公开(公告)号：US08007747B2

公开(公告)日：2011-08-30

申请号：US12317228

申请日：2008-12-19

申请人： Gershon Giter ,  Dmitry Volovik

发明人： Gershon Giter ,  Dmitry Volovik

IPC分类号： B01L3/00

CPC分类号： G01N35/1079 ,  B01L3/0231 ,  B01L9/54 ,  B01L2200/0684 ,  G01N35/1072 ,  G01N2035/0434 ,  Y10T436/2575

摘要： The present invention relates to a cartridge, system, and methods that can be used for automated handling of fluids, such as blood. The cartridge can be configured to obtain a fluid sample from a sealed container, e.g., a septum sealed container. The system can be configured to handle the cartridge for operations such as obtaining a sample and/or dispensing the sample from the cartridge into, for example, a microtiter plate. The method of the invention can employ the cartridge or system of the invention.

摘要翻译： 本发明涉及可用于自动处理诸如血液之类流​​体的盒，系统和方法。 盒可以被配置成从密封容器（例如隔膜密封容器）获得流体样品。 该系统可以被配置为处理用于操作的盒，例如获得样品和/或将样品从盒中分配到例如微量滴定板中。 本发明的方法可以采用本发明的盒或系统。

公开(公告)号：US07468164B2

公开(公告)日：2008-12-23

申请号：US10901855

申请日：2004-07-28

申请人： Gershon Giter ,  Dmitry Volovik

发明人： Gershon Giter ,  Dmitry Volovik

IPC分类号： B01L3/00

CPC分类号： G01N35/1079 ,  B01L3/0231 ,  B01L9/54 ,  B01L2200/0684 ,  G01N35/1072 ,  G01N2035/0434 ,  Y10T436/2575

摘要： The present invention relates to a cartridge, system, and methods that can be used for automated handling of fluids, such as blood. The cartridge can be configured to obtain a fluid sample from a sealed container, e.g., a septum sealed container. The system can be configured to handle the cartridge for operations such as obtaining a sample and/or dispensing the sample from the cartridge into, for example, a microtiter plate. The method of the invention can employ the cartridge or system of the invention.

摘要翻译： 本发明涉及可用于自动处理诸如血液之类流​​体的盒，系统和方法。 盒可以被配置成从密封容器（例如隔膜密封容器）获得流体样品。 该系统可以被配置为处理用于操作的盒，例如获得样品和/或将样品从盒中分配到例如微量滴定板中。 本发明的方法可以采用本发明的盒或系统。

公开(公告)号：US20090176316A1

公开(公告)日：2009-07-09

申请号：US12317228

申请日：2008-12-19

申请人： Gershon Giter ,  Dmitry Volovik

发明人： Gershon Giter ,  Dmitry Volovik

IPC分类号： G01N1/28 ,  G01N1/10

CPC分类号： G01N35/1079 ,  B01L3/0231 ,  B01L9/54 ,  B01L2200/0684 ,  G01N35/1072 ,  G01N2035/0434 ,  Y10T436/2575

摘要： The present invention relates to a cartridge, system, and methods that can be used for automated handling of fluids, such as blood. The cartridge can be configured to obtain a fluid sample from a sealed container, e.g., a septum sealed container. The system can be configured to handle the cartridge for operations such as obtaining a sample and/or dispensing the sample from the cartridge into, for example, a microtiter plate. The method of the invention can employ the cartridge or system of the invention.

摘要翻译： 本发明涉及可用于自动处理诸如血液之类流​​体的盒，系统和方法。 盒可以被配置成从密封容器（例如隔膜密封容器）获得流体样品。 该系统可以被配置为处理用于操作的盒，例如获得样品和/或将样品从盒中分配到例如微量滴定板中。 本发明的方法可以采用本发明的盒或系统。

公开(公告)号：US20060024211A1

公开(公告)日：2006-02-02

申请号：US10901855

申请日：2004-07-28

申请人： Gershon Giter ,  Dmitry Volovik

发明人： Gershon Giter ,  Dmitry Volovik

IPC分类号： B01L9/00

CPC分类号： G01N35/1079 ,  B01L3/0231 ,  B01L9/54 ,  B01L2200/0684 ,  G01N35/1072 ,  G01N2035/0434 ,  Y10T436/2575

摘要： The present invention relates to a cartridge, system, and methods that can be used for automated handling of fluids, such as blood. The cartridge can be configured to obtain a fluid sample from a sealed container, e.g., a septum sealed container. The system can be configured to handle the cartridge for operations such as obtaining a sample and/or dispensing the sample from the cartridge into, for example, a microtiter plate. The method of the invention can employ the cartridge or system of the invention.

公开(公告)号：US5769615A

公开(公告)日：1998-06-23

申请号：US685188

申请日：1996-07-18

申请人： Gershon Giter

发明人： Gershon Giter

IPC分类号： F04B49/00 ,  F04B5/00 ,  F04B5/02 ,  F04B13/00 ,  F04B49/12 ,  F04B39/08

CPC分类号： F04B13/00 ,  F04B49/12 ,  F04B2205/09

摘要： A single-piston, multimode fluid displacement pump comprising an elongated chamber, a piston reciprocally mounted within the chamber, a driving mechanism axially aligned with the chamber and piston for accurately positioning the piston within the chamber so as to define a measured fluid displacement, and ports for aspirating and dispensing fluid.

摘要翻译： 单活塞多模流体排出泵，包括细长室，活塞，其往复地安装在腔室内;驱动机构，其与腔室和活塞轴向对准，用于将活塞精确地定位在腔室内，以便限定测量的流体位移;以及 用于吸入和分配流体的端口。

公开(公告)号：US5658799A

公开(公告)日：1997-08-19

申请号：US477812

申请日：1995-06-07

申请人： Alfredo Choperena ,  Ross Krogh ,  Venkatesh Prasad ,  Gershon Giter

发明人： Alfredo Choperena ,  Ross Krogh ,  Venkatesh Prasad ,  Gershon Giter

IPC分类号： G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC分类号： G01N35/0092 ,  G01N35/021 ,  G01N2035/0467 ,  G01N2035/1025 ,  G01N35/0098 ,  G01N35/1004 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/115831 ,  Y10T436/2575

摘要： The invention provides a method for analyzing samples for different analytes. A plurality of assay resource stations are provided, each of which includes an assay resource capable of performing a predetermined operation upon a reaction vessel within a time cycle of fixed duration, as is an analyzer control means. Information identifying two samples and the analyte to be determined in each is provided to the analyzer control means. Assay resource requirements for the first assay are determined as a function of an integral number of time cycles and appropriate time cycles of each required assay resource are allocated to the first assay. Assay resource requirements for the second assay are also determined as a function of an integral number of time cycles and time cycles are allocated to the second assay according to the availability of the assay resources. The first and second assays are processed by automatically transferring each reaction vessel from one required assay resource station directly to the next required assay resource station.

摘要翻译： 本发明提供了一种用于分析不同分析物的样品的方法。 提供了多个测定资源站，每个测定资源站包括能够在固定持续时间的时间周期内对反应容器执行预定操作的测定资源，分析仪控制装置也是如此。 将识别出两个样品和待分析物的信息提供给分析仪控制装置。 第一个测定的测定资源要求被确定为整数时间周期的函数，并且将每个所需测定资源的适当时间周期分配给第一测定。 还根据测定资源的可用性，将第二测定的测定资源需求确定为整数倍的时间循环和时间循环分配给第二测定的函数。 通过将每个反应容器从一个所需的测定资源站自动转移到下一个所需的测定资源站来处理第一和第二测定。

公开(公告)号：US5575976A

公开(公告)日：1996-11-19

申请号：US480281

申请日：1995-06-07

申请人： Alfredo Choperena ,  Ross Krogh ,  Venkatesh Prasad ,  Gershon Giter

发明人： Alfredo Choperena ,  Ross Krogh ,  Venkatesh Prasad ,  Gershon Giter

IPC分类号： G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC分类号： G01N35/0092 ,  G01N35/021 ,  G01N2035/0467 ,  G01N2035/1025 ,  G01N35/0098 ,  G01N35/1004 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/115831 ,  Y10T436/2575

摘要： This invention provides an automated chemical analyzer with improved processing flexibility and ease. In one embodiment of this invention, the analyzer includes an incubation station, a wash station and a read station. The incubation station includes an elongated, movable track to carry reaction vessels along an incubation path, the wash station includes a movable track to carry vessels along a wash-cycle path, and the read station is adapted to move vessels along a read path. A first transfer station is positioned adjacent a first end of the wash-cycle path to transfer vessels from the incubation path to the wash-cycle path and a second transfer station is positioned adjacent a second end of the wash-cycle path and a first end of the read path for selectively transferring a vessel from the wash-cycle path to either the incubation path or the read path. Optimally, the first transfer station is positioned adjacent a second end of the read path, enabling the first transfer station to transfer a vessel from the read path to the incubation path, e.g., for disposal at a central waste container.

摘要翻译： 本发明提供一种自动化学分析仪，其具有改善的加工灵活性和容易性。 在本发明的一个实施例中，分析仪包括孵化站，洗涤站和读站。 孵化站包括细长的活动轨道，沿着孵化路径携带反应容器，洗涤站包括沿着洗涤循环路径运送血管的活动轨迹，并且读取站适于沿着读取路径移动容器。 第一转运站位于洗涤循环路径的第一端附近，以将容器从孵化路径转移到洗涤循环路径，并且第二转运站位于洗涤循环路径的第二端附近，第一端 用于选择性地将容器从洗涤循环路径转移到培养路径或读取路径的读取路径。 最佳地，第一传送站位于读路径的第二端附近，使得第一传送站能够将容器从读路径传送到孵育路径，例如用于在中央废物容器处理。

公开(公告)号：US5316726A

公开(公告)日：1994-05-31

申请号：US986883

申请日：1992-12-04

申请人： Arthur L. Babson ,  Arthur F. Ross ,  Douglas R. Olson ,  Gershon Giter ,  Victor R. Huebner

发明人： Arthur L. Babson ,  Arthur F. Ross ,  Douglas R. Olson ,  Gershon Giter ,  Victor R. Huebner

IPC分类号： G01N21/76 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N21/13 ,  G01N21/01

CPC分类号： G01N35/021 ,  G01N35/0092 ,  G01N35/0095 ,  G01N2035/00356 ,  G01N2035/00435 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0437 ,  G01N2035/0443 ,  G01N2035/0467 ,  G01N2035/1025 ,  G01N2035/1032 ,  G01N2035/1086 ,  G01N21/763 ,  G01N35/025 ,  Y10T436/111666 ,  Y10T436/113332

摘要： An automated immunoassay analyzer includes a computer controlled instrument (10) and display (16). The display (16) provides a real-time presentation of all operations being performed within the instrument (10). A large number of samples can be loaded into the instrument (10), and the order of testing the samples can be rearranged according to a priority determined by the operator at any time. A wide variety of immunoassays can be performed on each sample and several different immunoassays can be performed on any one sample. Information related to the type of immunoassays being performed on particular samples is collected by a bar code reader (44) and this information is conveyed to the computer (12) for presentation on the display (16). The computer (12) tracks the progress of each immunoassay through the reaction circuit to the detection station (46). The time to completion for particular immunoassays as well as the concentration information for recently completed immunoassays is provided in a readily usable format. The immunoassay automation process is improved by performing the washing operation with an assay tube (26) which allows water to be expelled by centrifugal forces generated by rotating the tube about its longitudinal axis; rather, than by using more conventional aspirating equipment. Bound label is detected by chemiluminescence using a photomultiplier tube (96).

摘要翻译： 自动免疫分析仪包括计算机控制仪器（10）和显示器（16）。 显示器（16）提供在仪器（10）内正在执行的所有操作的实时显示。 可以将大量样品加载到仪器（10）中，并且可以根据操作者在任何时间确定的优先级重新排列样品测试顺序。 可以对每个样品进行各种免疫测定，并且可以在任何一个样品上进行几种不同的免疫测定。 通过条形码读取器（44）收集与特定样品进行的免疫测定类型相关的信息，并将该信息传送到计算机（12）以呈现在显示器（16）上。 计算机（12）通过反应电路跟踪检测站（46）的每次免疫测定的进度。 针对特定免疫测定的完成时间以及最近完成的免疫测定的浓度信息以容易使用的形式提供。 通过用分析管（26）执行洗涤操作来改善免疫测定自动化过程，其允许通过围绕其纵向轴线旋转管而产生的离心力排出水; 而不是使用更传统的抽吸设备。 使用光电倍增管（96）通过化学发光检测结合标记。

公开(公告)号：US5693292A

公开(公告)日：1997-12-02

申请号：US477813

申请日：1995-06-07

申请人： Alfredo Choperena ,  Ross Krogh ,  Venkatesh Prasad ,  Gershon Giter

发明人： Alfredo Choperena ,  Ross Krogh ,  Venkatesh Prasad ,  Gershon Giter

IPC分类号： G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC分类号： G01N35/0092 ,  G01N35/021 ,  G01N2035/0467 ,  G01N2035/1025 ,  G01N35/0098 ,  G01N35/1004 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/115831 ,  Y10T436/2575

摘要： This invention provides an automated chemical analyzer with improved processing flexibility and ease. In one embodiment of this invention, the analyzer includes an incubation station, a wash station and a read station. The incubation station includes an elongated, movable track to carry reaction vessels along an incubation path, the wash station includes a movable track to carry vessels along a wash-cycle path, and the read station is adapted to move vessels along a read path. A first transfer station is positioned adjacent a first end of the wash-cycle path to transfer vessels from the incubation path to the wash-cycle path and a second transfer station is positioned adjacent a second end of the wash-cycle path and a first end of the read path for selectively transferring a vessel from the wash-cycle path to either the incubation path or the read path. The system also includes an analyzer controller having scheduling means for allocating assay resources to one of the reaction vessels and transfer control means for controlling the transfer of reaction vessels from one assay resource station to another according to a chronology selected from a plurality of different predetermined chronologies.

摘要翻译： 本发明提供一种自动化学分析仪，其具有改善的加工灵活性和容易性。 在本发明的一个实施例中，分析仪包括孵化站，洗涤站和读站。 孵化站包括细长的活动轨道，沿着孵化路径携带反应容器，洗涤站包括沿着洗涤循环路径运送血管的活动轨迹，并且读取站适于沿着读取路径移动容器。 第一转运站位于洗涤循环路径的第一端附近，以将容器从孵化路径转移到洗涤循环路径，并且第二转运站位于洗涤循环路径的第二端附近，第一端 用于选择性地将容器从洗涤循环路径转移到培养路径或读取路径的读取路径。 该系统还包括分析器控制器，其具有调度装置，用于将测定资源分配到反应容器之一和转移控制装置，用于控制反应容器从一个测定资源站到另一个测定资源站的转移，根据从多个不同的预定年表选择的年表 。

公开(公告)号：US5380487A

公开(公告)日：1995-01-10

申请号：US878956

申请日：1992-05-05

申请人： Alfredo Choperena ,  Ross Krogh ,  Venkatesh Prasad ,  Gershon Giter

发明人： Alfredo Choperena ,  Ross Krogh ,  Venkatesh Prasad ,  Gershon Giter

IPC分类号： G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N33/48 ,  B65G43/08

CPC分类号： G01N35/0092 ,  G01N35/021 ,  G01N2035/0467 ,  G01N2035/1025 ,  G01N35/0098 ,  G01N35/1004 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/115831 ,  Y10T436/2575

摘要： The present invention provides an analyzer which permits clinical analysis of samples for multiple analytes with a variety of assay protocols in a multiple chronology sequence while operating on a predetermined fizzed length cycle method of timing control. In this analyzer, assay resources (e.g. an incubator belt, a wash station, and a signal detection apparatus) are assigned fixed operating sequences which begin and end within a time cycle of fixed duration. Samples may be transferred directly from one assay resource to another without unnecessarily occupying any unused resources. The invention also contemplates a method of analyzing samples consistent with use of this analyzer. In this method, different samples having different assay protocols may be entered into the analyzer. The assay resource requirements of the first sample are determined and "time slots" of the assay resources are allocated to that sample. The second sample, which may have a different assay protocol from the first, is entered and its assay resource requirements are determined, and available time slots of the assay resources are assigned to the second assay. By assigning "time slots" of the resources to the samples, flexibility and throughput of the system may be maximized without unduly complicating the scheduling logic and control.

摘要翻译： 本发明提供了一种分析仪，其允许以多个时间序列中的多种测定方案临时分析多种分析物的样品，同时以预定的定时长度循环方法进行定时控制。 在该分析仪中，分析资源（例如，孵化器带，洗涤站和信号检测装置）被分配固定的操作序列，其在固定持续时间的时间周期内开始和结束。 样品可以直接从一个测定资源转移到另一个测定资源，而不必占用任何未使用的资源。 本发明还考虑了使用该分析仪分析样品的方法。 在该方法中，可以将不同的具有不同测定方案的样品输入分析仪。 确定第一个样品的测定资源需求，并将分析资源的“时隙”分配给该样品。 输入第二个样品，其可以具有与第一个不同的测定方案，并确定其测定资源需求，并将测定资源的可用时隙分配给第二测定。 通过将资源的“时隙”分配给样本，可以最大化系统的灵活性和吞吐量，而不会使调度逻辑和控制过度复杂化。