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公开(公告)号：US11293934B2
公开(公告)日：2022-04-05
申请号：US16307787
申请日：2017-04-24
Inventor： Takeshi Ishida , Sakuichiro Adachi , Yoshihiro Yamashita , Shunichirou Nobuki , Hisashi Yabutani , Isao Yamazaki , Michaela Windfuhr , Bernhard Hauptmann , Simon Kuester
Abstract: An automatic analyzer is equipped with a sterilization mechanism removably attached to an opening of a container that holds a reagent and having an ultraviolet light generation section that radiates ultraviolet light; a suction nozzle removably attached, together with the sterilization mechanism, to the opening of the container; an analysis section adding the reagent drawn in by suction from the container via the suction nozzle to the reagent, and executing an analysis operation; and a control section exercising variable control over an irradiation light intensity of the ultraviolet light generated by the ultraviolet light generation section.
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公开(公告)号：US10113962B2
公开(公告)日：2018-10-30
申请号：US14670861
申请日：2015-03-27
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Sakuichiro Adachi , Muneo Maeshima , Isao Yamazaki , Tomonori Mimura
Abstract: To be adapted to various types of latex reagents for detecting scattered light and thereby measuring agglutination reactions with high sensitivity while sufficiently ensuring integration time. To be adapted to various types of latex particles of different particle sizes, a plurality of light receivers are arranged in a plane perpendicular to the direction of cell movement by rotation of a cell disk. To ensure sufficient integration time, the angle between the optical axis of the irradiation light and each of a plurality of optical axes of scattered light viewed from above the cell is made equal to or less than 17.7° including a mounting error.
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公开(公告)号：US09575082B2
公开(公告)日：2017-02-21
申请号：US14786234
申请日：2014-06-05
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Sakuichiro Adachi , Hajime Yamazaki , Masahiko Iijima , Shigeki Matsubara
CPC classification number: G01N35/00584 , G01N21/272 , G01N21/51 , G01N21/532 , G01N21/59 , G01N21/82 , G01N35/00 , G01N2021/825 , G01N2035/00891
Abstract: The automatic analysis device includes an analysis unit that corrects, based on a measured value at the time of a first light amount measurement with water dispensed in the reaction cell before the sample is dispensed therein; a measured value at the time of a second light amount measurement after the sample and a preprocessing reagent are dispensed into the reaction cell; a liquid amount in the reaction cell at the time of the second light amount measurement; and a liquid amount in the reaction cell at the time of a third light amount measurement after the reaction reagent has been dispensed into the reaction cell and before the reaction reagent and the substance to be measured react with each other.
Abstract translation: 自动分析装置包括分析单元，其基于在将样品分配在其中之前，在反应池中分配的水进行第一光量测量时的测量值; 在将样品和预处理试剂分配到反应池中之后的第二光量测量时的测量值; 在第二光量测量时反应池中的液体量; 并且在反应试剂已经分配到反应池中之前并且在反应试剂和被测量物质彼此反应之前，在第三光量测量时在反应池中的液体量。
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公开(公告)号：US09023282B2
公开(公告)日：2015-05-05
申请号：US14484384
申请日：2014-09-12
Applicant: Hitachi High-Technologies Corporation
Inventor： Sakuichiro Adachi , Muneo Maeshima , Isao Yamazaki , Tomonori Mimura
CPC classification number: G01N21/51 , G01N15/0205 , G01N21/253 , G01N2015/0065 , G01N2035/00396 , G01N2035/0453
Abstract: To be adapted to various types of latex reagents for detecting scattered light and thereby measuring agglutination reactions with high sensitivity while sufficiently ensuring integration time. To be adapted to various types of latex particles of different particle sizes, a plurality of light receivers are arranged in a plane perpendicular to the direction of cell movement by rotation of a cell disk. To ensure sufficient integration time, the angle between the optical axis of the irradiation light and each of a plurality of optical axes of scattered light viewed from above the cell is made equal to or less than 17.7° including a mounting error.
Abstract translation: 适用于各种类型的用于检测散射光的乳胶试剂，从而以高灵敏度测量凝集反应，同时充分确保积分时间。 为了适应于各种类型的不同粒度的胶乳颗粒，多个光接收器通过旋转细胞盘而布置在垂直于细胞移动方向的平面中。 为了确保足够的积分时间，使得照射光的光轴与从电池单元的上方观察的散射光的多个光轴中的每一个之间的角度等于或小于包括安装误差的17.7°。
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公开(公告)号：US20140377853A1
公开(公告)日：2014-12-25
申请号：US14484384
申请日：2014-09-12
Applicant: Hitachi High-Technologies Corporation
Inventor： Sakuichiro Adachi , Muneo Maeshima , Isao Yamazaki , Tomonori Mimura
IPC: G01N21/51
CPC classification number: G01N21/51 , G01N15/0205 , G01N21/253 , G01N2015/0065 , G01N2035/00396 , G01N2035/0453
Abstract: To be adapted to various types of latex reagents for detecting scattered light and thereby measuring agglutination reactions with high sensitivity while sufficiently ensuring integration time. To be adapted to various types of latex particles of different particle sizes, a plurality of light receivers are arranged in a plane perpendicular to the direction of cell movement by rotation of a cell disk. To ensure sufficient integration time, the angle between the optical axis of the irradiation light and each of a plurality of optical axes of scattered light viewed from above the cell is made equal to or less than 17.7° including a mounting error.
Abstract translation: 适用于各种类型的用于检测散射光的乳胶试剂，从而以高灵敏度测量凝集反应，同时充分确保积分时间。 为了适应于各种类型的不同粒度的胶乳颗粒，多个光接收器通过旋转细胞盘而布置在垂直于细胞移动方向的平面中。 为了确保足够的积分时间，使得照射光的光轴与从电池单元的上方观察的散射光的多个光轴中的每一个之间的角度等于或小于包括安装误差的17.7°。
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Patent Agency Ranking
公开(公告)号：US11692929B2
公开(公告)日：2023-07-04
申请号：US16070306
申请日：2016-11-28
Applicant: Hitachi High-Technologies Corporation
Inventor： Sakuichiro Adachi , Masahiko Iijima , Yuto Kazama
IPC: G01N21/47 , G01N33/543 , G01N21/27 , G01N21/25 , G01N15/10 , B01L3/00 , G01N21/03 , G01N21/49 , G01N35/00
CPC classification number: G01N21/0332 , B01L3/50 , G01N15/1012 , G01N21/03 , G01N21/27 , G01N21/274 , G01N21/49 , G01N35/00 , G01N35/00584
Abstract: As a standard solution for evaluating a scattered light measuring optical system mounted on an automated analyzer, a standard solution containing an insoluble carrier at a concentration, at which transmittance is in a range of 10% to 50%, is used, and a light quantity of a light source is adjusted such that a scattered light detector outputs a predetermined value.
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公开(公告)号：US20150185242A1
公开(公告)日：2015-07-02
申请号：US14415300
申请日：2013-06-13
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Tomonori Mimura , Akihisa Makino , Manabu Ando , Sakuichiro Adachi
CPC classification number: G01N35/025 , G01N21/13 , G01N21/272 , G01N21/31 , G01N21/49 , G01N21/51 , G01N21/532 , G01N21/59 , G01N35/00613 , G01N2035/0453 , G01N2201/02 , G01N2201/062
Abstract: There is provided an automatic analyzer including: a sample pipetting mechanism 7, reagent pipetting mechanisms 12A and 12B, mixing mechanisms 33A and 33B, a scattered light photometer 40, and an absorption photometer 41 all located on a transfer path of reaction cells 2 arranged circumferentially on a disk-shaped reaction disk 1, the reaction cells 2 being transferred in the circumferential direction by rotation of the reaction disk 1. Scattered light intensity and absorbance are controlled to be measured by causing the reaction cells 2 to move past a scattered light detection position and a transmitted light detection position in the same process of movement, the two positions being established beforehand on the transfer path. This makes it possible to suppress the effects on measurement results of the difference in time between scattered light measurement and absorbance measurement thereby improving measurement accuracy.
Abstract translation: 提供了一种自动分析装置，其包括：样本移液机构7，试剂吸移机构12A和12B，混合机构33A和33B，散射光光度计40和吸收光度计41，其全部位于沿周向布置的反应单元2的传送路径上 在圆盘状的反应盘1上，反应池2通过反应盘1的旋转沿圆周方向转移。通过使反应池2移动经过散射光检测来控制分散的光强度和吸光度 位置和在相同移动过程中的透射光检测位置，两个位置预先在传送路径上建立。 这样可以抑制散射光测量和吸光度测量之间的时间差的测量结果的影响，从而提高测量精度。
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公开(公告)号：US10725028B2
公开(公告)日：2020-07-28
申请号：US15749197
申请日：2016-06-28
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Toshiyuki Inabe , Akihisa Makino , Sakuichiro Adachi , Chie Yabutani
IPC: G01N33/48 , G01N33/542 , G01N21/82 , G01N21/51 , G01N21/25 , G01N21/27 , G01N33/52 , G01N33/86 , G01N35/00 , G06G7/58
Abstract: The automatic analysis device is provided with (1) a measurement mechanism having a light measuring unit having a reaction container in which the sample is dispensed, a light source which emits light to the reaction container, and a detection unit that detects scattered light from the sample in the reaction container, (2) an amplifier circuit unit having an adder-subtractor that adds or subtracts a correction signal to or from a first measurement signal from the detection unit, and an amplifier circuit which amplifies the output signal by the adder-subtractor at a fixed amplification rate to output a second measurement signal, and (3) an arithmetic operation unit which calculates the correction signal on the basis of a difference between the signal level of the second measurement signal and a target value, and which executes an analysis action based on the second measurement signal after correction by means of the correction signal.
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公开(公告)号：US10168345B2
公开(公告)日：2019-01-01
申请号：US14411304
申请日：2013-05-30
Applicant: Hitachi High-Technologies Corporation
Inventor： Akiko Yokokawa , Tomonori Mimura , Sakuichiro Adachi
Abstract: An automatic analysis apparatus capable of improving detection sensitivity is provided. An optimum photometer between a light-scattering photometer and an absorptiometer based on a concentration range may be decided. A standard solution is measured multiple times at a normal calibration and a calibration curve is created. Calibration curves are individually created for an absorptiometer and a light-scattering photometer from the minimum and maximum measured values of the concentrations of each standard solution. The upper and lower limits of a standard solution concentration are computed from the minimum/maximum calibration curves. Sensitivity may be computed by using calibration parameters. Whether to use a concentration by absorption or a concentration by scattered light is decided based on the computed sensitivity. The computed sensitivities are compared between the concentration by absorption and the concentration by scattered light, and the use of the concentration of a higher sensitivity is decided.
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公开(公告)号：US09557264B2
公开(公告)日：2017-01-31
申请号：US14414782
申请日：2013-06-14
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Sakuichiro Adachi , Hajime Yamazaki , Masahiko Iijima
IPC: G01N21/00 , G01N21/64 , G01N21/66 , G01N15/06 , G01N21/49 , G01N21/51 , G01N15/14 , G01N21/25 , G01N21/27 , G01N21/82 , G01N35/02 , G01N21/31 , G01N21/47 , G01N35/00
CPC classification number: G01N21/49 , G01N15/1434 , G01N21/253 , G01N21/272 , G01N21/31 , G01N21/51 , G01N21/82 , G01N35/025 , G01N2021/4711 , G01N2021/825 , G01N2035/00396 , G01N2201/02 , G01N2201/062 , Y10T436/11
Abstract: To enable determination of if there is an influence of foreign-body reactions on the result of quantitative determination conducted with a scattered light measurement method. Proposed is an automatic analysis device including a light source configured to irradiate a reaction solution with light, a plurality of light receivers configured to receive scattered light generated from the reaction solution at different light-receiving angles, a first data processing unit configured to process reaction process data measured by one of the light receivers to quantitatively determine a concentration of a substance in the reaction solution, and a second data processing unit configured to determine if the quantitative determination of the concentration of the substance has been performed normally on the basis of a ratio of a plurality of computed values, the plurality of computed values having been calculated from a plurality of pieces of reaction process data measured by the respective light receivers.
Abstract translation: 为了能够确定异物反应对使用散射光测量方法进行的定量测定的结果是否有影响。 提出了一种自动分析装置，包括：被配置为用光照射反应溶液的光源;多个受光器，被配置为在不同的光接收角度处接收从反应溶液产生的散射光;第一数据处理单元，被配置为处理反应 由一个光接收器测量的过程数据，以定量地确定反应溶液中物质的浓度;以及第二数据处理单元，其被配置为基于以下方式确定物质浓度的定量确定是否正常进行： 多个计算值的多个计算值是根据由各个光接收器测量的多个反应过程数据计算出的。
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