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47 条记录 (耗时 0.039 秒)

    METHODS IN CELL CULTURES, AND RELATED INVENTIONS, EMPLOYING CERTAIN ADDITIVES
    4.
    发明申请
    METHODS IN CELL CULTURES, AND RELATED INVENTIONS, EMPLOYING CERTAIN ADDITIVES 有权
    细胞培养方法和相关发明，使用某些添加剂

    公开(公告)号：US20120164162A1

    公开(公告)日：2012-06-28

    申请号：US13389549

    申请日：2010-08-11

    申请人： Franz Kaufmann ,  Trine Hefsgaard Miller ,  Johannes Flothmann ,  Beate Winter ,  Andreas Hafner

    发明人： Franz Kaufmann ,  Trine Hefsgaard Miller ,  Johannes Flothmann ,  Beate Winter ,  Andreas Hafner

    IPC分类号： C12P21/00 ,  C12N9/00 ,  C12N1/20 ,  C07K14/575 ,  A61K39/00 ,  C07K14/00 ,  C07K14/555 ,  C07K14/715 ,  C07K14/475 ,  C07H21/00 ,  C12P19/34 ,  A61P37/04 ,  C07K14/525 ,  C07K14/54 ,  C12P1/04

    CPC分类号： C12N1/38 ,  C12P21/02

    摘要： A method for the manufacture of products by biotechnological methods in bacterial cell culture is disclosed as well as products obtained, the use of certain additives to the media used in the manufacture of said products in bacterial cell culture media, and the use of said additives in reducing the detrimental effects of radicals in the manufacture of the products, as well as aspects related to these invention embodiments. The manufacturing process or method comprises adding one or more radical scavenging and/or antioxidative additive preferably selected from the group consisting of sterically hindered nitroxyls, sterically hindered hydroxylamines, sterically hindered hydroxylamine salt compounds, sterically hindered amino compounds and sterically hindered N-hydrocarbyloxyamines, benzofuranone compounds, as obligatory component(s) to the medium used during biosynthesis.

    摘要翻译： 公开了通过生物技术在细菌细胞培养中制造产品的方法，以及获得的产品，在细菌细胞培养基中用于制造所述产品的培养基中使用某些添加剂，以及所述添加剂在 降低了在制造产品中自由基的有害影响，以及与本发明实施方案相关的方面。 制备方法或方法包括加入一种或多种自由基清除和/或抗氧化添加剂，其优选选自空间位阻硝酰基，空间位阻羟胺，空间位阻羟胺盐化合物，空间位阻氨基化合物和空间位阻N-烃氧基胺，苯并呋喃酮 作为生物合成过程中使用的培养基的强制性成分。

    SURFACE ACTIVE PROTEINS AS EXCIPIENTS IN SOLID PHARMACEUTICAL FORMULATIONS
    5.
    发明申请
    SURFACE ACTIVE PROTEINS AS EXCIPIENTS IN SOLID PHARMACEUTICAL FORMULATIONS 有权
    表面活性蛋白作为固体药物制剂的优点

    公开(公告)号：US20110268792A1

    公开(公告)日：2011-11-03

    申请号：US13130128

    申请日：2009-11-13

    申请人： Andreas Buthe ,  Andreas Hafner ,  Franz Kaufmann ,  Esther Gabor ,  Guido Meurer ,  Jürgen Eck ,  Gordon Bradley

    发明人： Andreas Buthe ,  Andreas Hafner ,  Franz Kaufmann ,  Esther Gabor ,  Guido Meurer ,  Jürgen Eck ,  Gordon Bradley

    IPC分类号： A61K9/48 ,  A61P39/00 ,  A61K9/16 ,  A61K9/02 ,  A61K9/00 ,  A61K9/38

    CPC分类号： A61K9/4891 ,  A61K9/0065 ,  A61K9/2063 ,  A61K9/2095 ,  A61K9/2873 ,  C07K14/37

    摘要： The invention relates to a use of surface active hydrophobins for applications in pharmaceutical technology, in particular as excipients for galenic use. Provided is a method for either admixture of hydrophobins to galenic compositions or for treating the surface of pharmaceutical forms with a hydrophobin-containing solution to modify the pharmaceutical properties of the galenic form. In a preferred embodiment of the invention hydrophobins are used to improve the properties of a pharmaceutical composition, e.g. to act as a surfactant or to increase resistance to disintegration of the galenic forms to achieve a retarded drug release. The galenic form to be modified by the use of surface active proteins as excipients can be capsules, tablets, pills, microparticles, vesicles, and suppositories, although further galenic forms are envisioned. The surface active proteins used for the purpose of present invention can either be isolated from their respective natural source or prepared by recombinant techniques and expression in a suitable host.

    摘要翻译： 本发明涉及用于制药技术中的表面活性疏水蛋白的用途，特别是作为涂覆液使用的赋形剂。 提供了将疏水蛋白与盖仑组合物混合或用含疏水蛋白的溶液处理药物形式的表面以改变盖仑膜形式的药物性质的方法。 在本发明的优选实施方案中，疏水蛋白用于改善药物组合物的性质，例如， 作为表面活性剂或增加耐受霜冻形式的崩解以实现延缓药物释放。 通过使用表面活性蛋白质作为赋形剂来修饰的盖仑形式可以是胶囊，片剂，丸剂，微粒，囊泡和栓剂，尽管可以预见到更多的盖仑制剂形式。 用于本发明目的的表面活性蛋白质可以从它们各自的天然来源中分离或者通过重组技术制备并在合适的宿主中表达。

    Methods in cell cultures, and related inventions, employing certain additives
    6.
    发明授权
    Methods in cell cultures, and related inventions, employing certain additives 有权
    使用某些添加剂的细胞培养方法和相关发明

    公开(公告)号：US08859235B2

    公开(公告)日：2014-10-14

    申请号：US13389549

    申请日：2010-08-11

    申请人： Franz Kaufmann ,  Trine Hefsgaard Miller ,  Johannes Flothmann ,  Beate Winter ,  Andreas Hafner

    发明人： Franz Kaufmann ,  Trine Hefsgaard Miller ,  Johannes Flothmann ,  Beate Winter ,  Andreas Hafner

    IPC分类号： C12P21/00 ,  C07K14/54 ,  C12P21/02 ,  C12N1/38

    CPC分类号： C12N1/38 ,  C12P21/02

    摘要： A method for the manufacture of products by biotechnological methods in bacterial cell culture is disclosed as well as products obtained, the use of certain additives to the media used in the manufacture of said products in bacterial cell culture media, and the use of said additives in reducing the detrimental effects of radicals in the manufacture of the products, as well as aspects related to these invention embodiments. The manufacturing process or method comprises adding one or more radical scavenging and/or antioxidative additive preferably selected from the group consisting of sterically hindered nitroxyls, sterically hindered hydroxylamines, sterically hindered hydroxylamine salt compounds, sterically hindered amino compounds and sterically hindered N-hydrocarbyloxyamines, benzofuranone compounds, as obligatory component(s) to the medium used during biosynthesis.

    摘要翻译： 公开了通过生物技术在细菌细胞培养中制造产品的方法，以及获得的产品，在细菌细胞培养基中用于制造所述产品的培养基中使用某些添加剂，以及所述添加剂在 降低了在制造产品中自由基的有害影响，以及与本发明实施方案相关的方面。 制备方法或方法包括加入一种或多种自由基清除和/或抗氧化添加剂，其优选选自空间位阻硝酰基，空间位阻羟胺，空间位阻羟胺盐化合物，空间位阻氨基化合物和空间位阻N-烃氧基胺，苯并呋喃酮 作为生物合成过程中使用的培养基的强制性成分。

    Surface active proteins as excipients in solid pharmaceutical formulations
    9.
    发明授权
    Surface active proteins as excipients in solid pharmaceutical formulations 有权
    表面活性蛋白作为固体药物制剂中的赋形剂

    公开(公告)号：US08226967B2

    公开(公告)日：2012-07-24

    申请号：US13130128

    申请日：2009-11-13

    申请人： Andreas Buthe ,  Andreas Hafner ,  Franz Kaufmann ,  Esther Gabor ,  Guido Meurer ,  Jürgen Eck ,  Gordon Bradley

    发明人： Andreas Buthe ,  Andreas Hafner ,  Franz Kaufmann ,  Esther Gabor ,  Guido Meurer ,  Jürgen Eck ,  Gordon Bradley

    IPC分类号： A01N25/34 ,  C07K1/00

    CPC分类号： A61K9/4891 ,  A61K9/0065 ,  A61K9/2063 ,  A61K9/2095 ,  A61K9/2873 ,  C07K14/37

    摘要： The invention relates to a use of surface active hydrophobins for applications in pharmaceutical technology, in particular as excipients for galenic use. Provided is a method for either admixture of hydrophobins to galenic compositions or for treating the surface of pharmaceutical forms with a hydrophobin-containing solution to modify the pharmaceutical properties of the galenic form. In a preferred embodiment of the invention hydrophobins are used to improve the properties of a pharmaceutical composition, e.g. to act as a surfactant or to increase resistance to disintegration of the galenic forms to achieve a retarded drug release. The galenic form to be modified by the use of surface active proteins as excipients can be capsules, tablets, pills, microparticles, vesicles, and suppositories, although further galenic forms are envisioned. The surface active proteins used for the purpose of present invention can either be isolated from their respective natural source or prepared by recombinant techniques and expression in a suitable host.

    摘要翻译： 本发明涉及用于制药技术中的表面活性疏水蛋白的用途，特别是作为涂覆液使用的赋形剂。 提供了将疏水蛋白与盖仑组合物混合或用含疏水蛋白的溶液处理药物形式的表面以改变盖仑膜形式的药物性质的方法。 在本发明的优选实施方案中，疏水蛋白用于改善药物组合物的性质，例如， 作为表面活性剂或增加耐受霜冻形式的崩解以实现延缓药物释放。 通过使用表面活性蛋白质作为赋形剂来修饰的盖仑形式可以是胶囊，片剂，丸剂，微粒，囊泡和栓剂，尽管可以预见到更多的盖仑制剂形式。 用于本发明目的的表面活性蛋白质可以从其各自的天然来源分离或通过重组技术制备并在合适的宿主中表达。