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1.发明授权Salts and mixtures of hyaluronic acid with pharmaceutically active substances, pharmaceutical compositions containing the same and methods for administration of such compositions 失效盐和透明质酸与药物活性物质的混合物，含有它们的药物组合物以及用于施用这些组合物的方法
公开(公告)号：US5442053A
公开(公告)日：1995-08-15
申请号：US931949
申请日：1992-08-19
IPC分类号： A61K20060101 , A61K9/00 , A61K9/06 , A61K9/08 , A61K9/12 , A61K31/715 , A61K38/18 , A61K45/06 , A61K45/08 , A61K47/26 , A61K47/36 , A61K47/48 , C01F20060101 , C08B37/08 , F17C1/02 , C07H5/04
CPC分类号： A61K31/715 , A61K38/1808 , A61K45/06 , A61K47/26 , A61K47/36 , A61K9/0014 , A61K9/0019 , A61K9/0048 , C08B37/0072 , A61K9/0043 , A61K9/0046 , A61K9/0051 , A61K9/12 , Y10S514/912
摘要： Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intraarticular injections.In addition, pharmaceutical preparations for topical administration are provided containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, aluminum or ammonium, or in the form of a salt with one or more pharmacologically active substances.
摘要翻译： 获得透明质酸的两种药学上可用的级分，其包含分子量在50,000和100,000之间的用于伤口愈合的第一级分，以及分子量在500,000和730,000之间的第二级分，其用于眼内和关节内注射。 此外，提供了用于局部给药的药物制剂，其含有药理活性物质以及透明质酸或其分子量级分。 透明质酸可以是游离酸的形式，或者可以是与碱金属或碱土金属，镁，铝或铵的盐，或者是与一种或多种药理学活性物质形式的盐。
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2.发明授权
公开(公告)号：US4736024A
公开(公告)日：1988-04-05
申请号：US847632
申请日：1986-04-03
IPC分类号： A61K9/00 , A61K20060101 , A61K9/06 , A61K9/08 , A61K31/05 , A61K31/16 , A61K31/195 , A61K31/22 , A61K31/27 , A61K31/335 , A61K31/34 , A61K31/40 , A61K31/415 , A61K31/46 , A61K31/495 , A61K31/505 , A61K31/51 , A61K31/52 , A61K31/57 , A61K31/635 , A61K31/70 , A61K31/715 , A61K38/00 , A61K38/18 , A61K38/22 , A61K45/00 , A61K45/06 , A61K45/08 , A61K47/00 , A61K47/36 , A61K47/48 , A61P17/00 , A61P25/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P43/00 , C01F20060101 , C08B37/08 , F17C1/02
CPC分类号： A61K31/715 , A61K38/1808 , A61K45/06 , A61K47/36 , A61K47/4823 , A61K9/0048 , C08B37/0072
摘要： Pharmaceutical preparations for topical administration containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, aluminum or ammonium, or in the form of a salt with one or more pharmacologically active substances.
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3.发明授权
公开(公告)号：US5166331A
公开(公告)日：1992-11-24
申请号：US452681
申请日：1989-12-19
IPC分类号： A61K20060101 , A61K9/00 , A61K9/06 , A61K9/08 , A61K9/12 , A61K31/715 , A61K38/18 , A61K45/06 , A61K45/08 , A61K47/26 , A61K47/36 , A61K47/48 , C01F20060101 , C08B37/08 , F17C1/02
CPC分类号： A61K31/715 , A61K38/1808 , A61K45/06 , A61K47/26 , A61K47/36 , A61K9/0014 , A61K9/0019 , A61K9/0048 , C08B37/0072 , A61K9/0043 , A61K9/0046 , A61K9/0051 , A61K9/12 , Y10S514/912
摘要： Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intraarticular injections.In addition, pharmaceutical preparations for topical administration are provided containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, aluminum or ammonium, or in the form of a salt with one or more pharmacologically active substances.
摘要翻译： 获得透明质酸的两种药学上可用的级分，其包含分子量在50,000和100,000之间的用于伤口愈合的第一级分，以及分子量在500,000和730,000之间的第二级分，其用于眼内和关节内注射。 此外，提供了用于局部给药的药物制剂，其含有药理活性物质以及透明质酸或其分子量级分。 透明质酸可以是游离酸的形式，或者可以是与碱金属或碱土金属，镁，铝或铵的盐，或者是与一种或多种药理学活性物质形式的盐。
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4.发明授权Gangliosides mixture, useful as a therapeutical tool for eliminating painful effects or peripheral neuropathies 失效神经节苷脂混合物，可用作消除疼痛作用或周围神经病变的治疗工具
公开(公告)号：US4707469A
公开(公告)日：1987-11-17
申请号：US744338
申请日：1985-06-13
IPC分类号： A61K31/715 , A61K31/70 , A61K31/7028 , A61P25/02 , A61P25/04 , C07H15/10
摘要： A ganglioside mixture, comprised of the gangliosides GM.sub.1, GD.sub.1a, GD.sub.1b and GT.sub.1b, has been found to possess significant analgesic or pain relieving activity. The mixture is, therefore, useful for treating pain due to various peripheral neuropathies and the mixture is more effective than the individual gangliosides which comprise the mixture.
摘要翻译： 已经发现由神经节苷脂GM1，GD1a，GD1b和GT1b组成的神经节苷脂混合物具有显着的止痛或止痛活性。 因此，混合物可用于治疗由于各种周围神经病变引起的疼痛，并且该混合物比包含该混合物的单个神经节苷脂更有效。
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5.发明授权
公开(公告)号：US4940694A
公开(公告)日：1990-07-10
申请号：US338516
申请日：1988-10-20
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/715 , A61K35/30 , A61P9/00 , A61P25/28 , C07H15/10
CPC分类号： C07H15/10
摘要： A pharmaceutical preparation containing the ganglio-side GM.sub.1 or an inner ester derivative thereof and a method for increasing cerebral blood flow in stroke victims by acute administration of GM.sub.1 or its inner ester derivative.
摘要翻译： 包含神经节GM1或其内酯衍生物的药物制剂和通过急性给药GM1或其内酯衍生物来增加卒中受试者的脑血流量的方法。
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公开(公告)号：US5631241A
公开(公告)日：1997-05-20
申请号：US426905
申请日：1995-04-21
IPC分类号： A61K20060101 , A61K9/00 , A61K9/06 , A61K9/08 , A61K9/12 , A61K31/715 , A61K38/18 , A61K45/06 , A61K45/08 , A61K47/26 , A61K47/36 , A61K47/48 , C01F20060101 , C08B37/08 , F17C1/02
CPC分类号： A61K31/715 , A61K38/1808 , A61K45/06 , A61K47/26 , A61K47/36 , A61K9/0014 , A61K9/0019 , A61K9/0048 , C08B37/0072 , A61K9/0043 , A61K9/0046 , A61K9/0051 , A61K9/12 , Y10S514/912
摘要： Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intraarticular injections. In addition, pharmaceutical preparations for topical administration are provided containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, aluminum or ammonium, or in the form of a salt with one or more pharmacologically active substances.
摘要翻译： 获得透明质酸的两种药学上可用的级分，其包含分子量在50,000和100,000之间的用于伤口愈合的第一级分，以及分子量在500,000和730,000之间的第二级分，其用于眼内和关节内注射。 此外，提供了用于局部给药的药物制剂，其含有药理活性物质以及透明质酸或其分子量级分。 透明质酸可以是游离酸的形式，或者可以是与碱金属或碱土金属，镁，铝或铵的盐，或者是与一种或多种药理学活性物质形式的盐。
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7.发明授权Biocompatible perforated membranes, processes for their preparation, their use as a support in the in vitro growth of epithelial cells, the artificial skin obtained in this manner, and its use in skin grafts 失效生物相容性穿孔膜，其制备方法，它们作为上皮细胞体外生长中的载体的用途，以这种方式获得的人造皮肤及其在皮肤移植物中的用途
公开(公告)号：US5658331A
公开(公告)日：1997-08-19
申请号：US478541
申请日：1995-06-07
CPC分类号： C12N5/0629 , A61F2/105 , A61L27/60 , C12N5/0062 , C12N5/0068 , A61K35/12 , C12N2533/70 , C12N2533/80 , C12N2539/10 , Y10T428/24273
摘要： The invention relates to biocompatible membranes constructed of materials of natural, synthetic or semisynthetic origin, and having a thickness of between 10 and 500.mu., characterized by containing an ordered series of holes of a constant size between 10 and 1000.mu., separated from each other by a constant distance of between 50 and 1000.mu., and obtained by perforation by mechanical, thermal laser or ultraviolet radiation means, they being suitable for use as a support for the in vitro growth of epithelial cells, the invention also relating to the artificial skin obtained thereby and its use in grafts.
摘要翻译： 本发明涉及由天然，合成或半合成来源的材料构成的生物相容性膜，其厚度为10至500微米，其特征在于包含彼此分离的10至1000微米的恒定尺寸的有序系列的孔 通过50至1000微米之间的恒定距离，并且通过机械，热激光或紫外线辐射手段穿孔获得，它们适合用作上皮细胞的体外生长的载体，本发明还涉及人造皮肤 由此获得并在移植中的应用。
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公开(公告)号：US5424294A
公开(公告)日：1995-06-13
申请号：US138184
申请日：1993-10-20
CPC分类号： C07H15/10
摘要： N-acyl-N,N'-di-lysogangliosides, N'-acyl-N,N'-di-lysogangliosides and N,N'-diacyl-N,N'-di-lysogangliosides, in which the acyl groups are derived from an organic acid of the aliphatic, aromatic, araliphatic, alicyclic or heterocyclic series and in which at least one of the two acyl groups is not aliphatic, and their preparation are disclosed. Also disclosed is the preparation of the esters, inner esters, amides and hydroxy peracylates of these compounds and salts thereof. These compounds are useful in the treatment of pathologies of the central and peripheral nervous systems.
摘要翻译： N-酰基-N，N'-二溶菌索双胞苷，N'-酰基-N，N'-二溶菌索双胍和N，N'-二酰基-N，N'-二赖藻糖苷，其中酰基衍生 来自脂族，芳族，芳脂族，脂环族或杂环系列的有机酸，其中两个酰基中的至少一个不是脂族的，并且其公开。 还公开了这些化合物的酯，内酯，酰胺和羟基过酰基化物及其盐的制备。 这些化合物可用于治疗中枢和周围神经系统的病理。
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公开(公告)号：US5336668A
公开(公告)日：1994-08-09
申请号：US722398
申请日：1991-06-20
IPC分类号： A23L29/00 , A61K8/00 , A61K8/30 , A61K8/64 , A61K8/72 , A61K8/73 , A61K9/00 , A61K47/00 , A61K47/36 , A61K47/48 , A61L15/00 , A61L15/16 , A61L15/28 , A61L17/00 , A61L17/10 , A61L27/00 , A61L27/20 , A61Q19/00 , C08B37/04 , C11D3/48 , A61K9/70 , A61K31/725 , C07H1/00
CPC分类号： A61K9/0014 , A61K47/36 , A61K47/4823 , A61K8/733 , A61K9/0019 , A61L15/28 , A61L17/10 , A61L27/20 , A61Q19/00 , C08B37/0084 , Y10S514/912
摘要： Total and partial esters of alginic acid which possess important bioplastic and pharmaceutical qualities and are useful in various fields including medical, surgical, cosmetics and foods.
摘要翻译： 藻酸的全部和部分酯具有重要的生物塑料和药物特性，可用于包括医疗，外科，化妆品和食品在内的各个领域。
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公开(公告)号：US4849413A
公开(公告)日：1989-07-18
申请号：US95223
申请日：1987-09-11
IPC分类号： C07H3/00 , A61K31/70 , A61K31/7028 , A61K31/715 , A61K35/30 , A61P25/00 , C07C68/00 , C07H3/06 , C07H7/033 , C07H15/04 , C07H15/10 , C08G18/08 , C08G18/18
CPC分类号： C07H15/10
摘要： New functional ganglioside derivatives comprising ester, amide and peracylated derivatives of gangliosides, preparation procedures therefor, pharmaceutical preparations containing the same, and the therapeutic use of the derivatives.
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