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公开(公告)号：US20100144798A1
公开(公告)日：2010-06-10
申请号：US12544323
申请日：2009-08-20
申请人： Frederick F. VanGoor , Sara Sabina Hadida Ruah , Ashvani Kumar Singh , Eric R. Olson , Lewis Ray Makings , Jesus E. Gonzalez, III , James Arvid Rader , Fred Chambers, III , Mark Thomas Miller , Peter Diederik Jan Grootenhuis , Yahua Liu
发明人： Frederick F. VanGoor , Sara Sabina Hadida Ruah , Ashvani Kumar Singh , Eric R. Olson , Lewis Ray Makings , Jesus E. Gonzalez, III , James Arvid Rader , Fred Chambers, III , Mark Thomas Miller , Peter Diederik Jan Grootenhuis , Yahua Liu
IPC分类号： A61K31/4439 , A61K31/415 , A61P1/12 , A61P13/12 , A61P15/10 , A61P27/02 , C12N5/00
CPC分类号： C07D231/12 , C07D231/16 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/14
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括囊性纤维化跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20120184583A1
公开(公告)日：2012-07-19
申请号：US13079192
申请日：2011-04-04
申请人： Frederick F. Van Goor , Sara Sabina Hadida-Ruah , Ashvani Kumar Singh , Eric R. Olson , Lewis Ray Makings , Jesus E. Gonzalez, III , James Arvid Rader , Fred Chambers, III , Mark Thomas Miller , Peter Diederik Jan Grootenhuis , Yahua Liu
发明人： Frederick F. Van Goor , Sara Sabina Hadida-Ruah , Ashvani Kumar Singh , Eric R. Olson , Lewis Ray Makings , Jesus E. Gonzalez, III , James Arvid Rader , Fred Chambers, III , Mark Thomas Miller , Peter Diederik Jan Grootenhuis , Yahua Liu
IPC分类号： A61K31/4439 , C12N5/071 , A61K31/4155 , A61K31/427 , A61K31/422 , A61P37/04 , A61P29/00 , A61P37/08 , A61P37/06 , A61P19/08 , A61P35/00 , A61P31/00 , A61P31/12 , A61P27/02 , A61P27/04 , A61P7/06 , A61P43/00 , A61P3/08 , A61P11/00 , A61P11/06 , A61P1/18 , A61P15/08 , A61P1/12 , A61P13/12 , A61P1/16 , A61P25/00 , A61P3/00 , A61K31/415
CPC分类号： C07D231/12 , C07D231/16 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/14
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括囊性纤维化跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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3.发明授权Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels 有权杂环色烯 - 螺环哌啶酰胺作为离子通道的调节剂公开(公告)号：US08598164B2
公开(公告)日：2013-12-03
申请号：US13102335
申请日：2011-05-06
申请人： Sara Sabina Hadida-Ruah , Edward Adam Kallel , Mark Thomas Miller , Joseph Pontillo , Vijayalaksmi Arumugam , Nicole Hilgraf , Jason McCartney , Peter Diederik Jan Grootenhuis , Corey Anderson , Mehdi Numa , Bryan A. Frieman , Brian Richard Bear , James Philip Johnson, Jr.
发明人： Sara Sabina Hadida-Ruah , Edward Adam Kallel , Mark Thomas Miller , Joseph Pontillo , Vijayalaksmi Arumugam , Nicole Hilgraf , Jason McCartney , Peter Diederik Jan Grootenhuis , Corey Anderson , Mehdi Numa , Bryan A. Frieman , Brian Richard Bear , James Philip Johnson, Jr.
IPC分类号： C07D491/22 , C07D498/22 , A61K31/5386 , A61K31/438
CPC分类号： C07D491/20 , C07D491/22 , C07D498/20 , C07D498/22 , C07D513/20
摘要： The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的杂环色烯 - 螺环哌啶酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20110306637A1
公开(公告)日：2011-12-15
申请号：US13112115
申请日：2011-05-20
申请人： Sara Sabina Hadida-Ruah , Peter Diederik Jan Grootenhuis , Mark Thomas Miller , Matthew Hamilton
发明人： Sara Sabina Hadida-Ruah , Peter Diederik Jan Grootenhuis , Mark Thomas Miller , Matthew Hamilton
IPC分类号： A61K31/454 , A61K31/427 , A61K31/4439 , A61K31/433 , A61K31/4245 , A61K31/4178 , A61K31/422 , A61P11/00 , A61P3/00 , A61P3/06 , A61P3/10 , A61P25/28 , A61P25/00 , A61P1/12 , A61P27/02 , A61P13/12 , C07D417/12
CPC分类号： C07D417/12 , C07D231/40 , C07D233/88 , C07D263/48 , C07D271/113 , C07D277/46 , C07D277/54 , C07D277/82 , C07D285/135 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/14 , C07D493/10
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US09365588B2
公开(公告)日：2016-06-14
申请号：US14355325
申请日：2012-11-02
申请人： Sara Sabina Hadida-Ruah , Peter Diederik Jan Grootenhuis , Mark Thomas Miller , Corey Anderson , Joseph Pontillo , Edward Adam Kallel , Mehdi Michael Djamel Numa , Bryan A. Frieman , Jason McCartney , Jennings Franklin Worley, III , Vijayalaksmi Arumugam , Johnny Uy , Nicole Hilgraf , Brian Richard Bear
发明人： Sara Sabina Hadida-Ruah , Peter Diederik Jan Grootenhuis , Mark Thomas Miller , Corey Anderson , Joseph Pontillo , Edward Adam Kallel , Mehdi Michael Djamel Numa , Bryan A. Frieman , Jason McCartney , Jennings Franklin Worley, III , Vijayalaksmi Arumugam , Johnny Uy , Nicole Hilgraf , Brian Richard Bear
IPC分类号： C07D498/20 , C07D491/20
CPC分类号： C07D498/20 , C07D491/20
摘要： The invention relates to benzoxazines useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的苯并恶嗪。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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6.发明授权Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels 有权吡咯并吡嗪 - 螺环哌啶酰胺作为离子通道的调节剂公开(公告)号：US08916565B2
公开(公告)日：2014-12-23
申请号：US13364586
申请日：2012-02-02
申请人： Sara Sabina Hadida Ruah , Edward Adam Kallel , Mark Thomas Miller , Vijayalaksmi Arumugam , Jason McCartney , Corey Anderson , Peter Diederik Jan Grootenhuis , Licong Jiang
发明人： Sara Sabina Hadida Ruah , Edward Adam Kallel , Mark Thomas Miller , Vijayalaksmi Arumugam , Jason McCartney , Corey Anderson , Peter Diederik Jan Grootenhuis , Licong Jiang
IPC分类号： A61K31/4985 , C07D471/20 , C07D519/00
CPC分类号： C07D471/20 , A61K31/499 , A61K31/506 , C07D519/00
摘要： The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds of formula (I) useful as inhibitors of ion channels: wherein R1, R2, R3, R4, A, m, n, and o are as defined in the description. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的式（I）吡咯并吡嗪 - 螺环哌啶酰胺化合物：其中R1，R2，R3，R4，A，m，n和o如说明书中所定义。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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7.发明申请PYRROLOPYRAZINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS 有权作为离子通道的调节剂的吡咯并吡咯嗪 - 螺环哌嗪类公开(公告)号：US20120196869A1
公开(公告)日：2012-08-02
申请号：US13364586
申请日：2012-02-02
申请人： Sara Sabina Hadida Ruah , Edward Adam Kallel , Mark Thomas Miller , Vijayalaksmi Arumugam , Jason McCartney , Corey Anderson , Peter Diederik Jan Grootenhuis , Licong Jiang
发明人： Sara Sabina Hadida Ruah , Edward Adam Kallel , Mark Thomas Miller , Vijayalaksmi Arumugam , Jason McCartney , Corey Anderson , Peter Diederik Jan Grootenhuis , Licong Jiang
IPC分类号： A61K31/499 , C12N5/071 , A61P29/00 , A61P19/02 , A61P25/06 , A61P25/00 , A61P25/08 , A61P25/28 , A61P25/22 , A61P25/24 , A61P25/18 , A61P9/06 , A61P25/14 , A61P5/00 , A61P21/00 , A61P1/00 , A61P9/10 , A61P9/12 , A61P9/00 , A61P7/06 , A61P1/18 , A61P13/10 , A61P13/00 , A61P17/04 , A61P27/16 , C07D471/20
CPC分类号： C07D471/20 , A61K31/499 , A61K31/506 , C07D519/00
摘要： The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的吡咯并吡嗪 - 螺环哌啶酰胺化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20170196862A2
公开(公告)日：2017-07-13
申请号：US14876525
申请日：2015-10-06
申请人： Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Ciemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
发明人： Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Ciemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
IPC分类号： A61K31/506 , A61K31/4418 , A61K31/444 , A61K31/44 , C07D213/84 , C07D231/14 , A61K31/415 , C07D209/42 , A61K31/404 , C07D401/12 , A61K31/4439 , C07D401/14 , C07D231/12 , A61K31/497 , C07D417/12 , C07D405/14 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4525 , A61J1/03 , C07D213/82
CPC分类号： A61K31/506 , A61J1/035 , A61K31/404 , A61K31/415 , A61K31/44 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4525 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , C07D209/18 , C07D209/42 , C07D209/49 , C07D213/64 , C07D213/73 , C07D213/82 , C07D213/84 , C07D231/12 , C07D231/14 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/14 , C07D407/12 , C07D413/14 , C07D417/12
摘要： The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
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9.发明授权公开(公告)号：US08828996B2
公开(公告)日：2014-09-09
申请号：US13418737
申请日：2012-03-13
申请人： Sara Sabina Hadida-Ruah , Hayley Marie Binch , Michael Paul DeNinno , Lev Tyler Dewey Fanning , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Nicole Hilgraf , Pramod Joshi , Edward Adam Kallel , Mark Thomas Miller , Joseph Pontillo , Alina Silina , Urvi Jagdishbhai Sheth , Dennis James Hurley , Vijayalaksmi Arumugam
发明人： Sara Sabina Hadida-Ruah , Hayley Marie Binch , Michael Paul DeNinno , Lev Tyler Dewey Fanning , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Nicole Hilgraf , Pramod Joshi , Edward Adam Kallel , Mark Thomas Miller , Joseph Pontillo , Alina Silina , Urvi Jagdishbhai Sheth , Dennis James Hurley , Vijayalaksmi Arumugam
IPC分类号： C07D498/10 , A61K31/537
CPC分类号： C07D498/10
摘要： The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的吗啉螺环哌啶酰胺化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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10.发明申请HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS 有权作为离子通道调节剂的杂环氯仿 - 哌啶胺公开(公告)号：US20110306607A1
公开(公告)日：2011-12-15
申请号：US13102335
申请日：2011-05-06
申请人： Sara Sabina Hadida-Ruah , Edward Adam Kallel , Mark Thomas Miller , Joseph Pontillo , Vijayalaksmi Arumugam , Nicole Hilgraf , Jason McCartney , Peter Diederik Jan Grootenhuis , Corey Anderson , Mehdi Numa , Bryan A. Frieman , Brian Richard Bear , James Philip Johnson, JR.
发明人： Sara Sabina Hadida-Ruah , Edward Adam Kallel , Mark Thomas Miller , Joseph Pontillo , Vijayalaksmi Arumugam , Nicole Hilgraf , Jason McCartney , Peter Diederik Jan Grootenhuis , Corey Anderson , Mehdi Numa , Bryan A. Frieman , Brian Richard Bear , James Philip Johnson, JR.
IPC分类号： A61K31/5386 , C07D491/22 , A61K31/438 , A61P25/00 , A61P19/02 , A61P25/06 , A61P25/08 , A61P25/28 , A61P25/18 , A61P25/22 , A61P25/24 , A61P21/00 , A61P9/06 , A61P25/14 , A61P1/00 , A61P13/00 , A61P3/10 , A61P9/10 , A61P9/12 , A61P29/00 , A61P7/06 , A61P1/18 , A61P13/10 , A61P13/08 , C07D498/22
CPC分类号： C07D491/20 , C07D491/22 , C07D498/20 , C07D498/22 , C07D513/20
摘要： The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的杂环色烯 - 螺环哌啶酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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