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1.发明申请Modulators of lanosterol synthetase for treating acne or hyperseborrhea 审中-公开用于治疗痤疮或高血脂的羊毛甾醇合成酶的调节剂公开(公告)号：US20100021893A1
公开(公告)日：2010-01-28
申请号：US12320171
申请日：2009-01-21
申请人： Fernand Labrie , Mohamed El-Alfy , Van Luu-The , Ezequiel L. Calvo , Jerome Aubert , Pascal Collette , Johannes Voegel
发明人： Fernand Labrie , Mohamed El-Alfy , Van Luu-The , Ezequiel L. Calvo , Jerome Aubert , Pascal Collette , Johannes Voegel
CPC分类号： G01N33/573 , C12Q1/25 , G01N33/6893 , G01N2333/99 , G01N2800/20
摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of lanosterol synthetase (LSS), and the use of modulators of the expression or activity of this enzyme for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or prognosis of these pathologies are also described.
摘要翻译： 用于筛选候选化合物以预防或治疗痤疮的体外方法包括测定化合物调节羊毛甾醇合成酶（LSS）的表达或活性的能力，以及使用表达或活性的调节剂 的这种酶用于治疗与过度脂肪相关的痤疮或皮肤病症; 还描述了这些病理学的体外诊断或预后的方法。
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公开(公告)号：US20100021892A1
公开(公告)日：2010-01-28
申请号：US12320170
申请日：2009-01-21
申请人： Fernand Labrie , Mohamed El-Alfy , Van Luu-The , Ezequiel L. Calvo , Jerome Aubert , Isabelle Carlavan , Sophie Deret , Johannes Voegel
发明人： Fernand Labrie , Mohamed El-Alfy , Van Luu-The , Ezequiel L. Calvo , Jerome Aubert , Isabelle Carlavan , Sophie Deret , Johannes Voegel
CPC分类号： G01N33/5008 , G01N2333/902 , G01N2500/00 , G01N2800/20
摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of sterol-C4-methyl oxidase (SC4MOL), and the use of modulators of the expression or activity of this enzyme for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or prognosis of these pathologies are also described.
摘要翻译： 用于筛选候选化合物以预防或治疗痤疮的体外方法包括测定化合物调节甾醇-C4-甲基氧化酶（SC4MOL）的表达或活性的能力，以及使用调节剂 该酶用于治疗与高脂血症相关的痤疮或皮肤病症的表达或活性; 还描述了这些病理学的体外诊断或预后的方法。
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公开(公告)号：US20100028879A1
公开(公告)日：2010-02-04
申请号：US12320169
申请日：2009-01-21
申请人： Fernand Labrie , Michel Rivier , Van Luu-The , Ezequiel L. Calvo , Jerome Aubert , Sophie Deret , Johannes Voegel
发明人： Fernand Labrie , Michel Rivier , Van Luu-The , Ezequiel L. Calvo , Jerome Aubert , Sophie Deret , Johannes Voegel
IPC分类号： C12Q1/68 , G01N33/573
CPC分类号： C12Q1/32 , G01N2333/904 , G01N2500/04 , G01N2800/20
摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of hydroxysteroid (17-beta) dehydrogenase type 7, and the use of modulators of the expression or activity of this enzyme for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or in vitro prognosis of these pathologies are also described.
摘要翻译： 用于筛选候选化合物以预防或治疗痤疮的体外方法包括测定化合物调节7型羟基类固醇（17-β）脱氢酶的表达或活性的能力，以及使用调节剂 该酶用于治疗与高脂血症相关的痤疮或皮肤病症的表达或活性; 还描述了这些病理学的体外诊断或体外预后的方法。
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公开(公告)号：US20090246776A1
公开(公告)日：2009-10-01
申请号：US12320166
申请日：2009-01-21
申请人： Fernand Labrie , Isabelle Carlavan , Pascal Collette , Ezequiel L. Calvo , Jerome Aubert , Johannes Voegel
发明人： Fernand Labrie , Isabelle Carlavan , Pascal Collette , Ezequiel L. Calvo , Jerome Aubert , Johannes Voegel
IPC分类号： C12Q1/68
CPC分类号： G01N33/6872 , C12Q1/6809 , C12Q1/6883 , C12Q1/6897 , C12Q2600/136 , C12Q2600/158 , G01N2500/00 , G01N2800/20
摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of the SCARB-1 receptor, and the use of modulators of the expression or activity of this receptor for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or prognosis of these pathologies are also described.
摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮的体外方法包括测定化合物调节SCARB-1受体的表达或活性的能力，以及使用表达或活性的调节剂 的这种受体用于治疗与高脂血症相关的痤疮或皮肤病症; 还描述了这些病理学的体外诊断或预后的方法。
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5.发明申请Compounds that modulate PPAR gamma-type receptors and cosmetic/pharmaceutical compositions comprising said compounds 失效调节PPARγ型受体的化合物和包含所述化合物的化妆品/药物组合物公开(公告)号：US20100247468A1
公开(公告)日：2010-09-30
申请号：US12585634
申请日：2009-09-21
申请人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
发明人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
IPC分类号： A61K8/49 , C07D417/10 , A61K31/427 , A61P17/14 , A61P35/00 , A61Q19/00 , A61Q5/00 , A61P17/10 , A61P3/04 , A61P3/06 , A61P3/10 , A61P19/02 , A61P9/10 , A61P9/12 , A61P11/06 , C07D333/24 , A61K31/381 , C07D213/75 , A61K31/4418 , C07D249/14 , A61K31/4196 , C07D213/56
CPC分类号： C07D213/75 , C07D213/55 , C07D239/26 , C07D239/42 , C07D249/14 , C07D277/30 , C07D277/48 , C07D307/54 , C07D333/24 , C07D401/12 , C07D409/04 , C07D413/06 , C07D417/06 , C07D417/10 , C07D417/12
摘要： Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.
摘要翻译： 具有以下通式（I）的新型化合物可用于人或兽医学（在皮肤病学以及心血管疾病，免疫疾病和/或与脂质代谢相关的疾病领域）的广泛应用中，或 ，或者配制成化妆品组合物。
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6.发明申请PACAP SIGNALING PATHWAY MODULATORS FOR TREATING INFLAMMATORY SKIN DISEASES HAVING A NEUROGENIC COMPONENT, NOTABLY ROSACEA, AND COMPOSITIONS COMPRISED THEREOF 审中-公开用于治疗具有神经细胞成分，非特异性ROSACEA及其组合物的炎症性皮肤疾病的PACAP信号途径调节剂公开(公告)号：US20110229423A1
公开(公告)日：2011-09-22
申请号：US13054769
申请日：2009-07-17
IPC分类号： A61K31/713 , G01N33/566 , C12Q1/68 , C07H21/02 , A61P29/00 , A61P17/10 , A61P17/02 , A61P17/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P31/10 , A61P23/00 , A61P37/08 , A61P39/06 , A61P37/06 , A61P17/08 , A61P17/12 , A61Q17/04 , A61P3/02
CPC分类号： G01N33/6881 , A61K9/0014 , A61K38/00 , G01N2500/04 , G01N2800/20 , G01N2800/202
摘要： Modulators of specific PACAP receptors are useful for treating inflammatory skin diseases having a neurogenic component, and more particularly rosacea and/or facial erythema, compositions containing these and screening methods are described for identifying PACAP signaling pathway modulators.
摘要翻译： 特异性PACAP受体的调节剂可用于治疗具有神经源成分的炎性皮肤疾病，更具体地，涉及红斑痤疮和/或面部红斑，含有这些和组合物的组合物和筛选方法用于鉴定PACAP信号通路调节剂。
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公开(公告)号：US08022079B2
公开(公告)日：2011-09-20
申请号：US12562665
申请日：2009-09-18
申请人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
发明人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
IPC分类号： A61K31/505 , A61K31/445 , A61K31/44 , A61K31/41 , A61K31/425 , A61K31/415 , A61K31/38 , A61K31/34 , C07D239/02 , C07D211/06 , C07D213/00 , C07D285/10 , C07D277/20 , C07D249/14 , C07D233/28 , C07D333/36 , C07D307/02
CPC分类号： C07D213/75 , C07D213/55 , C07D239/26 , C07D239/42 , C07D249/14 , C07D277/30 , C07D277/48 , C07D307/54 , C07D333/24 , C07D401/12 , C07D409/04 , C07D413/06 , C07D417/06 , C07D417/10 , C07D417/12
摘要： Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.
摘要翻译： 具有以下通式（I）的新型化合物可用于人或兽医学（在皮肤病学以及心血管疾病，免疫疾病和/或与脂质代谢相关的疾病领域）的广泛应用中，或 ，或者配制成化妆品组合物。
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8.发明授权Compounds that modulate PPARγ-type receptors and cosmetic/pharmaceutical compositions comprising said compounds 失效调节PPARγ型受体的化合物和包含所述化合物的化妆品/药物组合物公开(公告)号：US07968560B2
公开(公告)日：2011-06-28
申请号：US12585634
申请日：2009-09-21
申请人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
发明人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
IPC分类号： A61K31/505 , A61K31/445 , A61K31/44 , A61K31/41 , A61K31/425 , A61K31/415 , A61K31/38 , A61K31/34 , C07D239/02 , C07D211/06 , C07D213/00 , C07D285/10 , C07D277/20 , C07D249/14 , C07D233/28 , C07D333/36 , C07D307/02
CPC分类号： C07D213/75 , C07D213/55 , C07D239/26 , C07D239/42 , C07D249/14 , C07D277/30 , C07D277/48 , C07D307/54 , C07D333/24 , C07D401/12 , C07D409/04 , C07D413/06 , C07D417/06 , C07D417/10 , C07D417/12
摘要： Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.
摘要翻译： 具有以下通式（I）的新型化合物可用于人或兽医学（在皮肤病学以及心血管疾病，免疫疾病和/或与脂质代谢相关的疾病领域）的广泛应用中，或 ，或者配制成化妆品组合物。
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9.发明申请Novel compounds that modulate PPARy type receptors and cosmetic/pharmaceutical compositions comprised thereof 失效调节PPARγ型受体的新型化合物及其组合的美容/药物组合物公开(公告)号：US20060148862A1
公开(公告)日：2006-07-06
申请号：US11311449
申请日：2005-12-20
申请人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
发明人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
IPC分类号： A61K31/433 , A61K31/427 , A61K31/4245 , C07D417/02 , C07D413/02
CPC分类号： C07D213/75 , C07D213/55 , C07D239/26 , C07D239/42 , C07D249/14 , C07D277/30 , C07D277/48 , C07D307/54 , C07D333/24 , C07D401/12 , C07D409/04 , C07D413/06 , C07D417/06 , C07D417/10 , C07D417/12
摘要： Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.
摘要翻译： 具有以下通式（I）的新型化合物可用于人或兽医学（在皮肤病学以及心血管疾病，免疫疾病和/或与脂质代谢相关的疾病领域）的广泛应用中，或 ，或者配制成化妆品组合物。
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公开(公告)号：US20100099689A1
公开(公告)日：2010-04-22
申请号：US12562665
申请日：2009-09-18
申请人： Laurence CLARY , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
发明人： Laurence CLARY , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
IPC分类号： A61K31/505 , A61K31/425 , A61K31/506 , A61K31/44 , A61P17/00
CPC分类号： C07D213/75 , C07D213/55 , C07D239/26 , C07D239/42 , C07D249/14 , C07D277/30 , C07D277/48 , C07D307/54 , C07D333/24 , C07D401/12 , C07D409/04 , C07D413/06 , C07D417/06 , C07D417/10 , C07D417/12
摘要： Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.
摘要翻译： 具有以下通式（I）的新型化合物可用于人或兽医学（在皮肤病学以及心血管疾病，免疫疾病和/或与脂质代谢相关的疾病领域）的广泛应用中，或 ，或者配制成化妆品组合物。
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