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1.发明申请Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants 失效细菌ADP-核糖基化毒素的解毒突变体作为胃肠外辅助剂公开(公告)号：US20050106180A1
公开(公告)日：2005-05-19
申请号：US10927561
申请日：2004-08-26
申请人： Gail Barchfeld , Giuseppe Giudice , Rino Rappuoli
发明人： Gail Barchfeld , Giuseppe Giudice , Rino Rappuoli
IPC分类号： A61K39/00 , A61K39/10 , A61K39/106 , A61K39/108 , A61K39/145 , A61K39/21 , A61K39/245 , A61K39/39 , A61P31/04 , A61P31/12 , A61P31/16 , A61P31/18 , A61P31/22 , C07K14/235 , C07K14/245 , C07K14/28 , A61K39/02
CPC分类号： C07K14/235 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/245 , A61K39/39 , A61K2039/54 , A61K2039/545 , A61K2039/55544 , C07K14/245 , C07K14/28 , C12N2710/16634 , C12N2740/16234 , C12N2760/16134 , Y02A50/466
摘要： The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP- ribosylating toxins, particularly those from pertussis (PT), cholera (CT), and heat-labile E. coli (LT).
摘要翻译： 本发明提供包含细菌ADP-核糖基化毒素，特别是百日咳（PT），霍乱（CT）和热不稳定大肠杆菌（LT））的解毒突变体的肠外辅助剂。
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2.发明授权Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants 失效细菌ADP-核糖基化毒素的解毒突变体作为胃肠外辅助剂公开(公告)号：US06818222B1
公开(公告)日：2004-11-16
申请号：US09044696
申请日：1998-03-18
IPC分类号： A61K3902
CPC分类号： C07K14/235 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/245 , A61K39/39 , A61K2039/54 , A61K2039/545 , A61K2039/55544 , C07K14/245 , C07K14/28 , C12N2710/16634 , C12N2740/16234 , C12N2760/16134 , Y02A50/466
摘要： The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP-ribosylating toxins, particularly those from pertussis (PT), cholera (CT), and heat-labile E. coli (LT).
摘要翻译： 本发明提供包含细菌ADP-核糖基化毒素，特别是来自百日咳（PT），霍乱（CT）和热不稳定的大肠杆菌（LT））的解毒突变体的肠外辅助剂。
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公开(公告)号：US07056521B2
公开(公告)日：2006-06-06
申请号：US10927561
申请日：2004-08-26
IPC分类号： A61K39/02 , A61K45/00 , A61K39/10 , A61K39/295
CPC分类号： C07K14/235 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/245 , A61K39/39 , A61K2039/54 , A61K2039/545 , A61K2039/55544 , C07K14/245 , C07K14/28 , C12N2710/16634 , C12N2740/16234 , C12N2760/16134 , Y02A50/466
摘要： The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP-ribosylating toxins, particularly those from pertussis (PT), cholera (CT), and heat-labile E. coli (LT).
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4.发明申请Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants 审中-公开细菌ADP-核糖基化毒素的解毒突变体作为胃肠外辅助剂公开(公告)号：US20060159701A1
公开(公告)日：2006-07-20
申请号：US11367056
申请日：2006-03-02
IPC分类号： A61K39/116 , A61K39/108
CPC分类号： C07K14/235 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/245 , A61K39/39 , A61K2039/54 , A61K2039/545 , A61K2039/55544 , C07K14/245 , C07K14/28 , C12N2710/16634 , C12N2740/16234 , C12N2760/16134 , Y02A50/466
摘要： The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP-ribosylating toxins, particularly those from pertussis (PT), cholera (CT), and heat-labile E. coli (LT).
摘要翻译： 本发明提供包含细菌ADP-核糖基化毒素，特别是来自百日咳（PT），霍乱（CT）和热不稳定的大肠杆菌（LT））的解毒突变体的肠外辅助剂。
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公开(公告)号：US09669088B2
公开(公告)日：2017-06-06
申请号：US12744920
申请日：2008-11-25
申请人： Audino Podda , Rino Rappuoli
发明人： Audino Podda , Rino Rappuoli
IPC分类号： A61K39/145 , C07K14/11 , A61K39/12 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55566 , C12N2710/10343 , C12N2760/16134
摘要： H5N1 influenza viruses isolated from animals and humans since 2003 separate into distinct clades based on hemagglutinin amino acid sequences. According to the invention, multiple clades are used in influenza immunization. Thus there is a prime-boost immunization schedule where a subject receives a priming dose of a first clade of H5 influenza A virus and a boosting dose of a second clade of H5 influenza A virus. There is also an immunogenic composition comprising hemagglutinin antigens from more than one clade of H5 influenza A virus.
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公开(公告)号：US09636393B2
公开(公告)日：2017-05-02
申请号：US10148533
申请日：2000-11-29
IPC分类号： A61K39/095 , A61K39/00 , A61K39/42 , A61K47/48 , A61K39/116
CPC分类号： A61K39/095 , A61K39/116 , A61K47/6415 , A61K47/646 , A61K2039/55505 , A61K2039/55566 , A61K2039/6037 , A61K2039/6068
摘要： International patent application WO99/61053 discloses immunogenic compositions that comprise N. meningitidis serogroup C oligosaccharide conjugated to a carrier, in combination with N. meningitidis serogroup B outer membrane protein. These are disclosed in the present application in combination with further Neisserial proteins and/or protective antigens against other pathogenic organisms (e.g. Haemophilus influenzae, DTP, HBV, etc.).
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公开(公告)号：US08858958B2
公开(公告)日：2014-10-14
申请号：US12870708
申请日：2010-08-27
申请人： Michele Pallaoro , Derek O'Hagan , Rino Rappuoli
发明人： Michele Pallaoro , Derek O'Hagan , Rino Rappuoli
IPC分类号： A61K39/095 , A61K39/39 , A61K39/00 , A61K39/108 , A61K39/085 , A61K39/09 , A61K39/155
CPC分类号： A61K39/39 , A61K39/0002 , A61K39/0258 , A61K39/085 , A61K39/092 , A61K39/095 , A61K39/155 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , C12N2760/18534 , Y02A50/474
摘要： An immunological adjuvant comprises an aluminum salt, an immunostimulatory oligonucleotide and a polycationic polymer, wherein the oligonucleotide and the polymer ideally associate with each other to form a complex. The adjuvant can be included in a composition with an immunogen e.g. to elicit an immune response that protects against a bacterial disease or a fungal disease.
摘要翻译： 免疫佐剂包括铝盐，免疫刺激寡核苷酸和聚阳离子聚合物，其中寡核苷酸和聚合物理想地相互结合以形成络合物。 佐剂可以包括在具有免疫原的组合物中。 以引发免疫应答，防止细菌性疾病或真菌性疾病。
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8.发明授权Method for generating immune responses utilizing nucleic acids encoding fusion proteins comprising CD4 minimal modules and invasin polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutralization epitopes 失效使用编码融合蛋白的核酸产生免疫应答的方法，其包含能够结合HIV包膜并暴露神经中和表位的CD4最小模块和侵袭素多肽公开(公告)号：US08568734B2
公开(公告)日：2013-10-29
申请号：US13426295
申请日：2012-03-21
申请人： Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W Barnett , Indresh K. Srivastava , Rino Rappuoli
发明人： Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W Barnett , Indresh K. Srivastava , Rino Rappuoli
CPC分类号： C07K14/70514 , C07K2319/01
摘要： Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
摘要翻译： 描述了包含在非CD4主链中结合HIV Env多肽的CD4最小模块的融合蛋白。 还描述了这些融合蛋白与Env的复合物以及使用多核苷酸和多肽的诊断，治疗和预防的方法。
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公开(公告)号：US08398999B2
公开(公告)日：2013-03-19
申请号：US13556139
申请日：2012-07-23
IPC分类号： A61K39/095 , C07H21/04 , C12P21/04 , C07K14/00
CPC分类号： C07K14/22 , A61K38/164 , A61K39/095 , C07K2319/00
摘要： NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.
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公开(公告)号：US20130064846A1
公开(公告)日：2013-03-14
申请号：US13593464
申请日：2012-08-23
IPC分类号： A61K39/095 , A61P31/04 , A61P37/04 , C07K14/22
摘要： The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae, including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译： 本发明提供脑膜炎奈瑟菌（A＆B）菌株和来自淋病奈瑟氏球菌的蛋白质，包括氨基酸序列，相应的核苷酸序列，表达数据和血清学数据。 蛋白质是疫苗，免疫原性组合物和/或诊断的有用的抗原。
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