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公开(公告)号：US09090653B2
公开(公告)日：2015-07-28
申请号：US13913184
申请日：2013-06-07
申请人： Gilead Sciences, Inc. , Selcia Ltd.
发明人： Caroline Aciro , Victoria Alexandra Steadman , Simon Neil Pettit , Karine G. Poullennec , Linos Lazarides , David Kenneth Dean , Neil Andrew Dunbar , Adrian John Highton , Andrew John Keats , Dustin Scott Siegel , Kapil Kumar Karki , Adam James Schrier , Petr Jansa , Richard Mackman
IPC分类号： A61K38/21 , C07K5/02 , C07D487/08 , C07D498/08 , C07D498/18 , C07K5/062 , A61K38/12 , A61K39/29 , A61K45/06 , C07D471/18 , C07D498/22 , A61K38/55 , A61K31/403 , A61K31/497 , A61K31/504 , A61K31/7056 , A61K31/7072 , C07K5/078 , C07K5/065 , A61K38/15
CPC分类号： C07K5/06034 , A61K31/403 , A61K31/497 , A61K31/504 , A61K31/7056 , A61K31/7072 , A61K38/00 , A61K38/05 , A61K38/12 , A61K38/15 , A61K38/21 , A61K38/55 , A61K39/29 , A61K45/06 , C07D471/18 , C07D487/08 , C07D498/08 , C07D498/18 , C07D498/22 , C07K5/02 , C07K5/06052 , C07K5/0606 , C07K5/06078 , C07K5/06086 , C07K5/06139 , C07K5/06191 , C07K19/00 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/395 , A61K2300/00
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
摘要翻译： 提供式I化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗病毒感染，特别是丙型肝炎感染。
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公开(公告)号：US09145441B2
公开(公告)日：2015-09-29
申请号：US13913259
申请日：2013-06-07
申请人： Gilead Sciences, Inc. , Selcia Ltd.
发明人： Caroline Aciro , Victoria Alexandra Steadman , Simon Neil Pettit , Karine G. Poullennec , Linos Lazarides , David Kenneth Dean , Neil Andrew Dunbar , Adrian John Highton , Andrew John Keats , Dustin Scott Siegel , Kapil Kumar Karki , Adam James Schrier , Petr Jansa , Richard Mackman , Jean Yves Chiva
IPC分类号： A61K38/21 , C07K5/062 , C07D487/18 , C07D498/18 , A61K38/12 , A61K45/06
CPC分类号： C07K5/06052 , A61K38/12 , A61K38/21 , A61K45/06 , C07D487/18 , C07D498/18 , C07K5/06086 , C07K5/06139 , C07K5/06191 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/395
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
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公开(公告)号：US09512175B2
公开(公告)日：2016-12-06
申请号：US14821458
申请日：2015-08-07
申请人： Gilead Sciences, Inc. , Selcia Ltd.
发明人： Caroline Aciro , Jean Yves Chiva , David Kenneth Dean , Neil Andrew Dunbar , Adrian John Highton , Petr Jansa , Kapil Kumar Karki , Andrew John Keats , Linos Lazarides , Richard Mackman , Simon Neil Pettit , Karine G. Poullennec , Adam James Schrier , Dustin Scott Siegel , Victoria Alexandra Steadman
IPC分类号： A61K38/21 , C07K5/062 , C07K5/068 , C07K5/078 , C07K5/06 , C07D487/18 , C07D498/18 , A61K38/12 , A61K45/06
CPC分类号： C07K5/06052 , A61K38/12 , A61K38/21 , A61K45/06 , C07D487/18 , C07D498/18 , C07K5/06086 , C07K5/06139 , C07K5/06191 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/395
摘要： Provided are compounds of Formula: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
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公开(公告)号：US20130344029A1
公开(公告)日：2013-12-26
申请号：US13913184
申请日：2013-06-07
申请人： Selcia Ltd. , Gilead Sciences, Inc.
发明人： Caroline Aciro , Victoria Alexandra Steadman , Simon Neil Pettit , Karine G. Poullennac , Linos Lazarides , David Kenneth Dean , Neil Andrew Dunbar , Adrian John Highton , Andrew John Keats , Dustin Scott Siegel , Kapil Kumar Karki , Adam James Schrier , Petr Jansa , Richard Mackman
CPC分类号： C07K5/06034 , A61K31/403 , A61K31/497 , A61K31/504 , A61K31/7056 , A61K31/7072 , A61K38/00 , A61K38/05 , A61K38/12 , A61K38/15 , A61K38/21 , A61K38/55 , A61K39/29 , A61K45/06 , C07D471/18 , C07D487/08 , C07D498/08 , C07D498/18 , C07D498/22 , C07K5/02 , C07K5/06052 , C07K5/0606 , C07K5/06078 , C07K5/06086 , C07K5/06139 , C07K5/06191 , C07K19/00 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/395 , A61K2300/00
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
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公开(公告)号：US20150344521A1
公开(公告)日：2015-12-03
申请号：US14821458
申请日：2015-08-07
发明人： Caroline Aciro , Jean Yves Chiva , David Kenneth Dean , Neil Andrew Dunbar , Adrian John Highton , Petr Jansa , Kapil Kumar Karki , Andrew John Keats , Linos Lazarides , Richard Mackman , Simon Neil Pettit , Karine G. Poullennec , Adam James Schrier , Dustin Scott Siegel , Victoria Alexandra Steadman
CPC分类号： C07K5/06052 , A61K38/12 , A61K38/21 , A61K45/06 , C07D487/18 , C07D498/18 , C07K5/06086 , C07K5/06139 , C07K5/06191 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/395
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
摘要翻译： 提供式I化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗病毒感染，特别是丙型肝炎感染。
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公开(公告)号：US20150175655A1
公开(公告)日：2015-06-25
申请号：US14412331
申请日：2013-07-02
发明人： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil Kumar Karki , Ashley Anne Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-Jung Pyun , Michael Sangi , Adam James Schrier , Dustin Siegel , James G. Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel
摘要： Compounds of Formula I are disclosed, As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
摘要翻译： 公开了式I的化合物，以及其药学上可接受的盐。 还公开了使用所述化合物和含有所述化合物的药物组合物的方法。
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公开(公告)号：US20170210756A1
公开(公告)日：2017-07-27
申请号：US15227527
申请日：2016-08-03
发明人： Amy Cagulada , Johann Chan , Lina Chan , Denise A. Colby , Kapil Kumar Karki , Darryl Kato , Katie Ann Keaton , Sudha Kondapally , Christopher Levins , Adam Littke , Ruben Martinez , Dominika Pcion , Troy Reynolds , Bruce Ross , Michael Sangi , Adam J. Schrier , Pamela Seng , Dustin Siegel , Nathan Shapiro , Donald Tang , James G. Taylor , Jonathan Tripp , Andrew W. Waltman , Lawrence Yu
IPC分类号： C07D498/18 , C07C271/34 , C07C255/61 , C07C205/57 , C07C233/09 , C07C251/12 , C07D403/12 , C07D241/44
CPC分类号： C07D498/18 , C07C51/09 , C07C205/57 , C07C209/00 , C07C227/02 , C07C233/09 , C07C251/12 , C07C255/61 , C07C271/34 , C07C2601/02 , C07D241/44 , C07D403/12 , C07D453/02 , C07D498/16 , C07K5/0808
摘要： The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
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公开(公告)号：US09296782B2
公开(公告)日：2016-03-29
申请号：US13934090
申请日：2013-07-02
发明人： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil Kumar Karki , Ashley Anne Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-Jung Pyun , Michael Sangi , Adam James Schrier , Dustin Siegel , James G. Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel
IPC分类号： A61K6/00 , C07K1/00 , C07K5/08 , C07D498/16 , A61K31/4985 , C07D498/22 , A61K31/4745 , A61K31/506 , A61K31/519 , A61K45/06 , C07K5/087 , C07K5/083 , A61K38/21 , A61K38/06 , A61K38/00
CPC分类号： A61K31/498 , A61K31/10 , A61K31/401 , A61K31/4745 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K38/00 , A61K38/06 , A61K38/21 , A61K45/06 , C07D241/36 , C07D403/14 , C07D498/16 , C07D498/22 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/0827 , A61K2300/00
摘要： Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
摘要翻译： 公开的式I化合物及其药学上可接受的盐。 还公开了使用所述化合物和含有所述化合物的药物组合物的方法。
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公开(公告)号：US10030033B2
公开(公告)日：2018-07-24
申请号：US15227527
申请日：2016-08-03
发明人： Amy Cagulada , Johann Chan , Lina Chan , Denise A. Colby , Kapil Kumar Karki , Darryl Kato , Katie Ann Keaton , Sudha Kondappally , Chris Levins , Adam Littke , Ruben Martinez , Dominika Pcion , Troy Reynolds , Bruce Ross , Michael Sangi , Adam J. Schrier , Pamela Seng , Dustin Siegel , Nathan Shapiro , Donald Tang , James G. Taylor , Jonathan Tripp , Andrew W. Waltman , Lawrence Yu
IPC分类号： C07D498/16 , C07D403/12 , C07D498/18 , C07C271/34 , C07D241/44 , C07C205/57 , C07C233/09 , C07C251/12 , C07C255/61
摘要： The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
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公开(公告)号：US09873716B2
公开(公告)日：2018-01-23
申请号：US14740680
申请日：2015-06-16
发明人： Caroline Aciro , David Kenneth Dean , Neil Andrew Dunbar , Adrian John Highton , Petr Jansa , Kapil Kumar Karki , Andrew J. Keats , Linos Lazarides , Richard L. Mackman , Simon N. Pettit , Karine G. Poullennec , Adam James Schrier , Dustin Siegel , Victoria Alexandra Steadman
IPC分类号： A61K38/21 , C07K5/062 , C07D487/08 , C07D498/08 , C07D498/18 , A61K38/12 , A61K39/29 , A61K45/06 , C07K5/02 , C07D471/18 , C07D498/22 , A61K38/55 , A61K31/403 , A61K31/497 , A61K31/504 , A61K31/7056 , A61K31/7072 , C07K5/078 , C07K5/065 , A61K38/15 , A61K38/00
CPC分类号： C07K5/06034 , A61K31/403 , A61K31/497 , A61K31/504 , A61K31/7056 , A61K31/7072 , A61K38/00 , A61K38/05 , A61K38/12 , A61K38/15 , A61K38/21 , A61K38/55 , A61K39/29 , A61K45/06 , C07D471/18 , C07D487/08 , C07D498/08 , C07D498/18 , C07D498/22 , C07K5/02 , C07K5/06052 , C07K5/0606 , C07K5/06078 , C07K5/06086 , C07K5/06139 , C07K5/06191 , C07K19/00 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/395 , A61K2300/00
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
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