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公开(公告)号：US20120234394A1
公开(公告)日：2012-09-20
申请号：US13395721
申请日：2010-09-04
申请人： Jurl Seletzky , Joerg Kauling , Björn Frahm , Helmut Brod , Marc Jenne , Franz Schmitt
发明人： Jurl Seletzky , Joerg Kauling , Björn Frahm , Helmut Brod , Marc Jenne , Franz Schmitt
CPC分类号： C12M29/06 , B01F3/04248 , B01F2003/0417 , B01F2003/04297 , B01F2003/04333 , B01F2003/04368 , Y10T137/0329
摘要： The invention relates to a sparger for introducing a gas or gas mixture into a liquid and to a method for sparging liquids. The sparger according to the invention comprises a cavity, a gas inlet for routing a gas into the cavity and two or more faces, which are or can be pressed onto one another in a positive fashion such that a gas pressed into the cavity through the gas inlet escapes through the gaps occurring between the pressed together faces.
摘要翻译： 本发明涉及一种用于将气体或气体混合物引入液体的喷射器和用于喷射液体的方法。 根据本发明的分布器包括空腔，用于将气体引导到空腔中的气体入口和两个或更多个面，这两个或更多个面可以或可以以积极的方式彼此压紧，使得通过气体压入空腔中的气体 入口通过压制在一起的面之间的间隙逸出。
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公开(公告)号：US20110165677A1
公开(公告)日：2011-07-07
申请号：US13062556
申请日：2009-09-17
申请人： Helmut Brod , Björn Frahm , Joerg Kauling
发明人： Helmut Brod , Björn Frahm , Joerg Kauling
CPC分类号： B01F3/04269 , B01F11/0088 , B01F2003/04319 , B01F2003/04404 , C12M23/24 , C12M27/04 , C12M29/04 , C12M39/00
摘要： The invention relates to a process for reducing the amount of deposits during the culture of organisms, and in particular of cell cultures, where these have a tendency towards agglomeration or adhesion to the bioreactor and to its elements, or where these are readily susceptible to agglomeration or adhesion of cell debris or of substances.
摘要翻译： 本发明涉及一种减少生物体培养期间沉积物量的方法，特别是细胞培养物，其中这些沉积物具有聚集或粘附到生物反应器及其元件的趋势，或者其中容易易于聚集的方法 或细胞碎片或物质的粘附。
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公开(公告)号：US20110256624A1
公开(公告)日：2011-10-20
申请号：US13140464
申请日：2009-12-08
申请人： Marc Jenne , Björn Frahm , Joerg Kauling , Helmut Brod
发明人： Marc Jenne , Björn Frahm , Joerg Kauling , Helmut Brod
CPC分类号： C12M29/08
摘要： The invention relates to a bioreactor, to the use of the bioreactor for culturing microorganisms or cell cultures, and also to a method for culturing microorganisms or cell cultures.
摘要翻译： 本发明涉及使用生物反应器培养微生物或细胞培养物的生物反应器，以及培养微生物或细胞培养物的方法。
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公开(公告)号：US20110097800A1
公开(公告)日：2011-04-28
申请号：US12997281
申请日：2009-06-10
申请人： Joerg Kauling , Björn Frahm , Marc Jenne , Helmut Brod , Stephan Kirchner , Arndt Braun
发明人： Joerg Kauling , Björn Frahm , Marc Jenne , Helmut Brod , Stephan Kirchner , Arndt Braun
摘要： The invention relates to a device and a method for retaining and recirculating cells in a vessel through which flow passes continuously or batchwise.In addition, the invention relates to a method of producing a device by which cells can be retained and recirculated in a vessel through which flow passes continuously or batchwise.
摘要翻译： 本发明涉及一种用于保持和再循环在容器中的细胞的装置和方法，血液通过该细胞连续或间歇地流过。 此外，本发明涉及一种生产装置的方法，通过该装置可以将细胞保持和再循环在流过连续或间歇流过的容器中。
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公开(公告)号：US20120052578A1
公开(公告)日：2012-03-01
申请号：US13145823
申请日：2010-01-13
申请人： Joerg Kauling , Björn Frahm , Andre Pütz , Markus Schindler
发明人： Joerg Kauling , Björn Frahm , Andre Pütz , Markus Schindler
CPC分类号： A61K38/12 , B01F3/04517 , B01F3/04539 , B01F7/1675 , B01F7/18 , B01F11/0002 , C12M29/06
摘要： A gas-introduction system useful, for example, in biotechnology for supplying cells or microorganisms with oxygen. The gas-introduction system has a bubble column and a distributor. In the vessel there is situated a liquid medium which is to be supplied with gas. A vector is used as transport medium for the gas. The gas is introduced into the bubble column and here taken up by the vector. The vector is applied to the liquid surface via the distributor in droplet form, falls downward in the medium and releases to the medium some of the gas that has been taken up. At the bottom of the vessel is situated a collecting device in which the vector droplets coalesce and pass back into the bubble column. Disclosed are a bioreactor comprising the gas-introduction system and a method for introducing gas into a liquid medium, preferably an aqueous suspension containing cells or microorganisms.
摘要翻译： 气体导入系统，例如在用于向氧气供应细胞或微生物的生物技术中有用。 气体引入系统具有气泡塔和分配器。 在容器中设有要供应气体的液体介质。 载体用作气体的输送介质。 将气体引入气泡塔中，并将其从载体中吸收。 载体通过液滴形式的分配器施加到液体表面，在介质中向下落下，并向介质中释放出已经被吸收的一些气体。 在容器的底部设有收集装置，其中矢量液滴聚结并传回到气泡塔中。 公开了一种生物反应器，其包括气体引入系统和将气体引入液体介质，优选含有细胞或微生物的含水悬浮液的方法。
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公开(公告)号：US08869371B2
公开(公告)日：2014-10-28
申请号：US13201313
申请日：2010-02-03
CPC分类号： B23P19/02 , B01J19/123 , B01J19/242 , B01J2219/0002 , B29C65/66 , B29C66/1122 , B29C66/52272 , B29C66/53241 , B29C66/71 , B29C66/7465 , B29L2023/18 , C02F1/325 , C02F2201/004 , F16L11/118 , F16L11/1185 , F16L11/20 , Y10T29/49867 , Y10T29/49869 , Y10T29/4987 , Y10T29/49945 , Y10T29/53987 , B29K2027/18
摘要： Profiled hollow cylinders attached to a cylinder-shaped body as modules for radiating fluid media with electromagnetic radiation.
摘要翻译： 连接到圆柱形体的成型空心圆筒作为用电磁辐射辐射流体介质的模块。
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7.发明申请公开(公告)号：US20070003430A1
公开(公告)日：2007-01-04
申请号：US11079934
申请日：2005-03-14
申请人： Klaus Kaiser , Hans-Juergen Henzler , Joerg Kauling , Rolf Treckmann , Kathryn Remington , Cynthia Galloway
发明人： Klaus Kaiser , Hans-Juergen Henzler , Joerg Kauling , Rolf Treckmann , Kathryn Remington , Cynthia Galloway
IPC分类号： A61L2/10
CPC分类号： B01J19/123 , A23L3/28 , A61K41/0019 , A61L2/0005 , A61L2/0011 , A61L2/10 , A61M1/3681 , A61M1/3683 , A61M2205/053 , B01J19/2405 , B01J2219/00139 , B01J2219/00164 , B01J2219/00168 , C02F1/325 , C02F2201/32 , C02F2201/3223 , C02F2201/328 , Y10S422/905
摘要： A method of inactivating microorganisms such as viruses within a fluid such as a biological fluid is disclosed. The method includes the steps of providing a UV reactor, which may take the form of an elongated generally annular reaction chamber surrounding at least one elongated UV lamp, moving the fluid within the reaction chamber in a primary flow directed along the length of the UV lamp, and inducing a circulating secondary flow within the fluid with the secondary flow being superimposed on the primary flow. As the fluid moves through the reaction chamber in the primary flow, it is circulated repeatedly toward and away from the UV lamp in the circulating secondary flow to provide uniform and controllable exposure of the entire volume of fluid to ultraviolet radiation. Microorganisms such as viruses are thus inactivated while desirable components in the fluid, such as proteins, are preserved without the use of a free radical scavenger.
摘要翻译： 公开了一种灭活诸如生物流体之类的流体中的微生物如病毒的方法。 该方法包括以下步骤：提供UV反应器，UV反应器可采取围绕至少一个细长UV灯的细长的大致环形的反应室的形式，使反应室内的流体以沿着UV灯长度的一次流动 并且在所述流体中引起循环次级流，其中所述次流叠加在所述主流上。 当流体在初级流中移动通过反应室时，它在循环的二次流中反复地朝向和远离UV灯循环，以提供整个体积的流体对紫外线辐射的均匀和可控的曝光。 因此，微生物如病毒灭活，而流体中的期望组分（例如蛋白质）在不使用自由基清除剂的情况下被保存。
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公开(公告)号：US20110314655A1
公开(公告)日：2011-12-29
申请号：US13201313
申请日：2010-02-03
CPC分类号： B23P19/02 , B01J19/123 , B01J19/242 , B01J2219/0002 , B29C65/66 , B29C66/1122 , B29C66/52272 , B29C66/53241 , B29C66/71 , B29C66/7465 , B29L2023/18 , C02F1/325 , C02F2201/004 , F16L11/118 , F16L11/1185 , F16L11/20 , Y10T29/49867 , Y10T29/49869 , Y10T29/4987 , Y10T29/49945 , Y10T29/53987 , B29K2027/18
摘要： Profiled hollow cylinders attached to a cylinder-shaped body as modules for radiating fluid media with electromagnetic radiation.
摘要翻译： 连接到圆柱形体的成型空心圆筒作为用电磁辐射辐射流体介质的模块。
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公开(公告)号：US20120100605A1
公开(公告)日：2012-04-26
申请号：US13318660
申请日：2009-12-03
CPC分类号： B01J19/285 , B01F11/0002 , B01F15/00876 , C12M23/26 , C12M27/10 , G06K19/0716
摘要： A reactor is designed as a disposable element, a container receives the reactor, and a device comprises a reactor. A drive unit of the device generates a rotating-oscillating motion of the reactor, and the device is utilized for cultivating cells and/or microorganisms.
摘要翻译： 反应器设计为一次性元件，容器接收反应器，并且装置包括反应器。 该装置的驱动单元产生反应器的旋转振荡运动，并且该装置用于培养细胞和/或微生物。
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10.发明申请METHOD FOR THE SELECTIVE SEPARATION OF PEPTIDES AND PROTEINS BY MEANS OF A CRYSTALLIZATION PROCESS 审中-公开通过结晶过程选择性分离肽和蛋白质的方法公开(公告)号：US20110130542A1
公开(公告)日：2011-06-02
申请号：US12999193
申请日：2009-06-16
IPC分类号： C07K1/30
摘要： Method for removing and selective separating peptides and proteins from a solution by controlled crystallization.
摘要翻译： 通过受控结晶从溶液中去除和选择性分离肽和蛋白质的方法。
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