公开(公告)号：US09740912B2

公开(公告)日：2017-08-22

申请号：US13330900

申请日：2011-12-20

申请人： Ralf Schoenmeyer ,  Gerd Binnig ,  Guenter Schmidt ,  Maria Athelogou ,  Peter Ellenberg

发明人： Ralf Schoenmeyer ,  Gerd Binnig ,  Guenter Schmidt ,  Maria Athelogou ,  Peter Ellenberg

IPC分类号： G06K9/00 ,  G06K9/34 ,  G06T17/00 ,  G09G5/00 ,  G06T7/33

CPC分类号： G06K9/0014 ,  G06T7/33 ,  G06T2207/10056 ,  G06T2207/30024

摘要： A method for co-registering images of tissue slices stained with different biomarkers displays a first digital image of a first tissue slice on a graphical user interface such that an area of the first image is enclosed by a frame. Then a portion of a second image of a second tissue slice is displayed such that the area of the first image enclosed by the frame is co-registered with the displayed portion of the second image. The displayed portion of the second image has the shape of the frame. The tissue slices are both z slices of a tissue sample taken at corresponding positions in the x and y dimensions. The displayed portion of the second image is shifted in the x and y dimensions to coincide with the area of the first image that is enclosed by the frame as the user shifts the first image under the frame.

公开(公告)号：US08711149B2

公开(公告)日：2014-04-29

申请号：US13313685

申请日：2011-12-07

申请人： Guenter Schmidt ,  Arno Schaepe ,  Gerd Binnig

发明人： Guenter Schmidt ,  Arno Schaepe ,  Gerd Binnig

IPC分类号： G06T11/20

CPC分类号： G06F19/321 ,  G06F19/00 ,  G06K9/0014 ,  G06T7/0012 ,  G06T11/206 ,  G06T19/00 ,  G06T2200/24 ,  G06T2207/10056 ,  G06T2207/30024 ,  G06T2207/30072 ,  G06T2210/41

摘要： A method of intuitively displaying values obtained from analyzing bio-medical images includes displaying a table of the values in a first pane of a graphical user interface. The table contains a user selectable row that includes a reference value and two numerical values. The reference value refers to an image of a tissue slice. The first numerical value is generated by performing image analysis on the image, and the second numerical value indicates a health state of the tissue. The image is displayed in a second pane of the graphical user interface in response to the user selecting the user selectable row. A graphical plot with a selectable symbol associated with the image is displayed in a third pane. The symbol has a position in the plot defined by the values. Alternatively, in response to the user selecting the selectable symbol, the image is displayed in the second pane.

摘要翻译： 直观地显示从分析生物医学图像获得的值的方法包括在图形用户界面的第一窗格中显示值的表格。 该表包含用户可选行，其中包含一个参考值和两个数值。 参考值是指组织切片的图像。 通过对图像进行图像分析来生成第一数值，第二数值表示组织的健康状态。 响应于用户选择用户可选行，图像显示在图形用户界面的第二窗格中。 具有与图像相关联的可选符号的图形显示在第三窗格中。 符号在由值定义的图中具有位置。 或者，响应于用户选择可选择符号，在第二窗格中显示图像。

公开(公告)号：US20130108139A1

公开(公告)日：2013-05-02

申请号：US13282450

申请日：2011-10-26

申请人： Gerd Binnig ,  Maria Athelogou ,  Guenter Schmidt

发明人： Gerd Binnig ,  Maria Athelogou ,  Guenter Schmidt

IPC分类号： G06K9/34

CPC分类号： G06T7/0012 ,  G06K9/0014 ,  G06K9/34 ,  G06K9/4652 ,  G06K9/6215 ,  G06T7/11 ,  G06T7/155 ,  G06T7/187 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/30024

摘要： A method for determining whether a test biomarker is a stain for a type of cell component, such as membrane or nucleus, involves performing various segmentation processes on an image of tissue stained with the test biomarker. One segmentation process searches for a first cell component type, and another segmentation process searches for a second cell component type by segmenting only stained pixels. The test biomarker is identified as a stain for each component type if the process identifies the component based only on stained pixels. Whether the test biomarker is a membrane stain or nucleus stain is displayed on a graphical user interface. In addition, the method identifies stained pixels corresponding to a second cell component using pixels determined to correspond to a first cell component. An expression profile for the test biomarker is then displayed that indicates the proportion of stained pixels in each type of cell component.

公开(公告)号：US20130016886A1

公开(公告)日：2013-01-17

申请号：US13546182

申请日：2012-07-11

申请人： Ralf Schoenmeyer ,  Peter Ellenberg ,  Gerd Binnig ,  Maria Athelogou ,  Guenter Schmidt

发明人： Ralf Schoenmeyer ,  Peter Ellenberg ,  Gerd Binnig ,  Maria Athelogou ,  Guenter Schmidt

IPC分类号： G06K9/50

CPC分类号： G06T7/0012 ,  G06T11/206 ,  G06T2207/10061 ,  G06T2207/20016 ,  G06T2207/20021 ,  G06T2207/20221

摘要： High-resolution digital images of adjacent slices of a tissue sample are acquired, and tiles are defined in the images. Values associated with image objects detected in each tile are calculated. The tiles in adjacent images are co-registered. A first hyperspectral image is generated using a first image, and a second hyperspectral image is generated using a second image. A first pixel of the first hyperspectral image has a first pixel value corresponding to a local value obtained using image analysis on a tile in the first image. A second pixel of the second hyperspectral image has a second pixel value corresponding to a local value calculated from a tile in the second image. A third hyperspectral image is generated by combining the first and second hyperspectral images. The third hyperspectral image is then displayed on a computer monitor using a false-color encoding generated using the first and second pixel values.

摘要翻译： 获取组织样本的相邻切片的高分辨率数字图像，并且在图像中定义瓦片。 计算与每个图块中检测到的图像对象相关联的值。 相邻图像中的瓦片共同注册。 使用第一图像生成第一高光谱图像，并且使用第二图像生成第二高光谱图像。 第一高光谱图像的第一像素具有对应于在第一图像中的图块上使用图像分析获得的局部值的第一像素值。 第二高光谱图像的第二像素具有对应于从第二图像中的图块计算的局部值的第二像素值。 通过组合第一和第二高光谱图像来生成第三高光谱图像。 然后，使用使用第一和第二像素值生成的伪色编码，在计算机监视器上显示第三高光谱图像。

公开(公告)号：US07849516B2

公开(公告)日：2010-12-07

申请号：US12187759

申请日：2008-08-07

申请人： Gerd Binnig ,  Evangelos Elefheriou ,  Mark Lantz

发明人： Gerd Binnig ,  Evangelos Elefheriou ,  Mark Lantz

IPC分类号： G01Q80/00

CPC分类号： G11B9/1436 ,  B82Y10/00 ,  G01Q80/00 ,  G11B9/1454

摘要： A method of scanning over a substrate includes implementing a write mode of the substrate by scanning a probe across a substrate, the probe having a spring cantilever probe mechanically fixed to a probe holding structure, a tip with a nanoscale apex, and an actuator for lateral positioning of the tip; the actuator comprising a thermally switchable element and a heating element for heating the thermally switchable element; and heating the heating element to a given temperature so as to locally soften a portion of the substrate and applying a force to the softened portion of the substrate through the tip so as to create one or more indentation marks in the softened portion of the substrate.

摘要翻译： 一种在衬底上扫描的方法包括通过在衬底上扫描探针来实现衬底的写入模式，探针具有机械固定到探针保持结构的弹簧悬臂探针，具有纳米级顶点的尖端和用于侧向的致动器 尖端定位 致动器包括可热切换元件和用于加热热可切换元件的加热元件; 并且将加热元件加热到给定的温度，以局部软化基板的一部分，并通过尖端向基板的软化部分施加力，从而在基板的软化部分中产生一个或多个凹痕。

公开(公告)号：US20060187803A1

公开(公告)日：2006-08-24

申请号：US11329466

申请日：2006-01-11

申请人： Peter Baechtold ,  Johannes Bednorz ,  Gerd Binnig ,  Giovanni Cherubini ,  Evangelos Eleftheriou ,  Michel Despont

发明人： Peter Baechtold ,  Johannes Bednorz ,  Gerd Binnig ,  Giovanni Cherubini ,  Evangelos Eleftheriou ,  Michel Despont

IPC分类号： G11B9/00

CPC分类号： G11B11/007 ,  B82Y10/00 ,  G11B9/1472

摘要： A storage device including a storage medium for storing data in the form of topographic or magnetic marks. At least one probe is mounted on a common frame, the common frame and the storage medium designed for moving relative to each other for creating or detecting said marks. Each probe includes a tip facing the storage medium, a read sensing element, a write element and a capacitive platform, that forms a first electrode and is designed for a voltage potential applied to it independent from a control signal for said read sensing element and for said voltage potential applied to said capacitive platform being independent from a control signal for said write heating element. It further comprises a second electrode arranged in a fixed position relative to the storage medium forming a first capacitor together wherein said first electrode and a medium between the first and second electrode.

摘要翻译： 一种存储装置，包括用于以地形或磁标记的形式存储数据的存储介质。 至少一个探针安装在公共框架上，公共框架和存储介质被设计用于相对于彼此移动以创建或检测所述标记。 每个探针包括面向存储介质的尖端，读取感测元件，写入元件和电容平台，其形成第一电极，并被设计用于独立于用于所述读取感测元件的控制信号的施加于其的电压电位，并且为 施加到所述电容平台的所述电压电位独立于用于所述写入加热元件的控制信号。 它还包括布置在相对于存储介质固定位置的第二电极，形成第一电容器，其中所述第一电极和第一和第二电极之间的介质。

公开(公告)号：US20050280174A1

公开(公告)日：2005-12-22

申请号：US11156839

申请日：2005-06-20

申请人： Gerd Binnig ,  Walter Haeberle ,  Dorothea Wiesmann

发明人： Gerd Binnig ,  Walter Haeberle ,  Dorothea Wiesmann

IPC分类号： B29C37/02 ,  G01Q10/00 ,  G01Q70/16 ,  G01Q80/00 ,  G11B9/00

CPC分类号： G11B9/1454 ,  G01Q70/06 ,  G01Q80/00 ,  G11B9/1481

摘要： Provides surface treatment devices, surface scanning devices, methods of operating a surface treatment device and methods of operating a surface scanning device. An area within a medium comprises at least one sharpening location for sharpening a tip of a probe mechanically. The tip is conically shaped with a radius of an apex smaller than 100 nm. In the case of the surface treatment device the probe is designed for altering the surface of the medium. In the case of the surface scanning device the probe is designed for scanning the medium. The sharpening location is suited for sharpening the tip mechanically. For that purpose the probe and the medium are being moved relative to each other such that the tip is located in the sharpening location. Then the probe and/or the medium are moved relative to each other such, that the tip is mechanically sharpened.

摘要翻译： 提供表面处理装置，表面扫描装置，操作表面处理装置的方法和操作表面扫描装置的方法。 介质内的区域包括至少一个磨削位置，用于机械地磨削探头的尖端。 尖端圆锥形，顶点的半径小于100nm。 在表面处理装置的情况下，探针设计用于改变介质的表面。 在表面扫描装置的情况下，探针设计用于扫描介质。 磨削位置适用于机械地磨尖。 为此，探针和介质相对于彼此移动，使得尖端位于磨刀位置。 然后探针和/或介质相对于彼此移动，使得尖端被机械地磨削。

公开(公告)号：US06397141B1

公开(公告)日：2002-05-28

申请号：US09554949

申请日：2000-08-07

申请人： Gerd Binnig

发明人： Gerd Binnig

IPC分类号： G06F1900

CPC分类号： G08G1/163 ,  G08G1/096716 ,  G08G1/096725 ,  G08G1/096758 ,  G08G1/096775 ,  G08G1/096791

摘要： A method and an apparatus for signalling local traffic disturbances wherein a decentralised communication between vehicles is performed by exchanging their respective vehicle data. Through repeated evaluation of these individual vehicle data, each reference vehicle may determine a group of vehicles having relevance for itself from within a maximum group of vehicles and compare the group behavior of the relevant group with its own behavior. The results of this comparison are indicated in the reference vehicle, whereby a homogeneous flow of traffic may be generated, and the occurrence of accidents is reduced.

摘要翻译： 一种用于发信号通知本地业务干扰的方法和装置，其中通过交换其各自的车辆数据来执行车辆之间的分散通信。 通过对这些单个车辆数据的重复评估，每个参考车辆可以从最大车辆组内确定与自身相关的一组车辆，并将相关组的组行为与其自己的行为进行比较。 该比较的结果在参考车辆中指示，由此可能产生均匀的交通流量，并且减少事故的发生。

公开(公告)号：US08594410B2

公开(公告)日：2013-11-26

申请号：US12930873

申请日：2011-01-18

申请人： Guenter Schmidt ,  Gerd Binnig ,  Ralf Schoenmeyer ,  Arno Schaepe

发明人： Guenter Schmidt ,  Gerd Binnig ,  Ralf Schoenmeyer ,  Arno Schaepe

IPC分类号： G06K9/00 ,  G06K9/62

CPC分类号： G06T7/0014 ,  G01N2800/00 ,  G06K9/6253 ,  G06T7/0012 ,  G06T2207/10116 ,  G06T2207/30004 ,  G06T2207/30061 ,  G06T2207/30068

摘要： An image-based biomarker is generated using image features obtained through object-oriented image analysis of medical images. The values of a first subset of image features are measured and weighted. The weighted values of the image features are summed to calculate the magnitude of a first image-based biomarker. The magnitude of the biomarker for each patient is correlated with a clinical endpoint, such as a survival time, that was observed for the patient whose medical images were analyzed. The correlation is displayed on a graphical user interface as a scatter plot. A second subset of image features is selected that belong to a second image-based biomarker such that the magnitudes of the second image-based biomarker for the patients better correlate with the clinical endpoints observed for those patients. The second biomarker can then be used to predict the clinical endpoint of other patients whose clinical endpoints have not yet been observed.

摘要翻译： 使用通过医学图像的面向对象图像分析获得的图像特征来生成基于图像的生物标志物。 测量和加权图像特征的第一子集的值。 将图像特征的加权值相加以计算第一基于图像的生物标志物的大小。 每个患者的生物标志物的大小与对其医学图像分析的患者观察到的临床终点相关，例如存活时间。 相关性作为散点图显示在图形用户界面上。 选择属于第二基于图像的生物标志物的图像特征的第二子集，使得用于患者的第二基于图像的生物标志物的量级与对于那些患者观察到的临床终点更为相关。 然后可以将第二种生物标志物用于预测尚未观察到其临床终点的其他患者的临床终点。

公开(公告)号：US20120232930A1

公开(公告)日：2012-09-13

申请号：US13417268

申请日：2012-03-11

申请人： Guenter Schmidt ,  Arno Schaepe ,  Thomas Heydler ,  Markus Rinecker ,  Gerd Binnig

发明人： Guenter Schmidt ,  Arno Schaepe ,  Thomas Heydler ,  Markus Rinecker ,  Gerd Binnig

IPC分类号： G06Q50/24

CPC分类号： G06T7/0012 ,  A61B6/502 ,  A61B6/5217 ,  G06F19/321 ,  G06K9/6201 ,  G06Q10/10 ,  G06Q50/22 ,  G06T7/40 ,  G06T2207/10116 ,  G06T2207/30068 ,  G06T2207/30096 ,  G16H50/20 ,  G16H50/70

摘要： A clinical decision support system performs a similarity search to determine the probable outcome of applying on a current patient those clinical actions that were performed on similar patients. The system analyzes stored electronic health records of similar patients so as to recommend diagnostic and therapeutic steps for the current patient. The system receives the health record of the patient, determines which clinical actions were already applied on the patient, generates classifiers associated with potential future clinical actions, generates a success value for each health record of another patient using the classifiers, displays the health record of the other patient having the greatest success value, and indicates a proposed clinical action that is to be applied on the patient. The system also calculates a quality value indicating the probability that a sequence of clinical actions that were applied to a similar patient will be successful if applied to the patient.

摘要翻译： 临床决策支持系统执行相似性搜索以确定对当前患者应用对类似患者进行的临床行为的可能结果。 系统分析类似患者的存储电子健康记录，以便为当前患者推荐诊断和治疗步骤。 该系统接收患者的健康记录，确定哪些临床动作已经应用于患者，产生与潜在的未来临床行为相关联的分类器，使用分类器为另一患者的每个健康记录生成成功值，显示健康记录 其他患者具有最大的成功价值，并且指示将应用于患者的临床行动。 该系统还计算质量值，该质量值指示应用于类似患者的临床行为序列如果应用于患者则成功的概率。