摘要:
Process for producing a nitroetheneamine derivative or its stereoisomer, its tautomer or a salt thereof comprising reacting a compound of the formula with a compound of the formula R6—CH2NO2 to obtain a compound of the formula and reacting the resulting compound with a compound of the formula
摘要翻译:制备硝基乙烯胺衍生物或其立体异构体,其互变异构体或其盐的方法包括使制备式R 6 -CH 2 NO 2的化合物的化合物与式R 6 -CH 2 NO 2化合物反应,得到下式化合物,并使所得化合物与式
摘要:
A medical composition containing, as an active constituent, a nitroetheneamine derivative represented by the formula (I): wherein the substituents are as defined in the disclosure, its stereoisomers, its tautomers or a salt thereof.
摘要:
To provide cytokine production inhibitors useful as preventive or therapeutic medicines for diseases accompanied by hyperactivated immune functions. A cytokine production inhibitor containing, as an active ingredient, a thioamide compound represented by the formula (I) or a salt thereof: wherein A is N, NO, C—NO2 or C—CN; Hal is a halogen; M1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, amino, O, S, SO or SO2; M2 is amino, O, S or a single bond; R1 is a halogen, alkyl or the like; each of R2, R3, R4 and R5 is independently H, alkyl or the like; R6 is a halogen, alkyl or the like; Cy is cycloalkyl, cycloalkenyl, aryl or heterocyclyl; each of k, p and q is independently an integer of from 0 to 3; and r is an integer of from 0 to 5.
摘要翻译:提供可用作预防或治疗药物的细胞因子产生抑制剂,用于伴有过度活化的免疫功能的疾病。 含有式(I)所示的硫代酰胺化合物或其盐作为活性成分的细胞因子产生抑制剂:其中A为N,NO,C-NO 2或C-CN; 卤素是卤素; M 1是烷基,烯基,炔基,环烷基,环烯基,芳基,杂环基,氨基,O,S,SO或SO 2。 M 2是氨基,O,S或单键; R 1是卤素,烷基等; R 2,R 3,R 4和R 5各自独立地为H,烷基等; R 6是卤素,烷基等; Cy是环烷基,环烯基,芳基或杂环基; k,p和q各自独立地为0〜3的整数; r为0〜5的整数。
摘要:
To provide cytokine production inhibitors useful as preventive or therapeutic medicines for diseases accompanied by hyperactivated immune functions.A cytokine production inhibitor containing, as an active ingredient, a thioamide compound represented by the formula (I) or a salt thereof: wherein A is N, NO, C—NO2 or C—CN; Hal is a halogen; M1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, amino, O, S, SO or SO2; M2 is amino, O, S or a single bond; R1 is a halogen, alkyl or the like; each of R2, R3, R4 and R5 is independently H, alkyl or the like; R6 is a halogen, alkyl or the like; Cy is cycloalkyl, cycloalkenyl, aryl or heterocyclyl; each of k, p and q is independently an integer of from 0 to 3; and r is an integer of from 0 to 5.
摘要:
The present invention provides a preventive or therapeutic medicine for diabetes containing as an active ingredient a fused-heterocyclic compound of the formula (I′) or its salt: [wherein G is CN, NO2, CO2R4, CHO, SO2NRaRb or CONRaRb; R1 is a halogen atom, a —O—R5 group or a —S—R5 group; R2 is a halogen atom, a —O—R5 group (wherein R5 is as defined above) or an amino group which may be substituted; and each of R8 and R10 which are independent of each other, is a hydrogen atom, a halogen atom or an alkyl group].
摘要:
The present invention provides a cytokine production inhibitor containing as an active ingredient an aniline derivative of the formula (I) or a salt thereof: [wherein A is CO or SO2; Cy is an aryl group or a heterocyclic group; each of R1 and R2 which are independent of each other, is a halogen atom, a cyano group, a nitro group, an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, a cycloalkyl group which may be substituted, a cycloalkenyl group which may be substituted, an aryl group which may be substituted, a heterocyclic group which may be substituted, an amino group which may be substituted or a —B-Q group; R3 is a -M1-M2-R5 group; R4 is a hydrogen atom or an alkyl group which may be substituted; x is an integer of from 0 to 5; y is an integer of from 0 to 4; and z is an integer of from 0 to 1].
摘要翻译:本发明提供含有作为活性成分的式(I)的苯胺衍生物或其盐的细胞因子产生抑制剂:其中A为CO或SO 2; Cy是芳基或杂环基; R 1和R 2彼此独立的是卤素原子,氰基,硝基,可以被取代的烷基, 可被取代的烯基,可被取代的炔基,可被取代的环烷基,可被取代的环烯基,可被取代的芳基,可被取代的杂环基,氨基 其可以被取代或-BQ基团; R 3是一个-M 1 -M 2 -OR 5基团; R 4是氢原子或可被取代的烷基; x为0〜5的整数; y为0〜4的整数; z为0〜1的整数]。
摘要:
A diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW.sup.1 R.sup.1, --COCOR.sup.2, --CW.sup.1 NHCOR.sup.2, --C(.dbd.W.sup.1)W.sup.2 R.sup.3 or --CW.sup.1 N(R.sup.4)R.sup.5, and Y is alkyl, --CW.sup.3 R.sup.6, --COCOR.sup.7, --NHCOR.sup.7, --C(.dbd.W.sup.3)W.sup.4 R.sup.8, --(NH).sub.m SO.sub.2 R.sup.9, --(NH).sub.m SO.sub.2 OR.sup.10 or --(NH).sub.m SO.sub.2 N(R.sup.11)R.sup.12, as defined herein.
摘要翻译:式(I)的二氨基三氟甲基吡啶衍生物或其盐:其中X为-CW1R1,-COCOR2,-CW1NHCOR2,-C(= W1)W2R3或-CW1N(R4)R5,Y为烷基 ,-CW 3 R 6,-COCOR 7,-NHCOR 7,-C(= W 3)W 4 R 8, - (NH)m SO 2 R 9, - (NH)m SO 2 OR 10或 - (NH)m SO 2 N(R 11)R 12。
摘要:
A diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW.sup.1 R.sup.1, --COCOR.sup.2, --CW.sup.1 NHCOR.sup.2, --C(.dbd.W.sup.1)W.sup.2 R.sup.3 or --CW.sup.1 N(R.sup.4)R.sup.5, and Y is alkyl, --CW.sup.3 R.sup.6, --COCOR.sup.7, --NHCOR.sup.7, --C(.dbd.W.sup.3)W.sup.4 R.sup.8, --(NH).sub.m SO.sub.2 R.sup.9, --(NH).sub.m SO.sub.2 OR.sup.10 or --(NH).sub.m SO.sub.2 N(R.sup.11)R.sup.12, wherein each of R.sup.1, R.sup.6 and R.sup.9, which are independent from one another, is a chain hydrocarbon group which may be substituted, a monocyclic hydrocarbon group which may be substituted, a polycyclic hydrocarbon group which may be substituted, a monocyclic heterocycle group which may be substituted or a polycyclic heterocycle group which may be substituted, each of R.sup.2 and R.sup.7, which are independent from each other, is alkyl which may be substituted, alkoxy which may be substituted, phenyl which may be substituted or phenoxy which may be substituted, each of R.sup.3, R.sup.8 and R.sup.10, which are independent from one another, is alkyl which may be substituted, alkenyl which may be substituted, alkynyl which may be substituted, cycloalkyl which may be substituted, phenyl which may be substituted or benzyl which may be substituted, each of R.sup.4, R.sup.5, R.sup.11 and R.sup.12, which are independent from one another, is alkyl which may be substituted, each of W.sup.1, W.sup.2, W.sup.3 and W.sup.4, which are independent from one another, is an oxygen atom or a sulfur atom, and m is 0 or 1, provided that a combination wherein one of X and Y is --COCF.sub.2 X.sup.1 wherein X.sup.1 is a hydrogen atom, a halogen atom, alkyl or haloalkyl, and the other is --COCF.sub.2 X.sup.2 wherein X.sup.2 is a hydrogen atom, a halogen atom, alkyl, haloalkyl or alkylcarbonyl, or --COOX.sup.3 wherein X.sup.3 is alkyl which may be substituted or phenyl which may be substituted, is excluded.
摘要翻译:式(I)的二氨基三氟甲基吡啶衍生物或其盐:其中X为-CW1R1,-COCOR2,-CW1NHCOR2,-C(= W1)W2R3或-CW1N(R4)R5,Y为烷基 ,-CW 3 R 6,-COCOR 7,-NHCOR 7,-C(= W3)W 4 R 8, - (NH)m SO 2 R 9, - (NH)m SO 2 OR 10或 - (NH)m SO 2 N(R 11)R 12,其中R 1,R 6和R 9各自 彼此独立,可以被取代的链状烃基,可以被取代的单环烃基,可以被取代的多环烃基,可以被取代的单环杂环基或可以被取代的多环杂环基 取代的,R 2和R 7各自独立地为可以被取代的烷基,可以被取代的烷氧基,可以被取代的苯基或可被取代的苯氧基,R 3,R 8和R 10各自为 彼此独立地是可以被取代的烷基,可以被取代的链烯基,可被取代的炔基,其中的环烷基 可被取代的苯基或可被取代的苄基,R 4,R 5,R 11和R 12各自彼此独立地是可以被取代的烷基,各自为W1,W2,W3和W4, 其彼此独立的是氧原子或硫原子,并且m为0或1,条件是其中X和Y之一是-COCF 2 X 1的组合,其中X 1是氢原子,卤素原子,烷基或卤代烷基 另一个是-COCF 2 X 2,其中X 2是氢原子,卤原子,烷基,卤代烷基或烷基羰基,或-COOX 3,其中X 3是可被取代的烷基或可被取代的苯基。
摘要:
A diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW.sup.1 R.sup.1, --COCOR.sup.2, --CW.sup.1 NHCOR.sup.2, --C(.dbd.W.sup.1 (W.sup.2 W.sup.3 or --CW.sup.1 N(R.sup.4)R.sup.5, and Y is alkyl, --CW.sup.3 R.sup.6, --COCOR.sup.7, --NHCOR.sup.7, --C(.dbd.W.sup.3)W.sup.4 R.sup.8, --(NH).sub.m SO.sub.2 R.sup.9, --(NH).sub.m SO.sub.2 OR.sup.10 or --(NH).sub.m SO.sub.2 N R.sup.11)R.sup.12, wherein each of R.sup.1, R.sup.6 and R.sup.9, which are independent from one another, is a chain hydrocarbon group which may be substituted, a monocyclic hydrocarbon group which may be substituted, a polycyclic hydrocarbon group which may be substituted, a monocyclic heterocycle group which may be substituted or a polycyclic heterocycle group which may be substituted, each of R.sup.2 and R.sup.7, which are independent from each other, is alkyl which may be substituted, alkoxy which may be substituted, phenyl which may be substituted or phenoxy which may be substituted, each of R.sup.3, R.sup.8 and R.sup.10, which are independent from one another, is alkyl which may be substituted, alkenyl which may be substituted, alkynyl which may be substituted, cycloalkyl which may be substituted, phenyl which may be substituted or benzyl which may be substituted, each of R.sup.4, R.sup.5, R.sup.11 and R.sup.12, which are independent from one another, is alkyl which may be substituted, each of W.sup.1, W.sup.2, W.sup.3 and W.sup.4, which are independent from one another, is an oxygen atom or a sulfur atom, and m is 0 or 1, provided that a combination wherein one of X and Y is --COCF.sub.2 X.sup.1 wherein X.sup.1 is a hydrogen atom, a halogen atom, alkyl or haloalkyl, and the other is --COCF.sub.2 X.sup.2 wherein X.sub.2 is a hydrogen atom, a halogen atom, alkyl, haloalkyl or alkylcarbonyl, or --COOX.sup.3 wherein X.sup.3 is alkyl which may be substituted or phenyl which may be substituted, is excluded.
摘要翻译:式(I)的二氨基三氟甲基吡啶衍生物或其盐:其中X为-CW1R1,-COCOR2,-CW1NHCOR2,-C(= W1(W2W3或-CW1N(R4)R5,Y为烷基 ,-CW 3 R 6,-COCOR 7,-NHCOR 7,-C(= W 3)W 4 R 8, - (NH)m SO 2 R 9, - (NH)m SO 2 OR 10或 - (NH)m SO 2 N R 11)R 12,其中R 1,R 6和R 9 彼此独立地是可以被取代的链状烃基,可以被取代的单环烃基,可以被取代的多环烃基,可以被取代的单环杂环基或可以被取代的多环杂环基 相互独立的R 2和R 7各自为可被取代的烷基,可被取代的烷氧基,可被取代的烷氧基,可被取代的苯基或可被取代的苯氧基,R 3,R 8和R 10各自独立地 可以是可以被取代的烷基,可以被取代的链烯基,可被取代的炔基,其中的环烷基 可被取代的苯基或可被取代的苄基,R 4,R 5,R 11和R 12各自彼此独立地是可以被取代的烷基,各自为W1,W2,W3和W4, 其彼此独立的是氧原子或硫原子,并且m为0或1,条件是其中X和Y之一是-COCF 2 X 1的组合,其中X 1是氢原子,卤素原子,烷基或卤代烷基 另一个是-COCF 2 X 2,其中X 2是氢原子,卤原子,烷基,卤代烷基或烷基羰基,或-COOX 3,其中X 3是可被取代的烷基或可被取代的苯基。
摘要:
A novel pesticide is provided. The present invention provides a pesticide containing, as an active ingredient, a pyridyl-methanamine derivative represented by the formula (I) or its salt: wherein R1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, a heterocyclic group, etc.; each of R2 and R3 which are independent of each other, is hydrogen, halogen, cyano, nitro, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, a heterocyclic group, etc.; R4 is trifluoromethyl or chlorodifluoromethyl; R5 is hydrogen, halogen, cyano, nitro, alkyl, etc.; each of R6 and R7 which are independent of each other, is hydrogen, cyano, alkyl, haloalkyl, etc.; R8 is alkyl, cycloalkyl, alkoxyalkyl, alkoxyalkoxyalkyl, hydroxyalkyl, halogen, haloalkyl, cyano, nitro, etc.; and n is an integer of from 0 to 4.
摘要翻译:提供了一种新型农药。 本发明提供含有式(I)表示的吡啶基 - 甲胺衍生物或其盐的农药:其中R1是氢,烷基,烯基,炔基,芳基,杂环基等; R 2和R 3各自独立地为氢,卤素,氰基,硝基,烷基,环烷基,烯基,炔基,芳基,杂环基等。 R4是三氟甲基或氯二氟甲基; R5是氢,卤素,氰基,硝基,烷基等; R 6和R 7各自独立地为氢,氰基,烷基,卤代烷基等; R8是烷基,环烷基,烷氧基烷基,烷氧基烷氧基烷基,羟基烷基,卤素,卤代烷基,氰基,硝基等; n为0〜4的整数。