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公开(公告)号：US20090156429A1
公开(公告)日：2009-06-18
申请号：US12388358
申请日：2009-02-18
CPC分类号： G01J3/4406 , G01J3/021 , G01J3/10 , G01N21/6428 , G01N21/6458 , G01N2021/6419 , G01N2021/6441
摘要： The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput identification of informative SNPs, which could lead to more accurate diagnosis of inherited disease, better prognosis of risk susceptibilities, or identification of sporadic mutations. The PME technology has two main advantages that significantly increase fluorescence sensitivity: (1) optimal excitation of all fluorophores in the genomic assay and (2) “color-blind” detection, which collects considerably more light than standard wavelength resolved detection. Successful implementation of the PME technology will have broad application for routine usage in clinical diagnostics, forensics, and general sequencing methodologies and will have the capability, flexibility, and portability of targeted sequence variation assays for a large majority of the population.
摘要翻译： 本发明提供了一种称为脉冲 - 多重激发或PME的技术。 该技术提供了一种新的荧光检测方法，可应用于信息性SNP的高通量鉴定，这可以导致对遗传疾病的更准确的诊断，更好的预后风险易感性或散发性突变的鉴定。 PME技术有两个显着增加荧光灵敏度的主要优点：（1）基因组测定中所有荧光团的最佳激发和（2）“色盲”检测，其比标准波长分辨检测收集明显更多的光。 PME技术的成功实施将广泛应用于临床诊断，取证和一般测序方法中的常规应用，并将为大多数人群提供靶向序列变异测定的能力，灵活性和可移植性。
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公开(公告)号：US20120219029A1
公开(公告)日：2012-08-30
申请号：US13342471
申请日：2012-01-03
CPC分类号： G01J3/4406 , G01J3/021 , G01J3/10 , G01N21/6428 , G01N21/6458 , G01N2021/6419 , G01N2021/6441
摘要： The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput identification of informative SNPs, which could lead to more accurate diagnosis of inherited disease, better prognosis of risk susceptibilities, or identification of sporadic mutations. The PME technology has two main advantages that significantly increase fluorescence sensitivity: (1) optimal excitation of all fluorophores in the genomic assay and (2) “color-blind” detection, which collects considerably more light than standard wavelength resolved detection. Successful implementation of the PME technology will have broad application for routine usage in clinical diagnostics, forensics, and general sequencing methodologies and will have the capability, flexibility, and portability of targeted sequence variation assays for a large majority of the population.
摘要翻译： 本发明提供了一种称为脉冲 - 多重激发或PME的技术。 该技术提供了一种新的荧光检测方法，可应用于信息性SNP的高通量鉴定，这可以导致对遗传疾病的更准确的诊断，更好的预后风险易感性或散发性突变的鉴定。 PME技术有两个显着增加荧光灵敏度的主要优点：（1）基因组测定中所有荧光团的最佳激发和（2）“色盲”检测，其比标准波长分辨检测收集明显更多的光。 PME技术的成功实施将广泛应用于临床诊断，取证和一般测序方法中的常规应用，并将为大多数人群提供靶向序列变异测定的能力，灵活性和可移植性。
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公开(公告)号：US06995841B2
公开(公告)日：2006-02-07
申请号：US09941165
申请日：2001-08-28
CPC分类号： G01J3/4406 , G01J3/021 , G01J3/10 , G01N21/6428 , G01N21/6458 , G01N2021/6419 , G01N2021/6441
摘要： The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput identification of informative SNPs, which could lead to more accurate diagnosis of inherited disease, better prognosis of risk susceptibilities, or identification of sporadic mutations. The PME technology has two main advantages that significantly increase fluorescence sensitivity: (1) optimal excitation of all fluorophores in the genomic assay and (2) “color-blind” detection, which collects considerably more light than standard wavelength resolved detection. Successful implementation of the PME technology will have broad application for routine usage in clinical diagnostics, forensics, and general sequencing methodologies and will have the capability, flexibility, and portability of targeted sequence variation assays for a large majority of the population.
摘要翻译： 本发明提供了一种称为脉冲 - 多重激发或PME的技术。 该技术提供了一种新的荧光检测方法，可应用于信息性SNP的高通量鉴定，这可以导致对遗传疾病的更准确的诊断，更好的预后风险易感性或散发性突变的鉴定。 PME技术有两个显着增加荧光灵敏度的主要优点：（1）基因组测定中所有荧光团的最佳激发和（2）“色盲”检测，其比标准波长分辨检测收集明显更多的光。 PME技术的成功实施将广泛应用于临床诊断，取证和一般测序方法中的常规应用，并将为大多数人群提供靶向序列变异测定的能力，灵活性和可移植性。
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公开(公告)号：US08089628B2
公开(公告)日：2012-01-03
申请号：US12388358
申请日：2009-02-18
IPC分类号： G01N21/25
CPC分类号： G01J3/4406 , G01J3/021 , G01J3/10 , G01N21/6428 , G01N21/6458 , G01N2021/6419 , G01N2021/6441
摘要： The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput identification of informative SNPs, which could lead to more accurate diagnosis of inherited disease, better prognosis of risk susceptibilities, or identification of sporadic mutations. The PME technology has two main advantages that significantly increase fluorescence sensitivity: (1) optimal excitation of all fluorophores in the genomic assay and (2) “color-blind” detection, which collects considerably more light than standard wavelength resolved detection. Successful implementation of the PME technology will have broad application for routine usage in clinical diagnostics, forensics, and general sequencing methodologies and will have the capability, flexibility, and portability of targeted sequence variation assays for a large majority of the population.
摘要翻译： 本发明提供了一种称为脉冲 - 多重激发或PME的技术。 该技术提供了一种新的荧光检测方法，可应用于信息性SNP的高通量鉴定，这可以导致对遗传疾病的更准确的诊断，更好的预后风险易感性或散发性突变的鉴定。 PME技术有两个显着增加荧光灵敏度的主要优点：（1）基因组测定中所有荧光团的最佳激发和（2）“色盲”检测，其比标准波长分辨检测收集明显更多的光。 PME技术的成功实施将广泛应用于临床诊断，取证和一般测序方法中的常规应用，并将为大多数人群提供靶向序列变异测定的能力，灵活性和可移植性。
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公开(公告)号：US07511811B2
公开(公告)日：2009-03-31
申请号：US11248910
申请日：2005-10-12
IPC分类号： G01J3/30
CPC分类号： G01J3/4406 , G01J3/021 , G01J3/10 , G01N21/6428 , G01N21/6458 , G01N2021/6419 , G01N2021/6441
摘要： The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput identification of informative SNPs, which could lead to more accurate diagnosis of inherited disease, better prognosis of risk susceptibilities, or identification of sporadic mutations. The PME technology has two main advantages that significantly increase fluorescence sensitivity: (1) optimal excitation of all fluorophores in the genomic assay and (2) “color-blind” detection, which collects considerably more light than standard wavelength resolved detection. This technology differs significantly from the current state-of-the-art DNA sequencing instrumentation, which features single source excitation and color dispersion for DNA sequence identification. Successful implementation of the PME technology will have broad application for routine usage in clinical diagnostics, forensics, and general sequencing methodologies and will have the capability, flexibility, and portability of targeted sequence variation assays for a large majority of the population.
摘要翻译： 本发明提供了一种称为脉冲 - 多重激发或PME的技术。 该技术提供了一种新的荧光检测方法，可应用于信息性SNP的高通量鉴定，这可以导致对遗传疾病的更准确的诊断，更好的预后风险易感性或散发性突变的鉴定。 PME技术有两个显着增加荧光灵敏度的主要优点：（1）基因组测定中所有荧光团的最佳激发和（2）“色盲”检测，其比标准波长分辨检测收集明显更多的光。 该技术与目前最先进的DNA测序仪器显着不同，其具有用于DNA序列鉴定的单源激发和色散。 PME技术的成功实施将广泛应用于临床诊断，取证和一般测序方法中的常规应用，并将为大多数人群提供靶向序列变异测定的能力，灵活性和可移植性。
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公开(公告)号：US20060139634A1
公开(公告)日：2006-06-29
申请号：US11248910
申请日：2005-10-12
申请人： Graham Scott , Carter Kittrell , Robert Curl , Michael Metzker
发明人： Graham Scott , Carter Kittrell , Robert Curl , Michael Metzker
IPC分类号： G01J3/30
CPC分类号： G01J3/4406 , G01J3/021 , G01J3/10 , G01N21/6428 , G01N21/6458 , G01N2021/6419 , G01N2021/6441
摘要： The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput identification of informative SNPs, which could lead to more accurate diagnosis of inherited disease, better prognosis of risk susceptibilities, or identification of sporadic mutations. The PME technology has two main advantages that significantly increase fluorescence sensitivity: (1) optimal excitation of all fluorophores in the genomic assay and (2) “color-blind” detection, which collects considerably more light than standard wavelength resolved detection. This technology differs significantly from the current state-of-the-art DNA sequencing instrumentation, which features single source excitation and color dispersion for DNA sequence identification. Successful implementation of the PME technology will have broad application for routine usage in clinical diagnostics, forensics, and general sequencing methodologies and will have the capability, flexibility, and portability of targeted sequence variation assays for a large majority of the population.
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公开(公告)号：US5290275A
公开(公告)日：1994-03-01
申请号：US731010
申请日：1991-07-16
IPC分类号： A61B5/00 , A61B18/20 , A61B18/22 , A61B18/24 , B23K26/03 , B23K26/067 , G02B6/04 , G02B6/14 , G02B6/24 , G02B6/35 , G02B6/42 , A61B17/32
CPC分类号： B23K26/032 , A61B1/00096 , A61B18/20 , A61B18/245 , A61B5/0071 , A61B5/0075 , A61B5/0084 , B23K26/067 , G02B6/04 , G02B6/241 , G02B6/4296 , A61B2018/00636 , A61B2018/2238 , G01N2021/4747 , G02B6/14 , G02B6/3504 , G02B6/3508 , G02B6/3512 , G02B6/3516 , G02B6/3548 , G02B6/3598
摘要： A laser catheter is disclosed wherein optical fibers carrying laser light are mounted in a catheter for insertion into an artery to provide controlled delivery of a laser beam for percutaneous intravascular laser treatment of atherosclerotic disease. A transparent protective shield is provided at the distal end of the catheter for mechanically diplacing intravascular blood and protecting the fibers from the intravascular contents, as well as protecting the patient in the event of failure of the fiber optics. Multiple optical fibers allow the selection of tissue that is to be removed. A computer controlled system automatically aligns fibers with the laser and controls exposure time. Spectroscopic diagnostics determine what tissue is to be removed.
摘要翻译： 公开了一种激光导管，其中携带激光的光纤被安装在用于插入动脉的导管中以提供用于经皮血管内激光治疗动脉粥样硬化疾病的激光束的受控输送。 在导管的远端处提供透明保护屏蔽，用于机械地置换血管内血液并保护纤维免受血管内内容物的影响，并且在光纤故障的情况下保护患者。 多个光纤允许选择要去除的组织。 计算机控制系统自动将光纤与激光对准并控制曝光时间。 光谱诊断确定要去除什么组织。
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公开(公告)号：US5106387A
公开(公告)日：1992-04-21
申请号：US410897
申请日：1989-09-21
IPC分类号： A61B5/00 , A61B18/20 , A61B18/22 , A61B18/24 , B23K26/03 , B23K26/067 , G02B6/04 , G02B6/14 , G02B6/24 , G02B6/35 , G02B6/42
CPC分类号： G02B6/4296 , A61B1/00096 , A61B18/20 , A61B18/245 , A61B5/0071 , A61B5/0075 , A61B5/0084 , G02B6/04 , G02B6/241 , A61B2018/00636 , A61B2018/2238 , G01N2021/4747 , G02B6/14 , G02B6/3504 , G02B6/3508 , G02B6/3512 , G02B6/3516 , G02B6/3548 , G02B6/3598
摘要： A method of diagnosis of the type of tissue in an artery, including distinguishing artery wall from atheromateous plaque is described, in which a catheter with one or more optical fibers is enclosed at a distal end by an optical shield transparent to light radiation and wherein the proximal end of the catheter and optical fibers are coupled to a source of optical radiation. The catheter is inserted into an artery until the optical shield is brought into contact with a suspected arterial lesion or other tissue to be diagnosed.
摘要翻译： 描述了一种诊断动脉组织类型的方法，包括区分动脉壁与动脉粥样硬化斑块，其中具有一个或多个光纤的导管在远端被通过光辐射透明的光屏蔽封闭，并且其中 导管的近端和光纤耦合到光辐射源。 将导管插入动脉中，直到光学屏蔽与疑似动脉损伤或待诊断的其他组织接触。
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公开(公告)号：US5318024A
公开(公告)日：1994-06-07
申请号：US808001
申请日：1991-12-16
IPC分类号： A61B5/00 , A61B18/20 , A61B18/22 , A61B18/24 , B23K26/03 , B23K26/067 , G02B6/04 , G02B6/14 , G02B6/24 , G02B6/35 , G02B6/42
CPC分类号： B23K26/032 , A61B1/00096 , A61B18/20 , A61B18/245 , A61B5/0071 , A61B5/0075 , A61B5/0084 , B23K26/0648 , B23K26/0665 , B23K26/067 , G02B6/04 , G02B6/241 , G02B6/4296 , A61B2018/00636 , A61B2018/2238 , G01N2021/4747 , G02B6/14 , G02B6/3502 , G02B6/3504 , G02B6/3508 , G02B6/3512 , G02B6/3516 , G02B6/353 , G02B6/3548 , G02B6/3588 , G02B6/3598
摘要： A laser endoscope is disclosed for generating a spectrally resolved spatial image of tissue. Fiber optics positioned within an optically shielded endoscope are used to deliver laser radiation to tissue to be imaged. Radiation returning through the fiber optics from the tissue is spectrally resolved and used to generate an image of tissue that can assist in diagnosis and treatment.
摘要翻译： 公开了一种用于产生光谱分辨的组织空间图像的激光内窥镜。 定位在光屏蔽内窥镜内的光纤用于将激光辐射传送到要成像的组织。 通过纤维光学从组织返回的辐射被光谱解析并用于产生有助于诊断和治疗的组织图像。
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公开(公告)号：US5192278A
公开(公告)日：1993-03-09
申请号：US537925
申请日：1990-06-13
CPC分类号： G02B6/4296 , A61B18/245 , A61B2017/00061 , A61B2017/22061 , A61B2018/1861 , A61B2018/2238 , G02B6/3504 , G02B6/3508 , G02B6/3512 , G02B6/3516 , G02B6/3548 , G02B6/3598
摘要： A molded fiber-optic plug for retaining optical fibers in a fixed position within a laser catheter is disclosed in which an optically polished tubular moldable plug body is used to secure a plurality of optical fibers within a laser catheter.
摘要翻译： 公开了一种用于将光纤保持在激光导管内的固定位置的模制光纤塞，其中使用光学抛光的管状可模塑塞体将多个光纤固定在激光导管内。
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