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公开(公告)号：US6032464A
公开(公告)日：2000-03-07
申请号：US234236
申请日：1999-01-20
CPC分类号： F25B9/145 , F02G1/02 , F02G2243/54 , F25B2309/1403 , F25B2309/1405 , F25B2309/1413 , F25B2309/1415
摘要： A traveling-wave device is provided with the conventional moving pistons eliminated. Acoustic energy circulates in a direction through a fluid within a torus. A side branch may be connected to the torus for transferring acoustic energy into or out of the torus. A regenerator is located in the torus with a first heat exchanger located on a first side of the regenerator downstream of the regenerator relative to the direction of the circulating acoustic energy; and a second heat exchanger located on an upstream side of the regenerator. The improvement is a mass flux suppressor located in the torus to minimize time-averaged mass flux of the fluid. In one embodiment, the device further includes a thermal buffer column in the torus to thermally isolate the heat exchanger that is at the operating temperature of the device.
摘要翻译： 提供了消除常规移动活塞的行波装置。 声能在通过环面内的流体的方向上循环。 侧分支可以连接到环面以将声能传递到环面中或从环面传出。 再生器位于环形区域中，第一热交换器相对于循环声能的方向位于再生器下游的再生器的第一侧; 以及位于再生器的上游侧的第二热交换器。 改进是位于环面中的质量通量抑制器，以最小化流体的时间平均质量通量。 在一个实施例中，该装置还包括在环面中的热缓冲塔，以热隔离处于设备的工作温度的热交换器。
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公开(公告)号：US06658862B2
公开(公告)日：2003-12-09
申请号：US10125268
申请日：2002-04-18
IPC分类号： F25B900
CPC分类号： F02G1/0435 , F02G2243/54 , F25B9/145 , F25B2309/1402 , F25B2309/1407
摘要： A thermoacoustic device is formed with a resonator system defining at least one region of high specific acoustic impedance in an acoustic wave within the resonator system. A plurality of thermoacoustic units are cascaded together within the region of high specific acoustic impedance, where at least one of the thermoacoustic units is a regenerator unit.
摘要翻译： 热声装置形成有谐振器系统，其在谐振器系统内的声波中限定至少一个具有高声阻抗的区域。 多个热声单元在高声学阻抗的区域内级联在一起，其中至少一个热声单元是再生器单元。
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3.发明授权Method and apparatus for rapid stopping and starting of a thermoacoustic engine 失效用于快速停止和启动热声发动机的方法和装置公开(公告)号：US06644028B1
公开(公告)日：2003-11-11
申请号：US10176311
申请日：2002-06-20
IPC分类号： F01B2908
CPC分类号： F25B9/14 , F02G2243/54 , F25B9/145 , F25B2309/1403 , F25B2309/1424
摘要： A thermoacoustic engine-driven system with a hot heat exchanger, a regenerator or stack, and an ambient heat exchanger includes a side branch load for rapid stopping and starting, the side branch load being attached to a location in the thermoacoustic system having a nonzero oscillating pressure and comprising a valve, a flow resistor, and a tank connected in series. The system is rapidly stopped simply by opening the valve and rapidly started by closing the valve.
摘要翻译： 具有热交换器，再生器或堆叠的热声发动机驱动系统和环境热交换器包括用于快速停止和起动的侧分支负载，该侧分支负载附接到具有非零振荡的热声系统中的位置 压力并且包括串联连接的阀，流阻器和罐。 系统通过打开阀门即可快速停止，并通过关闭阀门快速启动。
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公开(公告)号：US6021643A
公开(公告)日：2000-02-08
申请号：US41374
申请日：1998-03-11
申请人： Gregory W. Swift , David L. Gardner
发明人： Gregory W. Swift , David L. Gardner
CPC分类号： F25B9/145 , F25J1/0007 , F25J1/001 , F25J1/0012 , F25J1/0022 , F25J1/0225 , F02G2243/52 , F25B2309/1407 , F25B2309/1408 , F25B2309/1411 , F25B2309/1419 , F25B2309/1423 , F25B2309/1424 , F25J2270/91
摘要： An orifice pulse tube refrigerator (PTR) having a pulse tube and a reservoir with a compliance value C is provided with a variable acoustic impedance connecting the pulse tube and the reservoir. The variable acoustic impedance includes two or more variable impedances, which may be an inertance and valves forming variable resistive members, wherein the resulting acoustic impedance has a phase angle that is variable for improved cooling efficiency. The inertance may also be variable to further provide for varying the phase angle. In another improvement, an acoustic transmission line connects the pulse tube and a driver unit for recovering power from the pulse tube for return to the driver to further increase the PTR operating efficiency.
摘要翻译： 具有脉冲管和符合值C的储存器的孔脉冲管制冷器（PTR）具有连接脉冲管和储存器的可变声阻抗。 可变声阻抗包括两个或多个可变阻抗，其可以是形成可变电阻构件的惯性和阀，其中所得到的声阻抗具有可变的相位角，以提高冷却效率。 惯性也可以是变化的，以进一步提供改变相位角。 在另一个改进中，声传输线连接脉冲管和驱动器单元，用于从脉冲管恢复功率以返回到驱动器，以进一步提高PTR操作效率。
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公开(公告)号：US5826571A
公开(公告)日：1998-10-27
申请号：US659723
申请日：1996-06-06
CPC分类号： A61M15/0091 , A61M15/0068 , A61M15/009
摘要： An inhalation device is provided for use with pressurized metered dose inhalers (MDIs). The device includes a mechanical mechanism for applying the force required to discharge the MDI, a breath-activated trigger for activating this mechanical mechanism, an auto-return mechanism for insuring recovery of the aerosol canister from the fired position and a dose counter for counting the doses dispensed or available. Arming of the device is achieved by removing the protective mouthpiece cover/dust cap. Activation of the MDI is set to occur at a point subsequent to the beginning of inhalation.
摘要翻译： 提供吸入装置用于加压计量吸入器（MDIs）。 该装置包括用于施加排出MDI所需的力的机械机构，用于启动该机械机构的呼吸启动触发器，用于确保气溶胶罐从燃烧位置恢复的自动返回机构，以及用于计数 剂量分配或可用。 通过拆下保护接口盖/防尘盖来实现设备的布防。 MDI的激活设置为在吸入开始之后的某一时刻发生。
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6.发明授权Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament 失效干粉药物吸入器，其具有用于触发药物递送的吸入激活流转移装置
公开(公告)号：US5692496A
公开(公告)日：1997-12-02
申请号：US690989
申请日：1996-08-01
CPC分类号： A61M15/0028 , A61M15/003 , A61M15/0033 , A61M15/0065 , A61M15/0091 , A61M2202/064
摘要： An inhalation-activated inhalator having a flow diverting means wherein the primary air flow channel is blocked for a brief period during inspiration with air flow during that period passing through a dosing chamber arrangement and connecting passage to inject medicament into the inspired air stream is provided. By diverting the inspired air stream in this fashion, powdered medicament may be provided for inhalation at a particular point in the patient's inspiration cycle, thereby optimizing the delivery of medicament to the lungs.
摘要翻译： 一种具有分流装置的吸入激活吸入器，其特征在于，在通过计量室装置的所述时间段期间，气流在空气流动期间短暂的一段时间内被阻塞，并且连接通道将药剂注入吸气空气流中。 通过以这种方式转移启发的气流，可以在患者的吸气周期中的特定点处提供粉末状药物用于吸入，从而优化药物向肺的递送。
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公开(公告)号：US4532123A
公开(公告)日：1985-07-30
申请号：US466500
申请日：1983-02-18
申请人： David L. Gardner
发明人： David L. Gardner
CPC分类号： B01J13/025 , A01N25/28 , A61K9/5073 , B01J13/125 , Y10S424/07 , Y10T428/2984 , Y10T428/2985
摘要： Dual Microcapsules are disclosed. The outer membrane encapsulates a liquid having one or more smaller microcapsules (Mini-Microcapsules) suspended therein. The Mini-Microcapsules contain a conjugate or a reaction product of a Drug which diffuses into the liquid in which Mini-Microcapsules are suspended. The suspending liquid contains an enzyme which reacts with Drug complex or reaction product to regenerate or release the Drug. The drug diffuses through the outer membrane into a host.
摘要翻译： 公开了双微胶囊。 外膜包封具有悬浮在其中的一个或多个较小微胶囊（微型微胶囊）的液体。 微型微胶囊含有扩散到悬浮有微型微胶囊的液体中的药物的缀合物或反应产物。 悬浮液含有与药物复合物或反应产物反应以再生或释放药物的酶。 药物通过外膜扩散到宿主体内。
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公开(公告)号：US07051734B2
公开(公告)日：2006-05-30
申请号：US10685187
申请日：2003-10-14
申请人： Robert A. Casper , John M. Snow , David L. Gardner , Vincent J. Sullivan , Anjana Bhuta Wills , Lawrence A. Monahan , Christopher J. Knors
发明人： Robert A. Casper , John M. Snow , David L. Gardner , Vincent J. Sullivan , Anjana Bhuta Wills , Lawrence A. Monahan , Christopher J. Knors
CPC分类号： B05B11/061 , A61M11/02 , A61M15/0028 , A61M15/0031 , A61M15/0081 , A61M15/08 , A61M2202/04 , A61M2202/064 , A61M2205/073 , B05B11/062
摘要： A medicament respiratory delivery device including a housing having a chamber including coaxially aligned inlet and outlet, a medicament cartridge located within the chamber having a passage therethrough and membranes sealing the passage having a burst pressure of less than 10 atmospheres, a manually actuatable fluid delivery device having an outlet in fluid communication with the chamber and a manually actuated valve located between the outlet of the fluid delivery device and the chamber inlet for delivery of fluid under pressure to the valve. The medicament respiratory delivery device of this invention may be utilized to deliver a controlled unit dose of an aerosolizable medicament on demand by first pressurizing a pressure chamber in the pressure delivery device upstream of the valve, then opening the valve to open the membranes and express the medicament through the chamber outlet.
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公开(公告)号：US06561186B2
公开(公告)日：2003-05-13
申请号：US09995923
申请日：2001-11-27
申请人： Robert A. Casper , Frank A. Leith , David L. Gardner , John M. Snow , Zachary W. Lyon , David S. Farrar
发明人： Robert A. Casper , Frank A. Leith , David L. Gardner , John M. Snow , Zachary W. Lyon , David S. Farrar
IPC分类号： A61M1500
CPC分类号： A61M15/0028 , A61M11/001 , A61M11/002 , A61M15/003 , A61M15/0033 , A61M15/0065 , A61M15/0091 , A61M15/0093 , A61M2202/064
摘要： An inhalation-activated inhalator having a primary inhalation passage and a secondary inhalation passage disposed in communication with the primary inhalation passage and a source of medicament. The primary inhalation passage has airflow inhibiting mechanism connected to a blocking plate positioned to selectively block fluid flow in the secondary inhalation passage. As the user's inhalation reaches a defined rate, the flow inhibiting mechanism restricts flow through the primary inhalation passage and moves the blocking plate to enable airflow through the secondary passage. Thus, as the user achieves a desired inhalation rate, the medicament is provided through the secondary inhalation passage, thereby optimizing the delivery of medicament to the lungs.
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公开(公告)号：US06550477B1
公开(公告)日：2003-04-22
申请号：US09492714
申请日：2000-01-27
申请人： Robert A. Casper , Frank A. Leith , David L. Gardner , John M. Snow , Zachary W. Lyon , David S. Farrar
发明人： Robert A. Casper , Frank A. Leith , David L. Gardner , John M. Snow , Zachary W. Lyon , David S. Farrar
IPC分类号： A61M1600
CPC分类号： A61M15/0028 , A61M11/001 , A61M11/002 , A61M15/003 , A61M15/0033 , A61M15/0065 , A61M15/0091 , A61M15/0093 , A61M2202/064
摘要： An inhalation-activated inhalator having a primary inhalation passage and a secondary inhalation passage disposed in communication with the primary inhalation passage and a source of medicament. The primary inhalation passage has airflow inhibiting mechanism connected to a blocking plate positioned to selectively block fluid flow in the secondary inhalation passage. As the user's inhalation reaches a defined rate, the flow inhibiting mechanism restricts flow through the primary inhalation passage and moves the blocking plate to enable airflow through the secondary passage. Thus, as the user achieves a desired inhalation rate, the medicament is provided through the secondary inhalation passage, thereby optimizing the delivery of medicament to the lungs.
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