公开(公告)号：US09709588B2

公开(公告)日：2017-07-18

申请号：US14890253

申请日：2014-05-19

Applicant: Hitachi High-Technologies Corporation

Inventor： Akihisa Makino ,  Mitsuhiro Hishinuma ,  Toshiyuki Shimamori ,  Masato Ishizawa

IPC: G01N35/04 ,  G01N35/10 ,  G01N35/02 ,  G01N35/00

CPC classification number: G01N35/1065 ,  G01N35/00871 ,  G01N35/0095 ,  G01N35/02 ,  G01N35/025 ,  G01N35/026 ,  G01N35/10 ,  G01N2035/00801 ,  G01N2035/00831 ,  G01N2035/0462 ,  G01N2035/0465 ,  G01N2035/0496 ,  G01N2035/1051

Abstract: An automatic analyzer with high processing capacity is capable of immediately measuring an emergency specimen rack. The automatic analyzer includes a conveying line for conveying a specimen rack, and an analysis unit which has a dispensing line in which a plurality of specimen racks are arranged for waiting until sample dispensing, and a sampling area for dispensing the sample to the analysis unit. A rack save area is provided in the dispensing line and at a position adjacent to the upstream side of the sampling area. When a specimen rack exists in the sampling area at the time of measuring an emergency specimen rack, a controller moves the specimen rack to the save area and positions the emergency specimen rack to be moved from a downstream side of the sampling area to the sampling area.

公开(公告)号：US09638640B2

公开(公告)日：2017-05-02

申请号：US14413447

申请日：2013-07-08

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Masahiko Iijima ,  Akihisa Makino ,  Manabu Ando

IPC: G01N21/75 ,  G01N1/38 ,  G01N21/47 ,  G01N35/00 ,  G01N21/59 ,  G01N35/04

CPC classification number: G01N21/75 ,  G01N1/38 ,  G01N21/47 ,  G01N21/59 ,  G01N35/00603 ,  G01N2035/0446 ,  G01N2201/02 ,  G01N2201/061 ,  G01N2201/12

Abstract: An automatic analyzer which can reduce the effort necessary for conducting a test of limit of detection/limit of quantification properties and managing the test results is provided. Operation condition-setting means for conducting an evaluation test for at least one of a limit of detection and a limit of quantification for each measurement item, determination condition-setting means for setting a determination condition of the evaluation test, and a calculation unit for obtaining a measurement result of a dilution series containing different dilution concentrations by controlling the sample-dispensing mechanism, the reagent-dispensing mechanism and the measurement unit based on the set operation condition, and calculating a test result of the evaluation test from the measurement result of the dilution series based on the set determination condition are disposed.

公开(公告)号：US20140356964A1

公开(公告)日：2014-12-04

申请号：US14367066

申请日：2012-11-22

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Akihisa Makino ,  Masahiko Iijima ,  Akiko Watanabe

IPC: G01N35/10

CPC classification number: G01N35/1002 ,  G01N21/532 ,  G01N35/00603 ,  G01N35/00663 ,  G01N35/00693 ,  G01N2035/00702 ,  Y10T436/11

Abstract: An automatic analyzer detects measurement value abnormalities stemming from reaction process anomalies caused by the presence of foreign matter or bubbles. It is determined whether the results of concentration calculation based on light quantity data from multiple target detectors each fall within an applicable determination range. If the results fall within the determination range, an average value of the results of concentration calculation with the target detectors is calculated, and if not, an out-of-determination-range flag is given. A default fluctuation range is retrieved regarding the average value of the results of concentration calculation. The fluctuation range of the results of concentration calculation with the multiple target detectors is calculated. If the fluctuation range is found to fall within the default range, the results of concentration calculation are output to a display; and if outside the default range, a reexamination request is displayed with an added measurement value abnormality alarm.

Abstract translation: 自动分析仪检测由异物或气泡的存在引起的反应过程异常引起的测量值异常。 确定基于来自多个目标检测器的光量数据的浓度计算的结果是否落入适用的确定范围内。 如果结果落在确定范围内，则计算与目标检测器的浓度计算结果的平均值，如果不是，则给出超出判定范围的标志。 检索浓度计算结果的平均值的默认波动范围。 计算多个目标检测器的浓度计算结果的波动范围。 如果发现波动范围在默认范围内，则将浓度计算的结果输出到显示器; 如果超出默认范围，将显示一个复查请求，并附加一个测量值异常报警。

公开(公告)号：US11199559B2

公开(公告)日：2021-12-14

申请号：US16666813

申请日：2019-10-29

Applicant: Hitachi High-Technologies Corporation

Inventor： Akihisa Makino ,  Mitsuhiro Hishinuma ,  Toshiyuki Shimamori ,  Masato Ishizawa

IPC: G01N35/04 ,  G01N35/10 ,  G01N35/00 ,  G01N35/02

Abstract: An automatic analyzer with high processing capacity is capable of immediately measuring an emergency specimen rack. The automatic analyzer includes a conveying line for conveying a specimen rack, and an analysis unit which has a dispensing line in which a plurality of specimen racks are arranged for waiting until sample dispensing, and a sampling area for dispensing the sample to the analysis unit. A rack save area is provided in the dispensing line and at a position adjacent to the upstream side of the sampling area. When a specimen rack exists in the sampling area at the time of measuring an emergency specimen rack, a controller moves the specimen rack to the save area and positions the emergency specimen rack to be moved from a downstream side of the sampling area to the sampling area.

公开(公告)号：US10788479B2

公开(公告)日：2020-09-29

申请号：US15812150

申请日：2017-11-14

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Akihisa Makino ,  Keiko Yoshikawa ,  Takeshi Yokokawa

IPC: G01N33/49 ,  G01N33/86 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10

Abstract: An automatic analyzer which realizes stable reagent heating and high dispensing accuracy includes a thermostat bath for controlling a reagent or a reaction solution in reaction cells arranged on a circumference of a reaction disk to have a constant temperature; a first reagent dispensing mechanism dispenses a reagent into the reaction cells; a photometer detects transmitted light or scattered light in the reaction cell; and a disposable reaction container for allowing the sample and the reagent to mix and react with each other. The analyzer also includes a second reagent dispensing mechanism with a reagent heating function which dispenses the reagent into the disposable reaction container; a coagulation time detection section; a reaction container temperature control block; a reagent dispensing syringe which is connected to the second reagent dispensing mechanism; and a fluid temperature control mechanism which controls the temperature of an internal fluid of the reagent dispensing syringe.

公开(公告)号：US10416179B2

公开(公告)日：2019-09-17

申请号：US15616296

申请日：2017-06-07

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Akihisa Makino ,  Hajime Yamazaki ,  Keiko Yoshikawa ,  Manabu Ando ,  Masahiko Iijima

IPC: G01N35/02 ,  G01N35/10 ,  G01N33/86 ,  G01N21/82 ,  G01N21/11 ,  G01N35/00 ,  G01N35/04

Abstract: A high-throughput automatic analyzer integrates a biochemical analysis section and a blood coagulation analysis section. The analyzer is capable of achieving a reduction in size, system cost, and lifecycle cost. The automatic analyzer includes: a reaction disk; a first reagent dispensing mechanism that dispenses a reagent to reaction cells on the reaction disk; a photometer that irradiates a reaction solution in the reaction cell with light; a reaction cell cleaning mechanism; a reaction vessel supply unit that supplies a disposable reaction vessel for mixing and reacting a sample and a reagent with each other; a second reagent dispensing mechanism that dispenses a reagent to the disposable reaction vessel; a blood coagulation time measuring section that irradiates a reaction solution in the disposable reaction vessel with light to detect transmitted or scattered light; and a sample dispensing mechanism that dispenses a sample to the reaction cell and the disposable reaction vessel.

公开(公告)号：US10295555B2

公开(公告)日：2019-05-21

申请号：US15032781

申请日：2014-12-08

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Chie Yabutani ,  Akihisa Makino ,  Shigeki Matsubara

IPC: G01N33/86 ,  G01N35/10 ,  G01N35/00 ,  G01N35/04 ,  G01N33/49

Abstract: A signal reference value (SLocal) is set at which a blood coagulation reaction time (T) of a blood coagulation time reference sample measured on the basis of the result of comparing a signal value (amount of transmitted light, amount of scattered light, amount of fluorescence, or turbidity) pertaining to blood coagulation time that varies temporally according to the mixing and reaction of the blood coagulation time reference sample and a reagent and a signal reference value (S) corresponds to an expected value (Te) for the blood coagulation reaction time that has been set beforehand so as to correspond to the blood coagulation time reference sample. As a result, it is possible to use the blood coagulation time reference sample to determine the state of the reagent and enhance the reliability of measurement results by setting a unique signal reference value for each reagent container.

公开(公告)号：US09696329B2

公开(公告)日：2017-07-04

申请号：US14402906

申请日：2013-05-24

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Akihisa Makino ,  Hajime Yamazaki ,  Keiko Yoshikawa ,  Manabu Ando ,  Masahiko Iijima

IPC: G01N35/02 ,  G01N35/10 ,  G01N33/86 ,  G01N21/82 ,  G01N21/11 ,  G01N35/00 ,  G01N35/04

CPC classification number: G01N35/025 ,  G01N21/11 ,  G01N21/82 ,  G01N33/86 ,  G01N35/00584 ,  G01N35/00693 ,  G01N35/0092 ,  G01N35/1004 ,  G01N2021/115 ,  G01N2035/00425 ,  G01N2035/00673 ,  G01N2035/0094 ,  G01N2035/0097 ,  G01N2035/0437 ,  G01N2035/0453

Abstract: A high-throughput automatic analyzer integrates a biochemical analysis section and a blood coagulation analysis section. The analyzer is capable of achieving a reduction in size, system cost, and lifecycle cost. The automatic analyzer includes: a reaction disk; a first reagent dispensing mechanism that dispenses a reagent to reaction cells on the reaction disk; a photometer that irradiates a reaction solution in the reaction cell with light; a reaction cell cleaning mechanism; a reaction vessel supply unit that supplies a disposable reaction vessel for mixing and reacting a sample and a reagent with each other; a second reagent dispensing mechanism that dispenses a reagent to the disposable reaction vessel; a blood coagulation time measuring section that irradiates a reaction solution in the disposable reaction vessel with light to detect transmitted or scattered light; and a sample dispensing mechanism that dispenses a sample to the reaction cell and the disposable reaction vessel.

公开(公告)号：US20150204794A1

公开(公告)日：2015-07-23

申请号：US14413447

申请日：2013-07-08

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Masahiko Iijima ,  Akihisa Makino ,  Manabu Ando

IPC: G01N21/75 ,  G01N21/47 ,  G01N1/38 ,  G01N21/59

CPC classification number: G01N21/75 ,  G01N1/38 ,  G01N21/47 ,  G01N21/59 ,  G01N35/00603 ,  G01N2035/0446 ,  G01N2201/02 ,  G01N2201/061 ,  G01N2201/12

Abstract: An automatic analyzer which can reduce the effort necessary for conducting a test of limit of detection/limit of quantification properties and managing the test results is provided. Operation condition-setting means for conducting an evaluation test for at least one of a limit of detection and a limit of quantification for each measurement item, determination condition-setting means for setting a determination condition of the evaluation test, and a calculation unit for obtaining a measurement result of a dilution series containing different dilution concentrations by controlling the sample-dispensing mechanism, the reagent-dispensing mechanism and the measurement unit based on the set operation condition, and calculating a test result of the evaluation test from the measurement result of the dilution series based on the set determination condition are disposed.

Abstract translation: 提供了一种可以减少进行检测限制/限制性能限制和管理测试结果所需的努力的自动分析仪。 用于对每个测量项目进行至少一个检测限和定量限制的评估测试的操作条件设置装置，用于设置评估测试的确定条件的确定条件设置装置，以及用于获得 通过基于设定的操作条件控制样品分注机构，试剂分注机构和测量单元，并根据测定结果计算评价试验的试验结果，对含有不同稀释浓度的稀释系列的测定结果进行计算， 设置基于设定判定条件的稀释系列。

公开(公告)号：US20150185242A1

公开(公告)日：2015-07-02

申请号：US14415300

申请日：2013-06-13

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Tomonori Mimura ,  Akihisa Makino ,  Manabu Ando ,  Sakuichiro Adachi

IPC: G01N35/02 ,  G01N21/31 ,  G01N21/13 ,  G01N21/49

CPC classification number: G01N35/025 ,  G01N21/13 ,  G01N21/272 ,  G01N21/31 ,  G01N21/49 ,  G01N21/51 ,  G01N21/532 ,  G01N21/59 ,  G01N35/00613 ,  G01N2035/0453 ,  G01N2201/02 ,  G01N2201/062

Abstract: There is provided an automatic analyzer including: a sample pipetting mechanism 7, reagent pipetting mechanisms 12A and 12B, mixing mechanisms 33A and 33B, a scattered light photometer 40, and an absorption photometer 41 all located on a transfer path of reaction cells 2 arranged circumferentially on a disk-shaped reaction disk 1, the reaction cells 2 being transferred in the circumferential direction by rotation of the reaction disk 1. Scattered light intensity and absorbance are controlled to be measured by causing the reaction cells 2 to move past a scattered light detection position and a transmitted light detection position in the same process of movement, the two positions being established beforehand on the transfer path. This makes it possible to suppress the effects on measurement results of the difference in time between scattered light measurement and absorbance measurement thereby improving measurement accuracy.

Abstract translation: 提供了一种自动分析装置，其包括：样本移液机构7，试剂吸移机构12A和12B，混合机构33A和33B，散射光光度计40和吸收光度计41，其全部位于沿周向布置的反应单元2的传送路径上 在圆盘状的反应盘1上，反应池2通过反应盘1的旋转沿圆周方向转移。通过使反应池2移动经过散射光检测来控制分散的光强度和吸光度 位置和在相同移动过程中的透射光检测位置，两个位置预先在传送路径上建立。 这样可以抑制散射光测量和吸光度测量之间的时间差的测量结果的影响，从而提高测量精度。