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74 条记录 (耗时 0.039 秒)

    Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates
    6.
    发明申请
    Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates 有权
    制备2-烷氧基亚甲基-4,4-二氟-3-氧代丁酸烷基酯的方法

    公开(公告)号：US20110004002A1

    公开(公告)日：2011-01-06

    申请号：US12919842

    申请日：2009-02-27

    申请人： Volker Maywald ,  Sebastian Peer Smidt ,  Bernd Wolf ,  Christopher Koradin ,  Thomas Zierke ,  Michael Rack ,  Michael Keil

    发明人： Volker Maywald ,  Sebastian Peer Smidt ,  Bernd Wolf ,  Christopher Koradin ,  Thomas Zierke ,  Michael Rack ,  Michael Keil

    IPC分类号： C07D231/14 ,  C07C69/66

    CPC分类号： C07D231/14 ,  C07C67/343 ,  C07C69/72

    摘要： A process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates (VI) where R is methyl or ethyl, from crude reaction mixtures of alkyl 4,4-difluoroacetoacetates (I) by a) reacting where M is a sodium or potassium ion, and without additional solvent to form an enolate (V) b) releasing the corresponding alkyl 4,4-difluoroacetoacetate (I) from the enolate (V) by means of acid, c) removing the salt formed from cation M and acid anion as a solid and d) converting (I), without isolation from the crude reaction mixture, to the alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrate (VI), and the use of (VI) for preparing 1-methyl-3-difluoromethyl-pyrazol-3-ylcarboxyates VII

    摘要翻译： 由烷基4,4-二氟乙酰乙酸酯（I）的粗反应混合物制备R为甲基或乙基的2-烷氧基亚甲基-4,4-二氟-3-氧代丁酸烷基酯（VI）的方法，通过a）使M 钠离子或钾离子，无另外的溶剂以形成烯醇化物（Ⅴ）b）通过酸从烯醇化物（Ⅴ）中释出相应的4,4-二氟乙酰乙酸烷基酯（Ⅰ），c）除去由阳离子M形成的盐 和酸阴离子作为固体，以及d）将（I）从粗反应混合物中分离出来，转化为2-烷氧基亚甲基-4,4-二氟-3-氧代丁酸烷基酯（VI），以及（VI）用于 制备1-甲基-3-二氟甲基 - 吡唑-3-基羧酸酯VII

    Method for production of aryl-substituted annelated pyrimidines
    8.
    发明申请
    Method for production of aryl-substituted annelated pyrimidines 审中-公开
    芳基取代的环状嘧啶的制备方法

    公开(公告)号：US20100087640A1

    公开(公告)日：2010-04-08

    申请号：US12521877

    申请日：2008-01-10

    申请人： Bernd Wolf ,  Volker Maywald ,  Michael Keil ,  Manuel Budich ,  Michael Rack ,  Manfred Ehresmann

    发明人： Bernd Wolf ,  Volker Maywald ,  Michael Keil ,  Manuel Budich ,  Michael Rack ,  Manfred Ehresmann

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： The present invention relates to a process for preparing aryl-substituted fused pyrimidines of the general formula (I) in which L1 to L5 are H, halogen, CN, NO2, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy etc.; Y1 to Y3 are C—RY or N; RY is H or optionally substituted C1-C4-alkyl or two adjacent RY together form a ring; X is OH, Cl or Br; which comprises (i) the reaction of a 2-phenylmalonate with a compound (III) or a tautomer thereof, in the presence of a suitable base, where the alcohol, released during the reaction, of the formula R—OH is continuously removed from the reaction mixture under reduced pressure; giving a compound of the formula (I) or a salt thereof in which X is OH, and, if X in the compounds of the general formula (I) is chlorine or bromine, (ii) the reaction of the compounds of the formula (I) obtained in step (i) or the salts with a halogenating agent.

    摘要翻译： 本发明涉及制备通式（I）的芳基取代的稠合嘧啶的方法，其中L 1至L 5为H，卤素，CN，NO 2，C 1 -C 4烷基，C 1 -C 4卤代烷基，C 1 -C 4 - 烷氧基，C1-C4-卤代烷氧基等; Y1至Y3为C-RY或N; RY为H或任选取代的C 1 -C 4烷基或两个相邻的RY一起形成环; X是OH，Cl或Br; 其包括（i）2-苯基丙二酸酯与化合物（III）或其互变异构体在合适的碱的存在下反应，其中反应期间释放的醇与式R-OH的连续从 减压下的反应混合物; 得到其中X是OH的式（I）化合物或其盐，并且如果通式（I）的化合物中的X是氯或溴，则（ii）式（I）化合物 I）或与卤化剂的盐。

    Method for producing oxime ethers
    9.
    发明授权
    Method for producing oxime ethers 失效
    生产肟醚的方法

    公开(公告)号：US06680410B2

    公开(公告)日：2004-01-20

    申请号：US10257327

    申请日：2002-10-10

    申请人： Roland Götz ,  Bernd Wolf ,  Michael Rack

    发明人： Roland Götz ,  Bernd Wolf ,  Michael Rack

    IPC分类号： C07C25156

    CPC分类号： C07C249/12 ,  C07C251/38

    摘要： A process for preparing oxime ethers of the formula I, in which the substituents R1 and R2 can be identical or different and can each be cyano, alkyl, haloalkyl, cycloalkyl, phenyl and naphthyl, and R3 can be alkyl, by alkylation of oximes of the formula II under basic conditions with an alkylating agent from the group of alkyl halides, dialkyl sulfates and dialkyl carbonates, wherein the reaction is carried out in a mixture consisting of 5 to 25% by weight of polar aprotic solvents selected from the group of nitrites, N-alkylpyrrolidones, cyclic urea derivatives, dimethylformamide and dimethylacetamide, 55 to 95% by weight of nonpolar solvents selected from the group of aliphatic hydrocarbons, aromatic hydrocarbons, alkyl alkylcarboxylates and ethers, and 0 to 25% by weight of water, the contents thereof totaling 100%.

    摘要翻译： 制备式I的肟醚的方法，其中取代基R 1和R 2可以相同或不同，并且各自可以是氰基，烷基，卤代烷基，环烷基，苯基和萘基，R 3， 可以通过烷基化剂从烷基卤化物，二烷基硫酸盐和碳酸二烷基酯在碱性条件下将式II的肟烷基化，其中该反应以5至25重量％的极性非质子 选自亚硝酸盐，N-烷基吡咯烷酮，环脲衍生物，二甲基甲酰胺和二甲基乙酰胺的溶剂，55至95重量％的选自脂族烃，芳烃，烷基烷基羧酸盐和醚的非极性溶剂，和0至25％ 水重量，总含量为100％。

    Preparation of halomethylbenzoyl cyanides and novel halomethylbenzoyl cyanides
    10.
    发明授权
    Preparation of halomethylbenzoyl cyanides and novel halomethylbenzoyl cyanides 失效
    制备卤代甲基苯甲酰氰和新的卤代甲基苯甲酰氰

    公开(公告)号：US5446199A

    公开(公告)日：1995-08-29

    申请号：US216416

    申请日：1994-03-23

    申请人： Heinz Isak ,  Thomas Wettling ,  Michael Keil ,  Bernd Wolf ,  Reinhard Doetzer

    发明人： Heinz Isak ,  Thomas Wettling ,  Michael Keil ,  Bernd Wolf ,  Reinhard Doetzer

    IPC分类号： C07C253/14 ,  C07C255/32 ,  C07C255/40

    CPC分类号： C07C255/40 ,  C07C253/14

    摘要： A process for preparing halomethylbenzoyl cyanides IPh-CO-CN I(Ph=phenyl radical substituted by chloromethyl or bromomethyl which, if desired, can additionally carry 1-4 further radicals) by reacting halomethylbenzoyl chlorides IIPh-CO-Cl IIwith an alkali metal cyanide or transition metal cyanide, if appropriate in an organic diluent, and novel halomethylbenzoyl cyanides I' ##STR1## (X=halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, CF.sub.3, C.sub.1 -C.sub.5 -alkyl-(C.sub.1 -C.sub.5 -alkyl)hydroxyimino or C.sub.1 -C.sub.5 -alkyl-(C.sub.2 -C.sub.5 -alkenyl)hydroxyimino; m=0 to 4 and Y=chloromethyl or bromomethyl) are described.The halomethylbenzoyl cyanides I are important intermediates for the synthesis of plant protection agents.

    摘要翻译： 制备卤代甲基苯甲酰基氰化物I Ph-CO-CNI（Ph =被氯甲基或溴甲基取代的苯基，如果需要，还可以另外携带1-4个基团），卤代甲基苯甲酰氯II Ph-CO-ClII与碱金属 氰化物或过渡金属氰化物，如果合适，在有机稀释剂中，和新的卤代甲基苯甲酰氰I'（X =卤素，C 1 -C 4 - 烷基，C 1 -C 4 - 烷氧基，CF 3，C 1 -C 5烷基 - （ C 1 -C 5 - 烷基）羟基亚氨基或C 1 -C 5 - 烷基 - （C 2 -C 5 - 烯基）羟基亚氨基; m = 0至4，Y =氯甲基或溴甲基）。 卤代甲基苯甲酰氰I是合成植物保护剂的重要中间体。