公开(公告)号：US20180286658A1

公开(公告)日：2018-10-04

申请号：US15763813

申请日：2015-10-09

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Kazushige NISHIMURA ,  Hiroyuki SATAKE ,  Masuyuki SUGIYAMA ,  Hideki HASEGAWA ,  Tomoyuki SAKAI

IPC: H01J49/16 ,  H01J49/26 ,  H01J49/06

CPC classification number: H01J49/165 ,  H01J49/0077 ,  H01J49/0445 ,  H01J49/062 ,  H01J49/167 ,  H01J49/26

Abstract: To reduce contamination of the apparatus with an additive and to quickly switch spraying and stopping of the additive, provided is an ion analyzer including: an ion source for ionizing a measurement target substance, a spray unit for atomizing and spraying toward the measurement target substance a liquid containing an additive that reacts with the measurement target substance; a separation analysis unit for separately analyzing an ion generated by a reaction between the measurement target substance and the additive; a detector for detecting the ion that has been separately analyzed by the separation analysis unit; and a control unit for lowering a flow rate of the additive supplied to the spray unit during a time when the additive is not necessary.

公开(公告)号：US20180265918A1

公开(公告)日：2018-09-20

申请号：US15775408

申请日：2015-12-01

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Masataka SHIRAI ,  Tomoyuki SAKAI ,  Kenko UCHIDA

IPC: C12Q1/6837 ,  C12Q1/6809 ,  C12N15/10 ,  C40B40/08 ,  C40B50/06 ,  G01N33/543

CPC classification number: C12Q1/6837 ,  C12N15/1003 ,  C12N15/1093 ,  C12N15/1096 ,  C12Q1/68 ,  C12Q1/6806 ,  C12Q1/6809 ,  C40B40/08 ,  C40B50/06 ,  G01N33/54306

Abstract: The purpose of the present invention is to provide a single cell analysis device in which the improvement of the nucleic acid capturing efficiency and the improvement of the cell capturing efficiency are both achieved and a highly accurate single cell analysis data is thereby obtained. The present invention relates to an improvement of a cell analysis device including a two-dimensional array chip having a plurality of cell capture parts capable of capturing a single cell in each of the capture parts, and nucleic acid capture parts corresponding to the respective cell capture parts, the nucleic acid capture parts being capable of capturing a nucleic acid extracted from the cell captured by the cell capture part.

公开(公告)号：US20140038274A1

公开(公告)日：2014-02-06

申请号：US14051540

申请日：2013-10-11

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Akira MAEKAWA ,  Tomoyuki SAKAI ,  Tsuyoshi SONEHARA ,  Satoshi TAKAHASHI

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  C12Q1/6837 ,  G01N21/6452 ,  Y10T436/143333 ,  C12Q2565/513

Abstract: The present invention relates to a nucleic acid analysis device in a nucleic acid analysis apparatus, whereby waste of reaction spots on the nucleic acid analysis device is eliminated and leakage of fluorescence excitation light to unobserved nucleic acid measurement regions is minimized. Specifically, the nucleic acid analysis device has a plurality of nucleic acid measurement regions, which are characterized in that one nucleic acid measurement region is disposed at a sufficient distance from the other nucleic acid measurement regions such that the other nucleic acid measurement regions do not enter an irradiation region.

Abstract translation: 本发明涉及核酸分析装置中的核酸分析装置，其中消除了核酸分析装置上的反应点的浪费，使荧光激发光向未观察到的核酸测量区域的泄漏最小化。 具体而言，核酸分析装置具有多个核酸测定区域，其特征在于，将一个核酸测定区域配置在距离其他核酸测定区域足够的距离，使得其他核酸测定区域不进入 照射区域。