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1.发明申请公开(公告)号：US20080312470A1
公开(公告)日：2008-12-18
申请号：US12197401
申请日：2008-08-25
IPC分类号： C07C237/26 , C07C225/20
CPC分类号： C07C49/835 , C07C225/20 , C07C237/24 , C07C2601/16 , C07C2602/28 , C07C2603/24
摘要： The present invention is directed to novel compounds which are derivatives of minocycline or doxycycline, pharmaceutical compositions containing same and use thereof in lowering excess IgE levels in a mammal suffering from a disease where IgE is pathogenic.
摘要翻译： 本发明涉及作为二甲胺四环素或多西环素的衍生物的新化合物，含有它们的药物组合物及其在降低IgE致病性疾病的哺乳动物中降低过量IgE水平的用途。
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2.发明授权公开(公告)号：US07649113B2
公开(公告)日：2010-01-19
申请号：US12197401
申请日：2008-08-25
IPC分类号： C07C233/00
CPC分类号： C07C49/835 , C07C225/20 , C07C237/24 , C07C2601/16 , C07C2602/28 , C07C2603/24
摘要： The present invention is directed to novel compounds which are derivatives of minocycline or doxycycline, pharmaceutical compositions containing same and use thereof in lowering excess IgE levels in a mammal suffering from a disease where IgE is pathogenic.
摘要翻译： 本发明涉及作为二甲胺四环素或多西环素的衍生物的新化合物，含有它们的药物组合物及其在降低IgE致病性疾病的哺乳动物中降低过量IgE水平的用途。
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公开(公告)号：US07425655B2
公开(公告)日：2008-09-16
申请号：US10544814
申请日：2004-02-09
CPC分类号： C07C49/835 , C07C225/20 , C07C237/24 , C07C2601/16 , C07C2602/28 , C07C2603/24
摘要： The present invention is directed novel compounds which are derivatives of minocycline or doxycycline, pharmaceutical compositions containing same and use thereof in lowering excess IgE levels in a mammal suffering from a disease where IgE is pathogenic.
摘要翻译： 本发明涉及作为二甲胺四环素或多西环素的衍生物的新型化合物，含有它们的药物组合物及其在降低IgE致病性疾病的哺乳动物中降低过量IgE水平的用途。
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公开(公告)号：US20060235081A1
公开(公告)日：2006-10-19
申请号：US10544814
申请日：2004-02-09
IPC分类号： A61K31/16 , A61K31/13 , A61K31/12 , C07C237/18
CPC分类号： C07C49/835 , C07C225/20 , C07C237/24 , C07C2601/16 , C07C2602/28 , C07C2603/24
摘要： The present invention is directed novel compounds which are derivatives of minocycline or doxycycline, pharmaceutical compositions containing same and use thereof in lowering excess IgE levels in a mammal suffering from a disease where IgE is pathogenic.
摘要翻译： 本发明涉及作为二甲胺四环素或多西环素的衍生物的新型化合物，含有它们的药物组合物及其在降低IgE致病性疾病的哺乳动物中降低过量IgE水平的用途。
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公开(公告)号：US06849639B2
公开(公告)日：2005-02-01
申请号：US09732546
申请日：2000-12-08
申请人： Celia Dominguez , Guoqing Chen , Ning Xi , Shimin Xu , Nianhe Han , Qingyian Liu , Qi Huang , Aaron Siegmund , Michael Handley , Longbin Liu , Alexander Kiselyov
发明人： Celia Dominguez , Guoqing Chen , Ning Xi , Shimin Xu , Nianhe Han , Qingyian Liu , Qi Huang , Aaron Siegmund , Michael Handley , Longbin Liu , Alexander Kiselyov
IPC分类号： C07D401/06 , A61K31/402 , A61K31/4025 , A61K31/4178 , A61K31/4355 , A61K31/438 , A61K31/4406 , A61K31/4709 , A61K31/496 , A61K31/506 , A61P3/10 , A61P9/00 , A61P9/10 , A61P17/02 , A61P19/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , C07D207/26 , C07D207/277 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/10
CPC分类号： C07D207/277 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/14
摘要： The invention comprises novel compounds that are effective in the prophylaxis and treatment of diseases, such as integrin receptors mediated diseases, in particular, diseases or conditions mediated by integrin receptors, such as a αvβ3, αvβ5, αvβ6, α5β1 and the like. The invention encompasses novel compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of such diseases and disorders. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 本发明包括有效预防和治疗诸如整联蛋白受体介导的疾病，特别是整联蛋白受体介导的疾病或病症的新型化合物，例如阿尔法派3，阿尔法派5，阿尔法博特6，α5β1等。 本发明包括新型化合物，其药学上可接受的盐，用于预防和治疗这些疾病和病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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6.发明申请BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS 审中-公开用于治疗炎症，心血管和中枢神经疾病的BIARYL PDE4抑制剂公开(公告)号：US20090324569A1
公开(公告)日：2009-12-31
申请号：US12275163
申请日：2008-11-20
申请人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Vincent Sandanayaka , Alexander Kiselyov , Adalie Motta , Gary Schiltz , Georgeta Hategan , Timothy Hagen
发明人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Vincent Sandanayaka , Alexander Kiselyov , Adalie Motta , Gary Schiltz , Georgeta Hategan , Timothy Hagen
IPC分类号： A61K31/44 , C07D401/04 , C07D231/12 , C07D237/14 , C07D277/38 , C07D285/135 , C07D213/72 , C07D403/10 , C07D413/06 , C07D401/06 , A61K31/4427 , A61K31/5377 , A61K31/4439 , A61K31/4412 , A61K31/4164 , A61K31/4245 , A61K31/445 , A61K31/437 , A61K31/415 , A61K31/506 , A61K31/54 , A61K31/122 , A61K31/435 , A61P9/00 , A61P35/00 , A61P11/00
CPC分类号： C07C217/84 , A61K31/136 , A61K31/397 , A61K31/41 , A61K31/426 , A61K31/437 , A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07C65/40 , C07C69/94 , C07C275/32 , C07C275/62 , C07C305/24 , C07C307/10 , C07D205/04 , C07D207/16 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/79 , C07D213/81 , C07D213/84 , C07D213/89 , C07D231/12 , C07D233/90 , C07D239/42 , C07D257/04 , C07D275/06 , C07D277/42 , C07D285/12 , C07D285/135 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D473/18 , C07D473/40
摘要： The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula I: A particular embodiment is
摘要翻译： 本发明涉及含有至少一个其它环的联芳基化合物属。 该化合物是可用于治疗和预防中风，心肌梗塞和心血管炎性疾病和病症的PDE4抑制剂。 该化合物具有通式I：具体实施方案是
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公开(公告)号：US20090318438A1
公开(公告)日：2009-12-24
申请号：US12286132
申请日：2008-09-25
申请人： Xiaoling Chen , Hai-Ying He , Joel Kawakami , Alexander Kiselyov , Xiaohu Ouyang , Vatee Pattaropong , Evgueni Piatnitski , Maria Carolina Tuma , John Kincaid
发明人： Xiaoling Chen , Hai-Ying He , Joel Kawakami , Alexander Kiselyov , Xiaohu Ouyang , Vatee Pattaropong , Evgueni Piatnitski , Maria Carolina Tuma , John Kincaid
IPC分类号： A61K31/5377 , A61K31/444 , C07D401/04 , A61K31/496 , C07D413/14 , A61P35/00 , C07D405/00 , C07D401/14 , A61K31/4439
CPC分类号： C07D401/04 , C07D249/14 , C07D263/48 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14
摘要： The present invention relates to heterocyclic compounds that have anticancer activity, and pharmaceutical compositions that contain such compounds, methods of treating diseases and conditions in mammals using such compounds and composition and methods for their manufacture.
摘要翻译： 本发明涉及具有抗癌活性的杂环化合物和含有这些化合物的药物组合物，使用这些化合物治疗哺乳动物疾病和病症的方法及其制备方法。
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公开(公告)号：US20070104694A1
公开(公告)日：2007-05-10
申请号：US11414860
申请日：2006-05-01
CPC分类号： A61L27/3839 , A61K35/12 , A61L27/3804 , A61L27/3895 , C12N5/0667 , C12N2539/10
摘要： A stem-cell-seeded porous scaffold implant and electromagnetic growth stimulation for treating or augmenting a breast tissue defect in a patient.
摘要翻译： 用于治疗或增加患者乳腺组织缺陷的干细胞种子多孔支架植入物和电磁生长刺激。
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公开(公告)号：US20060040956A1
公开(公告)日：2006-02-23
申请号：US11234713
申请日：2005-09-23
申请人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod Patel , Leon Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Yuan , Michael Croghan
发明人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod Patel , Leon Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Yuan , Michael Croghan
IPC分类号： A61K31/506 , C07D403/02
CPC分类号： C07D213/82 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/538 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/00 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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10.发明授权Biaryl PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders 有权用于治疗炎症，心血管和CNS疾病的二芳基PDE4抑制剂公开(公告)号：US08791267B2
公开(公告)日：2014-07-29
申请号：US13430164
申请日：2012-03-26
申请人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Vincent Sandanayaka , Alexander Kiselyov , Adalie Motta , Gary Schiltz , Georgeta Hategan , Timothy Hagen
发明人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Vincent Sandanayaka , Alexander Kiselyov , Adalie Motta , Gary Schiltz , Georgeta Hategan , Timothy Hagen
IPC分类号： C07D213/72 , A61K31/435
CPC分类号： C07C217/84 , A61K31/136 , A61K31/397 , A61K31/41 , A61K31/426 , A61K31/437 , A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07C65/40 , C07C69/94 , C07C275/32 , C07C275/62 , C07C305/24 , C07C307/10 , C07D205/04 , C07D207/16 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/79 , C07D213/81 , C07D213/84 , C07D213/89 , C07D231/12 , C07D233/90 , C07D239/42 , C07D257/04 , C07D275/06 , C07D277/42 , C07D285/12 , C07D285/135 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D473/18 , C07D473/40
摘要： The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula I: A particular embodiment is
摘要翻译： 本发明涉及含有至少一个其它环的联芳基化合物属。 该化合物是可用于治疗和预防中风，心肌梗塞和心血管炎性疾病和病症的PDE4抑制剂。 该化合物具有通式I：具体实施方案是
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