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24 条记录 (耗时 0.057 秒)

    Method for synthesising templated molecules
    7.
    发明授权
    Method for synthesising templated molecules 有权
    合成模板分子的方法

    公开(公告)号：US07413854B2

    公开(公告)日：2008-08-19

    申请号：US10507121

    申请日：2003-03-14

    申请人： Henrik Pedersen ,  Anette Holtmann ,  Thomas Franch ,  Alex Haahr Gouliaev ,  Jakob Felding

    发明人： Henrik Pedersen ,  Anette Holtmann ,  Thomas Franch ,  Alex Haahr Gouliaev ,  Jakob Felding

    IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12N15/1068 ,  C07B2200/11 ,  C07D405/04 ,  C07H21/00 ,  C07H21/04 ,  C12Q1/6816 ,  C40B40/06 ,  C40B40/14

    摘要： The invention relates to a method for synthesizing templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.

    摘要翻译： 本发明涉及一种合成连接于模板的模板分子的方法，其指导其合成。 该方法涉及模板，脚手架功能实体和连接到构件块的功能实体，其又附接模板。 支架功能实体和构建单元的功能实体都具有互补的二聚化结构域，使得当互补结构域彼此相互作用时，功能实体能够接近。 该方法可以用于产生可以选择用于生物活性的模板分子的文库。

    Quasirandom Structure and Function Guided Synthesis Methods
    8.
    发明申请
    Quasirandom Structure and Function Guided Synthesis Methods 有权
    Quasirandom结构与功能引导合成方法

    公开(公告)号：US20080193983A1

    公开(公告)日：2008-08-14

    申请号：US10539288

    申请日：2003-12-19

    申请人： Alex Haahr Gouliaev ,  Anette Holtmann ,  Henrik Pedersen ,  Thomas Franch

    发明人： Alex Haahr Gouliaev ,  Anette Holtmann ,  Henrik Pedersen ,  Thomas Franch

    IPC分类号： C12P19/34 ,  C07H21/04 ,  C07K5/08 ,  G01N33/50

    CPC分类号： C40B30/04 ,  C12N15/1068 ,  C40B20/04 ,  C40B40/06 ,  C40B50/04 ,  C40B50/08 ,  Y10T436/145555

    摘要： The present invention is directed to the synthesis of molecules guided b connector polynucleotides (CPNs capable of hybridizing to complementary connector polynucleotides (CCPNs) harbouring at least one functional entity comprising at least one reactive group. At least one of said CCPNs capable of hybridize to at least two CPNs. Each CPN will “call” for one or more CCPNs capable of hybridization to the CPN. Following the formation of a supramolecular hybridization complex comprising a plurality of CPNs and a plurality of CCPNs, the reaction of functional entity reactive groups result I the formation of a molecule comprising covalently linked functional entities. The formation of the molecule involves the transfer of functional entities from one or more “donor CCPNs” to at least on “acceptor CCPN” with which the transferred functional entities were not associated prior to the transfer.

    摘要翻译： 本发明涉及分子引导的b连接体多核苷酸（能够与包含至少一个包含至少一个反应性基团的至少一个功能实体的互补连接子多核苷酸（CCPN）杂交）的分子的合成，所述至少一种能够与 至少两个CPN，每个CPN将“呼叫”一个或多个能够与CPN杂交的CCPN，形成包含多个CPN和多个CCPN的超分子杂交复合物后，功能性实体反应性基团的反应导致I 分子的形成包括共价连接的功能实体。分子的形成涉及将功能性实体从一个或多个“供体CCPN”转移至至少在“受体CCPN”之间，转移的功能实体在其之前不相关联 转让。

    Quasirandom structure and function guided synthesis methods
    9.
    发明授权
    Quasirandom structure and function guided synthesis methods 有权
    曲斯兰结构和功能指导合成方法

    公开(公告)号：US09121110B2

    公开(公告)日：2015-09-01

    申请号：US10539288

    申请日：2003-12-19

    申请人： Alex Haahr Gouliaev ,  Anette Holtmann ,  Henrik Pedersen ,  Thomas Franch

    发明人： Alex Haahr Gouliaev ,  Anette Holtmann ,  Henrik Pedersen ,  Thomas Franch

    IPC分类号： C40B50/00 ,  C40B20/04 ,  C40B30/00 ,  C40B50/10 ,  C12Q1/68 ,  C07H21/02 ,  C40B30/04 ,  C12N15/10 ,  C40B40/06 ,  C40B50/08 ,  C40B50/04

    CPC分类号： C40B30/04 ,  C12N15/1068 ,  C40B20/04 ,  C40B40/06 ,  C40B50/04 ,  C40B50/08 ,  Y10T436/145555

    摘要： The present invention is directed to the synthesis of molecules guided by connector polynucleotides (CPNs) capable of hybridizing to complementary connector polynucleotides (CCPNs) harboring at least one functional entity comprising at least one reactive group. At least one of the CCPNs is capable of hybridizing to at least two CPNs. Each CPN will “call” for one or more CCPNs capable of hybridization to the CPN. Following the formation of a supramolecular hybridization complex comprising a plurality of CPNs and a plurality of CCPNs, the reaction of reactive groups results in the formation of a molecule comprising covalently linked functional entities. The formation of the molecule involves the transfer of functional entities from one or more “donor CCPNs” to at least one “acceptor CCPN” with which the transferred functional entities were not associated prior to the transfer.

    摘要翻译： 本发明涉及由能够与包含至少一个反应性基团的至少一个功能实体的互补连接多核苷酸（CCPN）杂交的连接体多核苷酸（CPN）引导的分子的合成。 至少有一个CCPN能够与至少两个CPN杂交。 每个CPN将“呼叫”一个或多个能够与CPN杂交的CCPN。 在形成包含多个CPN和多个CCPN的超分子杂交复合物之后，反应性基团的反应导致包含共价连接的功能性实体的分子的形成。 分子的形成涉及将功能性实体从一个或多个“供体CCPN”转移至至少一个转移的功能实体在转移之前与之不相关的“受体CCPN”。