公开(公告)号：US6086827A

公开(公告)日：2000-07-11

申请号：US70726

申请日：1998-05-01

申请人： Glenn A. Horner ,  Shirley J. Johnson ,  Robert E. Schneider ,  Robert J. Smith ,  Gus Tseo

发明人： Glenn A. Horner ,  Shirley J. Johnson ,  Robert E. Schneider ,  Robert J. Smith ,  Gus Tseo

IPC分类号： B01L9/00 ,  B01L9/06 ,  G01N33/53 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  B01L3/00

CPC分类号： B01L9/06 ,  B01L9/543 ,  G01N33/5304 ,  G01N35/026 ,  G01N2035/00277 ,  G01N2035/103 ,  G01N2035/1086 ,  Y10T436/113332

摘要： A reaction receptacle apparatus includes one or more individual receptacles for containing chemical or biological substances. The one or more receptacles are arranged to be engaged by tubular elements of a substance transfer device for transferring substances into or out of the individual receptacles. Multiple receptacles are coupled to one another by a connecting rib structure that defines straight shoulders along opposite sides of the reaction receptacle apparatus, and the shoulders support the apparatus within reaction receptacle apparatus carrying structures. A contact-limiting element holding structure for holding contact-limiting elements, such as protective tips for tubular elements, is associated with each individual receptacle and holds a contact-limiting element in an operative orientation so as to be operatively engageable by the tubular element of the substance transfer device. A receptacle apparatus manipulating structure permits the reaction receptacle apparatus to be moved from one location to another by a robotic manipulating device, and an information panel presents a surface on which human and/or machine readable information may be placed.

公开(公告)号：US06517783B2

公开(公告)日：2003-02-11

申请号：US09802648

申请日：2001-03-09

申请人： Glenn A. Horner ,  Shirley J. Johnson ,  Robert E. Schneider ,  Robert J. Smith ,  Gus Tseo

发明人： Glenn A. Horner ,  Shirley J. Johnson ,  Robert E. Schneider ,  Robert J. Smith ,  Gus Tseo

IPC分类号： B01L300

CPC分类号： B01L9/06 ,  B01L9/543 ,  G01N33/5304 ,  G01N35/026 ,  G01N2035/00277 ,  G01N2035/103 ,  G01N2035/1086 ,  Y10T436/113332

摘要： A reaction receptacle apparatus includes one or more individual receptacles for containing chemical or biological substances. The one or more receptacles are arranged to be engaged by tubular elements of a substance transfer device for transferring substances into or out of the individual receptacles. Multiple receptacles are coupled to one another by a connecting rib structure that defines straight shoulders along opposite sides of the reaction receptacle apparatus, and the shoulders support the apparatus within reaction receptacle apparatus carrying structures. A contact-limiting element holding structure for holding contact-limiting elements, such as protective tips for tubular elements, is associated with each individual receptacle and holds a contact-limiting element in an operative orientation so as to be operatively engageable by the tubular element of the substance transfer device. A receptacle apparatus manipulating structure permits the reaction receptacle apparatus to be moved from one location to another by a robotic manipulating device, and an information panel presents a surface on which human and/or machine readable information may be placed.

摘要翻译： 反应容器设备包括用于容纳化学或生物物质的一个或多个单独的容器。 一个或多个容器被布置成与用于将物质输送到单个容器中的物质转移装置的管状元件接合。 多个插座通过连接肋结构彼此联接，该连接肋结构沿着反应容器装置的相对侧限定了直的肩部，并且肩部将装置支撑在承载结构的反应容器装置内。 用于保持接触限制元件（例如管状元件的保护尖端）的接触限制元件保持结构与每个单独的接头相关联，并且将接触限制元件保持在可操作的方向上，以便可操作地通过管状元件的管状元件 物质转移装置。 容器设备操纵结构允许反应容器设备通过机器人操纵装置从一个位置移动到另一个位置，并且信息面板呈现可以放置人和/或机器可读信息的表面。

公开(公告)号：US06517782B1

公开(公告)日：2003-02-11

申请号：US09557574

申请日：2000-04-21

申请人： Glenn A. Horner ,  Shirley J. Johnson ,  Robert E. Schneider ,  Robert J. Smith ,  Gus Tseo

发明人： Glenn A. Horner ,  Shirley J. Johnson ,  Robert E. Schneider ,  Robert J. Smith ,  Gus Tseo

IPC分类号： B01L300

CPC分类号： B01L9/06 ,  B01L9/543 ,  G01N33/5304 ,  G01N35/026 ,  G01N2035/00277 ,  G01N2035/103 ,  G01N2035/1086 ,  Y10T436/113332

摘要： A reaction receptacle apparatus includes one or more individual receptacles for containing chemical or biological substances. The one or more receptacles are arranged to be engaged by tubular elements of a substance transfer device for transferring substances into or out of the individual receptacles. Multiple receptacles are coupled to one another by a connecting rib structure that defines straight shoulders along opposite sides of the reaction receptacle apparatus, and the shoulders support the apparatus within reaction receptacle apparatus carrying structures. A contact-limiting element holding structure for holding contact-limiting elements, such as protective tips for tubular elements, is associated with each individual receptacle and holds a contact-limiting element in an operative orientation so as to be operatively engageable by the tubular element of the substance transfer device. A receptacle apparatus manipulating structure permits the reaction receptacle apparatus to be moved from one location to another by a robotic manipulating device, and an information panel presents a surface on which human and/or machine readable information may be placed.

公开(公告)号：US07560256B2

公开(公告)日：2009-07-14

申请号：US11168374

申请日：2005-06-29

申请人： Kelly G. Ammann ,  Ralph E. Burns ,  Ernest V. Hansberry ,  Glenn A. Horner ,  Cheryl A. Jakub ,  John E. Kling ,  Donald J. Nieglos ,  Robert E. Schneider ,  Robert J. Smith

发明人： Kelly G. Ammann ,  Ralph E. Burns ,  Ernest V. Hansberry ,  Glenn A. Horner ,  Cheryl A. Jakub ,  John E. Kling ,  Donald J. Nieglos ,  Robert E. Schneider ,  Robert J. Smith

IPC分类号： C12P19/34 ,  C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C07H21/00

CPC分类号： C12Q1/6834 ,  B01F9/0001 ,  B01F9/0014 ,  B01F9/0021 ,  B01F2009/0074 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/06 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1827 ,  B03C1/282 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/26 ,  C12Q1/6813 ,  C12Q1/6832 ,  C12Q2537/10 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1065 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0437 ,  G01N2035/0455 ,  G01N2035/103 ,  Y10T29/53657 ,  Y10T29/53683 ,  Y10T29/53843 ,  Y10T156/1105 ,  Y10T156/1906 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： An automated process for detecting the presence of a target nucleic acid in a sample. The process includes separating the target nucleic acid from other material present in the sample at a first station, transferring the separated target nucleic acid from the first station to a second station using a rotatable transport mechanism, combining the transferred target nucleic acid and reagents for performing an amplification reaction at the second station, and performing an amplification reaction. A product of the amplification reaction is detected as an indication of the presence of the target nucleic acid in the sample.

摘要翻译： 用于检测样品中靶核酸的存在的自动化过程。 该方法包括在第一站将目标核酸与样品中存在的其他物质分离，使用可转移的转运机制将分离的目标核酸从第一站转移到第二站，将转移的靶核酸和试剂结合，以进行 第二站的扩增反应，进行扩增反应。 检测扩增反应的产物作为样品中靶核酸的存在的指示。

公开(公告)号：US20090095419A1

公开(公告)日：2009-04-16

申请号：US12335814

申请日：2008-12-16

申请人： Kelly G. Ammann ,  Ralph E. Burns ,  Ernest V. Hansberry ,  Glenn A. Horner ,  Cheryl A. Jakub ,  John E. Kling ,  Donald J. Nieglos ,  Robert E. Schneider ,  Robert J. Smith

发明人： Kelly G. Ammann ,  Ralph E. Burns ,  Ernest V. Hansberry ,  Glenn A. Horner ,  Cheryl A. Jakub ,  John E. Kling ,  Donald J. Nieglos ,  Robert E. Schneider ,  Robert J. Smith

IPC分类号： B29C63/00

CPC分类号： C12Q1/6834 ,  B01F9/0001 ,  B01F9/0014 ,  B01F9/0021 ,  B01F2009/0074 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/06 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1827 ,  B03C1/282 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/26 ,  C12Q1/6813 ,  C12Q1/6832 ,  C12Q2537/10 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1065 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0437 ,  G01N2035/0455 ,  G01N2035/103 ,  Y10T29/53657 ,  Y10T29/53683 ,  Y10T29/53843 ,  Y10T156/1105 ,  Y10T156/1906 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

公开(公告)号：US20080241837A1

公开(公告)日：2008-10-02

申请号：US11931722

申请日：2007-10-31

申请人： Kelly G. Ammann ,  Ralph E. Burns ,  Ernest V. Hansberry ,  Glenn A. Horner ,  Cheryl A. Jakub ,  John E. Kling ,  Donald J. Nieglos ,  Robert E. Schneider ,  Robert J. Smith

发明人： Kelly G. Ammann ,  Ralph E. Burns ,  Ernest V. Hansberry ,  Glenn A. Horner ,  Cheryl A. Jakub ,  John E. Kling ,  Donald J. Nieglos ,  Robert E. Schneider ,  Robert J. Smith

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6834 ,  B01F9/0001 ,  B01F9/0014 ,  B01F9/0021 ,  B01F2009/0074 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/06 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1827 ,  B03C1/282 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/26 ,  C12Q1/6813 ,  C12Q1/6832 ,  C12Q2537/10 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1065 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0437 ,  G01N2035/0455 ,  G01N2035/103 ,  Y10T29/53657 ,  Y10T29/53683 ,  Y10T29/53843 ,  Y10T156/1105 ,  Y10T156/1906 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

摘要翻译： 用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行分析方面的分析。 分析仪包括用于自动准备标本样品的台站，在规定温度下培养样品规定的时间，进行分析物分离程序，并确定目标分析物的存在。 自动插座输送系统将反应容器从一个站移动到另一个站。 分析仪还包括用于以机器可接近的方式携带多个样本管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及 用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化方法。 该过程通过在站之间自动移动包含固体支持材料和流体样品的多个反应容器中的每一个来进行，用于孵育反应容器的内容物并将与固体支持物结合的目标分析物与流体样品分离。 在分析物分离步骤之后和最终孵育步骤之前，将分离的分析物加入扩增试剂。

公开(公告)号：US07118892B2

公开(公告)日：2006-10-10

申请号：US10263939

申请日：2002-10-03

申请人： Kelly G. Ammann ,  Ralph E. Burns ,  Ernest V. Hansberry ,  Glenn A. Horner ,  Cheryl A. Jakub ,  John E. Kling ,  Donald J. Nieglos ,  Robert E. Schneider ,  Robert J. Smith

发明人： Kelly G. Ammann ,  Ralph E. Burns ,  Ernest V. Hansberry ,  Glenn A. Horner ,  Cheryl A. Jakub ,  John E. Kling ,  Donald J. Nieglos ,  Robert E. Schneider ,  Robert J. Smith

IPC分类号： C12P19/34 ,  C12Q1/68 ,  C12M1/34 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12Q1/6834 ,  B01F9/0001 ,  B01F9/0014 ,  B01F9/0021 ,  B01F2009/0074 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/06 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1827 ,  B03C1/282 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/26 ,  C12Q1/6813 ,  C12Q1/6832 ,  C12Q2537/10 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1065 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0437 ,  G01N2035/0455 ,  G01N2035/103 ,  Y10T29/53657 ,  Y10T29/53683 ,  Y10T29/53843 ,  Y10T156/1105 ,  Y10T156/1906 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： An automated process for preparing and amplifying a target nucleic acid sequence within a stand-alone unit.

摘要翻译： 用于在独立单元内制备和扩增靶核酸序列的自动化方法。

公开(公告)号：US06890742B2

公开(公告)日：2005-05-10

申请号：US09985064

申请日：2001-11-01

申请人： Kelly G. Ammann ,  Ralph E. Burns ,  Ernest V. Hansberry ,  Glenn A. Horner ,  Cheryl A. Jakub ,  John E. Kling ,  Donald J. Nieglos ,  Robert E. Schneider ,  Robert J. Smith

发明人： Kelly G. Ammann ,  Ralph E. Burns ,  Ernest V. Hansberry ,  Glenn A. Horner ,  Cheryl A. Jakub ,  John E. Kling ,  Donald J. Nieglos ,  Robert E. Schneider ,  Robert J. Smith

IPC分类号： B01L99/00 ,  B01F9/00 ,  B01F15/00 ,  B01L7/00 ,  C12M1/00 ,  C12M1/34 ,  C12M1/36 ,  C12P19/34 ,  C12Q1/68 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12Q1/6834 ,  B01F9/0001 ,  B01F9/0014 ,  B01F9/0021 ,  B01F2009/0074 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/06 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1827 ,  B03C1/282 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/26 ,  C12Q1/6813 ,  C12Q1/6832 ,  C12Q2537/10 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1065 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0437 ,  G01N2035/0455 ,  G01N2035/103 ,  Y10T29/53657 ,  Y10T29/53683 ,  Y10T29/53843 ,  Y10T156/1105 ,  Y10T156/1906 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

公开(公告)号：US06605213B1

公开(公告)日：2003-08-12

申请号：US09721921

申请日：2000-11-27

申请人： Kelly G. Ammann ,  Ralph E. Burns ,  Ernest V. Hansberry ,  Glenn A. Horner ,  Cheryl A. Jakub ,  John E. Kling ,  Donald J. Nieglos ,  Robert E. Schneider ,  Robert J. Smith

发明人： Kelly G. Ammann ,  Ralph E. Burns ,  Ernest V. Hansberry ,  Glenn A. Horner ,  Cheryl A. Jakub ,  John E. Kling ,  Donald J. Nieglos ,  Robert E. Schneider ,  Robert J. Smith

IPC分类号： B01D3506

CPC分类号： C12Q1/6834 ,  B01F9/0001 ,  B01F9/0014 ,  B01F9/0021 ,  B01F2009/0074 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/06 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1827 ,  B03C1/282 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/26 ,  C12Q1/6813 ,  C12Q1/6832 ,  C12Q2537/10 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1065 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0437 ,  G01N2035/0455 ,  G01N2035/103 ,  Y10T29/53657 ,  Y10T29/53683 ,  Y10T29/53843 ,  Y10T156/1105 ,  Y10T156/1906 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

摘要翻译： 用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行分析方面的分析。 分析仪包括用于自动准备标本样品，在规定温度下规定时间孵育样品，预处理分析物分离程序以及确定目标分析物的存在的站。 自动插座输送系统将反应容器从一个站移动到另一个站。 分析仪还包括用于以机器可接近的方式携带多个样本管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及 用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化方法。 该过程通过在站之间自动移动包含固体支持材料和流体样品的多个反应容器中的每一个来进行，用于孵育反应容器的内容物并将与固体支持物结合的目标分析物与流体样品分离。 在分析物分离步骤之后和最终孵育步骤之前，将分离的分析物加入扩增试剂。

公开(公告)号：US20080268528A1

公开(公告)日：2008-10-30

申请号：US11873818

申请日：2007-10-17

申请人： Kelly G. Ammann ,  Ralph E. Burns ,  Ernest V. Hansberry ,  Glenn A. Horner ,  Cheryl A. Jakub ,  John E. Kling ,  Donald J. Nieglos ,  Robert E. Schneider ,  Robert J. Smith

发明人： Kelly G. Ammann ,  Ralph E. Burns ,  Ernest V. Hansberry ,  Glenn A. Horner ,  Cheryl A. Jakub ,  John E. Kling ,  Donald J. Nieglos ,  Robert E. Schneider ,  Robert J. Smith

IPC分类号： C12M1/34 ,  C12M1/40

CPC分类号： C12Q1/6834 ,  B01F9/0001 ,  B01F9/0014 ,  B01F9/0021 ,  B01F2009/0074 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/06 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1827 ,  B03C1/282 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/26 ,  C12Q1/6813 ,  C12Q1/6832 ,  C12Q2537/10 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1065 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0437 ,  G01N2035/0455 ,  G01N2035/103 ,  Y10T29/53657 ,  Y10T29/53683 ,  Y10T29/53843 ,  Y10T156/1105 ,  Y10T156/1906 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

摘要翻译： 用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行分析方面的分析。 分析仪包括用于自动准备标本样品的台站，在规定温度下培养样品规定的时间，进行分析物分离程序，并确定目标分析物的存在。 自动插座输送系统将反应容器从一个站移动到另一个站。 分析仪还包括用于以机器可接近的方式携带多个样本管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及 用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化方法。 该过程通过在站之间自动移动包含固体支持材料和流体样品的多个反应容器中的每一个来进行，用于孵育反应容器的内容物并将与固体支持物结合的目标分析物与流体样品分离。 在分析物分离步骤之后和最终孵育步骤之前，将分离的分析物加入扩增试剂。