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公开(公告)号：US5506138A
公开(公告)日：1996-04-09
申请号：US166287
申请日：1993-12-13
CPC分类号： C12N15/86 , C07K14/80 , C12N9/0071 , C12N2710/24143
摘要： The present invention is related to the construction and application of vaccinia virus containing DNA sequences for encoding and efficient expression of enzymatically active cytochrome P-450 polypeptides in mammalian cells. Preparation and use of pure P1-450 and P3-450 cytochromes have been described.
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公开(公告)号：US5164313A
公开(公告)日：1992-11-17
申请号：US787777
申请日：1991-11-06
IPC分类号： C07K14/80 , C12N9/02 , C12N15/53 , C12N15/863
CPC分类号： C12N15/86 , C07K14/80 , C12N9/0071 , C12N2710/24143
摘要： The present invention is related to the construction and application of vaccinia virus containing DNA sequences for encoding and efficient expression of enzymatically active cytochrome P-450 polypeptides in mammalian cells. Preparation and use of pure P1-450 and P3-450 cytochromes have been described.
摘要翻译： 本发明涉及在哺乳动物细胞中用于编码和有效表达酶活性细胞色素P-450多肽的含有痘苗病毒的DNA序列的构建和应用。 已经描述了纯P1-450和P3-450细胞色素的制备和使用。
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3.发明授权Recombinant modified vaccinia ankara (MVA) vaccinia virus containing restructured insertion sites 有权含有重组插入位点的重组修饰牛痘安卡拉（MVA）痘苗病毒公开(公告)号：US09133480B2
公开(公告)日：2015-09-15
申请号：US13502205
申请日：2010-10-15
申请人： Bernard Moss , Linda S. Wyatt , Patricia L. Earl
发明人： Bernard Moss , Linda S. Wyatt , Patricia L. Earl
IPC分类号： C12N15/86 , C12N15/863 , C12N7/00 , C07K14/005 , A61K39/285 , A61K39/00
CPC分类号： C12N7/00 , A61K39/285 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N15/8636 , C12N2710/24121 , C12N2710/24133 , C12N2710/24143 , C12N2710/24152 , C12N2740/16122 , C12N2740/16222
摘要： The present invention relates to recombinant modified vaccinia Ankara (MVA) virus containing restructured sites useful for the integration of heterologous nucleic acid sequences into an intergenic region (IGR) of the virus genome, where the IGR is located between two adjacent, essential open reading frames (ORFs) of the vaccinia virus genome, wherein the adjacent essential ORFs are non-adjacent in a parental MVA virus used to construct the recombinant MVA virus, and to related nucleic acid constructs useful for inserting heterologous DNA into the genome of a vaccinia virus, and further to the use of the disclosed viruses as a medicine or vaccine.
摘要翻译： 本发明涉及含有用于将异源核酸序列整合到病毒基因组的基因间区域（IGR）中的重组位点的重组修饰牛痘安卡拉（MVA）病毒，其中IGR位于两个相邻的基本开放阅读框之间 （ORF），其中相邻的必需ORF在用于构建重组MVA病毒的亲代MVA病毒中不相邻，以及可用于将异源DNA插入痘苗病毒基因组中的相关核酸构建体， 并且进一步使用所公开的病毒作为药物或疫苗。
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公开(公告)号：US08404818B2
公开(公告)日：2013-03-26
申请号：US13038613
申请日：2011-03-02
CPC分类号： C07K16/081 , A61K39/00 , A61K2039/505 , A61K2039/545 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2710/24122 , G01N33/56983 , G01N2333/07
摘要： The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及结合或中和正痘病毒的单克隆抗体。 本发明提供了这样的抗体，这种抗体保留B5或A33结合能力的片段，完全人抗体保留B5或A33结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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公开(公告)号：US20110159036A1
公开(公告)日：2011-06-30
申请号：US11975643
申请日：2007-10-19
申请人： Bernard Moss , Patricia L. Earl , Linda Wyatt , Leigh Anne Eller , Thomas C. VanCott , Matthew Edward Harris
发明人： Bernard Moss , Patricia L. Earl , Linda Wyatt , Leigh Anne Eller , Thomas C. VanCott , Matthew Edward Harris
CPC分类号： C12N15/86 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C07K14/005 , C12N2710/24143 , C12N2740/16122 , C12N2740/16222 , C12N2830/00 , C12N2830/15 , C12N2830/60
摘要： The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
摘要翻译： 本发明提供了修饰的病毒安卡拉（MVA），一种表达人免疫缺陷病毒（HIV）env，gag和pol基因的痘苗病毒复制缺陷型菌株。
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公开(公告)号：US07494813B2
公开(公告)日：2009-02-24
申请号：US10959392
申请日：2004-10-05
申请人： Bernard Moss , Arban Domi
发明人： Bernard Moss , Arban Domi
CPC分类号： C12N15/86 , C12N15/70 , C12N2710/14143 , C12N2710/24043 , C12N2710/24143 , C12N2770/24143 , C12N2800/204
摘要： The invention relates to a VAC-BAC shuttle vector system for creation of recombinant poxviruses from DNA cloned in a bacterial artificial chromosome.
摘要翻译： 本发明涉及一种用于从克隆在细菌人造染色体中的DNA产生重组痘病毒的VAC-BAC穿梭载体系统。
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7.发明申请Recombinant Mva Viruses Expressing Clade A/G, Clade B, and Clade C Modified Hiv Env Gag and Pol Genes 有权表达进化枝A / G，克隆B和克隆C修饰的Hiv Env Gag和Pol基因的重组Mva病毒公开(公告)号：US20080193483A1
公开(公告)日：2008-08-14
申请号：US11574285
申请日：2005-08-29
申请人： Bernard Moss , Linda Wyatt , Harriet L. Robinson
发明人： Bernard Moss , Linda Wyatt , Harriet L. Robinson
IPC分类号： A61K39/285 , A61K48/00 , C12N7/01
CPC分类号： C12N15/86 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C07K14/005 , C12N2710/24143 , C12N2740/16023 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2830/00 , C12N2830/15 , C12N2830/60
摘要： The invention provides modified vaccinia Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
摘要翻译： 本发明提供了修饰的痘苗Ankara（MVA），一种表达人免疫缺陷病毒（HIV）env，gag和pol基因的痘苗病毒复制缺陷型菌株。
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公开(公告)号：US07208313B2
公开(公告)日：2007-04-24
申请号：US09991721
申请日：2001-11-13
IPC分类号： C12N15/863 , A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/5156 , C12N2710/24122 , C12N2710/24132 , C12N2710/24143
摘要： A composition of matter comprising a vaccinia virus expression vector with a negative thymidine kinase phenotype and a negative vaccinia virus growth factor phenotype.
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公开(公告)号：US5849304A
公开(公告)日：1998-12-15
申请号：US467324
申请日：1995-06-07
申请人： Bernard Moss , Sekhar Chakrabarti
发明人： Bernard Moss , Sekhar Chakrabarti
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/21 , C07K14/00 , C07K14/155 , C07K14/16 , C07K14/705 , C12N7/00 , C12P21/00 , A61K39/42 , C12N15/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2740/16122
摘要： A recombinant vaccinia virus capable of expressing HTLV-III envelope protein (env) has been constructed. The expressed env protein is recognized by sera obtained from AIDS patients. The synthesized env protein also produces antibodies when administered to a suitable host, such antibodies having specific binding affinity with the env protein.
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公开(公告)号：US5428143A
公开(公告)日：1995-06-27
申请号：US22095
申请日：1993-02-25
申请人： Edward A. Berger , Bernard Moss , Thomas R. Fuerst , Ira Pastan , David Fitzgerald , Tamio Mizukami , Vijay K. Chaudhary
发明人： Edward A. Berger , Bernard Moss , Thomas R. Fuerst , Ira Pastan , David Fitzgerald , Tamio Mizukami , Vijay K. Chaudhary
CPC分类号： C07K14/70514 , C07K14/21 , C07K16/00 , A61K38/00 , C07K2317/77 , C07K2319/00 , C07K2319/32 , C07K2319/55
摘要： A chimeric gene directing the synthesis of hybrid recombinant fusion protein in a suitable expression vector has been constructed. The fusion protein possesses the property of selective cytotoxicity against specific virus-infected cells. A CD4(178)-PE40 hybrid fusion protein has been made for selectively killing HIV-infected cells.
摘要翻译： 已经构建了在合适的表达载体中引导杂交重组融合蛋白的合成的嵌合基因。 融合蛋白具有对特定病毒感染细胞的选择性细胞毒性的特性。 已经制备了CD4（178）-PE40杂交融合蛋白，用于选择性地杀死HIV感染的细胞。
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