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    Method and device for automatic chemical analysis
    1.
    发明授权
    Method and device for automatic chemical analysis 失效
    自动化学分析方法和装置

    公开(公告)号：US5658799A

    公开(公告)日：1997-08-19

    申请号：US477812

    申请日：1995-06-07

    申请人： Alfredo Choperena ,  Ross Krogh ,  Venkatesh Prasad ,  Gershon Giter

    发明人： Alfredo Choperena ,  Ross Krogh ,  Venkatesh Prasad ,  Gershon Giter

    IPC分类号： G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

    CPC分类号： G01N35/0092 ,  G01N35/021 ,  G01N2035/0467 ,  G01N2035/1025 ,  G01N35/0098 ,  G01N35/1004 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/115831 ,  Y10T436/2575

    摘要： The invention provides a method for analyzing samples for different analytes. A plurality of assay resource stations are provided, each of which includes an assay resource capable of performing a predetermined operation upon a reaction vessel within a time cycle of fixed duration, as is an analyzer control means. Information identifying two samples and the analyte to be determined in each is provided to the analyzer control means. Assay resource requirements for the first assay are determined as a function of an integral number of time cycles and appropriate time cycles of each required assay resource are allocated to the first assay. Assay resource requirements for the second assay are also determined as a function of an integral number of time cycles and time cycles are allocated to the second assay according to the availability of the assay resources. The first and second assays are processed by automatically transferring each reaction vessel from one required assay resource station directly to the next required assay resource station.

    摘要翻译： 本发明提供了一种用于分析不同分析物的样品的方法。 提供了多个测定资源站，每个测定资源站包括能够在固定持续时间的时间周期内对反应容器执行预定操作的测定资源，分析仪控制装置也是如此。 将识别出两个样品和待分析物的信息提供给分析仪控制装置。 第一个测定的测定资源要求被确定为整数时间周期的函数，并且将每个所需测定资源的适当时间周期分配给第一测定。 还根据测定资源的可用性，将第二测定的测定资源需求确定为整数倍的时间循环和时间循环分配给第二测定的函数。 通过将每个反应容器从一个所需的测定资源站自动转移到下一个所需的测定资源站来处理第一和第二测定。

    Device for automatic chemical analysis
    2.
    发明授权
    Device for automatic chemical analysis 失效
    自动化学分析装置

    公开(公告)号：US5575976A

    公开(公告)日：1996-11-19

    申请号：US480281

    申请日：1995-06-07

    申请人： Alfredo Choperena ,  Ross Krogh ,  Venkatesh Prasad ,  Gershon Giter

    发明人： Alfredo Choperena ,  Ross Krogh ,  Venkatesh Prasad ,  Gershon Giter

    IPC分类号： G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

    CPC分类号： G01N35/0092 ,  G01N35/021 ,  G01N2035/0467 ,  G01N2035/1025 ,  G01N35/0098 ,  G01N35/1004 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/115831 ,  Y10T436/2575

    摘要： This invention provides an automated chemical analyzer with improved processing flexibility and ease. In one embodiment of this invention, the analyzer includes an incubation station, a wash station and a read station. The incubation station includes an elongated, movable track to carry reaction vessels along an incubation path, the wash station includes a movable track to carry vessels along a wash-cycle path, and the read station is adapted to move vessels along a read path. A first transfer station is positioned adjacent a first end of the wash-cycle path to transfer vessels from the incubation path to the wash-cycle path and a second transfer station is positioned adjacent a second end of the wash-cycle path and a first end of the read path for selectively transferring a vessel from the wash-cycle path to either the incubation path or the read path. Optimally, the first transfer station is positioned adjacent a second end of the read path, enabling the first transfer station to transfer a vessel from the read path to the incubation path, e.g., for disposal at a central waste container.

    摘要翻译： 本发明提供一种自动化学分析仪，其具有改善的加工灵活性和容易性。 在本发明的一个实施例中，分析仪包括孵化站，洗涤站和读站。 孵化站包括细长的活动轨道，沿着孵化路径携带反应容器，洗涤站包括沿着洗涤循环路径运送血管的活动轨迹，并且读取站适于沿着读取路径移动容器。 第一转运站位于洗涤循环路径的第一端附近，以将容器从孵化路径转移到洗涤循环路径，并且第二转运站位于洗涤循环路径的第二端附近，第一端 用于选择性地将容器从洗涤循环路径转移到培养路径或读取路径的读取路径。 最佳地，第一传送站位于读路径的第二端附近，使得第一传送站能够将容器从读路径传送到孵育路径，例如用于在中央废物容器处理。

    Device for automatic chemical analysis
    3.
    发明授权
    Device for automatic chemical analysis 失效
    自动化学分析装置

    公开(公告)号：US5693292A

    公开(公告)日：1997-12-02

    申请号：US477813

    申请日：1995-06-07

    申请人： Alfredo Choperena ,  Ross Krogh ,  Venkatesh Prasad ,  Gershon Giter

    发明人： Alfredo Choperena ,  Ross Krogh ,  Venkatesh Prasad ,  Gershon Giter

    IPC分类号： G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

    CPC分类号： G01N35/0092 ,  G01N35/021 ,  G01N2035/0467 ,  G01N2035/1025 ,  G01N35/0098 ,  G01N35/1004 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/115831 ,  Y10T436/2575

    摘要： This invention provides an automated chemical analyzer with improved processing flexibility and ease. In one embodiment of this invention, the analyzer includes an incubation station, a wash station and a read station. The incubation station includes an elongated, movable track to carry reaction vessels along an incubation path, the wash station includes a movable track to carry vessels along a wash-cycle path, and the read station is adapted to move vessels along a read path. A first transfer station is positioned adjacent a first end of the wash-cycle path to transfer vessels from the incubation path to the wash-cycle path and a second transfer station is positioned adjacent a second end of the wash-cycle path and a first end of the read path for selectively transferring a vessel from the wash-cycle path to either the incubation path or the read path. The system also includes an analyzer controller having scheduling means for allocating assay resources to one of the reaction vessels and transfer control means for controlling the transfer of reaction vessels from one assay resource station to another according to a chronology selected from a plurality of different predetermined chronologies.

    摘要翻译： 本发明提供一种自动化学分析仪，其具有改善的加工灵活性和容易性。 在本发明的一个实施例中，分析仪包括孵化站，洗涤站和读站。 孵化站包括细长的活动轨道，沿着孵化路径携带反应容器，洗涤站包括沿着洗涤循环路径运送血管的活动轨迹，并且读取站适于沿着读取路径移动容器。 第一转运站位于洗涤循环路径的第一端附近，以将容器从孵化路径转移到洗涤循环路径，并且第二转运站位于洗涤循环路径的第二端附近，第一端 用于选择性地将容器从洗涤循环路径转移到培养路径或读取路径的读取路径。 该系统还包括分析器控制器，其具有调度装置，用于将测定资源分配到反应容器之一和转移控制装置，用于控制反应容器从一个测定资源站到另一个测定资源站的转移，根据从多个不同的预定年表选择的年表 。

    Device for automatic chemical analysis
    4.
    发明授权
    Device for automatic chemical analysis 失效
    自动化学分析装置

    公开(公告)号：US5380487A

    公开(公告)日：1995-01-10

    申请号：US878956

    申请日：1992-05-05

    申请人： Alfredo Choperena ,  Ross Krogh ,  Venkatesh Prasad ,  Gershon Giter

    发明人： Alfredo Choperena ,  Ross Krogh ,  Venkatesh Prasad ,  Gershon Giter

    IPC分类号： G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N33/48 ,  B65G43/08

    CPC分类号： G01N35/0092 ,  G01N35/021 ,  G01N2035/0467 ,  G01N2035/1025 ,  G01N35/0098 ,  G01N35/1004 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/115831 ,  Y10T436/2575

    摘要： The present invention provides an analyzer which permits clinical analysis of samples for multiple analytes with a variety of assay protocols in a multiple chronology sequence while operating on a predetermined fizzed length cycle method of timing control. In this analyzer, assay resources (e.g. an incubator belt, a wash station, and a signal detection apparatus) are assigned fixed operating sequences which begin and end within a time cycle of fixed duration. Samples may be transferred directly from one assay resource to another without unnecessarily occupying any unused resources. The invention also contemplates a method of analyzing samples consistent with use of this analyzer. In this method, different samples having different assay protocols may be entered into the analyzer. The assay resource requirements of the first sample are determined and "time slots" of the assay resources are allocated to that sample. The second sample, which may have a different assay protocol from the first, is entered and its assay resource requirements are determined, and available time slots of the assay resources are assigned to the second assay. By assigning "time slots" of the resources to the samples, flexibility and throughput of the system may be maximized without unduly complicating the scheduling logic and control.

    摘要翻译： 本发明提供了一种分析仪，其允许以多个时间序列中的多种测定方案临时分析多种分析物的样品，同时以预定的定时长度循环方法进行定时控制。 在该分析仪中，分析资源（例如，孵化器带，洗涤站和信号检测装置）被分配固定的操作序列，其在固定持续时间的时间周期内开始和结束。 样品可以直接从一个测定资源转移到另一个测定资源，而不必占用任何未使用的资源。 本发明还考虑了使用该分析仪分析样品的方法。 在该方法中，可以将不同的具有不同测定方案的样品输入分析仪。 确定第一个样品的测定资源需求，并将分析资源的“时隙”分配给该样品。 输入第二个样品，其可以具有与第一个不同的测定方案，并确定其测定资源需求，并将测定资源的可用时隙分配给第二测定。 通过将资源的“时隙”分配给样本，可以最大化系统的灵活性和吞吐量，而不会使调度逻辑和控制过度复杂化。

    Device for automatic chemical analysis
    5.
    发明授权
    Device for automatic chemical analysis 失效
    自动化学分析装置

    公开(公告)号：US5846491A

    公开(公告)日：1998-12-08

    申请号：US370910

    申请日：1995-01-10

    申请人： Alfredo Choperena ,  Ross Krogh ,  Venkatesh Prasad ,  Gershon Giter

    发明人： Alfredo Choperena ,  Ross Krogh ,  Venkatesh Prasad ,  Gershon Giter

    IPC分类号： G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

    CPC分类号： G01N35/0092 ,  G01N35/021 ,  G01N2035/0467 ,  G01N2035/1025 ,  G01N35/0098 ,  G01N35/1004 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/115831 ,  Y10T436/2575

    摘要： This invention provides an automated chemical analyzer capable of automatically analyzing a plurality of samples for at least two different analytes. The analyzer includes a plurality of assay resource stations and an analyzer control means. Each assay resource station includes an assay resource capable of performing a predetermined operation upon a sample-containing reaction vessel within a fixed indexing time. The analyzer control means includes scheduling means for allocating assay resources to one of the reaction vessels as a function of that time cycle and a transfer control means for controlling transfer of reaction vessels directly from one assay resource station to another according to a chronology selected from a plurality of different predetermined chronologies.

    摘要翻译： 本发明提供一种能够自动分析至少两种不同分析物的多个样品的自动化学分析仪。 分析仪包括多个测定资源站和分析仪控制装置。 每个测定资源站包括能够在固定的分度时间内对含有样品的反应容器执行预定操作的测定资源。 分析仪控制装置包括调度装置，用于根据该时间周期将测定资源分配给一个反应容器;以及转移控制装置，用于根据选自以下的时间顺序控制从一个测定资源站到另一个测定资源站的反应容器的转移 多个不同的预定年表。

    APPARATUS AND METHODS FOR CONTROLLING AND AUTOMATING FLUID INFUSION ACTIVITIES
    7.
    发明申请
    APPARATUS AND METHODS FOR CONTROLLING AND AUTOMATING FLUID INFUSION ACTIVITIES 审中-公开
    控制和自动化流体输注活动的装置和方法

    公开(公告)号：US20070060874A1

    公开(公告)日：2007-03-15

    申请号：US11530576

    申请日：2006-09-11

    申请人： Matthew Nesbitt ,  Ross Krogh ,  Randy Stephens ,  Paul Niklewski ,  Michael Boehm ,  Satyajeet Parakh

    发明人： Matthew Nesbitt ,  Ross Krogh ,  Randy Stephens ,  Paul Niklewski ,  Michael Boehm ,  Satyajeet Parakh

    IPC分类号： A61M5/14

    CPC分类号： A61M5/14228 ,  A61M5/14 ,  A61M5/1408 ,  A61M5/142 ,  A61M5/168 ,  A61M5/16813 ,  A61M5/16831 ,  A61M5/1723 ,  A61M39/28

    摘要： The present invention provides apparatuses and methods to safely and economically deliver infusion fluid to a patient during a medical procedure. The infusion fluid may be a sedative, analgesic, amnestic or other pharmaceutical agent (drug) for alleviating a patient's pain and anxiety before, during and/or after a medical or surgical procedure. In general the apparatus comprises a microprocessor-based controller that receives inputs from a plurality of physiological monitors attached to a patient. The system controller processes the data from the physiological monitors and based upon a fluid infusion algorithm delivers infusion fluid to a patient. The physiological monitors monitor the patient throughout the course of the procedure and depending upon the health of the patient, drug delivery may be adjusted to optimize the procedure while ensuring the patient's health is maintained. Functionality detectors such as an occlusion sensor, air-in-line sensor and a fluid detection sensor alert a clinician to such hazards as a pressure build up in the infusion line, air-bubbles in the infusion line, and the absence of fluid in the infusion line.

    摘要翻译： 本发明提供了在医疗过程中安全和经济地将输注液输送到患者的装置和方法。 输液可以是用于在医疗或外科手术之前，期间和/或之后缓解患者的疼痛和焦虑的镇静剂，止痛剂，遗忘剂或其他药剂（药物）。 通常，该装置包括基于微处理器的控制器，其接收来自附接到患者的多个生理监视器的输入。 系统控制器处理来自生理监视器的数据，并且基于流体输注算法将输注流体输送给患者。 生理监护仪在整个程序过程中监测患者，并且根据患者的健康状况，可以调整药物递送以优化手术，同时确保维持患者的健康。 诸如遮挡传感器，一体式传感器和流体检测传感器的功能检测器警告临床医生诸如在输注管线中积聚的压力，输注管线中的气泡和在输液管线中不存在流体的危险 输液线。

    INTRAVENOUS PUMPING AIR MANAGEMENT SYSTEMS AND METHODS
    8.
    发明申请
    INTRAVENOUS PUMPING AIR MANAGEMENT SYSTEMS AND METHODS 失效
    空调泵送空气管理系统及方法

    公开(公告)号：US20120172800A1

    公开(公告)日：2012-07-05

    申请号：US12981152

    申请日：2010-12-29

    申请人： Thomas Dudar ,  Ross Krogh ,  James Martucci ,  Shmuel Sternberg

    发明人： Thomas Dudar ,  Ross Krogh ,  James Martucci ,  Shmuel Sternberg

    IPC分类号： A61M5/36 ,  A61M5/38

    CPC分类号： A61M5/172 ,  A61M5/36 ,  A61M5/365 ,  A61M5/38 ,  A61M5/385 ,  A61M2205/60

    摘要： An intravenous (“IV”) liquid delivery system includes: an IV pump tubing set; a shuttle pump or membrane pump actuator operable with the IV pump tubing set; upstream and downstream valve actuators operable with the IV pump tubing set; the IV pump tubing set including an air removal device; an air detector configured to sense air in the IV pump tubing set; a control unit configured and arranged to (i) open the upstream valve actuator and close the downstream valve actuator to allow the pump actuator to draw liquid into a pump actuation portion of the IV pump tubing set, and (ii) close the upstream valve actuator and open the downstream valve actuator to allow the pump actuator to push liquid out of the pump actuation portion, the system configured to attempt to remove the air via the air removal device while operating the upstream and downstream valve actuators according to (i) and (ii).

    摘要翻译： 静脉内（“IV”）液体输送系统包括：IV泵管组; 一个穿梭泵或膜泵驱动器，可与IV泵管组一起操作; 上游和下游阀致动器可与IV泵管组一起操作; 所述IV泵管组包括排气装置; 空气检测器，被配置为感测IV泵管组中的空气; 控制单元，其配置和布置成（i）打开上游阀致动器并关闭下游阀致动器以允许泵致动器将液体引入IV泵管组的泵致动部分，以及（ii）关闭上游阀致动器 并且打开下游阀致动器以允许泵致动器将液体推出泵致动部分，该系统构造成在根据（i）和（i）和（i））操作上游和下游阀致动器期间尝试经由除气装置去除空气， ii）。