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    Skin treatments with Smelophyllum capense extracts
    2.
    发明授权
    Skin treatments with Smelophyllum capense extracts 失效
    Smelophyllum capense提取物的皮肤护理

    公开(公告)号：US5807555A

    公开(公告)日：1998-09-15

    申请号：US849453

    申请日：1997-06-18

    申请人： Frederic Bonte ,  Marc Dumas ,  Catherine Lavaud ,  Georges Massiot

    发明人： Frederic Bonte ,  Marc Dumas ,  Catherine Lavaud ,  Georges Massiot

    IPC分类号： A61K8/96 ,  A61K8/00 ,  A61K8/44 ,  A61K8/73 ,  A61K8/97 ,  A61K31/70 ,  A61K36/00 ,  A61K36/18 ,  A61K36/77 ,  A61P17/00 ,  A61Q19/00 ,  A61Q19/08 ,  C12N5/00 ,  A61K35/78 ,  A61K31/375

    CPC分类号： A61Q19/08 ,  A61K36/77 ,  A61K8/97 ,  A61K2800/782 ,  Y10S514/844

    摘要： The present invention relates to a method and composition for topically administering a Smelophyllum capense extract as a cosmetic, dermatologic, or pharmaceutical composition to promote collagen synthesis. Administration of the composition results in the firming of the skin, improves healing and is suitable for treating various pathologies accompanied with a deficiency in collagen. The extract can also be added to cell culture medium used in the culture of skin cells, particularly skin fibroblasts. The composition can contain between 0.0001% and 1% by weight of the Smelophyllum capense extract, and the extract can be obtained by extraction with a polar solvent. The composition can contain other ingredients including ascorbic acid, madecassic acid, asiatic acid, madecassoside, asiaticoside, alpha-1-protease inhibitor, collagenase inhibitors, elastase inhibitors, lysine, proline, 2-oxoglutarate and ginsenoside Ro.

    摘要翻译： PCT No.PCT / FR95 / 01724 Sec。 371日期：1997年6月18日 102（e）1997年6月18日PCT 1995年12月22日PCT PCT。 WO96 / 20000 PCT公开号 日期：1996年7月4日本发明涉及一种局部给药Smelophyllum capense提取物作为促进胶原合成的化妆品，皮肤病学或药物组合物的方法和组合物。 组合物的施用导致皮肤紧致，改善愈合，适用于治疗伴有胶原蛋白缺乏症的各种病症。 提取物也可以添加到用于皮肤细胞，特别是皮肤成纤维细胞培养物的细胞培养基中。 该组合物可以含有重量百分比为0.0001％至1％的三叶草提取物，并且可以通过极性溶剂萃取获得提取物。 组合物可以含有其它成分，包括抗坏血酸，十五烷酸，积雪草酸，十八烷基硫苷，积雪草苷，α-1-蛋白酶抑制剂，胶原酶抑制剂，弹性蛋白酶抑制剂，赖氨酸，脯氨酸，2-氧戊二酸和人参皂甙Ro。

    Use of a tocopherol phosphate or one of its derivatives, for the preparation of cosmetic or pharmaceutical compositions and compositions so obtained
    8.
    发明授权
    Use of a tocopherol phosphate or one of its derivatives, for the preparation of cosmetic or pharmaceutical compositions and compositions so obtained 失效
    使用生育酚磷酸盐或其衍生物之一，用于制备如此获得的化妆品或药物组合物和组合物

    公开(公告)号：US5603949A

    公开(公告)日：1997-02-18

    申请号：US465610

    申请日：1995-06-05

    申请人： Alain Meybeck ,  Marc Dumas ,  Frederic Bonte ,  Christian Marechal

    发明人： Alain Meybeck ,  Marc Dumas ,  Frederic Bonte ,  Christian Marechal

    IPC分类号： A61K8/55 ,  A61K8/00 ,  A61K8/02 ,  A61K8/14 ,  A61K8/58 ,  A61K8/67 ,  A61K8/97 ,  A61K9/06 ,  A61K9/08 ,  A61K31/355 ,  A61K31/665 ,  A61K36/539 ,  A61Q1/00 ,  A61Q1/02 ,  A61Q1/12 ,  A61Q17/00 ,  A61Q19/00 ,  C07F9/655 ,  A61K9/127

    CPC分类号： C07F9/65522 ,  A61K31/355 ,  A61K31/665 ,  A61K8/678 ,  A61Q1/02 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/002 ,  A61K2800/75 ,  A61K2800/782 ,  Y10T428/2984

    摘要： Use of a tocopherol phosphate, other than alpha-tocopherol phosphate, especially in its dl or d form, or one of its esters having general formula (I) in which: R' is hydrogen atom, an alkyl radical having from 1 to 4 carbon atoms, such as the methyl or ethyl radical in particular, R'O is a tocopheryl radical; R" is a hydrogen atom, an alkyl radical having from 1 to 4 carbon atoms, such as the methyl or ethyl radical in particular, or R"O is an oxyethylene chain, of formula (a) in which R.sub.4 and R.sub.5 are independently a hydrogen atom or a methyl radical, and n is an integer of 1 or over; R.sub.1, R.sub.2 and R.sub.3 are independently a hydrogen atom or a methyl radical, it being understood that R.sub.1, R.sub.2 and R.sub.3 cannot simultaneously be a methyl radical. A represents the groups (b), or (c). The invention also concerns the use of cosmetically or of pharmaceutically acceptable salts of said compound in the preparation of a cosmetic or pharmaceutical, especially dermatological, composition characterized by having a reduced allergizing or irritating potential, or used in the prevention or treatment of allergic conditions, such as cutaneous allergy or bronchial or inflammatory asthma, or in the prevention or treatment of the harmful effects of free radicals.

    摘要翻译： 除了α-生育酚磷酸酯，特别是其dl或d形式之外的生育酚磷酸酯或其通式（I）的酯之一，其中：R'是氢原子，具有1至4个碳原子的烷基 原子，特别是甲基或乙基，R'O是生育酚基; R“是氢原子，具有1至4个碳原子的烷基，特别是甲基或乙基，或R'O是式（a）的氧化乙烯链，其中R 4和R 5是 独立地为氢原子或甲基，n为1以上的整数， R 1，R 2和R 3独立地为氢原子或甲基，应理解R1，R2和R3不能同时为甲基。 A代表组（b）或（c）。 本发明还涉及化妆品或药学上可接受的盐在制备化妆品或药物，特别是皮肤病学组合物中的用途，其特征在于具有降低的过敏或刺激性潜力，或用于预防或治疗过敏性疾病， 如皮肤过敏或支气管炎或炎症性哮喘，或预防或治疗自由基的有害作用。

    Use of a tocopherol phosphate or one of its derivatives for the preparation of cosmetic or pharmaceutical compositions and compositions so obtained
    10.
    发明授权
    Use of a tocopherol phosphate or one of its derivatives for the preparation of cosmetic or pharmaceutical compositions and compositions so obtained 失效
    使用生育酚磷酸酯或其衍生物之一用于制备如此获得的化妆品或药物组合物和组合物

    公开(公告)号：US5643597A

    公开(公告)日：1997-07-01

    申请号：US463237

    申请日：1995-06-05

    申请人： Alain Meybeck ,  Marc Dumas ,  Frederic Bonte ,  Christian Marechal

    发明人： Alain Meybeck ,  Marc Dumas ,  Frederic Bonte ,  Christian Marechal

    IPC分类号： A61K8/67 ,  A61K31/355 ,  A61K31/665 ,  A61K36/539 ,  A61Q1/02 ,  A61Q17/00 ,  A61Q19/00 ,  C07F9/655 ,  A61K9/127

    CPC分类号： A61Q19/002 ,  A61K31/355 ,  A61K31/665 ,  A61K8/678 ,  A61Q1/02 ,  A61Q17/00 ,  A61Q19/00 ,  C07F9/65522 ,  A61K2800/75 ,  A61K2800/782 ,  Y10S514/944

    摘要： Use of a tocopherol phosphate, other than alpha-tocopherol phosphate, especially in its dl or d form, or one of its esters having general formula (I) in which: R' is hydrogen atom, an alkyl radical having from 1 to 4 carbon atoms, such as the methyl or ethyl radical in particular, R'O is a tocopheryl radical; R" is a hydrogen atom, an alkyl radical having from 1 to 4 carbon atoms, such as the methyl or ethyl radical in particular, or R"O is an oxyethylene chain, of formula (a) in which R.sub.4 and R.sub.5 are independently a hydrogen atom or a methyl radical, and n is an integer of 1 or over; R.sub.1, R.sub.2 and R.sub.3 are independently a hydrogen atom or a methyl radical, it being understood that R.sub.1, R.sub.2 and R.sub.3 cannot simultaneously be a methyl radical. A represents the groups (b), or (c). The invention also concerns the use of cosmetically or of pharmaceutically acceptable salts of said compound in the preparation of cosmetic or pharmaceutical, especially dermatological, composition characterized by having a reduced allergizing or irritating potential, or used in the prevention or treatment of allergic conditions, such as cutaneous allergy or bronchial or inflammatory asthma, or in the prevention or treatment of the harmful effects of free radicals.

    摘要翻译： 除了α-生育酚磷酸酯，特别是其dl或d形式之外的生育酚磷酸酯或其通式（I）的酯之一，其中：R'是氢原子，具有1至4个碳原子的烷基 原子，特别是甲基或乙基，R'O是生育酚基; R“是氢原子，具有1至4个碳原子的烷基，特别是甲基或乙基，或R'O是式（a）的氧化乙烯链，其中R 4和R 5是 独立地为氢原子或甲基，n为1以上的整数， R 1，R 2和R 3独立地为氢原子或甲基，应理解R1，R2和R3不能同时为甲基。 A代表组（b）或（c）。 本发明还涉及化妆品或药学上可接受的盐在制备化妆品或药物，特别是皮肤病学组合物中的用途，其特征在于具有降低的过敏或刺激性潜力，或用于预防或治疗过敏性疾病，例如 作为皮肤过敏或支气管炎或炎性哮喘，或用于预防或治疗自由基的有害作用。