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    APPARATUS AND METHOD FOR OBTAINING AND PROVIDING IMAGING INFORMATION ASSOCIATED WITH AT LEAST ONE PORTION OF A SAMPLE, AND EFFECTING SUCH PORTION(S)
    4.
    发明申请
    APPARATUS AND METHOD FOR OBTAINING AND PROVIDING IMAGING INFORMATION ASSOCIATED WITH AT LEAST ONE PORTION OF A SAMPLE, AND EFFECTING SUCH PORTION(S) 有权
    用于获取和提供与至少一个样品部分相关的成像信息的装置和方法，以及影响这些部分

    公开(公告)号：US20130066215A1

    公开(公告)日：2013-03-14

    申请号：US13614459

    申请日：2012-09-13

    申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin

    发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin

    IPC分类号： A61B1/07

    CPC分类号： A61B1/07 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B18/22 ,  A61B2017/00061

    摘要： Exemplary apparatus and process can be provided for imaging information associated with at least one portion of a sample. For example, (i) first different wavelengths of at least one first electro-magnetic radiation can be provided within a first wavelength range provided on the portion of the sample so as to determine at least one first transverse location of the portion, and (ii) second different wavelengths of at least one second electro-magnetic radiation within a second wavelength range can be provided on the portion so as to determine at least one second transverse location of the portion. The first and second ranges can east partially overlap on the portion. Further, a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference can be obtained to determine a relative depth location of the portion.

    摘要翻译： 可以提供示例性装置和过程用于与样品的至少一部分相关联的成像信息。 例如，（i）可在提供在样品部分上的第一波长范围内提供至少一个第一电磁辐射的第一不同波长，以便确定该部分的至少一个第一横向位置，和（ii ）可以在该部分上提供在第二波长范围内的至少一个第二电磁辐射的第二不同波长，以便确定该部分的至少一个第二横向位置。 第一和第二范围可以在该部分上部分重叠。 此外，可以获得从样品返回的至少一个第三电磁辐射电磁辐射与从基准返回的至少一个第四电磁辐射之间的相对相位，以确定该部分的相对深度位置。

    SYSTEMS AND METHODS FOR GENERATING DATA USING ONE OR MORE ENDOSCOPIC MICROSCOPY TECHNIQUES
    5.
    发明申请
    SYSTEMS AND METHODS FOR GENERATING DATA USING ONE OR MORE ENDOSCOPIC MICROSCOPY TECHNIQUES 审中-公开
    使用一种或多种内窥镜显微技术产生数据的系统和方法

    公开(公告)号：US20070238955A1

    公开(公告)日：2007-10-11

    申请号：US11622854

    申请日：2007-01-12

    申请人： Guillermo J. Tearney ,  Nicusor Iftimia ,  Brett Eugene Bouma ,  Wang-Yuhl Oh

    发明人： Guillermo J. Tearney ,  Nicusor Iftimia ,  Brett Eugene Bouma ,  Wang-Yuhl Oh

    IPC分类号： A61B5/05

    CPC分类号： A61B5/0066 ,  A61B1/00096 ,  A61B1/00167 ,  A61B1/00172 ,  A61B1/06 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/0084 ,  G01B9/0205 ,  G01B9/02057 ,  G01B9/02079 ,  G01B9/02091 ,  G01N21/4795 ,  G02B23/2446

    摘要： Exemplary systems and methods for imaging at least one portion of a sample can be provided. For example, according to one exemplary embodiment of such systems and methods, it is possible to receive at least one first electro-magnetic radiation from the sample and at least one second electro-magnetic radiation from a reference using at least one arrangement. Such arrangement and the reference can be provided in an endoscope enclosure. The image data associated with the portion can be generated as a function of the first and second electro-magnetic radiations. In another exemplary embodiment, an endoscope arrangement can be provided for imaging such portion of the sample. The endoscope arrangement can include at least one interferometric arrangement configured to receive at least one electro-magnetic radiation from the sample, and situated within and at one end of an endoscope enclosure of the endoscope arrangement. According to yet another exemplary embodiment, at least one first Linnik interferometric arrangement at least one second fiber arrangement being in optical communication with the at least one first arrangement can be provided. The second arrangement can be configured to transmit an electro-magnetic radiation to the first arrangement. The first arrangement can be configured to receive an additional electro-magnetic radiation from the sample which can be associated with the first electro-magnetic radiation. The first arrangement can be configured to forward at least one third electro-magnetic radiation which is associated with the at least one second electro-magnetic radiation to the at least one second arrangement.

    摘要翻译： 可以提供用于对样品的至少一部分进行成像的示例性系统和方法。 例如，根据这样的系统和方法的一个示例性实施例，可以使用至少一种布置从样品和来自参考的至少一个第二电磁辐射接收至少一个第一电磁辐射。 这种布置和参考可以设置在内窥镜外壳中。 与该部分相关联的图像数据可以作为第一和第二电磁辐射的函数产生。 在另一个示例性实施例中，可以提供内窥镜装置用于对样品的这样的部分进行成像。 所述内窥镜装置可以包括至少一个干涉装置，其被配置为从所述样品接收至少一个电磁辐射，并且位于所述内窥镜装置的内窥镜罩的内部和一端。 根据另一示例性实施例，可以提供至少一个第一Linnik干涉布置，至少一个第二光纤布置与所述至少一个第一布置光学通信。 第二布置可以被配置为将电磁辐射传输到第一布置。 第一布置可以被配置为从样品接收可以与第一电磁辐射相关联的附加电磁辐射。 第一布置可以被配置为将与至少一个第二电磁辐射相关联的至少一个第三电磁辐射转发到至少一个第二布置。

    Methods and systems for performing angle-resolved fourier-domain optical coherence tomography
    6.
    发明授权
    Methods and systems for performing angle-resolved fourier-domain optical coherence tomography 有权
    用于进行角度分辨的傅里叶变换光学相干断层扫描的方法和系统

    公开(公告)号：US07982879B2

    公开(公告)日：2011-07-19

    申请号：US11677278

    申请日：2007-02-21

    申请人： Adrien E. Desjardins ,  Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett Eugene Bouma

    发明人： Adrien E. Desjardins ,  Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett Eugene Bouma

    IPC分类号： G01B9/02

    CPC分类号： G01N21/4795 ,  A61B5/0066 ,  A61B5/0073 ,  G01B9/02043 ,  G01B9/02087 ,  G01B9/02091 ,  G01B2290/70 ,  G01N2021/4714

    摘要： Arrangements, apparatus and methods are provided according to exemplary embodiments of the present invention. In particular, at least one first electro-magnetic radiation may be received and at least one second electro-magnetic radiation within a solid angle may be forwarded to a sample. The second electro-magnetic radiation may be associated with the first electro-magnetic radiation. A plurality of third electro-magnetic radiations can be received from the sample which is associated with the second electro-magnetic radiation, and at least one portion of the third electro-magnetic radiation is provided outside a periphery of the solid angle. Signals associated with each of the third electro-magnetic radiations can be simultaneously detected, with the signals being associated with information for the sample at a plurality of depths thereof. The depths can be determined using at least one of the third electro-magnetic radiations without a need to utilize another one of the third electro-magnetic radiations.

    摘要翻译： 根据本发明的示例性实施例提供了安排，装置和方法。 特别地，可以接收至少一个第一电磁辐射，并且将立体角内的至少一个第二电磁辐射转发到样品。 第二电磁辐射可以与第一电磁辐射相关联。 可以从与第二电磁辐射相关联的样品接收多个第三电磁辐射，并且第三电磁辐射的至少一部分设置在立体角的外围。 可以同时检测与每个第三电磁辐射相关联的信号，其中信号与样品在其多个深度处的信息相关联。 可以使用第三电磁辐射中的至少一个来确定深度，而不需要利用第三电磁辐射中的另一个。

    System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging
    7.
    发明授权
    System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging 有权
    可以使用频谱编码外差干涉测量技术进行成像的系统，方法和布置

    公开(公告)号：US07859679B2

    公开(公告)日：2010-12-28

    申请号：US11445131

    申请日：2006-05-31

    申请人： Brett Eugene Bouma ,  Guillermo J. Tearney ,  Dvir Yelin ,  Seok-Hyun Yun

    发明人： Brett Eugene Bouma ,  Guillermo J. Tearney ,  Dvir Yelin ,  Seok-Hyun Yun

    IPC分类号： G01B9/02 ,  G01B11/02

    CPC分类号： G01N21/4795 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/7257

    摘要： Systems, arrangements and methods for obtaining three-dimensional imaging data are provided. For example, a broadband light source can provide a particular radiation. A first electro-magnetic radiation can be focused and diffracted, and then provided to at least one sample to generate a spectrally-encoded line. A second electro-magnetic radiation may be provided to a reference, which may include a double-pass rapidly-scanning optical delay, where the first and second electro-magnetic radiations can be based on the particular radiation. An interference between a third electro-magnetic radiation (associated with the first electro-magnetic radiation) and a fourth electro-magnetic radiation (associated with the second electro-magnetic radiation) can be detected. The spectrally-encoded line may be scanned over the sample in a direction approximately perpendicular to the line. Image data containing three-dimensional information can then be obtained based on the interference. The exemplary imaging methods and systems can be used in a small fiber optic or endoscopic probe.

    摘要翻译： 提供了用于获得三维成像数据的系统，布置和方法。 例如，宽带光源可以提供特定的辐射。 可以将第一电磁辐射聚焦和衍射，然后提供给至少一个样品以产生光谱编码的线。 可以将第二电磁辐射提供给参考，其可以包括双遍快速扫描光学延迟，其中第一和第二电磁辐射可以基于特定辐射。 可以检测第三电磁辐射（与第一电磁辐射相关联）和第四电磁辐射（与第二电磁辐射相关联）之间的干扰。 光谱编码的线可以在大致垂直于线的方向上扫描样品。 然后可以基于干扰获得包含三维信息的图像数据。 示例性的成像方法和系统可以用于小型光纤或内窥镜探针。

    Systems and methods for generating data based on one or more spectrally-encoded endoscopy techniques
    8.
    发明授权
    Systems and methods for generating data based on one or more spectrally-encoded endoscopy techniques 有权
    基于一个或多个频谱编码的内窥镜技术产生数据的系统和方法

    公开(公告)号：US07796270B2

    公开(公告)日：2010-09-14

    申请号：US11621694

    申请日：2007-01-10

    申请人： Dvir Yelin ,  Seok-Hyun Yun ,  Brett Eugene Bouma ,  Guillermo J Tearney

    发明人： Dvir Yelin ,  Seok-Hyun Yun ,  Brett Eugene Bouma ,  Guillermo J Tearney

    IPC分类号： G01B9/02 ,  G01J3/45 ,  G01N21/00

    CPC分类号： G01N21/4795 ,  A61B5/0066 ,  A61B5/6852 ,  A61B5/7257 ,  A61B5/726 ,  G01B9/02002 ,  G01B9/02036 ,  G01B9/02037 ,  G01B9/02044 ,  G01B9/02091 ,  G01N21/359 ,  G01N2021/1782 ,  G01N2021/1787 ,  G01N2021/3595

    摘要： Exemplary systems and methods for generating data associated with at least one portion of a sample can be provided. For example, according to one exemplary embodiment of such systems and methods, it is possible to provide a particular radiation using at least one first arrangement. The particular radiation can include at least one first electro-magnetic radiation directed to at least one sample and at least one second electro-magnetic radiation directed to a reference arrangement. The first radiation and/or the second radiation can comprise a plurality of wavelengths. The first electro-magnetic radiation can be spectrally dispersed along at least one portion of the sample. The second electro-magnetic radiation measured at two or more different lengths of the reference arrangement with respect to the first arrangement. Data can be generated which is associated with the first and second electro-magnetic radiations obtained at the two different lengths using at least one second arrangement which comprises a spectrometer arrangement.

    摘要翻译： 可以提供用于产生与样品的至少一部分相关联的数据的示例性系统和方法。 例如，根据这样的系统和方法的一个示例性实施例，可以使用至少一个第一布置来提供特定的辐射。 特定的辐射可以包括被引导至至少一个样品的至少一个第一电磁辐射和指向参考装置的至少一个第二电磁辐射。 第一辐射和/或第二辐射可以包括多个波长。 第一电磁辐射可沿样品的至少一部分光谱分散。 在参考装置的两个或多个不同长度处相对于第一装置测量的第二电磁辐射。 可以生成与使用包括光谱仪布置的至少一个第二布置在两个不同长度获得的第一和第二电磁辐射相关联的数据。

    Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy
    9.
    发明授权
    Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy 有权
    使用光谱编码的内窥镜检查来测量振动的装置和方法

    公开(公告)号：US08045177B2

    公开(公告)日：2011-10-25

    申请号：US12104689

    申请日：2008-04-17

    申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin ,  Saumil Merchant ,  John Rosowski

    发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin ,  Saumil Merchant ,  John Rosowski

    IPC分类号： G01B11/02

    CPC分类号： A61B1/227 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/4504

    摘要： An apparatus and method according to an exemplary embodiment of to the present invention can provide imaging information associated with at least one portion of a sample. For example, at least two first different wavelengths of at least one first electro-magnetic radiation within a first wavelength range may be provided on the portion of the sample so as to determine at least one first transverse location of the portion. At least two second different wavelengths of at least one second electro-magnetic radiation may also be provided within a second wavelength range provided on the portion so as to determine at least one second transverse location of the portion. It is possible to obtain a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference to determine a motion of the portion or of particles within or on the portion, whereas the motion is effectuated by at least one of a sound wave. Further, the imaging information of the portion can be provided based on the first transverse location, the second transverse location and the motion.

    摘要翻译： 根据本发明的示例性实施例的装置和方法可以提供与样本的至少一部分相关联的成像信息。 例如，可以在样品的部分上提供在第一波长范围内的至少一个第一电磁辐射的至少两个第一不同波长，以便确定该部分的至少一个第一横向位置。 还可以在设置在该部分上的第二波长范围内提供至少两个第二不同波长的至少一个第二电磁辐射，以便确定该部分的至少一个第二横向位置。 可以获得从样品返回的至少一个第三电磁辐射电磁辐射和从参考返回的至少一个第四电磁辐射之间的相对相位，以确定该部分或颗粒的运动 或者在该部分上，而运动由声波中的至少一个来实现。 此外，可以基于第一横向位置，第二横向位置和运动来提供该部分的成像信息。