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    Biological patterns for diagnosis and treatment of cancer
    1.
    发明申请
    Biological patterns for diagnosis and treatment of cancer 审中-公开
    用于诊断和治疗癌症的生物学模式

    公开(公告)号：US20050244973A1

    公开(公告)日：2005-11-03

    申请号：US10845773

    申请日：2004-05-14

    申请人： Frank Andel ,  Hans Bitter ,  Mikhail Belov ,  Michael Brown ,  Alfred Greenquist ,  Jonathan Heller ,  Alexander Sassi ,  John Stults ,  Kathy Stults

    发明人： Frank Andel ,  Hans Bitter ,  Mikhail Belov ,  Michael Brown ,  Alfred Greenquist ,  Jonathan Heller ,  Alexander Sassi ,  John Stults ,  Kathy Stults

    IPC分类号： G01N33/48 ,  G01N33/574

    CPC分类号： G01N33/57434 ,  Y10T436/24

    摘要： The present invention provides methods for diagnosing cancers, such as prostate cancer. Also, methods for evaluating the prostate cancer state of a patient are described herein. These methods involve the detection, analysis, and classification of biological patterns in biological samples. The biological patterns are obtained using, for example, mass spectrometry systems, antibody based techniques, or nucleic acid based techniques. The present invention also includes therapeutic and prophylactic agents that target the biomarkers described herein. Also, the present invention provides methods for the treatment of prostate cancer using the markers described herein or agents that mimic the properties of these markers.

    摘要翻译： 本发明提供了诊断癌症的方法，例如前列腺癌。 此外，本文描述了用于评估患者的前列腺癌状态的方法。 这些方法涉及生物样品中生物样本的检测，分析和分类。 使用例如质谱系统，基于抗体的技术或基于核酸的技术获得生物学模式。 本发明还包括靶向本文所述的生物标志物的治疗和预防剂。 此外，本发明提供了使用本文所述的标记物治疗前列腺癌的方法或模拟这些标记的性质的试剂。

    Biological patterns for diagnosis and treatment of cancer
    2.
    发明申请
    Biological patterns for diagnosis and treatment of cancer 审中-公开
    用于诊断和治疗癌症的生物学模式

    公开(公告)号：US20070009970A1

    公开(公告)日：2007-01-11

    申请号：US11178245

    申请日：2005-07-08

    申请人： Jonathan Heller ,  Michael Brown ,  David de Valpine ,  Hans Bitter ,  Kathy Stults ,  Isabelle Guyon ,  Robert Tibshirani

    发明人： Jonathan Heller ,  Michael Brown ,  David de Valpine ,  Hans Bitter ,  Kathy Stults ,  Isabelle Guyon ,  Robert Tibshirani

    IPC分类号： G01N33/574 ,  G06F19/00

    CPC分类号： G01N33/57434 ,  G01N33/6848

    摘要： The present invention provides methods for diagnosing cancers, such as prostate cancer. Also, methods for evaluating the prostate cancer state of a patient are described herein. These methods involve the detection, analysis, and classification of biological patterns in biological samples. The biological patterns are obtained using, for example, mass spectrometry systems, antibody based techniques, or nucleic acid based techniques. The present invention also includes therapeutic and prophylactic agents that target the biomarkers described herein. Also, the present invention provides methods for the treatment of prostate cancer using the markers described herein or agents that mimic the properties of these markers.

    摘要翻译： 本发明提供了诊断癌症的方法，例如前列腺癌。 此外，本文描述了用于评估患者的前列腺癌状态的方法。 这些方法涉及生物样品中生物样本的检测，分析和分类。 使用例如质谱系统，基于抗体的技术或基于核酸的技术获得生物学模式。 本发明还包括靶向本文所述的生物标志物的治疗和预防剂。 此外，本发明提供了使用本文所述的标记物治疗前列腺癌的方法或模拟这些标记的性质的试剂。

    Methods and apparatus for self-optimization of electrospray ionization devices
    5.
    发明申请
    Methods and apparatus for self-optimization of electrospray ionization devices 审中-公开
    电喷雾离子化装置自优化的方法和装置

    公开(公告)号：US20050072915A1

    公开(公告)日：2005-04-07

    申请号：US10681742

    申请日：2003-10-07

    申请人： John Stults ,  Jonathan Heller

    发明人： John Stults ,  Jonathan Heller

    IPC分类号： H01J49/04

    CPC分类号： H01J49/0018 ,  H01J49/167

    摘要： An automated electrospray ionization (ESI) device and related methods to optimize electrospray interface conditions for mass spectrometric analysis. The optimization process can be performed with calibration or optimization solutions that produce expected ESI parameters such as an ESI signal or an ion current. The ESI device may include an input/output (I/O) controller that is coupled to an electrospray assembly including an XYZ stage for positioning an electrospray emitter relative to a mass spectrometer orifice. The I/O controller may be connected to a power supply for applying an adjustable electrospray ionization voltage, and an adjustable flow regulator that alters the flow of solution by modifying applied voltage and/or pressure. A central processing unit instructs the I/O controller to control selectively the electrospray assembly based on the resultant signals from the mass spectrometer or the ion currents within the mass spectrometer in accordance with a predetermined optimization algorithm. The resulting ESI signal or ion currents are monitored and provide feedback to the I/O controller which can automatically instruct selected system components to make adjustments as needed to attain optimal settings that produce expected ESI signals or ion currents in the mass spectrometer for selected solutions.

    摘要翻译： 自动电喷雾离子化（ESI）装置和相关方法来优化电喷雾界面条件进行质谱分析。 优化过程可以用产生ESI信号或离子电流等ESI参数的校准或优化解决方案进行。 ESI装置可以包括耦合到电喷组件的输入/输出（I / O）控制器，其包括用于相对于质谱仪孔口定位电喷发射器的XYZ级。 I / O控制器可以连接到用于施加可调节的电喷雾电离电压的电源，以及可调整的流量调节器，其通过修改施加的电压和/或压力来改变溶液的流动。 中央处理单元根据预定的优化算法指示I / O控制器基于质谱仪产生的信号或质谱仪内的离子电流来选择性地控制电喷雾组件。 监测所得到的ESI信号或离子电流，并向I / O控制器提供反馈，该控制器可以根据需要自动指示所选系统组件进行调整，以获得在质谱仪中为选定解决方案产生期望的ESI信号或离子电流的最佳设置。

    Microfluidic devices and methods
    6.
    发明申请
    Microfluidic devices and methods 审中-公开
    微流体装置和方法

    公开(公告)号：US20050000569A1

    公开(公告)日：2005-01-06

    申请号：US10794572

    申请日：2004-03-04

    申请人： Luc Bousse ,  Mingqi Zhao ,  John Stults ,  Jing Ni ,  Jonathan Heller ,  Uthara Srinivasan

    发明人： Luc Bousse ,  Mingqi Zhao ,  John Stults ,  Jing Ni ,  Jonathan Heller ,  Uthara Srinivasan

    IPC分类号： F15C1/04 ,  F16L58/04 ,  G01N20060101 ,  H01J49/04 ,  H01J49/16

    CPC分类号： H01J49/0018 ,  H01J49/165 ,  Y10T137/0402 ,  Y10T137/2082 ,  Y10T137/2191 ,  Y10T137/2224 ,  Y10T137/7036 ,  Y10T436/2575

    摘要： Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include first and second surfaces, at least one microchannel formed by the surfaces, and an outlet at an edge of the surfaces. Some embodiments also include a tip surface with one or more surface features for helping guide substances from the outlet of the device toward a mass spectrometer. In some embodiments, the surface feature(s) includes a groove, which may be hydrophilic along all or part of its length. Hydrophilic surfaces and/or hydrophobic surfaces may also help guide substances out of the outlet and/or toward the mass spectrometer. In some embodiments, the outlet and/or the tip surface is recessed back from an adjacent portion of the edge. A source of electrical potential can help move substances through the microchannel, separate substances and/or provide electrospray ionization.

    摘要翻译： 微流体装置向质谱仪提供物质。 微流体装置包括第一和第二表面，由表面形成的至少一个微通道和表面边缘处的出口。 一些实施例还包括具有一个或多个表面特征的尖端表面，用于帮助将物质从装置的出口引向质谱仪。 在一些实施例中，表面特征包括凹槽，其可以沿其长度的全部或部分亲水。 亲水表面和/或疏水表面还可以帮助将物质引出出口和/或朝向质谱仪。 在一些实施例中，出口和/或尖端表面从边缘的相邻部分向后凹陷。 电势源可以帮助物质通过微通道，分离物质和/或提供电喷雾电离。

    Managing structured and unstructured data within electronic communications
    7.
    发明授权
    Managing structured and unstructured data within electronic communications 有权
    在电子通信中管理结构化和非结构化数据

    公开(公告)号：US08060536B2

    公开(公告)日：2011-11-15

    申请号：US11959231

    申请日：2007-12-18

    申请人： Guy Bavly ,  Jonathan Heller ,  Ehud Waizer

    发明人： Guy Bavly ,  Jonathan Heller ,  Ehud Waizer

    IPC分类号： G06F17/30 ,  G06Q30/00

    CPC分类号： G06F17/30876 ,  G06F17/30557 ,  G06Q10/10 ,  G06Q30/0621

    摘要： This disclosure provides various embodiments of systems, methods, and software for managing structured and unstructured data within electronic communications. In one implementation, software identifies an electronic communication associated with a user in an enterprise application; creates a link between an unstructured data element associated with the electronic communication and a structured data element associated with the enterprise application, where the link created at least partially based on one or more attributes of the electronic communication and an active process of the enterprise application; and stores the link in a link repository.

    摘要翻译： 本公开提供了用于在电子通信内管理结构化和非结构化数据的系统，方法和软件的各种实施例。 在一个实现中，软件识别与企业应用中的用户相关联的电子通信; 在与电子通信相关联的非结构化数据元素与与企业应用相关联的结构化数据元素之间创建链接，其中链路至少部分地基于电子通信的一个或多个属性和企业应用的活动过程而创建; 并将链接存储在链接库中。

    Managing Structured and Unstructured Data within Electronic Communications
    8.
    发明申请
    Managing Structured and Unstructured Data within Electronic Communications 有权
    管理电子通信中的结构化和非结构化数据

    公开(公告)号：US20090157812A1

    公开(公告)日：2009-06-18

    申请号：US11959231

    申请日：2007-12-18

    申请人： Guy Bavly ,  Jonathan Heller ,  Ehud Waizer

    发明人： Guy Bavly ,  Jonathan Heller ,  Ehud Waizer

    IPC分类号： G06F15/16 ,  G06F17/30

    CPC分类号： G06F17/30876 ,  G06F17/30557 ,  G06Q10/10 ,  G06Q30/0621

    摘要： This disclosure provides various embodiments of systems, methods, and software for managing structured and unstructured data within electronic communications. In one implementation, software identifies an electronic communication associated with a user in an enterprise application; creates a link between an unstructured data element associated with the electronic communication and a structured data element associated with the enterprise application, where the link created at least partially based on one or more attributes of the electronic communication and an active process of the enterprise application; and stores the link in a link repository.

    摘要翻译： 本公开提供了用于在电子通信内管理结构化和非结构化数据的系统，方法和软件的各种实施例。 在一个实现中，软件识别与企业应用中的用户相关联的电子通信; 在与电子通信相关联的非结构化数据元素与与企业应用相关联的结构化数据元素之间创建链接，其中链路至少部分地基于电子通信的一个或多个属性和企业应用的活动过程而创建; 并将链接存储在链接库中。