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公开(公告)号：US10744499B2
公开(公告)日：2020-08-18
申请号：US14888225
申请日：2014-04-17
摘要： A biological sample holder for holding a solid phase sample, including a handle, and a seal area suitable for being received in an opening of a sample receiving chamber of a cassette, mountable to a sample analysis instrument. The holder further includes a stem connected to the seal and a sample retainer connected to the stem for retaining solids in the retainer, the sample retainer including a perforated wall region for allowing fluids to pass through the wall but preventing the solid phase sample from passing through the wall.
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公开(公告)号：US10370649B2
公开(公告)日：2019-08-06
申请号：US15317039
申请日：2015-06-17
摘要： The present invention relates to the field of nucleic acid collection and storage, and in particular to the collection and long-term storage of nuclei. The invention provides a device and method which can be used to capture and store nuclei at ambient temperatures allowing the subsequent isolation of nucleic acids by passive washing with a wash buffer. The present invention also provides a kit including the device of the invention suitable for carrying out the method of the invention.
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3.发明授权公开(公告)号：US10085726B2
公开(公告)日：2018-10-02
申请号：US15101113
申请日：2014-11-25
发明人： Cheryl Louise Potts , Peter James Tatnell , Geraint Seymour , Alan Stuart Pierce , Michael John Smith , Samantha Jane Ogden , Neil John Williams , Christopher Burrows , Jared William Harris Evans , Ashley Edward Bryant , Sean Robert Sweeney
摘要： A controlled transfer biological sample material collection device is disclosed which comprises: a body; and a sample collection member for collecting the biological sample material (not shown), the body housing a sample storage medium for generally dry storage of the biological material, the collection member being moveable from an exposed position (shown in FIG. 8) where collection of a biological sample is possible, to a transfer position (shown in FIG. 9) which effects transfer of at least a portion of the collected sample to said medium. The device is characterized in that the body slideably supports the sample collection member, and in that the body or collection member include a ramp-like projection portion (116 FIG. 10) operable to force the collection member into the transfer position against the medium and to effect said transfer as the collection member slides within the body.
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公开(公告)号：US20140298926A1
公开(公告)日：2014-10-09
申请号：US14358918
申请日：2012-11-30
CPC分类号： G01N35/00663 , A61B10/0096 , B01L3/505 , B01L9/52 , B01L2200/025 , B01L2300/0609 , B01L2300/0825 , B01L2300/0829 , C12Q1/6806 , G01N35/00029
摘要： Disclosed is a biological sample holder, a container for storing multiple holders, and an automated holder retrieval system. The sample holder may comprise an elongate generally planar support including a handle end and an opposing biological sample storage end, wherein, a substrate for accepting a biological sample is mounted to the holder at said sample storage end. Optionally the substrate is so mounted within a recess in the surface of the support and the recess has a local surface providing a reaction surface for allowing a sub-sample to be removed from the medium by mechanical action, such as cutting or punching. The container may include an array of wells each well being generally square or rectangular in plan and the holders dimensioned so that they are held diagonally in a respective well. The automated biological sample storage apparatus may include a mechanical handling device, and an associated electronic control capable of controlling the mechanical handing device to pick a predetermined sample holder from an associated well, or to place a predetermined sample holder into an associated well, optionally removing or replacing a container lid where a lid is used.
摘要翻译： 公开了一种生物样本保持器，用于存储多个保持器的容器和自动保持器检索系统。 样品保持器可以包括细长的大致平面的支撑件，其包括手柄端和相对的生物样品储存端，其中，用于接受生物样品的基底在所述样品储存端安装到保持器。 可选地，衬底被安装在支撑体表面的凹部内，并且凹部具有提供反应表面的局部表面，用于通过诸如切割或冲压之类的机械作用使子样品从介质中移除。 容器可以包括孔的阵列，每个孔的平面大致为正方形或矩形，并且保持器的尺寸使得它们被对角地保持在相应的孔中。 自动生物样品存储装置可以包括机械处理装置和相关联的电子控制装置，其能够控制机械处理装置从相关联的井中挑取预定的样品架，或者将预定的样品架放置在相关的井中， 或更换使用盖子的容器盖子。
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公开(公告)号：US10252265B2
公开(公告)日：2019-04-09
申请号：US15121147
申请日：2015-02-20
摘要： A microfluidic device 100 is disclosed comprising a body 112 including a biological sample S and/or reagent R receiving slot 122. The sample and reagent are carried on a solid support 10. The device 100 includes two punch assemblies 130 for removing portions of the solid support 10 and delivering them, together with the sample and/or reagent(s), to a receiving chamber 126 for subsequent processing. The device can be used for various assays including those which require just the addition of water in the reaction chamber with no pre-treatment of sample prior delivery into the chamber.
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公开(公告)号：US20160317748A1
公开(公告)日：2016-11-03
申请号：US15103934
申请日：2014-11-26
CPC分类号： A61M5/3145 , A61M5/165 , A61M2005/3128 , A61M2205/75 , B01L3/5635 , B01L2200/0631 , B01L2300/0681 , B01L2300/08 , B01L2300/0858 , B01L2300/12 , B01L2400/06 , B01L2400/0605 , G01N2001/4088
摘要： The present invention provides a device comprising: a housing comprising a first opening for connecting to a liquid source, a second opening for connecting with an apparatus for drawing in and expelling liquid, and a valve means comprising a filter carrier and a filter, the filter carrier supporting the filter and being movable within the housing; wherein the valve means permits liquid that is drawn into the housing from the liquid source by the apparatus to enter the apparatus by bypassing the filter but which forces liquid that is subsequently pushed from the apparatus through the second opening into the housing to be filtered through the filter.
摘要翻译： 本发明提供了一种装置，包括：壳体，包括用于连接到液体源的第一开口，用于与用于吸入和排出液体的装置连接的第二开口，以及包括过滤器载体和过滤器的阀装置， 载体，其支撑过滤器并且可在壳体内移动; 其中所述阀装置允许由所述装置从所述液体源吸入到所述壳体中的液体通过旁路所述过滤器而进入所述装置，但所述液体迫使液体随后从所述装置通过所述第二开口推入所述壳体以通过所述第二开口被过滤 过滤。
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7.发明申请CONTROLLED TRANSFER BIOLOGICAL SAMPLE COLLECTION DEVICES AND METHODS OF USING SUCH DEVICES 审中-公开控制转移生物样品采集装置和使用这种装置的方法公开(公告)号：US20160302775A1
公开(公告)日：2016-10-20
申请号：US15101113
申请日：2014-11-25
发明人： Cheryl Louise Potts , Peter James Tatnell , Geraint Seymour , Alan Stuart Pierce , Michael John Smith , Samantha Jane Ogden , Neil John Williams , Christopher Burrows , Jared William Harris Evans , Ashley Edward Bryant , Sean Robert Sweeney
CPC分类号： A61B10/0096 , A61B10/0045 , B01L3/508 , B01L2200/141 , B01L2300/0809 , C12Q1/24 , G01N1/30
摘要： A controlled transfer biological sample material collection device is disclosed which comprises: a body; and a sample collection member for collecting the biological sample material (not shown), the body housing a sample storage medium for generally dry storage of the biological material, the collection member being moveable from an exposed position (shown in FIG. 8) where collection of a biological sample is possible, to a transfer position (shown in FIG. 9) which effects transfer of at least a portion of the collected sample to said medium. The device is characterised in that the body slideably supports the sample collection member, and in that the body or collection member include a ramp-like projection portion (116 FIG. 10) operable to force the collection member into the transfer position against the medium and to effect said transfer as the collection member slides within the body.
摘要翻译： 公开了一种受控转移生物样品材料收集装置，其包括：主体; 以及用于收集生物样本材料（未示出）的样本收集构件，所述身体容纳用于生物材料的大体干燥储存的样本存储介质，所述收集构件可从收集的暴露位置（图8所示）移动 生物样品的转移位置（图9所示），其可以将所收集的样品的至少一部分转移到所述培养基。 该装置的特征在于，主体可滑动地支撑样本收集构件，并且身体或收集构件包括可操作以迫使收集构件抵抗介质的转移位置的斜坡状突出部分（116），以及 以在收集构件在体内滑动时实现所述转移。
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公开(公告)号：US20140234125A1
公开(公告)日：2014-08-21
申请号：US14346850
申请日：2012-09-26
发明人： David Gwyn Treharne , Geraint Seymour , Navin Deepal Pathirana , Christopher Burrows , Neil John Williams , Aidan PAUL Vaughan , Robert William Richardson
CPC分类号： B01L3/02 , B01L3/0289 , B01L3/502 , B01L9/00 , B01L2200/025 , F04B43/00 , G01N2001/4088
摘要： The disclosure relates to an in-hand operable compressor 200 for compressing syringeless filter devices 100. The compressor 200 includes a base 220 having a receiving well 222 adapted to receive a bottom portion of the uncompressed device 100, and a discrete top 210 having a receiving recess (212 FIG. 4) adapted to receive a top portion of the uncompressed device 100, said base and top being brought together in use by hand compression to cause compression of the device 100 located in the well and recess of the compressor. Surface formations 250 and 252 (FIG. 2) are complementary and inhibit misalignment of said well and recess during the in-hand compression.
摘要翻译： 本公开涉及一种用于压缩无袖过滤器装置100的可手动操作的压缩机200.压缩机200包括具有适于接收未压缩装置100的底部的接收阱222的基座220和具有接收的离散顶部210 适于接纳未压缩装置100的顶部的凹部（212图4），所述基部和顶部在使用中通过手动压缩在一起，以使位于压缩机的井和凹部内的装置100压缩。 表面构造250和252（图2）是互补的，并且在手压缩期间阻止所述井和凹槽的未对准。
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公开(公告)号：USD705819S1
公开(公告)日：2014-05-27
申请号：US29453396
申请日：2013-04-29
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10.发明授权公开(公告)号：US10150118B2
公开(公告)日：2018-12-11
申请号：US14894682
申请日：2014-05-14
发明人： Peter James Tatnell , Stevan Paul Tortorella , Geraint Seymour , Cheryl Louise Potts , Alan Stuart Pierce , Samantha Jane Ogden , Neil John Williams
摘要： A controlled transfer biological sample material collection device is disclosed which includes a body and a sample collection member for collecting the biological sample material, the body housing a sample storage medium for generally dry storage of the biological material, the collection member being moveable from an exposed position where collection of a biological sample is possible, to a transfer position which effects transfer of at least a portion of the collected sample to said medium. The body of the device slideably supports the sample collection member, and the body or collection member includes a ramp-like projection portion operable to force the collection member into the transfer position against the medium and to effect the transfer as the collection member slides within the body.
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