-
公开(公告)号：US07478265B2
公开(公告)日：2009-01-13
申请号：US10964862
申请日：2004-10-14
IPC分类号： G06F11/00
CPC分类号： G11B20/18
摘要： Method, system, and apparatus for executing input/output operations. The method including selecting a level of error recovery for input/output operations, receiving a request to execute the input/output operation, attempting the input/output operation, and when the input/output operation fails, performing the level of error recovery specified. The selection of the error recovery level may be done by a user, or embedded within the input/output request itself.
摘要翻译： 用于执行输入/输出操作的方法，系统和装置。 该方法包括选择输入/输出操作的错误恢复级别，接收执行输入/输出操作的请求，尝试输入/输出操作，以及何时输入/输出操作失败，执行指定的错误恢复级别。 错误恢复级别的选择可由用户完成，或嵌入在输入/输出请求本身内。
-
公开(公告)号：US20060085665A1
公开(公告)日：2006-04-20
申请号：US10964862
申请日：2004-10-14
申请人： Frederick Knight , Susan Rundbaken , Rick Wagner
发明人： Frederick Knight , Susan Rundbaken , Rick Wagner
IPC分类号： G06F11/00
CPC分类号： G11B20/18
摘要： Method, system, and apparatus for executing input/output operations. The method including selecting a level of error recovery for input/output operations, receiving a request to execute the input/ output operation, attempting the input/output operation, and when the input/output operation fails, performing the level of error recovery specified. The selection of the error recovery level may be done by a user, or embedded within the input/output request itself.
摘要翻译： 用于执行输入/输出操作的方法，系统和装置。 该方法包括选择输入/输出操作的错误恢复级别，接收执行输入/输出操作的请求，尝试输入/输出操作，以及何时输入/输出操作失败，执行指定的错误恢复级别。 错误恢复级别的选择可由用户完成，或嵌入在输入/输出请求本身内。
-
公开(公告)号：US20090137422A1
公开(公告)日：2009-05-28
申请号：US12335433
申请日：2008-12-15
CPC分类号： G01N33/6872 , C12Q1/04 , G01N21/78 , G01N33/54373
摘要： The invention provides methods for identifying modulators of ion channels without the use of recombinant cell lines over-expressing the ion channel proteins or the use of detection labels.
-
4.发明授权Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines 失效增强的三螺旋和双螺旋形成与含有修饰嘧啶的低聚物公开(公告)号：US06380368B1
公开(公告)日：2002-04-30
申请号：US08599738
申请日：1996-02-12
申请人： Brian Froehler , Rick Wagner , Mark Mattencci , Robert J. Jones , Arnold J. Gutierrez , Jeff Pudlo
发明人： Brian Froehler , Rick Wagner , Mark Mattencci , Robert J. Jones , Arnold J. Gutierrez , Jeff Pudlo
IPC分类号： C07H2102
CPC分类号： C07H19/06 , C07H19/10 , C07H19/20 , C07H21/00 , C12Q1/6839 , C12Q2525/101
摘要： Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capable of (i) forming triplexes with various target sequences such as virus or oncogene sequences by coupling into the major groove of a target DNA duplex at physiological pH or (ii) forming duplexes by binding to single-stranded DNA or to RNA encoded by target genes. The oligomers of the invention can be incorporated into pharmaceutically acceptable carriers and can be constructed to have any desired sequence, provided the sequence normally includes one or more bases that is replaced with the analogs of the invention. Compositions of the invention can be used as pharmaceutical agents to treat various diseases such as those caused by viruses and can be used for diagnostic purposes in order to detect viruses or disease conditions.
摘要翻译： 公开了与仅含有常规碱的低聚物相比，具有增强形成双链体或三链体的能力的新型低聚物。 低聚物含有5-（1-丙炔基）尿嘧啶，5-（1-丙炔基）胞嘧啶或相关类似物的碱基。 本发明的寡聚体能够（i）通过在生理pH下偶联到目标DNA双链体的主要沟槽中或（ii）通过结合单链DNA形成双链体，形成具有各种靶序列的病毒或致癌基因序列的三链体 或由靶基因编码的RNA。 本发明的寡聚体可以并入药学上可接受的载体中，并且可以被构建成具有任何所需的序列，条件是序列通常包括用本发明的类似物代替的一个或多个碱基。 本发明的组合物可以用作药剂来治疗由病毒引起的各种疾病，并且可以用于诊断目的以检测病毒或疾病状况。
-
5.发明授权Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines 失效增强的三螺旋和双螺旋形成与含有修饰嘧啶的低聚物
公开(公告)号：US5645985A
公开(公告)日：1997-07-08
申请号：US976103
申请日：1992-11-25
申请人： Brian Froehler , Rick Wagner , Mark Matteucci , Robert J. Jones , Arnold J. Gutierrez , Jeff Pudlo
发明人： Brian Froehler , Rick Wagner , Mark Matteucci , Robert J. Jones , Arnold J. Gutierrez , Jeff Pudlo
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K48/00 , C07H19/00 , C07H19/06 , C07H19/067 , C07H19/073 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/09 , C12Q1/68
摘要： Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capable of (i) forming triplexes with various target sequences such as virus or oncogene sequences by coupling into the major groove of a target DNA duplex at physiological pH or (ii) forming duplexes by binding to single-stranded DNA or to RNA encoded by target genes. The oligomers of the invention can be constructed to have any desired sequence, provided the sequence normally includes one or more bases that is replaced with the analogs of the invention. Compositions of the invention can be used used for diagnostic purposes in order to detect viruses or disease conditions.
摘要翻译： 公开了与仅含有常规碱的低聚物相比，具有增强形成双链体或三链体的能力的新型低聚物。 低聚物含有5-（1-丙炔基）尿嘧啶，5-（1-丙炔基）胞嘧啶或相关类似物的碱基。 本发明的寡聚体能够（i）通过在生理pH下偶联到目标DNA双链体的主要沟槽中或（ii）通过结合单链DNA形成双链体，形成具有各种靶序列的病毒或致癌基因序列的三链体 或由靶基因编码的RNA。 本发明的低聚物可被构建成具有任何所需的序列，条件是序列通常包括用本发明的类似物代替的一个或多个碱基。 本发明的组合物可以用于诊断目的，以便检测病毒或疾病状况。
-
6.发明申请Use of Induced Pluripotent Cells and other Cells for Screening Compound Libraries 审中-公开使用诱导多能细胞和其他细胞筛选化合物库公开(公告)号：US20110237535A1
公开(公告)日：2011-09-29
申请号：US13073233
申请日：2011-03-28
申请人： Alexander Yuzhakov , Eric Sandberg , Steven Shamah , Rick Wagner
发明人： Alexander Yuzhakov , Eric Sandberg , Steven Shamah , Rick Wagner
IPC分类号： A61K31/704 , C12Q1/02 , C12Q1/68 , A61K31/138 , A61K31/4412 , A61K31/135
CPC分类号： G01N33/5014 , G01N33/5058 , G01N33/5061 , G01N33/5088 , G01N2800/32
摘要： The invention provides methods for screening test compounds or toxins for effects on cells. The invention also provides methods for determining frequency, amplitude and kinetic profiles of cells.
摘要翻译： 本发明提供了筛选测试化合物或毒素对细胞效果的方法。 本发明还提供了确定细胞的频率，幅度和动力学特征的方法。
-
公开(公告)号：US20100291575A1
公开(公告)日：2010-11-18
申请号：US12781513
申请日：2010-05-17
申请人： Steven Shamah , Lance G. Laing , Alexander Yuzhakov , Rick Wagner , Marla Abodeely , Bennett Rockney , Stephen C. Schulz , Zinkal Padalia , Michael Getman , Eric Sandberg
发明人： Steven Shamah , Lance G. Laing , Alexander Yuzhakov , Rick Wagner , Marla Abodeely , Bennett Rockney , Stephen C. Schulz , Zinkal Padalia , Michael Getman , Eric Sandberg
IPC分类号： C12Q1/68 , G01N33/567 , C12Q1/02
CPC分类号： G01N33/54373 , G01N21/7743 , G01N33/5044 , G01N33/5064 , G01N33/5073
摘要： The invention provides methods of label-free detection of changes in cell populations and mixed cell populations.
摘要翻译： 本发明提供了无标记检测细胞群体和混合细胞群体变化的方法。
-
8.发明授权公开(公告)号：US07057027B2
公开(公告)日：2006-06-06
申请号：US10730643
申请日：2003-12-08
申请人： Brian Froehler , Rick Wagner , Mark Mattencci , Robert J. Jones , Arnold J. Gutierrez , Jeff Pudlo
发明人： Brian Froehler , Rick Wagner , Mark Mattencci , Robert J. Jones , Arnold J. Gutierrez , Jeff Pudlo
CPC分类号： C07H19/06 , C07H19/10 , C07H19/20 , C07H21/00 , C12Q1/6839 , C12Q2525/101
摘要： Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capable of (i) forming triplexes with various target sequences such as virus or oncogene sequences by coupling into the major groove of a target DNA duplex at physiological pH or (ii) forming duplexes by binding to single-stranded DNA or to RNA encoded by target genes. The oligomers of the invention can be incorporated into pharmaceutically acceptable carriers and can be constructed to have any desired sequence, provided the sequence normally includes one or more bases that is replaced with the analogs of the invention. Compositions of the invention can be used as pharmaceutical agents to treat various diseases such as those caused by viruses and can be used for diagnostic purposes in order to detect viruses or disease conditions.
-
9.发明授权公开(公告)号：US06875593B2
公开(公告)日：2005-04-05
申请号：US10294203
申请日：2002-11-14
申请人： Brian Froehler , Rick Wagner , Mark Matteucci , Robert J. Jones , Arnold J. Gutierrez , Jeff Pudlo
发明人： Brian Froehler , Rick Wagner , Mark Matteucci , Robert J. Jones , Arnold J. Gutierrez , Jeff Pudlo
IPC分类号： C07H19/06 , C07H19/10 , C07H19/20 , C07H21/00 , C12Q1/68 , H04L12/24 , C12P19/34 , C07H21/02
CPC分类号： C07H19/06 , C07H19/10 , C07H19/20 , C07H21/00 , C12Q1/6839 , C12Q2525/101
摘要： Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capable of (i) forming triplexes with various target sequences such as virus or oncogene sequences by coupling into the major groove of a target DNA duplex at physiological pH or (ii) forming duplexes by binding to single-stranded DNA or to RNA encoded by target genes. The oligomers of the invention can be incorporated into pharmaceutically acceptable carriers and can be constructed to have any desired sequence, provided the sequence normally includes one or more bases that is replaced with the analogs of the invention. Compositions of the invention can be used as pharmaceutical agents to treat various diseases such as those caused by viruses and can be used for diagnostic purposes in order to detect viruses or disease conditions.
-
公开(公告)号：US20090130703A1
公开(公告)日：2009-05-21
申请号：US12335393
申请日：2008-12-15
IPC分类号： C12Q1/02
CPC分类号： G01N21/63 , C40B30/04 , C40B30/10 , G01N21/4788 , G01N21/7743 , G01N33/54373
摘要： Methods are provided to detect changes in cells without the use of detection labels.
摘要翻译： 提供方法来检测细胞的变化，而不使用检测标记。
-
-
-
-
-
-
-
-
-
搜索结果
22 条记录 (耗时 0.033 秒)
