公开(公告)号：US20070099955A1

公开(公告)日：2007-05-03

申请号：US11552169

申请日：2006-10-24

申请人： Gregory Shutske ,  Keith Harris ,  Kenneth Bordeau ,  Michael Angelastro ,  Stanly John ,  Joseph Klein ,  Jinqi Lu ,  Catherine Bomont

发明人： Gregory Shutske ,  Keith Harris ,  Kenneth Bordeau ,  Michael Angelastro ,  Stanly John ,  Joseph Klein ,  Jinqi Lu ,  Catherine Bomont

IPC分类号： A61K31/4709 ,  A61K31/452 ,  C07D405/02

CPC分类号： C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： The present invention provides compounds of formula I: a stereoisomer or a pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, X and n are defined as defined herein. Additionally, a method for treating dopamine-related neurological disorders selected form the group consisting of neurological, psychological, cardiovascular, cognitive or attention disorders, substance abuse and addictive behavior, or a combination thereof, comprising administering to a patient in need of such treatment a therapeutically effective amount of compounds of formula I.

摘要翻译： 本发明提供式I化合物：其立体异构体或其药学上可接受的盐，其中R 1，R 2，R 3， R 4，X和n定义如本文所定义。 另外，一种治疗多巴胺相关神经系统疾病的方法，其选自神经学，心理学，心血管学，认知或注意障碍，药物滥用和成瘾行为或其组合，其包括向需要这种治疗的患者施用 治疗有效量的式I化合物。

公开(公告)号：US07652007B2

公开(公告)日：2010-01-26

申请号：US10779439

申请日：2004-02-13

申请人： Stefanie Flohr ,  Siegfried Stengelin ,  Matthias Gossel ,  Thomas Klabunde ,  Petra Stahl ,  Pavel Safar ,  James Spoonamore ,  Martin Smrcina ,  Joseph Klein ,  Gregory Merriman ,  Brian Whiteley ,  Carolina Lanter ,  Kenneth Bordeau ,  Zhaoxia Yang

发明人： Stefanie Flohr ,  Siegfried Stengelin ,  Matthias Gossel ,  Thomas Klabunde ,  Petra Stahl ,  Pavel Safar ,  James Spoonamore ,  Martin Smrcina ,  Joseph Klein ,  Gregory Merriman ,  Brian Whiteley ,  Carolina Lanter ,  Kenneth Bordeau ,  Zhaoxia Yang

IPC分类号： C07D487/00 ,  A61K31/495 ,  A01N43/60

CPC分类号： C07D487/04

摘要： Nitrogen-substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives, processes for the preparation and their use as medicamentsThe invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof.Compounds of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for preparing them are described. The compounds are suitable for example as anorectic agents.

摘要翻译： 氮取代六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物，其制备方法及其作为药物的用途本发明涉及取代的六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物 以及其生理上耐受的盐和生理功能衍生物。 描述了其中基团具有所述含义的式I化合物及其生理上耐受的盐及其制备方法。 该化合物适合于例如厌食剂。

公开(公告)号：US20050085483A1

公开(公告)日：2005-04-21

申请号：US10779439

申请日：2004-02-13

申请人： Stefanie Flohr ,  Siegfried Stengelin ,  Matthias Gossel ,  Thomas Klabunde ,  Petra Stahl ,  Pavel Safar ,  James Spoonamore ,  Martin Smrcina ,  Joseph Klein ,  Gregory Merriman ,  Brian Whiteley ,  Carolina Lanter ,  Kenneth Bordeau ,  Zhaoxia Yang

发明人： Stefanie Flohr ,  Siegfried Stengelin ,  Matthias Gossel ,  Thomas Klabunde ,  Petra Stahl ,  Pavel Safar ,  James Spoonamore ,  Martin Smrcina ,  Joseph Klein ,  Gregory Merriman ,  Brian Whiteley ,  Carolina Lanter ,  Kenneth Bordeau ,  Zhaoxia Yang

IPC分类号： C07D487/04 ,  A61K31/519

CPC分类号： C07D487/04

摘要： Nitrogen-substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives, processes for the preparation and their use as medicaments The invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof. in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for preparing them are described. The compounds are suitable for example as anorectic agents.

摘要翻译： 氮取代六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物，其制备方法及其作为药物的用途本发明涉及取代的六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物 以及其生理上耐受的盐和生理功能衍生物。 其中基团具有所述含义，并且描述了其生理上耐受的盐及其制备方法。 该化合物适合于例如厌食剂。

公开(公告)号：US20070197539A1

公开(公告)日：2007-08-23

申请号：US11677067

申请日：2007-02-21

申请人： Petra Lennig ,  Siegfried Stengelin ,  Thomas Klabunde ,  Matthias Gossel ,  Pavel Safar ,  Martin Smrcina ,  James Spoonamore ,  Gregory Merriman ,  Joseph Klein ,  Brian Whiteley ,  Carolina Lanter ,  Kenneth Bordeau ,  Zhaoxia Yang

发明人： Petra Lennig ,  Siegfried Stengelin ,  Thomas Klabunde ,  Matthias Gossel ,  Pavel Safar ,  Martin Smrcina ,  James Spoonamore ,  Gregory Merriman ,  Joseph Klein ,  Brian Whiteley ,  Carolina Lanter ,  Kenneth Bordeau ,  Zhaoxia Yang

IPC分类号： A61K31/519 ,  C07D487/04

CPC分类号： C07D487/04

摘要： The invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives substituted with amino acids, and to the physiologically tolerated salts thereof, processes for their preparation and their use as medicaments

摘要翻译： 本发明涉及被氨基酸取代的取代六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物及其生理学上可耐受的盐，其制备方法及其用作药物

公开(公告)号：US11279484B2

公开(公告)日：2022-03-22

申请号：US16259297

申请日：2019-01-28

申请人： Joseph Klein

发明人： Joseph Klein

IPC分类号： B64D1/18 ,  B64C39/02 ,  A62C3/02

摘要： An aircraft for unmanned firefighting may include a water tank fillable via a scoop operation during flight of the aircraft, and configured to be emptied by a release operation at a target of interest, a communications module configured to employ wireless communication via a ground link and/or a satellite link to provide real time or near real time communication with a remote configuration or monitoring facility, an imaging module configured to obtain image data at the target of interest for identifying updated target information, and a navigation module configured to enable remote or autonomous operation of the aircraft during the scoop operation and the release operation.

公开(公告)号：US07436363B1

公开(公告)日：2008-10-14

申请号：US11864261

申请日：2007-09-28

申请人： Joseph Klein ,  Vladimir Kimelblat

发明人： Joseph Klein ,  Vladimir Kimelblat

IPC分类号： H01Q1/38

CPC分类号： H01Q9/0414 ,  H01Q5/00 ,  H01Q5/378 ,  H01Q19/005

摘要： The present invention is a dual frequency and circularly polarized microstrip antenna with a ground plane, a mid layer above the ground plane with a parasitically driven resonant mid patch (for transmissions at a second frequency), a top layer with a directly driven patch parasitically driving the mid patch (for transmissions at a first frequency), and parasitic elements.

摘要翻译： 本发明是一种双频和圆极化微带天线，具有接地平面，地面上方的中间层，具有寄生驱动谐振中间贴片（用于在第二频率传输），具有直接驱动贴片寄生驱动的顶层 中间补丁（用于第一个频率的传输）和寄生元件。

公开(公告)号：US5298907A

公开(公告)日：1994-03-29

申请号：US905796

申请日：1992-06-29

申请人： Joseph Klein

发明人： Joseph Klein

IPC分类号： H01Q1/12 ,  H01Q21/24 ,  H01Q1/32 ,  H01Q1/50

CPC分类号： H01Q21/24 ,  H01Q1/1285

摘要： A vehicle antenna for a cellular telephone has a balanced-unbalanced (BALUN) transformer that is connected to the telephone and is coupled to a horizontally polarized antenna on the interior of the vehicle and to a vertically polarized antenna that is located on the exterior of the vehicle. The vertically polarized component of a received signal is combined with the horizontally polarized component of the same signal in the transformer element and is applied to the cellular telephone. Signals to be transmitted are applied to the the transformer element and are divided into two portions, one of which is applied to the vertically polarized antenna and the other of which is applied to the horizontally polarized antenna. Because signals from a remote cellular transmitter cell arrive with both a vertical and a horizontal component, the antenna of the present invention retrieves the horizontal component which would otherwise be lost and combines it with the vertical component for more reliable signal reception.

摘要翻译： 用于蜂窝电话的车载天线具有连接到电话的平衡不平衡（BALUN）变压器，并且耦合到车辆内部的水平极化天线和位于车辆外部的垂直极化天线 车辆。 接收信号的垂直极化分量与变压器元件中相同信号的水平极化分量组合，并被施加到蜂窝电话。 要发送的信号被施加到变压器元件并且被分成两部分，其中一个被施加到垂直极化天线，并且另一个施加到水平极化天线。 因为来自远程蜂窝发射机小区的信号同时到达垂直和水平分量，所以本发明的天线检索否则将丢失的水平分量，并且将其与垂直分量相组合，以便更可靠的信号接收。

公开(公告)号：US09755585B1

公开(公告)日：2017-09-05

申请号：US15256880

申请日：2016-09-06

申请人： Joseph Klein

发明人： Joseph Klein

IPC分类号： H03G3/20 ,  H03F1/34 ,  H03F3/193 ,  H03F3/21

CPC分类号： H03F3/21 ,  H03F1/0227 ,  H03F1/0238 ,  H03F1/30 ,  H03F3/193 ,  H03F2200/102 ,  H03F2200/195 ,  H03F2200/207 ,  H03F2200/321 ,  H03F2200/447 ,  H03F2200/451 ,  H03F2200/468

摘要： The present invention provides an RF power amplifier architecture which with dynamic digital control of the amplification by incorporating digitized RF input and output signal envelope data and environmental temperature sensor(s) readings into an arbitrary control algorithm implemented on a digital processor. Via the combination of digitally controlled DC/DC converter and a D/A converter, the quiescent bias of the power FET of the RF output stage can become a realization of virtually any function of the feedback and input data.

公开(公告)号：US20080039456A1

公开(公告)日：2008-02-14

申请号：US11794764

申请日：2006-01-05

申请人： Joel Gelder ,  Joseph Klein ,  Yochai Basel ,  Anat Reizelman ,  Susanna Tchilibon ,  Orly Mouallem

发明人： Joel Gelder ,  Joseph Klein ,  Yochai Basel ,  Anat Reizelman ,  Susanna Tchilibon ,  Orly Mouallem

IPC分类号： A61K31/4188 ,  A61K31/429 ,  A61K31/437 ,  A61K31/53 ,  A61K31/5377 ,  A61P17/02 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P9/10 ,  C07D491/147 ,  C07D513/04 ,  C07D513/14 ,  C07D513/22

CPC分类号： A61K31/41

摘要： Disclosed are novel rigidified compounds having a rhodanine-like residue and at least one aryl or heteroaryl residue linked to the rhodanine-like residue, whereby a core structure of these compounds, as defined in the specification, is characterized as having one or zero free-to-rotate bonds. Also disclosed are pharmaceutical compositions containing these rigidified compounds and uses thereof for modulating the activity of heparanase and hence in the treatment of heparanase-associated diseases and disorders, and uses thereof for modulating the activity of heparin-binding proteins and hence in the treatment of heparin-binding proteins-associated diseases and disorders as well as in the treatment of medical conditions that are at least partially treatable by rhodanine or a rhodanine analog.

摘要翻译： 公开了具有绕丹宁样残基和连接到绕丹宁样残基的至少一个芳基或杂芳基残基的新型硬化化合物，由此如说明书中所定义的这些化合物的核心结构的特征在于具有一个或多个自由基， 旋转键。 还公开了含有这些硬化化合物的药物组合物及其用于调节乙酰肝素酶的活性，因此用于治疗乙酰肝素酶相关疾病和病症的用途及其用于调节肝素结合蛋白的活性的用途，因此用于治疗肝素 结合蛋白相关的疾病和病症，以及治疗至少可以通过绕丹宁或绕丹宁类似物治疗的医学病症。

公开(公告)号：US20080009929A1

公开(公告)日：2008-01-10

申请号：US11823521

申请日：2007-06-28

申请人： Charmaine Harris ,  Joseph Klein

发明人： Charmaine Harris ,  Joseph Klein

IPC分类号： A61N1/05

CPC分类号： A61M29/00 ,  A61B17/34 ,  A61B17/3401 ,  A61B17/3468 ,  A61M25/0102 ,  A61M25/06 ,  A61M25/0662 ,  A61N1/0551 ,  A61N1/0553

摘要： In general, the invention is directed to a technique for percutaneously introducing a stimulation lead into a target stimulation site via the epidural region proximate the spine of a patient. The process of introducing the stimulation lead may include the use of a hollow stimulation lead introducer, which comprises an elongated sheath and an elongated dilator. The dilator fits within the sheath and serves to widen a path through the epidural region for the introduction of a stimulation lead. At least a portion of the stimulation lead introducer has an oblong cross-section, allowing passage of stimulation leads such as paddle leads. The stimulation lead introducer may enter the epidural region proximate a spine of a patient via a guidewire. The stimulation lead introducer provides a path through the epidural region of a patient to a target stimulation site. A stimulation lead may travel through the path to reach the target stimulation site where it may provide therapy to the patient.

摘要翻译： 通常，本发明涉及一种经刺激引线经由靠近患者脊柱的硬膜外区域经皮引入目标刺激部位的技术。 引入刺激引线的过程可以包括使用中空刺激引导引导器，其包括细长护套和细长扩张器。 扩张器适合护套内，用于扩大通过硬膜外区域的路径以引入刺激引线。 刺激引导引导器的至少一部分具有长方形横截面，允许刺激引线例如桨导线通过。 刺激引导引导器可经由导丝进入患者脊柱附近的硬膜外区域。 刺激引导引导器提供穿过患者的硬膜外区域到目标刺激部位的路径。 刺激引线可以穿过路径到达目标刺激部位，在那里可以向患者提供治疗。