公开(公告)号：US20080274157A1

公开(公告)日：2008-11-06

申请号：US12079629

申请日：2008-03-26

申请人： Gordana Vunjak-Novakovic ,  Katherine G. Truncale ,  Moon Hae Sunwoo ,  Arthur A. Gertzman

发明人： Gordana Vunjak-Novakovic ,  Katherine G. Truncale ,  Moon Hae Sunwoo ,  Arthur A. Gertzman

IPC分类号： A61K35/32 ,  A61F2/00 ,  A61P19/00

CPC分类号： A61K35/32 ,  A61B17/00491 ,  A61F2/30744 ,  A61F2/30756 ,  A61F2/3859 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/2867 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30759 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2310/00365 ,  A61F2310/00383 ,  A61K38/00 ,  A61K38/363 ,  A61K38/4833 ,  A61L24/0005 ,  A61L24/0015 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3687 ,  A61L27/38 ,  A61L27/48 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2300/43 ,  A61L2300/64 ,  A61L2430/06 ,  A61K2300/00

摘要： The invention is directed toward a cartilage repair assembly comprising a shaped structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that said shaped bone and cartilage cap when centered in the bore does not engage the side wall of the bore and is positioned from the side wall of the bone a distance ranging from 10 microns to 1000 microns and is surrounded by milled cartilage and a fibrin thrombin glue. A method for inserting the assembly into a cartilage defect area is disclosed.

摘要翻译： 本发明涉及一种软骨修复组件，其包括具有整体上覆软骨帽的软骨下骨的成形结构，其被处理以除去生物可吸收载体中的细胞碎片和蛋白聚糖和研磨的软骨。 该成形结构的尺寸适于装配在软骨缺损区域中的钻孔中，使得当在孔中心定位时所述成形的骨和软骨帽不接合孔的侧壁并且从骨的侧壁定位一定距离 范围从10微米到1000微米，被碾磨的软骨和纤维蛋白凝血酶胶包围。 公开了一种将组件插入软骨缺损区域的方法。

公开(公告)号：US20090043389A1

公开(公告)日：2009-02-12

申请号：US12191490

申请日：2008-08-14

申请人： GORDANA VUNJAK-NOVAKOVIC ,  Arthur A. Gertzman ,  Moon Hae Sunwoo ,  William W. Tomford ,  Katherine G. Truncale

发明人： GORDANA VUNJAK-NOVAKOVIC ,  Arthur A. Gertzman ,  Moon Hae Sunwoo ,  William W. Tomford ,  Katherine G. Truncale

IPC分类号： A61F2/08

CPC分类号： A61F2/28 ,  A61B17/00491 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2/3859 ,  A61F2/4644 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/2867 ,  A61F2002/30004 ,  A61F2002/30062 ,  A61F2002/30112 ,  A61F2002/30113 ,  A61F2002/30121 ,  A61F2002/30125 ,  A61F2002/30136 ,  A61F2002/30153 ,  A61F2002/30179 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30228 ,  A61F2002/3028 ,  A61F2002/30759 ,  A61F2002/30764 ,  A61F2002/4635 ,  A61F2210/0004 ,  A61F2230/0004 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/0019 ,  A61F2230/0058 ,  A61F2230/0063 ,  A61F2230/0069 ,  A61F2250/0014 ,  A61F2310/00365 ,  A61F2310/00383 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3683 ,  A61L27/48 ,  A61L27/52 ,  A61L2430/06

摘要： The invention is directed toward a cartilage repair assembly comprising a shaped structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that said shaped bone and cartilage cap when centered in the bore does not engage the side wall of the bore in an interference fit and is surrounded by milled cartilage and carrier. A method for inserting the assembly into a cartilage defect area is disclosed.

摘要翻译： 本发明涉及一种软骨修复组件，其包括具有整体上覆软骨帽的软骨下骨的成形结构，其被处理以除去生物可吸收载体中的细胞碎片和蛋白聚糖和研磨的软骨。 成形结构的尺寸适于装配在软骨缺损区域中的钻孔中，使得当在孔中心定位时所述成形的骨和软骨帽不会以过盈配合接合孔的侧壁并被碾磨的软骨和载体包围 。 公开了一种将组件插入软骨缺损区域的方法。

公开(公告)号：US20090291112A1

公开(公告)日：2009-11-26

申请号：US12322996

申请日：2009-02-09

申请人： Katherine G. Truncale ,  Arthur A. Gertzman ,  Moon Hae Sunwoo ,  William W. Tomford ,  Judith I. Yannariello-Brown ,  Yen-Chen Huang

发明人： Katherine G. Truncale ,  Arthur A. Gertzman ,  Moon Hae Sunwoo ,  William W. Tomford ,  Judith I. Yannariello-Brown ,  Yen-Chen Huang

IPC分类号： A61F2/28 ,  A61K38/18 ,  A61K38/00 ,  A61K35/32 ,  A61K35/28 ,  A61K38/28

CPC分类号： A61F2/28 ,  A61F2/30756 ,  A61F2/3859 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/30004 ,  A61F2002/30062 ,  A61F2002/30136 ,  A61F2002/30224 ,  A61F2002/30233 ,  A61F2002/3024 ,  A61F2002/30299 ,  A61F2002/30327 ,  A61F2002/30764 ,  A61F2002/30785 ,  A61F2002/4645 ,  A61F2210/0004 ,  A61F2230/0004 ,  A61F2230/0069 ,  A61F2230/0093 ,  A61F2250/0014 ,  A61F2250/0039 ,  A61F2310/00365 ,  A61F2310/00383 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3804 ,  A61L27/48 ,  A61L2430/06 ,  C08L89/00

摘要： An allograft osteochondral plug is combined with a mixture that includes freeze-milled cartilage particles, and such combination is used to repair defects in articular cartilage. The plug includes an subchondral bone portion and an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans. At least a portion of the plug has a lateral dimension selected to form an interference fit against a tissue layer exposed as a result of a bore formed in a defect area in articular cartilage of a host. The cartilage particle mixture is placed adjacent at least a portion of the plug for promoting cartilage cell migration into (i.e., from the adjacent host cartilage) and proliferation in the bore, and for enhancing tissue integration between the plug and patient (i.e., host) tissue when the plug is inserted into the bore. Methods for surgical implantation of the plug into a patient are also disclosed.

摘要翻译： 同种异体骨软骨塞与包括冷冻研磨的软骨颗粒的混合物组合，并且这种组合用于修复关节软骨中的缺陷。 塞子包括软骨下骨部分和整合的上覆软骨帽，其被处理以除去细胞碎片和蛋白聚糖。 插塞的至少一部分具有选择的横向尺寸，以形成对由于在主体的关节软骨中的缺陷区域中形成的孔而暴露的组织层的干涉配合。 将软骨颗粒混合物放置在插塞的至少一部分附近，用于促进软骨细胞迁移（即，从相邻的宿主软骨）和孔中的增殖，并且用于增强插塞和患者（即宿主）之间的组织整合， 当插头插入孔中时的组织。 还公开了将插塞外科植入患者体内的方法。

公开(公告)号：US08292968B2

公开(公告)日：2012-10-23

申请号：US12931427

申请日：2011-02-01

申请人： Katherine G. Truncale ,  Eric J. Semler ,  Arthur A. Gertzman ,  Moon Hae Sunwoo ,  William W. Tomford ,  Roman Shikhanovich

发明人： Katherine G. Truncale ,  Eric J. Semler ,  Arthur A. Gertzman ,  Moon Hae Sunwoo ,  William W. Tomford ,  Roman Shikhanovich

IPC分类号： A61F2/28

CPC分类号： A61F2/30756 ,  A61B17/00491 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/3859 ,  A61F2/3872 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/2842 ,  A61F2002/30057 ,  A61F2002/30059 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30227 ,  A61F2002/30233 ,  A61F2002/30235 ,  A61F2002/30327 ,  A61F2002/30331 ,  A61F2002/30354 ,  A61F2002/30387 ,  A61F2002/30448 ,  A61F2002/30459 ,  A61F2002/30461 ,  A61F2002/30492 ,  A61F2002/30604 ,  A61F2002/30759 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30772 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30795 ,  A61F2002/3085 ,  A61F2002/30932 ,  A61F2002/3096 ,  A61F2002/4635 ,  A61F2002/4646 ,  A61F2002/4649 ,  A61F2210/0004 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0066 ,  A61F2220/0075 ,  A61F2230/0069 ,  A61F2250/0039 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/43 ,  A61L2430/06 ,  C08L89/00

摘要： A construct for repairing articular cartilage defects includes a cap member and a base member. The cap member has an upper section and a stem depending from a central region thereof. The upper section includes a peripheral region. The stem includes a cavity. The base member has first and second ends, the first end including an annular recess dimensioned such that the stem is receivable therein. The first end also includes an annular edge positioned laterally outwardly from the annular recess, for abutting and supporting the peripheral region of the upper section when the stem is received in the annular recess. The base member further includes an island which is surrounded by the annular recess and receivable in the cavity of the stem, such that the island is abuttable with and may thereby support the central region of the upper section when the stem is received in the annular recess.

摘要翻译： 用于修复关节软骨缺损的构造包括帽构件和基底构件。 盖构件具有从其中心区域悬垂的上部部分和茎部。 上部包括外围区域。 杆包括一个空腔。 基部构件具有第一端和第二端，第一端包括尺寸为使得杆可接收在其中的环形凹部。 第一端还包括从环形凹部横向向外定位的环形边缘，用于当杆被容纳在环形凹部中时抵靠并支撑上部的周边区域。 基部构件还包括岛，该岛由环形凹部包围并且可接收在杆的空腔中，使得当杆被容纳在环形凹部中时，岛可抵靠并且从而支撑上部的中心区域 。

公开(公告)号：US20090319045A1

公开(公告)日：2009-12-24

申请号：US12381072

申请日：2009-03-05

申请人： Katherine G. Truncale ,  Eric J. Semler ,  Arthur A. Gertzman ,  Moon Hae Sunwoo ,  William W. Tomford ,  Roman Shikhanovich ,  Alex B. Callahan ,  Judith I. Yannariello-Brown ,  Morris L. Jacobs ,  John C. Munson ,  Yen-Chen Huang

发明人： Katherine G. Truncale ,  Eric J. Semler ,  Arthur A. Gertzman ,  Moon Hae Sunwoo ,  William W. Tomford ,  Roman Shikhanovich ,  Alex B. Callahan ,  Judith I. Yannariello-Brown ,  Morris L. Jacobs ,  John C. Munson ,  Yen-Chen Huang

IPC分类号： A61F2/28 ,  A61F2/02

CPC分类号： A61F2/30756 ,  A61B17/00491 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/3859 ,  A61F2/3872 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/2842 ,  A61F2002/30057 ,  A61F2002/30059 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30227 ,  A61F2002/30233 ,  A61F2002/30235 ,  A61F2002/30327 ,  A61F2002/30331 ,  A61F2002/30354 ,  A61F2002/30387 ,  A61F2002/30448 ,  A61F2002/30459 ,  A61F2002/30461 ,  A61F2002/30492 ,  A61F2002/30604 ,  A61F2002/30759 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30772 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30795 ,  A61F2002/3085 ,  A61F2002/30932 ,  A61F2002/3096 ,  A61F2002/4635 ,  A61F2002/4646 ,  A61F2002/4649 ,  A61F2210/0004 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0066 ,  A61F2220/0075 ,  A61F2230/0069 ,  A61F2250/0039 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/43 ,  A61L2430/06 ,  C08L89/00

摘要： Constructs that are at least partially constructed of allograft cancellous bone are disclosed, along with cartilage particles that may be used with the constructs for repairing articular cartilage defects. A multi-piece construct includes a base member, a cap member and at least one pin that secures the cap member to the base member. The base member may be constructed of mineralized cancellous bone, and is used to replace the subchondral bone removed when a surgeon cuts a bore in the area of an adjacent cartilage defect. The base member includes a blind bore and first and second through-going transverse bores in opposite sides of a wall of the base member. The cap member includes an upper section that has a thickness that is similar to that of a patient's surrounding articular cartilage layer and a stem depending from the upper section that is dimensioned to be received in and by the blind bore of the base member. The stem includes a transverse through-going bore, which may be aligned with the transverse through-going bores of the base member to receive the pin therein when the construct has been assembled. The cap member is at least partially formed of demineralized allograft cancellous bone, into which a mixture containing lyophilized, freeze-milled allograft cartilage particles may be infused for the repair of articular cartilage defects. The cartilage particles have a size within a range of from about 10 microns to about 210 microns.

摘要翻译： 公开了至少部分由同种异体移植松质骨构成的构造物，以及可用于修复关节软骨缺损的构建体的软骨颗粒。 多件式构件包括底座构件，帽构件以及将盖构件固定到基座构件的至少一个销。 基部构件可以由矿化松质骨构成，并且当外科医生切割相邻软骨缺损区域中的孔时，用于替代被去除的软骨下骨。 基部构件包括盲孔以及在基部构件的壁的相对侧中的第一和第二穿过横向孔。 盖构件包括具有与患者周围的关节软骨层的厚度相似的厚度的上部部分和从上部部分延伸的杆部，该上部部分的尺寸设计成被接纳在基部构件的盲孔内和通过该盲孔。 所述杆包括横向通孔，所述横向通孔可以与所述基部构件的横向贯穿孔对齐，以在所述构造件已经组装时将其插入其中。 盖构件至少部分地由软化的同种异体移植松质骨形成，含有冻干的冷冻研磨的同种异体移植软骨颗粒的混合物可以被注入其中，用于修复关节软骨缺损。 软骨颗粒的尺寸在约10微米至约210微米的范围内。

公开(公告)号：US20110166669A1

公开(公告)日：2011-07-07

申请号：US12931427

申请日：2011-02-01

申请人： Katherine G. Truncale ,  Eric J. Semler ,  Arthur A. Gertzman ,  Moon Hae Sunwoo ,  William W. Tomford ,  Roman Shikhanovich

发明人： Katherine G. Truncale ,  Eric J. Semler ,  Arthur A. Gertzman ,  Moon Hae Sunwoo ,  William W. Tomford ,  Roman Shikhanovich

IPC分类号： A61F2/28

CPC分类号： A61F2/30756 ,  A61B17/00491 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/3859 ,  A61F2/3872 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/2842 ,  A61F2002/30057 ,  A61F2002/30059 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30227 ,  A61F2002/30233 ,  A61F2002/30235 ,  A61F2002/30327 ,  A61F2002/30331 ,  A61F2002/30354 ,  A61F2002/30387 ,  A61F2002/30448 ,  A61F2002/30459 ,  A61F2002/30461 ,  A61F2002/30492 ,  A61F2002/30604 ,  A61F2002/30759 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30772 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30795 ,  A61F2002/3085 ,  A61F2002/30932 ,  A61F2002/3096 ,  A61F2002/4635 ,  A61F2002/4646 ,  A61F2002/4649 ,  A61F2210/0004 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0066 ,  A61F2220/0075 ,  A61F2230/0069 ,  A61F2250/0039 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/43 ,  A61L2430/06 ,  C08L89/00

摘要： Constructs that are at least partially constructed of allograft cancellous bone are disclosed, along with cartilage particles that may be used with the constructs for repairing articular cartilage defects. A multi-piece construct includes a base member, a cap member and at least one pin that secures the cap member to the base member. The base member may be constructed of mineralized cancellous bone, and is used to replace the subchondral bone removed when a surgeon cuts a bore in the area of an adjacent cartilage defect. The base member includes a blind bore and first and second through-going transverse bores in opposite sides of a wall of the base member. The cap member includes an upper section that has a thickness that is similar to that of a patient's surrounding articular cartilage layer and a stem depending from the upper section that is dimensioned to be received in and by the blind bore of the base member. The stem includes a transverse through-going bore, which may be aligned with the transverse through-going bores of the base member to receive the pin therein when the construct has been assembled. The cap member is at least partially formed of demineralized allograft cancellous bone, into which a mixture containing lyophilized, freeze-milled allograft cartilage particles may be infused for the repair of articular cartilage defects. The cartilage particles have a size within a range of from about 10 microns to about 210 microns.

摘要翻译： 公开了至少部分由同种异体移植松质骨构成的构造物，以及可用于修复关节软骨缺损的构建体的软骨颗粒。 多件式构件包括底座构件，帽构件以及将盖构件固定到基座构件的至少一个销。 基部构件可以由矿化松质骨构成，并且当外科医生切割相邻软骨缺损区域中的孔时，用于替代被去除的软骨下骨。 基部构件包括盲孔以及在基部构件的壁的相对侧中的第一和第二穿过横向孔。 盖构件包括具有与患者周围的关节软骨层的厚度相似的厚度的上部部分和从上部部分延伸的杆部，该上部部分的尺寸设计成被接纳在基部构件的盲孔内和通过该盲孔。 所述杆包括横向通孔，所述横向通孔可以与所述基部构件的横向贯穿孔对齐，以在所述构造件已经组装时将其插入其中。 盖构件至少部分地由软化的同种异体移植松质骨形成，含有冻干的冷冻研磨的同种异体移植软骨颗粒的混合物可以被注入其中，用于修复关节软骨缺损。 软骨颗粒的尺寸在约10微米至约210微米的范围内。

公开(公告)号：US20110070271A1

公开(公告)日：2011-03-24

申请号：US12924132

申请日：2010-09-21

申请人： Katherine G. Truncale ,  Moon Hae Sunwoo ,  Arthur A. Gertzman ,  William W. Tomford

发明人： Katherine G. Truncale ,  Moon Hae Sunwoo ,  Arthur A. Gertzman ,  William W. Tomford

IPC分类号： A61K35/32 ,  A61K9/00 ,  A61K38/20 ,  A61P19/04

CPC分类号： A61F2/30756 ,  A61B17/00491 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/3859 ,  A61F2/3872 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/2842 ,  A61F2002/30057 ,  A61F2002/30059 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30227 ,  A61F2002/30233 ,  A61F2002/30235 ,  A61F2002/30327 ,  A61F2002/30331 ,  A61F2002/30354 ,  A61F2002/30387 ,  A61F2002/30448 ,  A61F2002/30459 ,  A61F2002/30461 ,  A61F2002/30492 ,  A61F2002/30604 ,  A61F2002/30759 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30772 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30795 ,  A61F2002/3085 ,  A61F2002/30932 ,  A61F2002/3096 ,  A61F2002/4635 ,  A61F2002/4646 ,  A61F2002/4649 ,  A61F2210/0004 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0066 ,  A61F2220/0075 ,  A61F2230/0069 ,  A61F2250/0039 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/43 ,  A61L2430/06 ,  C08L89/00

摘要： Constructs that are at least partially constructed of allograft cancellous bone are disclosed, along with cartilage particles that may be used with the constructs for repairing articular cartilage defects. A multi-piece construct includes a base member, a cap member and at least one pin that secures the cap member to the base member. The base member may be constructed of mineralized cancellous bone, and is used to replace the subchondral bone removed when a surgeon cuts a bore in the area of an adjacent cartilage defect. The base member includes a blind bore and first and second through-going transverse bores in opposite sides of a wall of the base member. The cap member includes an upper section that has a thickness that is similar to that of a patient's surrounding articular cartilage layer and a stem depending from the upper section that is dimensioned to be received in and by the blind bore of the base member. The stem includes a transverse through-going bore, which may be aligned with the transverse through-going bores of the base member to receive the pin therein when the construct has been assembled. The cap member is at least partially formed of demineralized allograft cancellous bone, into which a mixture containing lyophilized, freeze-milled allograft cartilage particles may be infused for the repair of articular cartilage defects. The cartilage particles have a size within a range of from about 10 microns to about 210 microns.

公开(公告)号：USRE43258E1

公开(公告)日：2012-03-20

申请号：US12966674

申请日：2010-12-13

申请人： Katherine G. Truncale ,  Moon Hae Sunwoo ,  Arthur A. Gertzman ,  William W. Tomford

发明人： Katherine G. Truncale ,  Moon Hae Sunwoo ,  Arthur A. Gertzman ,  William W. Tomford

IPC分类号： A61K35/32

摘要： The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers with allogenic chondrocytes or bone marrow cells in an amount exceeding the natural occurrence of same in hyaline cartilage and adding a cell growth additive.

摘要翻译： 本发明涉及一种无菌软骨缺损植入物材料，其包含在生物可吸收载体中的尺寸范围为0.01mm至1.0mm的经研磨的冻干同种异体移植软骨片，其取自透明质酸钠，透明质酸及其衍生物，明胶，胶原，壳聚糖 ，藻酸盐，缓冲的PBS，葡聚糖或具有同种异体软骨细胞或骨髓细胞的聚合物，其数量超过透明软骨中自然发生的量，并加入细胞生长添加剂。

公开(公告)号：US20100274362A1

公开(公告)日：2010-10-28

申请号：US12657207

申请日：2010-01-14

申请人： Avner Yayon ,  Katherine G. Truncale ,  Hilla Barkay-Olami ,  Alex B. Callahan ,  Arthur A. Gertzman ,  Yen-Chen Huang ,  Morris L. Jacobs ,  John C. Munson ,  Eric J. Semler ,  Roman Shikhanovich ,  Baruch Stern ,  Moon Hae Sunwoo ,  William W. Tomford ,  Judith I. Yannariello-Brown

发明人： Avner Yayon ,  Katherine G. Truncale ,  Hilla Barkay-Olami ,  Alex B. Callahan ,  Arthur A. Gertzman ,  Yen-Chen Huang ,  Morris L. Jacobs ,  John C. Munson ,  Eric J. Semler ,  Roman Shikhanovich ,  Baruch Stern ,  Moon Hae Sunwoo ,  William W. Tomford ,  Judith I. Yannariello-Brown

IPC分类号： A61F2/02 ,  A61K9/19 ,  A61K9/00 ,  A61K38/18 ,  A61P19/00

CPC分类号： A61K9/19 ,  A61K35/32 ,  A61K38/1825 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/602

摘要： Mixtures, such as gels or pastes, comprising freeze-milled cartilage particles and exogenous growth factors are used for repairing chondral defects. Such mixtures may be applied to constructs comprising cancellous bone for implantation at the defect site. Suitable growth factors include variants of FGF-2, particularly variants that include a sole amino acid substitution for asparagine at amino acid 111 of the β8-β9 loop of the FGF-2 peptide. Such FGF-2 variants are released slowly and continuously at a constant rate from cartilage pastes. In other embodiments, the amino acid substituted for asparigine is glycine. Other variants that may be used include FGF-9 variants having truncated chains and a sole amino acid substitution in the β8-β9 loop of the FGF-9 peptide either for tryptophan at amino acid 144 or for asparagine at amino acid 143.

摘要翻译： 使用包含冷冻研磨的软骨颗粒和外源生长因子的混合物，例如凝胶或糊剂来修复软骨缺陷。 可以将这样的混合物施用于包含用于在缺损部位植入的松质骨的构建体。 合适的生长因子包括FGF-2的变体，特别是包括在FGF-2肽的8-＆amp; B9环的氨基酸111处的天冬酰胺的唯一氨基酸取代的变体。 这样的FGF-2变体以软骨糊剂的恒定速率缓慢且连续地释放。 在其它实施方案中，取代天冬酰胺的氨基酸是甘氨酸。 可以使用的其它变体包括FGF-9变体，其具有截短的链和唯一的氨基酸取代在FGF-9肽的8-＆Bgr9环中，对于在氨基酸144处的色氨酸或在氨基酸143处的天冬酰胺 。

公开(公告)号：US07488348B2

公开(公告)日：2009-02-10

申请号：US11151270

申请日：2005-06-14

申请人： Katherine G. Truncale ,  Moon Hae Sunwoo ,  Arthur A. Gertzman ,  William W. Tomford ,  Judith I. Yannariello-Brown

发明人： Katherine G. Truncale ,  Moon Hae Sunwoo ,  Arthur A. Gertzman ,  William W. Tomford ,  Judith I. Yannariello-Brown

IPC分类号： A61F2/28

CPC分类号： A61F2/30756 ,  A61F2/28 ,  A61F2/30767 ,  A61F2/3859 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/30004 ,  A61F2002/30062 ,  A61F2002/3021 ,  A61F2002/30224 ,  A61F2002/30233 ,  A61F2002/3024 ,  A61F2002/30678 ,  A61F2002/30764 ,  A61F2210/0004 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2250/0014 ,  A61F2310/00365 ,  A61F2310/00383 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3683

摘要： The invention is directed toward a cartilage repair assembly comprising a cylindrically shaped allograft structure of subchondral bone with an integral overlying smaller diameter cartilage cap which is treated to remove cellular debris and proteoglycans. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the subchondral bone of the structure engages the side wall of the bone portion of the drilled bore in an interference fit while the cartilage cap is spaced from cartilage portion of the side wall of the drilled bore forming a gap in which a milled cartilage and biocompatible carrier mixture is placed allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.

摘要翻译： 本发明涉及一种软骨修复组件，其包括软骨下骨的圆柱形同种异体移植结构，其具有整体上覆的较小直径软骨帽，其被处理以除去细胞碎片和蛋白聚糖。 该成形结构的尺寸适于装配在软骨缺损区域中的钻孔中，使得该结构的软骨下骨以过盈配合接合钻孔的骨部分的侧壁，同时软骨帽与软骨部分的软骨部分间隔开 钻孔的侧壁形成间隙，其中放置了碾磨的软骨和生物相容的载体混合物，允许细胞转移到整个缺陷区域。 还公开了将成形的同种异体移植结构插入软骨缺损区域的方法。