic compositions with broader range. In addition, the immunogenic polypeptides may also include flanking portions of the GBS 80 protein.
摘要翻译： 本发明涉及源自无乳链球菌（GBS）蛋白GBS 80中的表位的免疫原性多肽及其作为预防，诊断和治疗组合物的用途。 本发明还提供编码免疫原性多肽的核酸。 还提供了可用于制备这种免疫原性多肽的载体和用这些载体转化的宿主细胞。 特别地，本发明涉及衍生自GBS80的组免疫原性多肽。组合物可以单独或与其它抗原成分一起包括一种或多种免疫原性多肽。 例如，免疫原性多肽可以与其他GBS抗原组合以提供更宽范围的治疗组合物。 此外，免疫原性多肽还可以包括GBS 80蛋白的侧翼部分。
-
公开(公告)号：US07838010B2
公开(公告)日：2010-11-23
申请号：US11792038
申请日：2005-10-11
CPC分类号： C07K14/315 , A61K39/00 , A61K2039/505 , A61K2039/523 , A61K2039/53
摘要： Group A streptococcal (GAS) antigens useful for providing immunity against pyogenes infection.
摘要翻译： A组链球菌（GAS）抗原，可用于提供免疫化脓性感染。
-
公开(公告)号：US09206399B2
公开(公告)日：2015-12-08
申请号：US11666786
申请日：2005-10-28
IPC分类号： A61K39/095 , C12N9/10 , A61K39/108
CPC分类号： C07K14/245 , A61K39/00 , A61K39/0258 , A61K39/095 , C07K14/22 , C12N9/1051 , Y02A50/474
摘要： Knockout of the meningococcal mltA homolog gives bacteria that spontaneously release vesicles that are rich in immunogenic outer membrane proteins and that can elicit cross-protective antibody responses with higher bactericidal titres than OMVs prepared by normal production processes. Thus the invention provides a bacterium having a knockout mutation of its mltA gene. The invention also provides a bacterium, wherein the bacterium: (i) has a cell wall that includes peptidoglycan; and (ii) does not express a protein having the lytic transglycosylase activity of MltA protein. The invention also provides compositions comprising vesicles that, during culture of bacteria of the invention, are released into the culture medium.
摘要翻译： 脑膜炎球菌mltA同系物的敲除使细菌自发释放富含免疫原性外膜蛋白的囊泡，并且能够以比正常生产过程制备的OMV更高的杀菌滴度引发交叉保护性抗体应答。 因此，本发明提供了具有其mltA基因的敲除突变的细菌。 本发明还提供了一种细菌，其中所述细菌：（i）具有包含肽聚糖的细胞壁; 和（ii）不表达具有MltA蛋白的裂解转糖苷酶活性的蛋白质。 本发明还提供包含囊泡的组合物，其在本发明的细菌培养期间释放到培养基中。
-
公开(公告)号：US20110206692A1
公开(公告)日：2011-08-25
申请号：US12304018
申请日：2007-06-11
IPC分类号： A61K39/40 , C07K14/195 , C07K16/12 , C07K16/46 , A61K39/02 , C07K1/18 , C07K1/14 , A61P31/04 , B01D57/02
CPC分类号： A61K39/092 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/315 , G01N33/56944 , G01N2469/20
摘要： The invention relates to isolated or purified bacterial adhesin conformers, preferably with improved stability and/or immunogenicity. In a preferred aspect, the invention comprises an isolated bacterial adhesin conformer F. Also provided are methods of isolation and/or separation of such adhesin conformers. The compositions may include one or more of the immunogenic polypeptides either alone or with other antigenic components. For example, the immunogenic polypeptides may be combined with other bacterial antigens to provide therapeutic compositions with broader range.
摘要翻译： 本发明涉及分离或纯化的细菌粘附素构象异构体，优选具有改善的稳定性和/或免疫原性。 在优选的方面，本发明包括分离的细菌粘附素构象体F.还提供了这种粘附素构象异构体的分离和/或分离的方法。 组合物可以单独或与其它抗原成分一起包括一种或多种免疫原性多肽。 例如，免疫原性多肽可以与其他细菌抗原组合以提供更宽范围的治疗组合物。
-
公开(公告)号：US08147849B2
公开(公告)日：2012-04-03
申请号：US12706387
申请日：2010-02-16
IPC分类号： A61K39/09 , C12P21/06 , C07K14/315 , C12N15/09
CPC分类号： C07K14/315 , A61K39/00
摘要： The invention provides protective antigens for Group B streptococcus hypervirulent strains. The fragments are useful in vaccine compositions to induce protection against S. agalactiae, particularly against hypervirulent strains.
摘要翻译： 本发明提供了B组链球菌高毒力菌株的保护性抗原。 这些片段可用于疫苗组合物中，以诱导针对无精子症的保护，特别是针对高毒力菌株。
-
公开(公告)号：US20100015212A1
公开(公告)日：2010-01-21
申请号：US11666786
申请日：2005-10-28
CPC分类号： C07K14/245 , A61K39/00 , A61K39/0258 , A61K39/095 , C07K14/22 , C12N9/1051 , Y02A50/474
摘要： Knockout of the meningococcal mltA homolog gives bacteria that spontaneously release vesicles that are rich in immunogenic outer membrane proteins and that can elicit cross-protective antibody responses with higher bactericidal titres than OMVs prepared by normal production processes. Thus the invention provides a bacterium having a knockout mutation of its mltA gene. The invention also provides a bacterium, wherein the bacterium: (i) has a cell wall that includes peptidoglycan; and (ii) does not express a protein having the lytic transglycosylase activity of MltA protein. The invention also provides compositions comprising vesicles that, during culture of bacteria of the invention, are released into the culture medium.
摘要翻译： 脑膜炎球菌mltA同系物的敲除使细菌自发释放富含免疫原性外膜蛋白的囊泡，并且能够以比正常生产过程制备的OMV更高的杀菌滴度引发交叉保护性抗体应答。 因此，本发明提供了具有其mltA基因的敲除突变的细菌。 本发明还提供了一种细菌，其中所述细菌：（i）具有包含肽聚糖的细胞壁; 和（ii）不表达具有MltA蛋白的裂解转糖苷酶活性的蛋白质。 本发明还提供包含囊泡的组合物，其在本发明的细菌培养期间释放到培养基中。
-
公开(公告)号：US20120141521A1
公开(公告)日：2012-06-07
申请号：US13339628
申请日：2011-12-29
申请人： Domenico Maione , Guido Grandi , Nathalie Norais
发明人： Domenico Maione , Guido Grandi , Nathalie Norais
IPC分类号： A61K39/09 , A61P37/04 , A61P31/04 , C07K14/315
CPC分类号： A61K39/092 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/315 , G01N33/56944 , G01N2469/20
摘要： The invention relates to immunogenic polypeptides derived from epitopes in a Streptococcus agalactiae (“GBS”) protein GBS 80 and their use as prophylactic, diagnostic and therapeutic compositions. The invention also provides nucleic acids encoding the immunogenic polypeptides. Also provided are vectors useful for making such immunogenic polypeptides and host cells transformed with such vectors. In particular, the invention relates to a group immunogenic polypeptides derived from GBS 80. The compositions may include one or more of the immunogenic polypeptides either alone or with other antigenic components. For example, the immunogenic polypeptides may be combined with other GBS antigens to provide therapeutic compositions with broader range. In addition, the immunogenic polypeptides may also include flanking portions of the GBS 80 protein
摘要翻译： 本发明涉及源自无乳链球菌（GBS）蛋白GBS 80中的表位的免疫原性多肽及其作为预防，诊断和治疗组合物的用途。 本发明还提供编码免疫原性多肽的核酸。 还提供了可用于制备这种免疫原性多肽的载体和用这些载体转化的宿主细胞。 特别地，本发明涉及衍生自GBS80的组免疫原性多肽。组合物可以单独或与其它抗原成分一起包括一种或多种免疫原性多肽。 例如，免疫原性多肽可以与其他GBS抗原组合以提供更宽范围的治疗组合物。 此外，免疫原性多肽还可以包括GBS 80蛋白的侧翼部分
-
-
-
-
-
-
-
-
-
搜索结果
157 条记录 (耗时 0.04 秒)
