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公开(公告)号：US20050203050A1
公开(公告)日：2005-09-15
申请号：US11128063
申请日：2005-05-12
申请人： Gary Nabel , Elizabeth Nabel , Manfred Boehm
发明人： Gary Nabel , Elizabeth Nabel , Manfred Boehm
CPC分类号： C12N9/1205 , A61K38/00 , A61K48/00 , C07K14/4738 , C12N2799/022
摘要： Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing mutations that prevent their inhibition with serine/threonine kinases.
摘要翻译： 本文公开了用于改变细胞增殖的新型组合物和方法。 包括野生型和突变型hKIS多肽以及含有突变的细胞周期蛋白激酶抑制剂，其具有预防丝氨酸/苏氨酸激酶的抑制作用。
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公开(公告)号：US20060239975A1
公开(公告)日：2006-10-26
申请号：US11475827
申请日：2006-06-27
申请人： Gary Nabel , Zhi-yong Yang , Elizabeth Nabel
发明人： Gary Nabel , Zhi-yong Yang , Elizabeth Nabel
CPC分类号： C12N15/86 , A61K9/0019 , A61K31/70 , A61K31/711 , A61K38/1709 , A61K38/1774 , A61K38/45 , A61K48/005 , C12N2710/10343 , A61K2300/00
摘要： The p21 gene encodes a cyclin dependent kinase inhibitor which affects cell cycle progression, but the role of this gene product in altering tumor growth has not been established. The present inventors have now discovered that the growth of malignant cells in vivo is inhibited by expression of p21. Expression of p21 resulted in an accumulation of cells in G0/G1, alteration in morphology, and cell differentiation.
摘要翻译： p21基因编码影响细胞周期进程的细胞周期蛋白依赖性激酶抑制剂，但该基因产物在改变肿瘤生长中的作用尚未确定。 本发明人现已发现，通过p21的表达抑制体内恶性细胞的生长。 p21的表达导致细胞在G0 / G1 / 1中的积累，形态的改变和细胞分化。
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3.发明申请Methods for coating stents with DNA and expression of recombinant genes from DNA coated stents in vivo 审中-公开用DNA包被支架的方法和从DNA涂层支架体内重组基因的表达公开(公告)号：US20050038499A1
公开(公告)日：2005-02-17
申请号：US10946785
申请日：2004-09-22
申请人： Elizabeth Nabel , Gary Nabel , Zhi-yong Yang
发明人： Elizabeth Nabel , Gary Nabel , Zhi-yong Yang
CPC分类号： A61L31/16 , A61F2/82 , A61K9/0024 , A61K31/711 , A61K38/45 , A61K38/50 , A61K48/00 , A61L31/10 , A61L2300/252 , A61L2300/258 , A61L2300/416 , A61L2300/606 , C08L89/00
摘要： The present invention describes DNA coated stents and methods of using the same to treat or prevent vascular diseases, such as restenosis.
摘要翻译： 本发明描述了DNA涂覆的支架及其使用方法来治疗或预防血管疾病如再狭窄。
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公开(公告)号：US20080095835A1
公开(公告)日：2008-04-24
申请号：US11981179
申请日：2007-10-31
申请人： Gary Nabel , Zhi-yong Yang , Elizabeth Nabel
发明人： Gary Nabel , Zhi-yong Yang , Elizabeth Nabel
IPC分类号： A61K31/711 , A61K9/127 , A61P35/00 , A61P9/00
CPC分类号： C12N15/86 , A61K9/0019 , A61K31/70 , A61K31/711 , A61K38/1709 , A61K38/1774 , A61K38/45 , A61K48/005 , C12N2710/10343 , A61K2300/00
摘要： The p21 gene encodes a cyclin dependent kinase inhibitor which affects cell cycle progression, but the role of this gene product in altering tumor growth has not been established. The present inventors have now discovered that the growth of malignant cells in vivo is inhibited by expression of p21. Expression of p21 resulted in an accumulation of cells in G0/G1, alteration in morphology, and cell differentiation.
摘要翻译： p21基因编码影响细胞周期进程的细胞周期蛋白依赖性激酶抑制剂，但该基因产物在改变肿瘤生长中的作用尚未确定。 本发明人现已发现，通过p21的表达抑制体内恶性细胞的生长。 p21的表达导致细胞在G0 / G1 / 1中的积累，形态的改变和细胞分化。
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5.发明申请Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor 审中-公开通过细胞的位点特异性滴注或细胞的位点特异性转化及其试剂盒来治疗疾病公开(公告)号：US20070287682A1
公开(公告)日：2007-12-13
申请号：US11788728
申请日：2007-04-20
申请人： Elizabeth Nabel , Gary Nabel
发明人： Elizabeth Nabel , Gary Nabel
CPC分类号： A61K39/00 , A61B17/22 , A61B2017/22038 , A61B2017/22054 , A61B2017/22082 , A61B2017/22084 , A61K9/0024 , A61K31/70 , A61K47/6957 , A61K48/00 , A61L29/16 , A61L2300/252 , A61L2300/258 , A61L2300/626 , A61L2300/64
摘要： A method for the direct treatment towards the specific sites of a disease is disclosed. This method is based on the delivery of proteins by catheterization to discrete blood vessel segments using genetically modified or normal cells or other vector systems. Endothelial cells expressing recombinant therapeutic agent or diagnostic proteins are situated on the walls of the blood vessel or in the tissue perfused by the vessel in a patient. This technique, provides for the transfer of cells or vectors and expression of recombinant genes in vivo and allows the introduction of proteins of therapeutic or diagnostic value for the treatment of diseases.
摘要翻译： 公开了一种直接治疗疾病特定部位的方法。 该方法基于通过导管插入到使用遗传修饰或正常细胞或其他载体系统的离散血管段的蛋白质递送。 表达重组治疗剂或诊断性蛋白质的内皮细胞位于血管壁或患者血管灌注的组织中。 该技术提供细胞或载体的转移和体内重组基因的表达，并允许引入用于治疗疾病的治疗或诊断价值的蛋白质。
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公开(公告)号：US20060239990A1
公开(公告)日：2006-10-26
申请号：US11263657
申请日：2005-10-31
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0362 , A61K31/7105 , A61K38/45 , A61K48/00 , C12N9/1007 , C12N15/8509 , C12N2310/11 , C12N2310/122 , C12N2310/14 , C12Q1/48 , G01N33/573 , G01N33/57496 , G01N2333/91011 , G01N2500/00 , G01N2500/10
摘要： The invention provides insight into the function of Protein Arginine N-Methyltransferase-2 (PRMT-2) and provides methods for modulating PRMT-2 activity or expression in cells. The methods of the invention can be used to inhibit the function of NFκB, E2F1 and STAT3 and have utility for treating a variety of conditions including, for example, inflammation, HIV infection, cancer and obesity.
摘要翻译： 本发明提供了蛋白精氨酸N-甲基转移酶-2（PRMT-2）的功能的了解，并提供了调节细胞中PRMT-2活性或表达的方法。 本发明的方法可用于抑制NFκB，E2F1和STAT3的功能，并且可用于治疗各种病症，包括炎症，HIV感染，癌症和肥胖症。
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公开(公告)号：US08268323B2
公开(公告)日：2012-09-18
申请号：US13232775
申请日：2011-09-14
申请人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
发明人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
IPC分类号： A61K39/21 , A61K39/385 , A61K9/127 , G01N33/53
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C07K14/70514 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： Stabilized forms of gp120 polypeptide, nucleic acids encoding these stabilized forms, vectors comprising these nucleic acids, and methods of using these polypeptides, nucleic acids, vectors and host cells are disclosed. Crystal structures and computer systems including atomic coordinates for stabilized forms of gp120, and gp120 with an extended V3 loop, and methods of using these structures and computer systems are also disclosed.
摘要翻译： 公开了稳定形式的gp120多肽，编码这些稳定形式的核酸，包含这些核酸的载体，以及使用这些多肽，核酸，载体和宿主细胞的方法。 还公开了包括gp120的稳定形式的原子坐标和具有扩展的V3循环的gp120的晶体结构和计算机系统，以及使用这些结构和计算机系统的方法。
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8.发明授权Conformationally stabilized HIV envelope immunogens and triggering HIV-I envelope to reveal cryptic V3-loop epitopes 有权构象稳定的艾滋病毒包膜免疫原，并引发HIV-1信封揭示神秘的V3环表位公开(公告)号：US08044185B2
公开(公告)日：2011-10-25
申请号：US12065894
申请日：2006-09-06
申请人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Chih-Chin Huang , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
发明人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Chih-Chin Huang , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C07K14/70514 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： Stabilized forms of gp120 polypeptide, nucleic acids encoding these stabilized forms, vectors comprising these nucleic acids, and methods of using these polypeptides, nucleic acids, vectors and host cells are disclosed. Crystal structures and computer systems including atomic coordinates for stabilized forms of gp120, and gp120 with an extended V3 loop, and methods of using these structures and computer systems are also disclosed.
摘要翻译： 公开了稳定形式的gp120多肽，编码这些稳定形式的核酸，包含这些核酸的载体，以及使用这些多肽，核酸，载体和宿主细胞的方法。 还公开了包括gp120的稳定形式的原子坐标和具有扩展的V3循环的gp120的晶体结构和计算机系统，以及使用这些结构和计算机系统的方法。
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公开(公告)号：US20090155853A1
公开(公告)日：2009-06-18
申请号：US12092811
申请日：2006-11-20
申请人： Gary Nabel , Wataru Akahata
发明人： Gary Nabel , Wataru Akahata
CPC分类号： C12N15/87 , A61K48/00 , C07K14/005 , C07K2319/74 , C07K2319/80 , C12N2710/10322
摘要： The invention relates to fusion proteins useful in delivering a targeted nucleic acid to a target cell, comprising a gene delivery fusion protein (GDFP), said GDFP comprising a nucleic acid binding domain (NBD) that binds to the targeted nucleic acid, fused to a gene delivery domain (GDD) that mediates delivery of the targeted nucleic acid to the target cell, wherein said GDD comprises one or more components that facilitate delivery of a targeted nucleic acid to a target cell, and wherein one of said components is a transport/localization component and wherein said transport/localization component is an adenovirus protein V or derivative thereof that retains protein V activity, and related methods of making and using thereof.
摘要翻译： 本发明涉及可用于将靶向核酸递送至靶细胞的融合蛋白，其包含基因递送融合蛋白（GDFP），所述GDFP包含与靶向核酸结合的核酸结合结构域（NBD），其与 介导靶向核酸向靶细胞递送的基因递送结构域（GDD），其中所述GDD包含有利于将靶向核酸递送至靶细胞的一种或多种组分，并且其中所述组分之一是转运/ 定位组分，其中所述转运/定位组分是保留蛋白V活性的腺病毒蛋白V或其衍生物，以及其制备和使用的相关方法。
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10.发明申请公开(公告)号：US20090110690A1
公开(公告)日：2009-04-30
申请号：US12065883
申请日：2006-09-06
申请人： Peter D. Kwong , Tongqing Zhou , Ling Xu , Gary Nabel , Barna Dey , Richard Wyatt , James Arthos , Joseph Sodroski , Shi-Hua Xiang , Dennis Burton
发明人： Peter D. Kwong , Tongqing Zhou , Ling Xu , Gary Nabel , Barna Dey , Richard Wyatt , James Arthos , Joseph Sodroski , Shi-Hua Xiang , Dennis Burton
IPC分类号： A61K39/21 , C07K14/16 , C07H21/04 , C12N15/63 , C12N5/06 , A61P31/18 , C12N5/22 , A61K38/16 , A61K31/7052
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C07K14/70514 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： The present disclosure relates to stabilized forms of the HIV gp120 envelope protein in complex with the broadly neutralizing CD4-binding site antibody b12, to crystalline forms of the stabilized forms of the HIV gp120 envelope protein in complex with the broadly neutralizing CD4-binding site antibody b12, and to the high resolution structure obtained from these crystals by X-ray diffraction methods. Methods for identifying immunogenic polypeptides based on these structures are also disclosed.
摘要翻译： 本公开涉及与广泛中和的CD4结合位点抗体b12复合的HIV gp120包膜蛋白的稳定形式，与广泛中和的CD4结合位点抗体复合的HIV gp120包膜蛋白的稳定形式的结晶形式 b12，以及通过X射线衍射法从这些晶体获得的高分辨率结构。 还公开了基于这些结构鉴定免疫原性多肽的方法。
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