-
公开(公告)号：US20130078217A1
公开(公告)日：2013-03-28
申请号：US13624093
申请日：2012-09-21
申请人： Guoqiang Wang , In Jong Kim , Yat Sun Or
发明人： Guoqiang Wang , In Jong Kim , Yat Sun Or
IPC分类号： C07H19/06 , C07H19/10 , A61K45/06 , C07H19/14 , C07H19/12 , A61K31/706 , C07H19/16 , A61K31/7076 , A61K31/7072 , A61K38/21
CPC分类号： C07H19/06 , A61K31/015 , A61K31/427 , A61K31/7056 , A61K31/706 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K38/21 , A61K38/212 , A61K38/215 , A61K45/06 , C07H19/067 , C07H19/073 , C07H19/10 , C07H19/11 , C07H19/12 , C07H19/14 , C07H19/16 , C07H19/167 , C07H19/173 , C07H19/207 , C07H19/213 , A61K2300/00
摘要： The present invention relates to 2′-chloroacetylenyl-substituted nucleoside derivatives of the general formula (I): As well as pharmaceutical compositions comprising such compounds and methods to treat or prevent an HIV infection, HBV infection, HCV infection or abnormal cellular proliferation, comprising administering said compounds or compositions. In addition, the present invention includes processes for the preparation of such compounds, and the related β-D and β-L-nucleoside derivatives.
摘要翻译： 本发明涉及通式（I）的2'-氯乙酰基取代的核苷衍生物：以及包含这些化合物的药物组合物以及治疗或预防HIV感染，HBV感染，HCV感染或异常细胞增殖的方法，包括 给药所述化合物或组合物。 此外，本发明包括制备这些化合物的方法，以及相关的β-和β-半胱氨酸衍生物。
-
公开(公告)号：US20090264380A1
公开(公告)日：2009-10-22
申请号：US12399801
申请日：2009-03-06
申请人： In Jong Kim , Tongzhu Liu , Jiang Long , Guoqiang Wang , Yao-Ling Qiu , Heejin Kim , Yanchun Wang , Ly Tam Phan , Yat Sun Or
发明人： In Jong Kim , Tongzhu Liu , Jiang Long , Guoqiang Wang , Yao-Ling Qiu , Heejin Kim , Yanchun Wang , Ly Tam Phan , Yat Sun Or
IPC分类号： A61K31/7048 , C07H17/08 , A61P31/04 , A61P29/00
CPC分类号： C07D493/08 , C07F9/65586 , C07H17/08
摘要： The present invention discloses compounds of formula I, II or X, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I，II或X的化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
-
公开(公告)号：US08354383B2
公开(公告)日：2013-01-15
申请号：US12399801
申请日：2009-03-06
申请人： In Jong Kim , Tongzhu Liu , Jiang Long , Guoqiang Wang , Yao-Ling Qiu , Heejin Kim , Yanchun Wang , Ly Tam Phan , Yat Sun Or
发明人： In Jong Kim , Tongzhu Liu , Jiang Long , Guoqiang Wang , Yao-Ling Qiu , Heejin Kim , Yanchun Wang , Ly Tam Phan , Yat Sun Or
CPC分类号： C07D493/08 , C07F9/65586 , C07H17/08
摘要： The present invention discloses compounds of formula I, II or X, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I，II或X的化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
-
公开(公告)号：US20110206637A1
公开(公告)日：2011-08-25
申请号：US13032942
申请日：2011-02-23
申请人： Yat Sun Or , In Jong Kim , Guoqiang Wang , Jiang Long
发明人： Yat Sun Or , In Jong Kim , Guoqiang Wang , Jiang Long
CPC分类号： C07K7/56 , A61K38/21 , Y02A50/463 , A61K2300/00
摘要： The present invention provides antiviral compounds of formula (I), as well as pharmaceutical compositions comprising these compounds, methods for synthesizing these compounds and methods of using these compounds for treating a viral infection.
摘要翻译： 本发明提供式（I）的抗病毒化合物，以及包含这些化合物的药物组合物，合成这些化合物的方法和使用这些化合物治疗病毒感染的方法。
-
公开(公告)号：US08575119B2
公开(公告)日：2013-11-05
申请号：US13624093
申请日：2012-09-21
申请人： Guoqiang Wang , In Jong Kim , Yat Sun Or
发明人： Guoqiang Wang , In Jong Kim , Yat Sun Or
CPC分类号： C07H19/06 , A61K31/015 , A61K31/427 , A61K31/7056 , A61K31/706 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K38/21 , A61K38/212 , A61K38/215 , A61K45/06 , C07H19/067 , C07H19/073 , C07H19/10 , C07H19/11 , C07H19/12 , C07H19/14 , C07H19/16 , C07H19/167 , C07H19/173 , C07H19/207 , C07H19/213 , A61K2300/00
摘要： The present invention relates to 2′-chloroacetylenyl-substituted nucleoside derivatives of the general formula (I): As well as pharmaceutical compositions comprising such compounds and methods to treat or prevent an HIV infection, HBV infection, HCV infection or abnormal cellular proliferation, comprising administering said compounds or compositions. In addition, the present invention includes processes for the preparation of such compounds, and the related β-D and β-L-nucleoside derivatives.
摘要翻译： 本发明涉及通式（I）的2'-氯乙酰基取代的核苷衍生物：以及包含这些化合物的药物组合物以及治疗或预防HIV感染，HBV感染，HCV感染或异常细胞增殖的方法，包括 给药所述化合物或组合物。 此外，本发明包括制备这些化合物的方法和相关的β-D和β-L-核苷衍生物。
-
公开(公告)号：US20120237480A1
公开(公告)日：2012-09-20
申请号：US13422268
申请日：2012-03-16
申请人： YAT SUN OR , Jun Ma , Guoqiang Wang , In Jong Kim , Jiang Long , Yao-Ling Qiu
发明人： YAT SUN OR , Jun Ma , Guoqiang Wang , In Jong Kim , Jiang Long , Yao-Ling Qiu
IPC分类号： A61K31/706 , C07H19/12 , C07H19/173 , C07H19/044 , C07H19/10 , C07H19/20 , C07H19/11 , C07H19/213 , A61K31/7076 , A61K31/708 , A61K31/7068 , A61K31/7072 , A61P31/14 , A61K38/21 , A61P31/04 , A61P31/10 , A61P35/00 , A61P37/02 , C07H19/073
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/706 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/55 , A61K45/06 , A61K2300/00 , A61K31/426 , A61K31/13
摘要： The present invention relates to 2′-allene-substituted nucleoside derivatives of the general formula (I): As well as pharmaceutical compositions comprising such compounds and methods to treat or prevent an HIV infection, HBV infection, HCV infection or abnormal cellular proliferation, comprising administering said compounds or compositions. In addition, the present invention includes processes for the preparation of such compounds, and the related β-D and β-L-nucleoside derivatives.
摘要翻译： 本发明涉及通式（I）的2'-连烯取代的核苷衍生物：以及包含这些化合物的药物组合物以及治疗或预防HIV感染，HBV感染，HCV感染或异常细胞增殖的方法，包括 给药所述化合物或组合物。 此外，本发明包括制备这些化合物的方法，以及相关的β-和β-半胱氨酸衍生物。
-
公开(公告)号：US20090118506A1
公开(公告)日：2009-05-07
申请号：US12212596
申请日：2008-09-17
申请人： IN JONG KIM , Tongzhu Liu , Yao-Ling Qiu , Guoqiang Wang , Jiang Long , Heejin Kim , Yanchun Wang , Ly Tam Phan , Yat Sun Or
发明人： IN JONG KIM , Tongzhu Liu , Yao-Ling Qiu , Guoqiang Wang , Jiang Long , Heejin Kim , Yanchun Wang , Ly Tam Phan , Yat Sun Or
IPC分类号： C07D405/14 , C07D417/14 , C07D413/14 , C07D401/14
CPC分类号： C07H17/08 , C07D213/69 , C07D213/80 , C07D309/40 , C07D498/12
摘要： The present invention discloses compounds of formula I, II or, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I，II或其药学上可接受的盐，酯或前药的化合物：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
-
公开(公告)号：US08623814B2
公开(公告)日：2014-01-07
申请号：US13032942
申请日：2011-02-23
申请人： Yat Sun Or , In Jong Kim , Guoqiang Wang , Jiang Long
发明人： Yat Sun Or , In Jong Kim , Guoqiang Wang , Jiang Long
CPC分类号： C07K7/56 , A61K38/21 , Y02A50/463 , A61K2300/00
摘要： The present invention provides antiviral compounds of formula (I), as well as pharmaceutical compositions comprising these compounds, methods for synthesizing these compounds and methods of using these compounds for treating a viral infection.
摘要翻译： 本发明提供式（I）的抗病毒化合物，以及包含这些化合物的药物组合物，合成这些化合物的方法和使用这些化合物治疗病毒感染的方法。
-
公开(公告)号：US09085599B2
公开(公告)日：2015-07-21
申请号：US13422268
申请日：2012-03-16
申请人： Yat Sun Or , Jun Ma , Guoqiang Wang , In Jong Kim , Jiang Long , Yao-Ling Qiu
发明人： Yat Sun Or , Jun Ma , Guoqiang Wang , In Jong Kim , Jiang Long , Yao-Ling Qiu
IPC分类号： A61K31/706 , C07H19/12 , C07H19/173 , C07H19/044 , C07H19/10 , C07H19/11 , C07H19/06 , A61K38/55 , A61K45/06 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/706 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/55 , A61K45/06 , A61K2300/00 , A61K31/426 , A61K31/13
摘要： The present invention relates to 2′-allene-substituted nucleoside derivatives of the general formula (I): As well as pharmaceutical compositions comprising such compounds and methods to treat or prevent an HIV infection, HBV infection, HCV infection or abnormal cellular proliferation, comprising administering said compounds or compositions. In addition, the present invention includes processes for the preparation of such compounds, and the related β-D and β-L-nucleoside derivatives.
摘要翻译： 本发明涉及通式（I）的2'-连烯取代的核苷衍生物：以及包含这些化合物的药物组合物以及治疗或预防HIV感染，HBV感染，HCV感染或异常细胞增殖的方法，包括 给药所述化合物或组合物。 此外，本发明包括制备这些化合物的方法，以及相关的β-和β-半胱氨酸衍生物。
-
公开(公告)号：US09193740B2
公开(公告)日：2015-11-24
申请号：US12907614
申请日：2010-10-19
申请人： Yonghua Gai , Yat Sun Or , Guoqiang Wang
发明人： Yonghua Gai , Yat Sun Or , Guoqiang Wang
IPC分类号： C07D498/22 , A61K38/12 , A61K38/21 , A61P31/14 , A61K31/495 , A61K45/06
CPC分类号： C07D498/22 , A61K31/495 , A61K45/06
摘要： The present invention discloses compounds of formula Ia or Ib or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式Ia或Ib的化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
-
-
-
-
-
-
-
-
-
搜索结果
92 条记录 (耗时 0.038 秒)
