公开(公告)号：US06759399B1

公开(公告)日：2004-07-06

申请号：US09535711

申请日：2000-03-27

申请人： Francis Petit ,  Daniel Philibert ,  Nick Goeders

发明人： Francis Petit ,  Daniel Philibert ,  Nick Goeders

IPC分类号： A61K3156

CPC分类号： A61K31/58 ,  A61K31/585

摘要： The method of treating narcotic withdrawal symptoms in warm-blooded animals comprising administering to warm-blooded animals in need thereof an amount of a compound having anti-mineralocorticoid activity sufficient to treat narcotic withdrawal symptoms.

摘要翻译： 在温血动物中治疗麻醉戒断症状的方法包括向有需要的温血动物给予一定量的具有足以治疗麻醉戒断症状的抗盐皮质激素活性的化合物。

公开(公告)号：US06147066A

公开(公告)日：2000-11-14

申请号：US43382

申请日：1998-03-16

申请人： Francis Petit ,  Daniel Philibert ,  Nick Goeders

发明人： Francis Petit ,  Daniel Philibert ,  Nick Goeders

IPC分类号： A61K45/00 ,  A61K31/58 ,  A61K31/585 ,  A61P25/30 ,  A61P25/36 ,  A61K31/56

CPC分类号： A61K31/58 ,  A61K31/585

摘要： Compounds having antimineralocorticoid activity suitable for preparing drugs for treating or preventing conditions related to drug dependence or to the spontaneous or induced withdrawal syndrome caused by narcotics or mixtures thereof, and compositions containing same, are disclosed.

摘要翻译： PCT No.PCT / FR96 / 01459 Sec。 371日期：1998年3月16日 102（e）1998年3月16日PCT PCT 1996年9月19日PCT公布。 出版物WO97 / 10827 日期1997年3月27日公开了具有适合于制备用于治疗或预防与药物依赖性有关的药物或由麻醉剂或其混合物引起的自发或诱发戒断综合征的药物的组合物和含有其的组合物。

公开(公告)号：US20080139489A1

公开(公告)日：2008-06-12

申请号：US11863329

申请日：2007-09-28

申请人： Francis Petit ,  Francoise Vacheron

发明人： Francis Petit ,  Francoise Vacheron

IPC分类号： A61K31/7048 ,  A61P7/00

CPC分类号： A61K31/7052

摘要： The invention relates to a novel therapeutic application of ketolides. The invention relates to the use of ketolides for the preparation of pharmaceutical compositions intended for preventing arterial thrombotic complications associated with atherosclerosis.

摘要翻译： 本发明涉及一种新型的酮内酯治疗应用。 本发明涉及用于制备用于预防与动脉粥样硬化相关的动脉血栓并发症的药物组合物的酮内酯的用途。

公开(公告)号：US4892976A

公开(公告)日：1990-01-09

申请号：US219926

申请日：1988-07-15

申请人： Jean Cordier ,  Bernard Dussart ,  Francis Petit ,  Yves Castanet ,  Serge Melloul ,  Andre Mortreux

发明人： Jean Cordier ,  Bernard Dussart ,  Francis Petit ,  Yves Castanet ,  Serge Melloul ,  Andre Mortreux

IPC分类号： B01J27/08 ,  B01J27/128 ,  B01J31/28 ,  C07B61/00 ,  C07C45/00 ,  C07C45/49 ,  C07C47/02 ,  C07C47/06 ,  C07C67/00

CPC分类号： C07C45/49

摘要： The process for the preparation of an aldehyde of formula R--CHO in which R is an alkyl group of C.sub.1 -C.sub.7 comprises according to the invention the reaction on an alkyl formate of formula H--COOR in which R has the meaning given above, of a gas constituted mainly by CO, in the presence of(a) a catalyst based on a metal chosen from among Rh, Ru, Ir, mixtures of them or a mixture of Rh and/or Ru and/or Ir with Co, Ni or Fe,(b) a promoter chosen from among iodides and mixtures of covalent compounds of iodine and a phosphine or a tertiary amine,(c) a solvent consisting of a cyclic N-alkyl amide.

摘要翻译： 制备其中R为C 1 -C 7烷基的式R-CHO的醛的方法包括根据本发明的式H-COOR烷基甲酸酯的反应，其中R具有上述含义， 在（a）基于选自Rh，Ru，Ir的金属的催化剂，它们的混合物或Rh和/或Ru和/或Ir与Co，Ni或其混合物的混合物的存在下，主要由CO构成的气体 Fe，（b）选自碘化物的促进剂和碘和膦或叔胺的共价化合物的混合物，（c）由环状N-烷基酰胺组成的溶剂。

公开(公告)号：US4877908A

公开(公告)日：1989-10-31

申请号：US107919

申请日：1987-10-13

申请人： Michele Petit ,  Andre Mortreux ,  Francis Petit ,  Gerard Buono

发明人： Michele Petit ,  Andre Mortreux ,  Francis Petit ,  Gerard Buono

IPC分类号： B01J31/18 ,  B01J31/00 ,  B01J31/24 ,  C07B31/00 ,  C07B53/00 ,  C07B61/00 ,  C07C1/00 ,  C07C2/32 ,  C07C2/42 ,  C07C2/46 ,  C07C2/52 ,  C07C11/02 ,  C07C13/20 ,  C07C29/136 ,  C07C29/88 ,  C07C33/22 ,  C07C45/49 ,  C07C45/50 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C231/20 ,  C07C233/47 ,  C07F7/18 ,  C07F9/46 ,  C07F9/50 ,  C07F9/53 ,  C07F9/572 ,  C07F15/00

CPC分类号： C07F15/0073 ,  C07C2/465 ,  C07C2/52 ,  C07C45/505 ,  C07F7/188 ,  C07F9/46 ,  C07F9/572 ,  C07C2101/16 ,  C07C2531/22

摘要： Chiral phosphorus-containing ligands comprising at least one amine radical and at least one dihydrocarbylphosphinoxy radical of the formula W=OP (R).sub.2, in which R is a hydrocarbon radical selected from the group consisting of alkyl, aryl, and cycloalkyl radicals, wherein the ligand is selected from the group consisting of:those of the formula ##STR1## those of the formula ##STR2## those of the formula ##STR3## those of the formula ##STR4## in which formulae: R.sub.1 and R.sub.2 are selected from the group consisting of a hydrogen atom and hydrocarbon radicals;R.sub.3 and R.sub.4, which must be different from one another, are selected from the group consisting of a hydrogen atom and hydrocarbon radicals that may or may not carry at least one functional group selected from the group consisting of the alcohol, thiol, thioether, amine, imine, acid, ester, amide, and ether functional groups; andR.sub.5 and R.sub.6 are selected from the group consisting of hydrogen atoms and hydrocarbon radicals that may or may not contain functional groups.A process for their manufacture comprises reacting an optically active amino alcohol, in a hydrocarbon solvent at a temperature between -50.degree. and 80.degree. C. and under an inert gas atmosphere, with at least one compound of the formula P(R).sub.2 Y in which Y is chosen from among the halogen atoms and amine radicals, the compound being present in a molar ratio, relative to the amino alcohol, greater than or equal to the number of P(R).sub.2 groups to be introduced into the chiral molecule.The chiral phosphorous-containing ligands are used by reacting at least one organic compound that does not possess a center of asymmetry with (A), on the one hand, at least one transition metal complex of formula MZq in which M is a metal in group VIII of the Periodic Classification, q is the coordination number of the metal M, and Z is an atom or molecule capable of complexing the metal M and (B), on the other hand, at least one ligand L.

公开(公告)号：US4593140A

公开(公告)日：1986-06-03

申请号：US732544

申请日：1985-05-10

申请人： Andre Mortreux ,  Francis Petit ,  Philippe Denis ,  Gerard Buono ,  Gilbert Peiffer

发明人： Andre Mortreux ,  Francis Petit ,  Philippe Denis ,  Gerard Buono ,  Gilbert Peiffer

IPC分类号： C07C2/40 ,  C07C2/46 ,  C07C2/52 ,  C07C2/02

CPC分类号： C07C2/52 ,  C07C2/403 ,  C07C2/406 ,  C07C2/465 ,  C07C2531/22 ,  C07C2531/24

摘要： The process according to the invention consists in dimerizing a conjugated diene in the presence of a catalyst obtained by bringing together (A) at least one nickel complex of formula NiZ.sub.q in which q is the coordination number of the nickel and Z is at least one ligand capable of complexing nickel and (B) at least one phosphorus-containing ligand of general formula ##STR1## in which: R.sub.1 is chosen from a hydrogen atom and hydrocarbon radicals,R.sub.2 and R.sub.3, which may be identical or different, are chosen from a hydrogen atom and hydrocarbon radicals optionally bearing at least one group chosen from alcohol, thiol, thioether, amine, imine, acid, ester, amide and ether groups, andm is greater than or equal to 1.

摘要翻译： 根据本发明的方法包括在通过将（A）至少一种式NiZq的镍络合物（其中q为镍的配位数，Z为至少一个配体）的催化剂存在下将共轭二烯二聚化 能够络合镍和（B）至少一种通式为“IMAGE”的含磷配体，其中：R 1选自氢原子和烃基，R 2和R 3可以相同或不同，选自 氢原子和烃基任选具有至少一个选自醇，硫醇，硫醚，胺，亚胺，酸，酯，酰胺和醚基团的基团，m大于或等于1。

公开(公告)号：US5674864A

公开(公告)日：1997-10-07

申请号：US449290

申请日：1995-05-24

申请人： Fran.cedilla.ois Clemence ,  Odile Le Martret ,  Francis Petit

发明人： Fran.cedilla.ois Clemence ,  Odile Le Martret ,  Francis Petit

IPC分类号： A61K31/17 ,  C07C319/20 ,  C07C323/41 ,  C07C323/44 ,  C07C327/30 ,  C07C327/42 ,  C07C331/24 ,  C07C335/04 ,  C07D211/58 ,  C07D213/75 ,  C07D243/08 ,  C07D243/24 ,  C07D295/10 ,  C07D295/15 ,  C07D295/215 ,  C07D295/32 ,  A61K31/54 ,  A61K31/535 ,  C07D401/02 ,  C07D403/02

CPC分类号： C07D213/75 ,  C07C323/44 ,  C07C327/30 ,  C07D211/58 ,  C07D243/08 ,  C07D243/24 ,  C07D295/15 ,  C07D295/215

摘要： Novel .alpha.-mercapto-alkylamines in all possible racemic, enantiomeric and diastereoisomeric forms of the formula ##STR1## wherein the substituents are as defined in the specification.

摘要翻译： 新颖的α-巯基 - 烷基胺在所有可能的外消旋，对映异构体和非对映异构体形式的式IA中，其中取代基如说明书中所定义。

公开(公告)号：US5214205A

公开(公告)日：1993-05-25

申请号：US868186

申请日：1992-04-14

申请人： Yves Castanet ,  Bruno Seuillet ,  Andre Mortreux ,  Francis Petit

发明人： Yves Castanet ,  Bruno Seuillet ,  Andre Mortreux ,  Francis Petit

IPC分类号： B01J31/20 ,  B01J31/24 ,  C07B61/00 ,  C07C51/12 ,  C07C51/56 ,  C07C53/12

CPC分类号： C07C53/12 ,  C07C51/56

摘要： The invention relates to a process for the preparation of acetic anhydride, characterized in that a gas containing essentially CO, at a pressure of at least 1 MPa, is reacted with methyl formate in the presence ofa) a rhodium-based catalyst,b) two iodine-containing promoters of different kind, successively ionic and covalent, andc) an N-substituted cyclic amide as solvent.

摘要翻译： 本发明涉及一种制备乙酸酐的方法，其特征在于在a）铑基催化剂存在下，使基本上含有至少1MPa压力的CO的气体与甲酸甲酯反应，b） 两种不同种类的含碘促进剂，连续离子和共价，和c）N-取代的环状酰胺作为溶剂。

公开(公告)号：US5118824A

公开(公告)日：1992-06-02

申请号：US646642

申请日：1991-02-06

申请人： Eric Paumard ,  Andre Mortreuz ,  Francis Petit

发明人： Eric Paumard ,  Andre Mortreuz ,  Francis Petit

IPC分类号： B01J31/12 ,  B01J31/24 ,  C07C45/50 ,  C07F15/00

CPC分类号： C07F15/0093 ,  B01J31/121 ,  B01J31/2414 ,  C07C45/50 ,  B01J2231/321 ,  B01J2531/828

摘要： The invention relates to platinum hydrides, a process for their preparation and their use as components of catalytic systems. The platinum hydrides have a bridged bimetallic structure represented by the general formula: ##STR1## wherein: M is a metal of valence n, at least equal to 2,X is a halogen atom, andP P is a schematic representation of a ligand of the general formula: ##STR2## in which: R.sub.1, R.sub.2, R.sub.5, and R.sub.6, identical or different, are chosen from among aliphatic or cycloaliphatic hydrocarbon radicals with 1 to 8 carbon atoms and aromatic hydrocarbon radicals with 6 to 10 carbon atoms,R.sub.3 and R.sub.4, identical or different, are chosen from among a hydrogen atom and aliphatic hydrocarbon radicals with 1 to 8 carbon atoms, possibly functionalized and/or together forming a ring, andm is an integer higher than or equal to 4.

摘要翻译： PCT No.PCT / FR89 / 00416 Sec。 371日期1991年2月6日 102（e）1991年2月6日PCT PCT 1989年8月9日PCT公布。 出版物WO90 / 01486 日期1990年02月22日。本发明涉及氢化铂，其制备方法及其作为催化体系成分的用途。 铂氢化物具有由以下通式表示的桥连双金属结构：其中：M是价数n至少等于2的金属，X是卤素原子，PP是a的示意图 具有以下通式的配体：其中：R 1，R 2，R 5和R 6相同或不同，选自具有1至8个碳原子的脂族或脂环族烃基和具有6至 10个碳原子，R3和R4相同或不同，选自具有1至8个碳原子的氢原子和脂族烃基，可能官能化和/或一起形成环，m是高于或等于 4。

公开(公告)号：US4839358A

公开(公告)日：1989-06-13

申请号：US159265

申请日：1988-02-23

申请人： Jean-Paul Vevert ,  Francoise Delevallee ,  Jean-Claude Gasc ,  Francis Petit

发明人： Jean-Paul Vevert ,  Francoise Delevallee ,  Jean-Claude Gasc ,  Francis Petit

IPC分类号： C07D295/22 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4468 ,  A61K31/495 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/54 ,  A61K31/55 ,  A61P3/00 ,  A61P25/04 ,  A61P25/24 ,  A61P25/26 ,  C07D211/56 ,  C07D265/30 ,  C07D277/04 ,  C07D295/32

CPC分类号： C07D295/32

摘要： Novel .alpha.-mercaptomethyl-benzene propanamides of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and ##STR2## R.sub.1 ' is selected from the group consisting of alkyl of 1 to 5 carbon atoms and aryl optionally substituted with at least one member of the group consisting of --OH, --NO.sub.2, halogen and alkyl and alkoxy of 1 to 5 carbon atoms, X and X' are individually selected from the group consisting of hydrogen, alkyl and alkoxy of 1 to 5 carbon atoms, --OH, halogen and --CF.sub.3, R.sub.2 is selected from the group consisting of pyrrolidinyl, morpholinyl, piperidinyl, piperazinyl, tetrahydrothiazinyl and hexahydroazepinyl, all optionally substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 5 carbon atoms, --OH, --NO.sub.2, --CF.sub.3, halogen and acyl of an organic carboxylic acid of 1 to 7 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having analgesic activity, antidepression and anxiolytic properties.

摘要翻译： 式Ⅰ的新型α-巯基甲基 - 苯丙酰胺，其中R 1选自氢和R 1'选自1至5个碳原子的烷基和任选被 由-OH，-NO 2，卤素和1至5个碳原子的烷基和烷氧基组成的组中的至少一个成员，X和X'分别选自氢，烷基和1至5个碳原子的烷氧基， -OH，卤素和-CF 3，R 2选自吡咯烷基，吗啉基，哌啶基，哌嗪基，四氢噻嗪基和六氢氮杂卟啉，全部任选被至少一个由1至5个碳原子的烷基和烷氧基组成的组取代 具有1至7个碳原子的有机羧酸的-OH，-NO 2，-CF 3，卤素和酰基及其具有止痛活性，抗抑郁和抗焦虑性质的无毒的药学上可接受的酸加成盐。