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26 条记录 (耗时 0.025 秒)

    Alpha-mercaptomethyl-benzene propanamides, pharmaceutical compositions and use
    1.
    发明授权
    Alpha-mercaptomethyl-benzene propanamides, pharmaceutical compositions and use 失效
    α-巯基甲基苯丙酰胺，药物组合物和用途

    公开(公告)号：US4839358A

    公开(公告)日：1989-06-13

    申请号：US159265

    申请日：1988-02-23

    申请人： Jean-Paul Vevert ,  Francoise Delevallee ,  Jean-Claude Gasc ,  Francis Petit

    发明人： Jean-Paul Vevert ,  Francoise Delevallee ,  Jean-Claude Gasc ,  Francis Petit

    IPC分类号： C07D295/22 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4468 ,  A61K31/495 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/54 ,  A61K31/55 ,  A61P3/00 ,  A61P25/04 ,  A61P25/24 ,  A61P25/26 ,  C07D211/56 ,  C07D265/30 ,  C07D277/04 ,  C07D295/32

    CPC分类号： C07D295/32

    摘要： Novel .alpha.-mercaptomethyl-benzene propanamides of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and ##STR2## R.sub.1 ' is selected from the group consisting of alkyl of 1 to 5 carbon atoms and aryl optionally substituted with at least one member of the group consisting of --OH, --NO.sub.2, halogen and alkyl and alkoxy of 1 to 5 carbon atoms, X and X' are individually selected from the group consisting of hydrogen, alkyl and alkoxy of 1 to 5 carbon atoms, --OH, halogen and --CF.sub.3, R.sub.2 is selected from the group consisting of pyrrolidinyl, morpholinyl, piperidinyl, piperazinyl, tetrahydrothiazinyl and hexahydroazepinyl, all optionally substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 5 carbon atoms, --OH, --NO.sub.2, --CF.sub.3, halogen and acyl of an organic carboxylic acid of 1 to 7 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having analgesic activity, antidepression and anxiolytic properties.

    摘要翻译： 式Ⅰ的新型α-巯基甲基 - 苯丙酰胺，其中R 1选自氢和R 1'选自1至5个碳原子的烷基和任选被 由-OH，-NO 2，卤素和1至5个碳原子的烷基和烷氧基组成的组中的至少一个成员，X和X'分别选自氢，烷基和1至5个碳原子的烷氧基， -OH，卤素和-CF 3，R 2选自吡咯烷基，吗啉基，哌啶基，哌嗪基，四氢噻嗪基和六氢氮杂卟啉，全部任选被至少一个由1至5个碳原子的烷基和烷氧基组成的组取代 具有1至7个碳原子的有机羧酸的-OH，-NO 2，-CF 3，卤素和酰基及其具有止痛活性，抗抑郁和抗焦虑性质的无毒的药学上可接受的酸加成盐。

    Process for the preparation of aldehydes
    4.
    发明授权
    Process for the preparation of aldehydes 失效
    醛的制备方法

    公开(公告)号：US4892976A

    公开(公告)日：1990-01-09

    申请号：US219926

    申请日：1988-07-15

    申请人： Jean Cordier ,  Bernard Dussart ,  Francis Petit ,  Yves Castanet ,  Serge Melloul ,  Andre Mortreux

    发明人： Jean Cordier ,  Bernard Dussart ,  Francis Petit ,  Yves Castanet ,  Serge Melloul ,  Andre Mortreux

    IPC分类号： B01J27/08 ,  B01J27/128 ,  B01J31/28 ,  C07B61/00 ,  C07C45/00 ,  C07C45/49 ,  C07C47/02 ,  C07C47/06 ,  C07C67/00

    CPC分类号： C07C45/49

    摘要： The process for the preparation of an aldehyde of formula R--CHO in which R is an alkyl group of C.sub.1 -C.sub.7 comprises according to the invention the reaction on an alkyl formate of formula H--COOR in which R has the meaning given above, of a gas constituted mainly by CO, in the presence of(a) a catalyst based on a metal chosen from among Rh, Ru, Ir, mixtures of them or a mixture of Rh and/or Ru and/or Ir with Co, Ni or Fe,(b) a promoter chosen from among iodides and mixtures of covalent compounds of iodine and a phosphine or a tertiary amine,(c) a solvent consisting of a cyclic N-alkyl amide.

    摘要翻译： 制备其中R为C 1 -C 7烷基的式R-CHO的醛的方法包括根据本发明的式H-COOR烷基甲酸酯的反应，其中R具有上述含义， 在（a）基于选自Rh，Ru，Ir的金属的催化剂，它们的混合物或Rh和/或Ru和/或Ir与Co，Ni或其混合物的混合物的存在下，主要由CO构成的气体 Fe，（b）选自碘化物的促进剂和碘和膦或叔胺的共价化合物的混合物，（c）由环状N-烷基酰胺组成的溶剂。

    Process for dimerizing conjugated dienes
    6.
    发明授权
    Process for dimerizing conjugated dienes 失效
    二聚共轭二烯的方法

    公开(公告)号：US4593140A

    公开(公告)日：1986-06-03

    申请号：US732544

    申请日：1985-05-10

    申请人： Andre Mortreux ,  Francis Petit ,  Philippe Denis ,  Gerard Buono ,  Gilbert Peiffer

    发明人： Andre Mortreux ,  Francis Petit ,  Philippe Denis ,  Gerard Buono ,  Gilbert Peiffer

    IPC分类号： C07C2/40 ,  C07C2/46 ,  C07C2/52 ,  C07C2/02

    CPC分类号： C07C2/52 ,  C07C2/403 ,  C07C2/406 ,  C07C2/465 ,  C07C2531/22 ,  C07C2531/24

    摘要： The process according to the invention consists in dimerizing a conjugated diene in the presence of a catalyst obtained by bringing together (A) at least one nickel complex of formula NiZ.sub.q in which q is the coordination number of the nickel and Z is at least one ligand capable of complexing nickel and (B) at least one phosphorus-containing ligand of general formula ##STR1## in which: R.sub.1 is chosen from a hydrogen atom and hydrocarbon radicals,R.sub.2 and R.sub.3, which may be identical or different, are chosen from a hydrogen atom and hydrocarbon radicals optionally bearing at least one group chosen from alcohol, thiol, thioether, amine, imine, acid, ester, amide and ether groups, andm is greater than or equal to 1.

    摘要翻译： 根据本发明的方法包括在通过将（A）至少一种式NiZq的镍络合物（其中q为镍的配位数，Z为至少一个配体）的催化剂存在下将共轭二烯二聚化 能够络合镍和（B）至少一种通式为“IMAGE”的含磷配体，其中：R 1选自氢原子和烃基，R 2和R 3可以相同或不同，选自 氢原子和烃基任选具有至少一个选自醇，硫醇，硫醚，胺，亚胺，酸，酯，酰胺和醚基团的基团，m大于或等于1。

    Platinum hydrides with bridges bimetallic structure, method for their preparation and their application to the catalysis of chemical reactions
    9.
    发明授权
    Platinum hydrides with bridges bimetallic structure, method for their preparation and their application to the catalysis of chemical reactions 失效
    具有桥接双金属结构的铂盐，其制备方法及其对化学反应的催化应用

    公开(公告)号：US5118824A

    公开(公告)日：1992-06-02

    申请号：US646642

    申请日：1991-02-06

    申请人： Eric Paumard ,  Andre Mortreuz ,  Francis Petit

    发明人： Eric Paumard ,  Andre Mortreuz ,  Francis Petit

    IPC分类号： B01J31/12 ,  B01J31/24 ,  C07C45/50 ,  C07F15/00

    CPC分类号： C07F15/0093 ,  B01J31/121 ,  B01J31/2414 ,  C07C45/50 ,  B01J2231/321 ,  B01J2531/828

    摘要： The invention relates to platinum hydrides, a process for their preparation and their use as components of catalytic systems. The platinum hydrides have a bridged bimetallic structure represented by the general formula: ##STR1## wherein: M is a metal of valence n, at least equal to 2,X is a halogen atom, andP P is a schematic representation of a ligand of the general formula: ##STR2## in which: R.sub.1, R.sub.2, R.sub.5, and R.sub.6, identical or different, are chosen from among aliphatic or cycloaliphatic hydrocarbon radicals with 1 to 8 carbon atoms and aromatic hydrocarbon radicals with 6 to 10 carbon atoms,R.sub.3 and R.sub.4, identical or different, are chosen from among a hydrogen atom and aliphatic hydrocarbon radicals with 1 to 8 carbon atoms, possibly functionalized and/or together forming a ring, andm is an integer higher than or equal to 4.

    摘要翻译： PCT No.PCT / FR89 / 00416 Sec。 371日期1991年2月6日 102（e）1991年2月6日PCT PCT 1989年8月9日PCT公布。 出版物WO90 / 01486 日期1990年02月22日。本发明涉及氢化铂，其制备方法及其作为催化体系成分的用途。 铂氢化物具有由以下通式表示的桥连双金属结构：其中：M是价数n至少等于2的金属，X是卤素原子，PP是a的示意图 具有以下通式的配体：其中：R 1，R 2，R 5和R 6相同或不同，选自具有1至8个碳原子的脂族或脂环族烃基和具有6至 10个碳原子，R3和R4相同或不同，选自具有1至8个碳原子的氢原子和脂族烃基，可能官能化和/或一起形成环，m是高于或等于 4。