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    Catalyst for hydrogenation treatment and method for hydrogenation treatment of hydrocarbon oil
    3.
    发明授权
    Catalyst for hydrogenation treatment and method for hydrogenation treatment of hydrocarbon oil 失效
    用于氢化处理的催化剂和烃油的氢化处理方法

    公开(公告)号：US06306289B1

    公开(公告)日：2001-10-23

    申请号：US09423833

    申请日：1999-11-16

    申请人： Fumitaka Hayashi ,  Akira Kamo ,  Hiroshi Toshima

    发明人： Fumitaka Hayashi ,  Akira Kamo ,  Hiroshi Toshima

    IPC分类号： C10G4500

    CPC分类号： B01J23/88 ,  B01J21/02 ,  B01J21/10 ,  B01J21/12 ,  B01J23/85 ,  B01J23/882 ,  B01J23/883 ,  B01J35/002 ,  B01J35/10 ,  B01J35/1019 ,  B01J35/108 ,  B01J37/0205 ,  B01J37/03 ,  C10G45/08

    摘要： A hydrotreating catalyst having both a high desulfurization activity and a denitrogenation activity and a method of hydrotreating a hydrocarbon oil using the same is provided. A hydrotreatment catalyst comprising a silica-alumina carrier loaded with at least one hydrogenation-active component; wherein (1) the silica content is in the range of 2 to 40% by weight based on the total weight of the carrier; and (2) in the spectrum obtained by nuclear magnetic resonance analysis (29Si-NMR), (i) the area of the peak at −80 ppm is 10% or more of the combined area of all the peaks; and (ii) the combined area of peaks at −80 ppm, −86 ppm and −92 ppm is 20% or more of the combined area of all peaks; a hydrotreating catalyst comprising a silica-alumina carrier containing a specific amount of a third component loaded with at lest one hydrogenation-active metal component and having a specific pore structure; and a method of hydrotreating a hydrocarbon oil comprising contacting a hydrocarbon oil with hydrogen in the presence of said hydrotreating catalyst.

    摘要翻译： 提供具有高脱硫活性和脱氮活性的加氢处理催化剂，以及使用其加氢处理烃油的方法。一种加氢处理催化剂，其包含负载有至少一种氢化活性组分的二氧化硅 - 氧化铝载体; 其中（1）基于所述载体的总重量，二氧化硅含量在2-40重量％的范围内; 和（2）在通过核磁共振分析（29Si-NMR）获得的光谱中，（i）-80ppm处的峰面积为所有峰的组合面积的10％以上; 和（ii）-80ppm，-86ppm和-92ppm的峰的组合面积为所有峰的组合面积的20％或更多; 加氢处理催化剂，其包含含有特定量的第三组分的二氧化硅 - 氧化铝载体，所述第三组分装载有至少一种氢化活性金属组分并具有特定孔结构; 以及加氢处理烃油的方法，包括在所述加氢处理催化剂存在下使烃油与氢气接触。

    Toll-like receptor 5 ligands and methods of use
    4.
    发明授权
    Toll-like receptor 5 ligands and methods of use 有权
    Toll样受体5配体及使用方法

    公开(公告)号：US08703146B2

    公开(公告)日：2014-04-22

    申请号：US10991347

    申请日：2004-11-16

    申请人： Alan Aderem ,  Fumitaka Hayashi ,  Kelly D. Smith ,  David M. Underhill ,  Adrian Ozinsky

    发明人： Alan Aderem ,  Fumitaka Hayashi ,  Kelly D. Smith ,  David M. Underhill ,  Adrian Ozinsky

    IPC分类号： A61K39/112

    CPC分类号： C07K14/195 ,  A61K39/00 ,  A61K2039/55516 ,  C07K14/255 ,  C07K2319/00

    摘要： The invention provides an immunomodulatory flagellin peptide having substantially the same amino acid sequence GALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQ (SEQ ID NO:44), or a modification thereof, and having toll like receptor 5 (TLR5) binding. The immunomodulatory flagellin peptide also can have substantially the same amino acid sequence TQFSGVKVLAQDNTLTIQVGANDGETIDIDLKQINS QTLGLDTL (SEQ ID NO:45); EGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVNG (SEQ ID NO:46) or MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANF TANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQS (SEQ ID NO:47), or a modification thereof. Also provided is an immunomodulatory flagellin peptide having substantially the same amino acid sequence LQKIDAALAQVDTLRSDLGAVQNRFNSAITNL (SEQ ID NO:48), or a modification thereof, and having toll like receptor 5 (TLR5) binding. The immunomodulatory flagellin peptide also can have substantially the same amino acid sequence TLRSDLGAVQNRFNSAITNLGNTVNNLSS (SEQ ID NO:49) or EQAAKTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLSS (SEQ ID NO:50), or a modification thereof. Further provided is an immunomodulatory flagellin peptide having substantially the same amino acid sequence GALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAE ITQ (SEQ ID NO:44) and substantially the same amino acid sequence LQKIDAALAQVDTLRSDLGAVQNRFNSAITNL (SEQ ID NO:48), or a modification thereof, and having toll like receptor 5 (TLR5) binding. Methods of using immunomodulatory flagellin peptides additionally are provided.

    摘要翻译： 本发明提供具有基本上相同的氨基酸序列GALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQ（SEQ ID NO：44）或其修饰，并具有与受体5（TLR5）结合的通路的免疫调节鞭毛蛋白肽。 免疫调节鞭毛蛋白肽也可以具有基本相同的氨基酸序列TQFSGVKVLAQDNTLTIQVGANDGETIDIDLKQINS QTLGLDTL（SEQ ID NO：45）; 或其修饰物。（SEQ ID NO：46）或MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANF TANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQS（SEQ ID NO：47）或其修饰。 还提供了具有基本上相同的氨基酸序列LQKIDAALAQVDTLRSDLGAVQNRFNSAITNL（SEQ ID NO：48）或其修饰，并具有与受体5（TLR5）结合的通路的免疫调节鞭毛蛋白肽。 免疫调节鞭毛蛋白肽也可以具有基本上相同的氨基酸序列TLRSDLGAVQNRFNSAITNLGNTVNNLSS（SEQ ID NO：49）或EQAAKTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLSS（SEQ ID NO：50）或其修饰。 还提供了具有基本上相同的氨基酸序列GALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAE ITQ（SEQ ID NO：44）和基本上相同的氨基酸序列LQKIDAALAQVDTLRSDLGAVQNRFNSAITNL（SEQ ID NO：48）或其修饰，并具有类似受体5的氨基酸序列的免疫调节鞭毛蛋白肽 （TLR5）结合。 另外提供了使用免疫调节鞭毛蛋白肽的方法。

    Toll-like receptor 5 ligands and methods of use
    9.
    发明申请
    Toll-like receptor 5 ligands and methods of use 有权
    Toll样受体5配体及使用方法

    公开(公告)号：US20050147627A1

    公开(公告)日：2005-07-07

    申请号：US10991347

    申请日：2004-11-16

    申请人： Alan Aderem ,  Fumitaka Hayashi ,  Kelly Smith ,  David Underhill ,  Adrian Ozinsky

    发明人： Alan Aderem ,  Fumitaka Hayashi ,  Kelly Smith ,  David Underhill ,  Adrian Ozinsky

    IPC分类号： A61K39/00 ,  C07K14/195 ,  C07K14/255 ,  A61K39/02 ,  C12N9/00

    CPC分类号： C07K14/195 ,  A61K39/00 ,  A61K2039/55516 ,  C07K14/255 ,  C07K2319/00

    摘要： The invention provides an immunomodulatory flagellin peptide having substantially the same amino acid sequence GALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQ (SEQ ID NO:44), or a modification thereof, and having toll like receptor 5 (TLR5) binding. The immunomodulatory flagellin peptide also can have substantially the same amino acid sequence TQFSGVKVLAQDNTLTIQVGANDGETIDIDLKQINS QTLGLDTL (SEQ ID NO:45); EGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVNG (SEQ ID NO:46) or MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANF TANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQS (SEQ ID NO:47), or a modification thereof. Also provided is an immunomodulatory flagellin peptide having substantially the same amino acid sequence LQKIDAALAQVDTLRSDLGAVQNRFNSAITNL (SEQ ID NO:48), or a modification thereof, and having toll like receptor 5 (TLR5) binding. The immunomodulatory flagellin peptide also can have substantially the same amino acid sequence TLRSDLGAVQNRFNSAITNLGNTVNNLSS (SEQ ID NO:49) or EQAAKTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLSS (SEQ ID NO:50), or a modification thereof. Further provided is an immunomodulatory flagellin peptide having substantially the same amino acid sequence GALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAE ITQ (SEQ ID NO:44) and substantially the same amino acid sequence LQKIDAALAQVDTLRSDLGAVQNRFNSAITNL (SEQ ID NO:48), or a modification thereof, and having toll like receptor 5 (TLR5) binding. Methods of using immunomodulatory flagellin peptides additionally are provided.

    摘要翻译： 本发明提供具有基本上相同的氨基酸序列GALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQ（SEQ ID NO：44）或其修饰，并具有与受体5（TLR5）结合的通路的免疫调节性鞭毛蛋白肽。 免疫调节鞭毛蛋白肽也可以具有基本相同的氨基酸序列TQFSGVKVLAQDNTLTIQVGANDGETIDIDLKQINS QTLGLDTL（SEQ ID NO：45）; 或其修饰物。（SEQ ID NO：46）或MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANF TANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQS（SEQ ID NO：47）或其修饰。 还提供了具有基本上相同的氨基酸序列LQKIDAALAQVDTLRSDLGAVQNRFNSAITNL（SEQ ID NO：48）或其修饰，并具有与受体5（TLR5）结合的通路的免疫调节鞭毛蛋白肽。 免疫调节鞭毛蛋白肽也可以具有基本上相同的氨基酸序列TLRSDLGAVQNRFNSAITNLGNTVNNLSS（SEQ ID NO：49）或EQAAKTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLSS（SEQ ID NO：50）或其修饰。 还提供了具有基本上相同的氨基酸序列GALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAE ITQ（SEQ ID NO：44）和基本上相同的氨基酸序列LQKIDAALAQVDTLRSDLGAVQNRFNSAITNL（SEQ ID NO：48）或其修饰，并具有类似受体5的氨基酸序列的免疫调节鞭毛蛋白肽 （TLR5）结合。 另外提供了使用免疫调节鞭毛蛋白肽的方法。