Compositions and methods for prion decontamination
    3.
    发明申请
    Compositions and methods for prion decontamination 有权
    朊蛋白去污的组成和方法

    公开(公告)号:US20110311510A1

    公开(公告)日:2011-12-22

    申请号:US13221417

    申请日:2011-08-30

    IPC分类号: A01N63/02 A01P1/00 A01N37/44

    摘要: The invention relates to compositions and methods for prion degradation, decontamination or disinfection. The composition comprises an oxidizing agent, one or more proteases and a surfactant such as an ionic surfactant/detergent. The method comprises contacting a prion contaminated entity with a prion-degrading composition comprising an effective amount of an oxidizing agent, an effective amount of at least one protease, and an effective amount of a surfactant. The components of the composition may be contacted with a prion-contaminated entity sequentially or simultaneously using an aqueous composition. Typically at least two different proteases are used for optimal efficacy. Preferably the oxidizing agent comprises peracetyl ions or a source thereof. The invention also relates to kits comprising the various reagents.

    摘要翻译: 本发明涉及朊病毒降解,去污或消毒的组合物和方法。 组合物包含氧化剂,一种或多种蛋白酶和表面活性剂如离子表面活性剂/洗涤剂。 该方法包括使朊病毒污染的实体与包含有效量的氧化剂,有效量的至少一种蛋白酶和有效量的表面活性剂的朊病毒降解组合物接触。 组合物的组分可以使用水性组合物依次或同时与朊病毒污染的实体接触。 通常使用至少两种不同的蛋白酶来获得最佳疗效。 优选地,氧化剂包括全乙酰离子或其源。 本发明还涉及包含各种试剂的试剂盒。

    PHARMACEUTICAL COMPOSITIONS
    5.
    发明申请
    PHARMACEUTICAL COMPOSITIONS 审中-公开
    药物组合物

    公开(公告)号:US20100055133A1

    公开(公告)日:2010-03-04

    申请号:US12540144

    申请日:2009-08-12

    摘要: The present invention provides for a pharmaceutical composition that includes tetrabenazine and a release-retarding agent; and a method of treating a hyperkinetic movement disorder (e.g., Huntington's disease, chorea associated with Huntington's disease, hemiballismus, senile chorea, tic disorders, tardive dyskinesia, myoclonlus, dystoniia and/or Tourette's syndrome). The method includes administering an effective amount of the pharmaceutical composition, for a period of time effective to treat the hyperkinetic movement disorder.

    摘要翻译: 本发明提供一种药物组合物,其包含丁苯那嗪和释放阻滞剂; 以及治疗过度运动障碍(例如亨廷顿舞蹈病,与亨廷顿舞蹈病,偏头痛,老年性舞蹈病,抽搐障碍,迟发性运动障碍,肌阵挛,肌张力障碍和/或图雷特综合征相关的舞蹈病)的方法。 该方法包括给予有效量的药物组合物一段有效治疗过度运动障碍的时间。

    Fuel oil composition
    7.
    发明授权
    Fuel oil composition 有权
    燃油组成

    公开(公告)号:US07497880B2

    公开(公告)日:2009-03-03

    申请号:US10856724

    申请日:2004-05-28

    申请人: Graham Jackson

    发明人: Graham Jackson

    IPC分类号: C10L1/18

    摘要: A fuel oil composition comprising a fuel oil and 0.1 to 10,000 ppm of a polymeric condensation product which is formed by the reaction of an aliphatic aldehyde or ketone, or a reactive equivalent, with either (i) a straight or branched chain C1-C7 alkyl ester of p-hydroxybenzoic acid, or with (ii) a branched chain C8-C16 alkyl ester of p-hydroxybenzoic acid, or with (iii) a mixture of long chain C8-C18 alkyl esters of p-hydroxybenzoic acid, at least one of said alkyls being branched. The polymeric condensation product improves the cold flow characteristics of the fuel oil.

    摘要翻译: 一种燃料油组合物,其包含燃料油和0.1至10,000ppm的聚合缩合产物,其通过脂族醛或酮或反应性当量与(i)直链或支链C 1 -C 7烷基 对 - 羟基苯甲酸的酯或与(ii)对羟基苯甲酸的支链C 8 -C 16烷基酯或(iii)对羟基苯甲酸的长链C8-C18烷基酯的混合物,至少一种 的所述烷基是支链的。 聚合物缩合产物改善了燃油的冷流特性。

    Prion decontamination
    10.
    发明申请
    Prion decontamination 审中-公开
    朊病毒去污

    公开(公告)号:US20060217282A1

    公开(公告)日:2006-09-28

    申请号:US10532265

    申请日:2003-10-29

    IPC分类号: C11D3/386

    摘要: The present invention relates to methods for prion decontamination comprising (i) contacting an entity to be decontaminated with a detergent, (ii) contacting said entity with one or more protease(s), and optionally (iii) autoclaving said entity. The invention further relates to kits comprising detergents and proteases for prion decontamination, and compositions comprising detergents and proteases for prion decontamination.

    摘要翻译: 本发明涉及用于朊病毒去污的方法,其包括(i)使待去污染的实体与洗涤剂接触,(ii)使所述实体与一种或多种蛋白酶接触,和任选地(iii)高压灭菌所述实体。 本发明还涉及包含用于朊病毒去污的洗涤剂和蛋白酶的试剂盒,以及包含洗涤剂和蛋白酶用于朊病毒去污的组合物。