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15 条记录 (耗时 0.029 秒)

    Intraocular lens anchoring filament to lens element fixation method
    3.
    发明授权
    Intraocular lens anchoring filament to lens element fixation method 失效
    人工晶状体固定丝与透镜元件固定方法

    公开(公告)号：US4964206A

    公开(公告)日：1990-10-23

    申请号：US507855

    申请日：1990-04-12

    申请人： Randall L. Knoll ,  James E. Aysta ,  Wilhelm Lewon

    发明人： Randall L. Knoll ,  James E. Aysta ,  Wilhelm Lewon

    IPC分类号： A61F2/16

    CPC分类号： A61F2/1613 ,  A61F2002/1686 ,  Y10S623/901 ,  Y10T29/49812 ,  Y10T29/49885 ,  Y10T29/49945

    摘要： Disclosed is an intraocular lens comprising a lens element and a plurality of haptics extending therefrom, at least one of the haptics having an anchoring filament with an enlarged complete or partial mushroom-shaped end fixedly disposed inside a passage in the lens element. Also disclosed is a method for fixing a haptic having an anchoring filament to a lens element in a soft intraocular lens comprising the steps of (a) forming in the lens element a passage having a width that is less than the greatest width of the anchoring filament, (b) lubricating the anchoring filament of the haptic, the passage in the lens element, or both, (c) inserting the anchoring filament end-first into the passage, and (d) washing the intraocular lens to remove the lubricant.

    摘要翻译： 公开了一种包括透镜元件和从其延伸的多个触觉件的眼内透镜，至少一个触觉件具有锚固细丝，其具有固定地设置在透镜元件的通道内的扩大的完整或部分蘑菇形端。 还公开了一种用于将具有锚定细丝的触觉件固定到软性眼内透镜中的透镜元件的方法，包括以下步骤：（a）在透镜元件中形成宽度小于锚定细丝的最大宽度的通道 ，（b）润滑触觉件的锚固细丝，透镜元件中的通道或两者，（c）将锚定丝线首先插入通道中，以及（d）洗涤眼内透镜以除去润滑剂。

    Vascular prosthesis and method of making the same
    5.
    发明授权
    Vascular prosthesis and method of making the same 失效
    血管假体及其制作方法

    公开(公告)号：US4286341A

    公开(公告)日：1981-09-01

    申请号：US041607

    申请日：1979-05-23

    申请人： Raymond T. Greer ,  Bradley H. Vale ,  Randall L. Knoll

    发明人： Raymond T. Greer ,  Bradley H. Vale ,  Randall L. Knoll

    IPC分类号： A61F2/00 ,  A61F2/06 ,  A61L27/14 ,  A61L33/06 ,  A61F1/24

    CPC分类号： A61L27/14 ,  A61F2/06 ,  A61L33/064 ,  A61F2250/0023

    摘要： A vascular prosthesis and its method of fabrication. The prosthesis takes the form of a flexible and conformable support tube having a luminal surface formed of a smooth, homogenous, and substantially non-thrombogenic hydrogel having relatively small pores or microvoids suitable for tissue ingrowth but resistant to thrombus formation, and having an outer surface formed of essentially the same hydrogel having a heterogenous microstructure which includes relatively large pores or macrovoids especially suitable for cellular ingrowth from perigraft sources and attachment sites. In one embodiment, the tubular substrate is foraminous and the inner and outer hydrogel layers merge through the interstices of the substrate to provide a unified ground substance characterized by strata having selectively different pore characteristics for promoting effective endothelialization and for reducing possibilities of thrombotic occlusion.

    摘要翻译： 血管假体及其制造方法。 假体呈柔性且适形的支撑管的形式，其具有由光滑，均匀且基本上非血栓形成的水凝胶形成的腔表面，其具有适于组织向内生长但抗血栓形成但具有外表面的较小孔或微孔 由具有异质微结构的基本上相同的水凝胶形成，其包含相对较大的孔或大孔，特别适合于来自围网源和附着位点的细胞向内生长。 在一个实施方案中，管状基质是有孔的并且内部和外部水凝胶层合并通过基底的间隙以提供统一的研磨物质，其特征在于具有选择性不同的孔特性的层，用于促进有效的内皮化和减少血栓闭塞的可能性。

    Implantable medical device with compressible fixation member
    6.
    发明授权
    Implantable medical device with compressible fixation member 失效
    具有可压缩固定构件的植入式医疗装置

    公开(公告)号：US08676319B2

    公开(公告)日：2014-03-18

    申请号：US12915935

    申请日：2010-10-29

    申请人： Randall L. Knoll

    发明人： Randall L. Knoll

    IPC分类号： A61N1/375

    CPC分类号： A61N1/375

    摘要： An implantable medical device and method of implanting a medical device, the device including a housing surrounding an operative component and a resiliently deformable fixation member. The fixation member includes a ring shaped annulus circumscribing the housing and a plurality of elongated struts having a proximal end affixed to the housing and a distal end affixed to the annulus. The fixation member may be comprised of a hydrogel such that it may be in a smaller, dehydrated form during implantation, and then may absorb fluid to expand to a larger, hydrated form after insertion to engage the surrounding tissue.

    摘要翻译： 一种植入式医疗装置和植入医疗装置的方法，所述装置包括围绕操作部件的壳体和可弹性变形的固定部件。 固定构件包括环绕壳体的环形环形空间和多个细长支柱，其具有固定到壳体的近端和固定到环形空间的远端。 固定构件可以由水凝胶构成，使得其在植入期间可以处于较小的脱水形式，然后可以在插入之后吸收流体以扩大至更大的水合形式以接合周围组织。

    Microchanneled active fluid transport devices
    7.
    发明授权
    Microchanneled active fluid transport devices 失效
    微通道活性流体输送装置

    公开(公告)号：US06290685B1

    公开(公告)日：2001-09-18

    申请号：US09099269

    申请日：1998-06-18

    申请人： Thomas I. Insley ,  Raymond P. Johnston ,  Randall L. Knoll

    发明人： Thomas I. Insley ,  Raymond P. Johnston ,  Randall L. Knoll

    IPC分类号： A61M1100

    CPC分类号： F28F21/065 ,  A61M1/008 ,  F28F2260/02 ,  Y10S366/03

    摘要： An active fluid transport device (10, 40, 54, 60) that includes a layer (12) of polymeric material. The layer (12) has a structured surface (13) that includes a plurality of substantially discrete flow channels (16). The flow channels (16) have a minimum aspect ratio of about 10 to 1 and a hydraulic radius no greater than about 300 micrometers. The device may also include a connector (20, 55) that allows a potential source (14) external to the structured surface (13) to be placed in fluid communication with the discrete flow channels (16). The potential source (14) promotes fluid movement through the flow channels (16) from a first location to a second location.

    摘要翻译： 包括聚合物材料层（12）的主动流体输送装置（10,40,54,60）。 层（12）具有包括多个基本上离散的流动通道（16）的结构化表面（13）。 流动通道（16）具有约10比1的最小纵横比和不大于约300微米的液压半径。 该装置还可以包括允许结构化表面（13）外部的潜在源（14）与离散流动通道（16）流体连通的连接器（20,55）。 潜在源（14）促进流体通过流动通道（16）从第一位置运动到第二位置。

    System for enhanced cardiac function with combined PESP/NES
    8.
    发明授权
    System for enhanced cardiac function with combined PESP/NES 有权
    使用PESP / NES组合增强心脏功能的系统

    公开(公告)号：US07289850B2

    公开(公告)日：2007-10-30

    申请号：US11116941

    申请日：2005-04-28

    申请人： John E. Burnes ,  Lawrence J. Mulligan ,  Randall L. Knoll

    发明人： John E. Burnes ,  Lawrence J. Mulligan ,  Randall L. Knoll

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3627 ,  A61N1/36114 ,  A61N1/36564

    摘要： In some embodiments, a method of applying stimulation pulse therapy to excitable tissue may include one or more of the following steps: (a) delivering a PESP stimulation therapy to the excitable tissue for a cardiac cycle, (b) delivering a NES stimulation therapy to the excitable tissue during certain cardiac cycles, (c) determining physiologic demand of the patient based on at least one physiologic measurement, (d) determining physiologic demand being placed on a heart based on at least one physiologic measurement, and ceasing the delivery of the NES and PESP stimulation therapy when physiologic demand returns to a base level, and (e) determining physiologic demand being placed on a heart based on at least one physiologic measurement, and modulating the ratio of the number of cardiac cycles in which the NES stimulation therapy is delivered to the number of cardiac cycles in which the PESP stimulation therapy is delivered based on physiologic demand.

    摘要翻译： 在一些实施方案中，将刺激脉冲治疗应用于可兴奋组织的方法可以包括以下步骤中的一个或多个：（a）将PESP刺激疗法递送至心脏周期的可兴奋组织，（b）将NES刺激疗法递送至 （c）基于至少一个生理测量来确定患者的生理需求，（d）基于至少一个生理测量来确定置于心脏上的生理需求，并且停止递送 NES和PESP刺激治疗，当生理需求恢复到基础水平时，以及（e）基于至少一个生理测量来确定置于心脏上的生理需求，以及调节NES刺激疗法的心脏周期数 基于生理需求被传递到其中递送PESP刺激疗法的心脏周期数。