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公开(公告)号：US06498340B2
公开(公告)日：2002-12-24
申请号：US09760248
申请日：2001-01-12
申请人： Gordon A. Anderson , Michael D. Brands , James E. Bruce , Ljiljana Pasa-Tolic , Richard D. Smith
发明人： Gordon A. Anderson , Michael D. Brands , James E. Bruce , Ljiljana Pasa-Tolic , Richard D. Smith
IPC分类号： H01J4900
CPC分类号： H01J49/0009
摘要： A method whereby a mass spectra generated by a mass spectrometer is calibrated by shifting the parameters used by the spectrometer to assign masses to the spectra in a manner which reconciles the signal of ions within the spectra having equal mass but differing charge states, or by reconciling ions having known differences in mass to relative values consistent with those known differences. In this manner, the mass spectrometer is calibrated without the need for standards while allowing the generation of a highly accurate mass spectra by the instrument.
摘要翻译： 通过移动光谱仪使用的参数来校准光谱仪产生的质谱的方法来校准光谱仪产生的质谱，方法是以质量相同但不同电荷状态的光谱中的离子信号进行协调，或通过调和 具有与已知差异一致的质量与相对值之间的已知差异的离子。 以这种方式，质谱仪被校准，而不需要标准，同时允许通过仪器产生高精度的质谱。
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公开(公告)号：US20140299766A1
公开(公告)日：2014-10-09
申请号：US14146922
申请日：2014-01-03
IPC分类号： H01J49/06
CPC分类号： H01J49/062 , G01N27/622 , H01J49/06
摘要： An ion manipulation method and device is disclosed. The device includes a pair of substantially parallel surfaces. An array of inner electrodes is contained within, and extends substantially along the length of, each parallel surface. The device includes a first outer array of electrodes and a second outer array of electrodes. Each outer array of electrodes is positioned on either side of the inner electrodes, and is contained within and extends substantially along the length of each parallel surface. A DC voltage is applied to the first and second outer array of electrodes. A RF voltage, with a superimposed electric field, is applied to the inner electrodes by applying the DC voltages to each electrode. Ions either move between the parallel surfaces within an ion confinement area or along paths in the direction of the electric field, or can be trapped in the ion confinement area.
摘要翻译： 公开了一种离子操作方法和装置。 该装置包括一对基本上平行的表面。 内部电极的阵列包含在每个平行表面内并且基本上沿着每个平行表面的长度延伸。 该装置包括电极的第一外部阵列和第二外部电极阵列。 每个外部电极阵列位于内部电极的任一侧上，并且基本上沿着每个平行表面的长度容纳并延伸。 DC电压施加到第一和第二外部电极阵列。 通过向每个电极施加直流电压，将具有叠加电场的RF电压施加到内部电极。 离子在离子限制区域内的平行表面之间或沿着电场方向的路径移动，或者可以被捕获在离子限制区域中。
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公开(公告)号：US20150076343A1
公开(公告)日：2015-03-19
申请号：US14528917
申请日：2014-10-30
IPC分类号： H01J49/06
CPC分类号： H01J49/062 , G01N27/622 , H01J49/06
摘要： An ion manipulation method and device to prevent loss of ions is disclosed. The device includes a pair of surfaces. An inner array of electrodes is coupled to the surfaces. A RF voltage and a DC voltage are alternately applied to the inner array of electrodes. The applied RF voltage is alternately positive and negative so that immediately adjacent or nearest neighbor RF applied electrodes are supplied with RF signals that are approximately 180 degrees out of phase.
摘要翻译： 公开了一种用于防止离子损失的离子操作方法和装置。 该装置包括一对表面。 电极的内部阵列耦合到表面。 RF电压和DC电压交替施加到电极的内部阵列。 施加的RF电压交替地是正的和负的，使得紧邻或最近邻RF施加的电极被提供有大约相差180度的RF信号。
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公开(公告)号：US08907273B1
公开(公告)日：2014-12-09
申请号：US14292437
申请日：2014-05-30
申请人： Tsung-Chi Chen , Keqi Tang , Yehia M. Ibrahim , Richard D. Smith , Gordon A. Anderson , Erin M. Baker
发明人： Tsung-Chi Chen , Keqi Tang , Yehia M. Ibrahim , Richard D. Smith , Gordon A. Anderson , Erin M. Baker
IPC分类号： H01J49/06
CPC分类号： H01J49/062 , G01N27/622 , H01J49/06
摘要： An ion manipulation method and device is disclosed. The device includes a pair of substantially parallel surfaces. An array of inner electrodes is contained within, and extends substantially along the length of, each parallel surface. The device includes a first outer array of electrodes and a second outer array of electrodes. Each outer array of electrodes is positioned on either side of the inner electrodes, and is contained within and extends substantially along the length of each parallel surface. A DC voltage is applied to the first and second outer array of electrodes. A RF voltage, with a superimposed electric field, is applied to the inner electrodes by applying the DC voltages to each electrode. Ions either move between the parallel surfaces within an ion confinement area or along paths in the direction of the electric field, or can be trapped in the ion confinement area. A predetermined number of pairs of surfaces are disposed in one or more chambers, forming a multiple-layer ion mobility cyclotron device.
摘要翻译： 公开了一种离子操作方法和装置。 该装置包括一对基本平行的表面。 内部电极的阵列包含在每个平行表面内并且基本上沿着每个平行表面的长度延伸。 该装置包括电极的第一外部阵列和第二外部电极阵列。 每个外部电极阵列位于内部电极的任一侧上，并且基本上沿着每个平行表面的长度容纳并延伸。 DC电压施加到第一和第二外部电极阵列。 通过向每个电极施加直流电压，将具有叠加电场的RF电压施加到内部电极。 离子在离子限制区域内的平行表面之间或沿着电场方向的路径移动，或者可以被捕获在离子限制区域中。 预定数量的一对表面设置在一个或多个室中，形成多层离子迁移回旋加速器装置。
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公开(公告)号：US08969800B1
公开(公告)日：2015-03-03
申请号：US14528917
申请日：2014-10-30
IPC分类号： H01J49/26
CPC分类号： H01J49/062 , G01N27/622 , H01J49/06
摘要： An ion manipulation method and device to prevent loss of ions is disclosed. The device includes a pair of surfaces. An inner array of electrodes is coupled to the surfaces. A RF voltage and a DC voltage are alternately applied to the inner array of electrodes. The applied RF voltage is alternately positive and negative so that immediately adjacent or nearest neighbor RF applied electrodes are supplied with RF signals that are approximately 180 degrees out of phase.
摘要翻译： 公开了一种用于防止离子损失的离子操作方法和装置。 该装置包括一对表面。 电极的内部阵列耦合到表面。 RF电压和DC电压交替施加到电极的内部阵列。 施加的RF电压交替地是正的和负的，使得紧邻或最近邻RF施加的电极被提供有大约相差180度的RF信号。
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公开(公告)号：US08901490B1
公开(公告)日：2014-12-02
申请号：US14292448
申请日：2014-05-30
申请人： Tsung-Chi Chen , Keqi Tang , Yehia M. Ibrahim , Richard D. Smith , Gordon A. Anderson , Erin M. Baker
发明人： Tsung-Chi Chen , Keqi Tang , Yehia M. Ibrahim , Richard D. Smith , Gordon A. Anderson , Erin M. Baker
IPC分类号： H01J49/42
CPC分类号： H01J49/062 , G01N27/622 , H01J49/06
摘要： An ion manipulation method and device is disclosed. The device includes a pair of substantially parallel surfaces. An array of inner electrodes is contained within, and extends substantially along the length of, each parallel surface. The device includes a first outer array of electrodes and a second outer array of electrodes. Each outer array of electrodes is positioned on either side of the inner electrodes, and is contained within and extends substantially along the length of each parallel surface. A DC voltage is applied to the first and second outer array of electrodes. A RF voltage, with a superimposed electric field, is applied to the inner electrodes by applying the DC voltages to each electrode. Ions either move between the parallel surfaces within an ion confinement area or along paths in the direction of the electric field, or can be trapped in the ion confinement area. The surfaces are housed in a chamber, and at least one electrically insulative shield is coupled to an inner surface of the chamber for increasing a mean-free-path between two adjacent electrodes in the chamber.
摘要翻译： 公开了一种离子操作方法和装置。 该装置包括一对基本平行的表面。 内部电极的阵列包含在每个平行表面内并且基本上沿着每个平行表面的长度延伸。 该装置包括电极的第一外部阵列和第二外部电极阵列。 每个外部电极阵列位于内部电极的任一侧上，并且基本上沿着每个平行表面的长度容纳并延伸。 DC电压施加到第一和第二外部电极阵列。 通过向每个电极施加直流电压，将具有叠加电场的RF电压施加到内部电极。 离子在离子限制区域内的平行表面之间或沿着电场方向的路径移动，或者可以被捕获在离子限制区域中。 表面容纳在腔室中，并且至少一个电绝缘屏蔽件联接到腔室的内表面，以增加腔室中两个相邻电极之间的平均自由程。
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公开(公告)号：US08835839B1
公开(公告)日：2014-09-16
申请号：US14146922
申请日：2014-01-03
IPC分类号： H01J49/06
CPC分类号： H01J49/062 , G01N27/622 , H01J49/06
摘要： An ion manipulation method and device is disclosed. The device includes a pair of substantially parallel surfaces. An array of inner electrodes is contained within, and extends substantially along the length of, each parallel surface. The device includes a first outer array of electrodes and a second outer array of electrodes. Each outer array of electrodes is positioned on either side of the inner electrodes, and is contained within and extends substantially along the length of each parallel surface. A DC voltage is applied to the first and second outer array of electrodes. A RF voltage, with a superimposed electric field, is applied to the inner electrodes by applying the DC voltages to each electrode. Ions either move between the parallel surfaces within an ion confinement area or along paths in the direction of the electric field, or can be trapped in the ion confinement area.
摘要翻译： 公开了一种离子操作方法和装置。 该装置包括一对基本上平行的表面。 内部电极的阵列包含在每个平行表面内并且基本上沿着每个平行表面的长度延伸。 该装置包括电极的第一外部阵列和第二外部电极阵列。 每个外部电极阵列位于内部电极的任一侧上，并且基本上沿着每个平行表面的长度容纳并延伸。 DC电压施加到第一和第二外部电极阵列。 通过向每个电极施加直流电压，将具有叠加电场的RF电压施加到内部电极。 离子在离子限制区域内的平行表面之间或沿着电场方向的路径移动，或者可以被捕获在离子限制区域中。
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公开(公告)号：US09063086B1
公开(公告)日：2015-06-23
申请号：US14179329
申请日：2014-02-12
CPC分类号： G01N27/622
摘要： A method and apparatus for compressing ions inside an ion mobility device is disclosed. Ions are introduced into the mobility device. The ions are subjected to a non-constant electric field to form a potential gradient along a portion of the device so that ions with similar mobilities bunch together into sharper peaks while maintaining separation between other ions. The potential gradient progressively increases or decreases along the length of the device.
摘要翻译： 公开了一种用于在离子迁移率装置内压缩离子的方法和装置。 离子被引入到移动设备中。 离子受到非恒定电场以沿器件的一部分形成电位梯度，使得具有相似迁移率的离子聚集在一起成为更尖锐的峰，同时保持其他离子之间的分离。 电位梯度沿器件的长度逐渐增加或减小。
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公开(公告)号：US08772711B1
公开(公告)日：2014-07-08
申请号：US14011529
申请日：2013-08-27
CPC分类号： H01J49/063 , H01J49/0063
摘要： A method of dissociating ions in a multipole ion guide is disclosed. A stream of charged ions is supplied to the ion guide. A main RF field is applied to the ion guide to confine the ions through the ion guide. An excitation RF field is applied to one pair of rods of the ion guide. The ions undergo dissociation when the applied excitation RF field is resonant with a secular frequency of the ions. The multipole ion guide is, but not limited to, a quadrupole, a hexapole, and an octopole.
摘要翻译： 公开了一种在多极离子导向器中离解离子的方法。 将带电离子流供给到离子导向器。 将主RF场施加到离子导向器以将离子限制在离子导向器上。 激发RF场施加到离子导向器的一对杆上。 当所施加的激发RF场与离子的长期频率谐振时，离子发生解离。 多极离子导向器是但不限于四极，六极和八极。
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10.发明授权Microchip and wedge ion funnels and planar ion beam analyzers using same 有权Microchip和楔形离子漏斗以及使用其的平面离子束分析仪公开(公告)号：US08299443B1
公开(公告)日：2012-10-30
申请号：US13087100
申请日：2011-04-14
CPC分类号： H01J49/0018 , H01J49/066
摘要： Electrodynamic ion funnels confine, guide, or focus ions in gases using the Dehmelt potential of oscillatory electric field. New funnel designs operating at or close to atmospheric gas pressure are described. Effective ion focusing at such pressures is enabled by fields of extreme amplitude and frequency, allowed in microscopic gaps that have much higher electrical breakdown thresholds in any gas than the macroscopic gaps of present funnels. The new microscopic-gap funnels are useful for interfacing atmospheric-pressure ionization sources to mass spectrometry (MS) and ion mobility separation (IMS) stages including differential IMS or FAIMS, as well as IMS and MS stages in various configurations. In particular, “wedge” funnels comprising two planar surfaces positioned at an angle and wedge funnel traps derived therefrom can compress ion beams in one dimension, producing narrow belt-shaped beams and laterally elongated cuboid packets. This beam profile reduces the ion density and thus space-charge effects, mitigating the adverse impact thereof on the resolving power, measurement accuracy, and dynamic range of MS and IMS analyzers, while a greater overlap with coplanar light or particle beams can benefit spectroscopic methods.
摘要翻译： 电动离子漏斗使用振荡电场的Dehmelt电位限制，引导或聚焦气体中的离子。 描述了处于或接近大气压力的新漏斗设计。 在这种压力下的有效离子聚焦是通过极大幅度和频率的场来实现的，微观间隙允许在任何气体中具有比当前漏斗的宏观间隙高得多的电击穿阈值。 新的微间隙漏斗可用于将大气压电离源与包括差分IMS或FAIMS的质谱（MS）和离子迁移率分离（IMS）阶段以及各种配置的IMS和MS阶段进行接口。 特别地，包括两个定位在一个角度的平坦表面的楔形漏斗和从其衍生的楔形漏斗捕获器可以在一个维度上压缩离子束，产生窄的带状波束和横向细长的长方体分组。 这种光束轮廓降低了离子密度，从而降低了空间电荷效应，减轻了MS和IMS分析仪的分辨率，测量精度和动态范围的不利影响，而与共面光或粒子束的更大重叠可有利于光谱方法 。
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