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公开(公告)号：US5824094A
公开(公告)日：1998-10-20
申请号：US954293
申请日：1997-10-17
申请人： Hassan Serhan , James Kuras , Carl McMillin , Maarten Persenaire
发明人： Hassan Serhan , James Kuras , Carl McMillin , Maarten Persenaire
CPC分类号： A61F2/442 , A61F2/3094 , A61F2002/30069 , A61F2002/30112 , A61F2002/30131 , A61F2002/30187 , A61F2002/3023 , A61F2002/30563 , A61F2002/30574 , A61F2002/30769 , A61F2002/30805 , A61F2002/30878 , A61F2002/30879 , A61F2002/30884 , A61F2002/30957 , A61F2002/30967 , A61F2230/0004 , A61F2230/0013 , A61F2230/0034 , A61F2230/0069 , A61F2310/00023 , A61F2310/00407
摘要： A spinal disc prosthesis (10) to replace a damaged spinal disc in a spinal column (16) of a human, includes an elastomeric core (200) having upper and lower surfaces (202, 212) which are parallel to each other. An upper rigid plate (20) has opposed first and second surfaces (42, 52). The first surface (42) is affixed to the upper surface (202) of the elastomeric core. The second surface (52) is inclined relative to the first surface (42). A lower rigid plate (120) has opposed third and fourth surfaces (142, 152). The third surface (142) is affixed to the lower surface (212) of the elastomeric core (200) and extends parallel to the first surface (42). The fourth surface (152) is inclined relative to the third surface (142). The second and fourth surfaces (52, 152) are inclined relative to each other.
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公开(公告)号：US06669732B2
公开(公告)日：2003-12-30
申请号：US09921082
申请日：2001-08-02
申请人： Hassan Serhan , James Kuras , Carl McMillin , Maarten Persenaire
发明人： Hassan Serhan , James Kuras , Carl McMillin , Maarten Persenaire
IPC分类号： A61F244
CPC分类号： A61F2/442 , A61F2/3094 , A61F2002/30069 , A61F2002/30112 , A61F2002/30131 , A61F2002/30187 , A61F2002/3023 , A61F2002/30563 , A61F2002/30574 , A61F2002/30769 , A61F2002/30805 , A61F2002/30878 , A61F2002/30879 , A61F2002/30884 , A61F2002/30957 , A61F2002/30967 , A61F2230/0004 , A61F2230/0013 , A61F2230/0034 , A61F2230/0069 , A61F2310/00023 , A61F2310/00407
摘要： A spinal disc prosthesis (10) to replace a damaged spinal disc in a spinal column (16) of a human, includes an elastomeric core (200) having upper and lower surfaces (202, 212) which are parallel to each other. An upper rigid plate (20) has opposed first and second surfaces (42, 52). The first surface (42) is affixed to the upper surface (202) of the elastomeric core. The second surface (52) is inclined relative to the first surface (42). A lower rigid plate (120) has opposed third and fourth surfaces (142, 152). The third surface (142) is affixed to the lower surface (212) of the elastomeric core (200) and extends parallel to the first surface (42). The fourth surface (152) is inclined relative to the third surface (142). The second and fourth surfaces (52, 152) are inclined relative to each other.
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公开(公告)号：US08845733B2
公开(公告)日：2014-09-30
申请号：US13163427
申请日：2011-06-17
IPC分类号： A61F2/44 , A61M29/02 , A61B17/17 , A61B17/16 , A61M25/00 , A61B5/00 , A61M25/01 , A61B17/02 , A61B17/34
CPC分类号： A61F2/4455 , A61B5/4893 , A61B17/1659 , A61B17/1671 , A61B17/1757 , A61B2017/0256 , A61B2017/3433 , A61F2/30771 , A61F2/4425 , A61F2/446 , A61F2/4465 , A61F2/447 , A61F2/4611 , A61F2/4637 , A61F2002/30326 , A61F2002/30523 , A61F2002/30593 , A61F2002/443 , A61F2002/4623 , A61F2002/4642 , A61M25/0054 , A61M25/0133 , A61M29/02
摘要： An intervertebral fusion device comprising inferior and superior fusion cage devices that provide an ability to correct spondylolisthesis via in-situ adjustment.
摘要翻译： 一种椎间融合装置，其包括通过原位调整提供矫正脊椎前移的能力的下部和上部融合笼装置。
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4.发明授权Transdiscal administration of specific inhibitors of pro-inflammatory cytokines 有权跨时间给药促炎细胞因子的特异性抑制剂公开(公告)号：US08728523B2
公开(公告)日：2014-05-20
申请号：US12291378
申请日：2008-11-07
申请人： Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
发明人： Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
IPC分类号： A61K45/00 , A61K39/395
CPC分类号： A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要： The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
摘要翻译： 本发明涉及将高特异性细胞因子拮抗剂注射到患病的椎间盘中。
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公开(公告)号：US08636802B2
公开(公告)日：2014-01-28
申请号：US10793967
申请日：2004-03-06
IPC分类号： A61F2/44
CPC分类号： A61B17/7065 , A61B17/7062 , A61B17/7068 , A61B2017/00075 , A61B2017/00221 , A61B2017/00964 , A61B2017/567 , A61B2017/681 , A61F2/4405 , A61F2002/482
摘要： An interspinous process having a general horseshoe shape, a cushion element within the horseshoe and a porous coating on its outer surface.
摘要翻译： 具有一般马蹄形的棘突间过程，马蹄形内的缓冲元件和其外表面上的多孔涂层。
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公开(公告)号：US20130289356A1
公开(公告)日：2013-10-31
申请号：US13925145
申请日：2013-06-24
申请人： Tony Tannoury , Michael J. O'Neil , Derek Shaw , Hassan Serhan
发明人： Tony Tannoury , Michael J. O'Neil , Derek Shaw , Hassan Serhan
IPC分类号： A61B1/32
CPC分类号： A61B1/32 , A61B17/0218
摘要： A self-retaining neural retraction clip, preferably having controlled retraction level and an off-set retraction means. This device can reduce operative site clutter to enhance disc access while providing consistent and stable dural retraction.
摘要翻译： 一种自我保持神经回缩夹，优选具有受控缩回水平和偏移缩回装置。 该装置可以减少手术部位杂乱，增强椎间盘通路，同时提供一致稳定的硬脑膜回缩。
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7.发明授权Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints 有权将高特异性细胞因子抑制剂的跨荚膜施用于矫形关节公开(公告)号：US08361467B2
公开(公告)日：2013-01-29
申请号：US10630227
申请日：2003-07-30
申请人： Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Martin A. Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura J. Brown , Jeff Geesin , Pamela L. Plouhar , Catherine Smith , John Siekierka
发明人： Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Martin A. Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura J. Brown , Jeff Geesin , Pamela L. Plouhar , Catherine Smith , John Siekierka
IPC分类号： A61K39/395 , A61K39/00 , A61K38/18
CPC分类号： A61K38/30 , A61K31/198 , A61K31/436 , A61K38/1816 , A61K2039/505
摘要： The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory interleukin; ii) an inhibitor of TNF-α synthesis; iii) an inhibitor of membrane-bound TNF-α; iv) an inhibitor of a natural receptor of TNF-α; v) an inhibitor of NO synthase, vi) an inhibitor of PLA2 enzyme; vii) an anti-proliferative agent; viii) an anti-oxidant; ix) an apoptosis inhibitor selected from the group consisting of EPO mimetic peptides, EPO mimetibodies, IGF-I, IGF-II, and caspase inhibitors, and x) an inhibitor of MMPs; and xi) an inhibitor of p38 kinase.
摘要翻译： 本发明涉及向患病关节中透射施用高特异性拮抗剂，所述高特异性拮抗剂选自：i）促炎白细胞介素的抑制剂; ii）TNF-α合成抑制剂; iii）膜结合TNF-α的抑制剂; iv）TNF-α的天然受体的抑制剂; v）NO合酶抑制剂，vi）PLA2酶抑制剂; vii）抗增殖剂; viii）抗氧化剂; ix）选自EPO模拟肽，EPO模拟物，IGF-I，IGF-II和胱天蛋白酶抑制剂的细胞凋亡抑制剂，和x）MMP的抑制剂; 和xi）p38激酶的抑制剂。
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公开(公告)号：US08267883B2
公开(公告)日：2012-09-18
申请号：US12817585
申请日：2010-06-17
申请人： Thomas M. DiMauro , Jeffrey K. Sutton , Mohamed Attawia , Hassan Serhan , John Daniel Malone , Timothy Beardsley
发明人： Thomas M. DiMauro , Jeffrey K. Sutton , Mohamed Attawia , Hassan Serhan , John Daniel Malone , Timothy Beardsley
CPC分类号： A61L31/146 , A61B17/866 , A61F2/30767 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/38 , A61F2/4455 , A61F2002/30663 , A61F2002/30929 , A61F2002/30981 , A61F2002/3611 , A61F2002/3625 , A61F2002/443 , A61F2310/00023 , A61F2310/00604 , A61F2310/0061 , A61F2310/00616 , A61L27/06 , A61L27/427 , A61L27/56 , A61L31/022 , A61L31/124 , A61M5/158 , A61N5/0601 , A61N5/0624 , A61N2005/0651 , A61N2005/0661 , B01J35/004
摘要： An implant comprises a photocatalytic layer on at least one surface and is adapted to act as a sensor. In some embodiments, the photocatalytic layer is a semiconductor oxide that is doped. According to some embodiments, the implant comprises a wave guide. According to some embodiments the implant comprises a light port. According to some embodiments, the implant comprises a reflective material on a surface of the waveguide. According to some embodiments the implant comprises a composite material comprising a first material that has a transmissivity when exposed to a predetermined wavelength of light and a second material that has photocatalytic activity when exposed to the predetermined wavelength of light. According to some embodiments the implant comprises a light source adapted to irradiate the photocatalytic surface.
摘要翻译： 植入物包括在至少一个表面上的光催化层，并且适于作为传感器。 在一些实施方案中，光催化层是掺杂的半导体氧化物。 根据一些实施例，植入物包括波导。 根据一些实施例，植入物包括光端口。 根据一些实施例，植入物在波导的表面上包括反射材料。 根据一些实施例，植入物包括复合材料，其包括当暴露于预定波长的光时具有透射率的第一材料和当暴露于预定波长的光时具有光催化活性的第二材料。 根据一些实施例，植入物包括适于照射光催化表面的光源。
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公开(公告)号：US07879102B2
公开(公告)日：2011-02-01
申请号：US10676868
申请日：2003-09-30
申请人： Michael Slivka , Hassan Serhan
发明人： Michael Slivka , Hassan Serhan
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61F2/4611 , A61F2002/30062 , A61F2002/30289 , A61F2002/30291 , A61F2002/30299 , A61F2002/30677 , A61F2002/4435 , A61F2002/444 , A61F2002/4445 , A61F2002/445 , A61F2002/4495 , A61F2210/0004 , A61F2230/0091 , A61F2230/0093 , A61F2310/00365 , Y10S623/902
摘要： A minimally invasive spinal disc defect repair method is disclosed. The method relates to insertion of disc defect repair materials that are substantially two-dimensionally shaped and which allow for insertion and preferably self retention within the disc defect with plugging of the annulus fibrosis.
摘要翻译： 公开了一种微创脊髓缺损修复方法。 该方法涉及基本上二维成形的盘缺损修复材料的插入，并且允许插入并且优选地自我保留在椎间盘缺损中，同时堵塞环状纤维化。
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公开(公告)号：US07744555B2
公开(公告)日：2010-06-29
申请号：US10774105
申请日：2004-02-06
申请人： Thomas M. DiMauro , Jeffrey K. Sutton , Mohamed Attawia , Hassan Serhan , John Daniel Malone , Tim Beardsley
发明人： Thomas M. DiMauro , Jeffrey K. Sutton , Mohamed Attawia , Hassan Serhan , John Daniel Malone , Tim Beardsley
CPC分类号： A61F2/30767 , A61B17/866 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/38 , A61F2/4455 , A61F2002/30663 , A61F2002/30668 , A61F2002/30929 , A61F2002/30981 , A61F2002/3611 , A61F2002/3625 , A61F2002/443 , A61F2250/0001 , A61F2310/00023 , A61F2310/00604 , A61F2310/0061 , A61F2310/00616 , A61L27/06 , A61L27/427 , A61L27/56 , A61L31/022 , A61L31/124 , A61L31/146 , A61M5/158 , A61N5/0601 , A61N5/0624 , A61N2005/0651 , A61N2005/0661 , B01J35/004
摘要： An implant comprises a photocatalytic layer on at least one surface. In some embodiments, the photocatalytic layer is a semiconductor oxide that is doped. According to some embodiments, the implant comprises a wave guide. According to some embodiments the implant comprises a light port. According to some embodiments, the implant comprises a reflective material on a surface of the waveguide. According to some embodiments the implant comprises a composite material comprising a first material that has a transmissivity when exposed to a predetermined wavelength of light and a second material that has photocatalytic activity when exposed to the predetermined wavelength of light. According to some embodiments the implant comprises a light source adapted to irradiate the photocatalytic surface.
摘要翻译： 植入物包括在至少一个表面上的光催化层。 在一些实施方案中，光催化层是掺杂的半导体氧化物。 根据一些实施例，植入物包括波导。 根据一些实施例，植入物包括光端口。 根据一些实施例，植入物在波导的表面上包括反射材料。 根据一些实施例，植入物包括复合材料，其包括当暴露于预定波长的光时具有透射率的第一材料和当暴露于预定波长的光时具有光催化活性的第二材料。 根据一些实施例，植入物包括适于照射光催化表面的光源。
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