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    Extracellular recording electrode
    1.
    发明授权
    Extracellular recording electrode 有权
    细胞外记录电极

    公开(公告)号：US07041492B2

    公开(公告)日：2006-05-09

    申请号：US10048662

    申请日：2001-06-20

    申请人： Hiroaki Oka ,  Tetsuo Yukimasa ,  Ryuta Ogawa ,  Hirokazu Sugihara ,  Katsuyuki Tsuji ,  Yukifumi Yoshimoto

    发明人： Hiroaki Oka ,  Tetsuo Yukimasa ,  Ryuta Ogawa ,  Hirokazu Sugihara ,  Katsuyuki Tsuji ,  Yukifumi Yoshimoto

    IPC分类号： C12M1/42

    CPC分类号： A61N1/0492 ,  A61N1/0476 ,  A61N1/0551 ,  G01N33/4836

    摘要： A multiple electrode includes a plurality of micro-electrodes provided on a substrate, and a wiring portion for providing an electrical signal to the micro-electrodes or extracting an electrical signal from the micro-electrodes. Each micro-electrode has porous conductive material on its surface, and the impedance of the micro-electrode is 50 kΩ or less. Preferably, the porous conductive material is gold, and formed by the passage of current at a current density of 1.0 to 5.0 A/dm2 for 10 to 360 sec. The multiple electrode may include micro-electrodes provided on a substrate in the form of a matrix, a lead line connected to the micro-electrodes, and an electrical junction connected to an end of the lead line.

    摘要翻译： 多个电极包括设置在基板上的多个微电极和用于向微电极提供电信号或从微电极提取电信号的布线部分。 每个微电极在其表面上具有多孔导电材料，微电极的阻抗为50kΩ以下。 优选地，多孔导电材料是金，并且通过电流以1.0至5.0A / dm 2的电流通过10至360秒形成。 多个电极可以包括以矩阵形式设置在基板上的微电极，连接到微电极的引线和连接到引线的端部的电连接。

    Extracellular recording multiple electrode
    2.
    发明授权
    Extracellular recording multiple electrode 有权
    细胞外记录多电极

    公开(公告)号：US06894511B2

    公开(公告)日：2005-05-17

    申请号：US10019417

    申请日：2001-07-12

    申请人： Tetsuo Yukimasa ,  Hiroaki Oka ,  Ryuta Ogawa ,  Hirokazu Sugihara

    发明人： Tetsuo Yukimasa ,  Hiroaki Oka ,  Ryuta Ogawa ,  Hirokazu Sugihara

    IPC分类号： G01N33/483 ,  C12M1/00 ,  G01N27/30 ,  G01N27/403 ,  G01N33/487 ,  G01R27/08

    CPC分类号： G01N33/48728

    摘要： A multiple electrode for measuring electro-physiological characteristics of a biological specimen includes a plurality of micro-electrode provided on a first region on a substrate, and a reference electrode provided in a second region on the substrate. The reference electrode includes at least one stimulus reference electrode for applying an electrical signal to the plurality of micro-electrodes. Preferably, the reference electrode includes at least one measurement reference electrode for detecting an electrical signal from the plurality of micro-electrodes, and the stimulus reference electrode is electrically insulated from the measurement reference electrode. Preferably, the second region is placed at a distance from an outer edge of the first region, and surrounds the first region.

    摘要翻译： 用于测量生物样品的电生理特性的多电极包括设置在基板上的第一区域上的多个微电极和设置在基板上的第二区域中的参考电极。 参考电极包括用于向多个微电极施加电信号的至少一个激励参考电极。 优选地，参考电极包括用于检测来自多个微电极的电信号的至少一个测量参考电极，并且刺激参考电极与测量参考电极电绝缘。 优选地，第二区域被放置在距离第一区域的外边缘一定距离处，并且围绕第一区域。

    Method for extracting significant signal, recording medium and program
    3.
    发明授权
    Method for extracting significant signal, recording medium and program 有权
    提取重要信号，记录介质和程序的方法

    公开(公告)号：US06999905B2

    公开(公告)日：2006-02-14

    申请号：US10296007

    申请日：2002-04-26

    申请人： Ryuta Ogawa ,  Hiroaki Oka ,  Nobuhiko Ozaki ,  Hirokazu Sugihara

    发明人： Ryuta Ogawa ,  Hiroaki Oka ,  Nobuhiko Ozaki ,  Hirokazu Sugihara

    IPC分类号： G06F15/00

    CPC分类号： G01D1/14

    摘要： A method for extracting a signal of interest from a signal generated from at least one subject, comprises the steps of (A) obtaining a time-series signal generated from the subject as a data group consisting of a plurality of pieces of data, (B) obtaining a plurality of extracted data groups from the data group, wherein each extracted data group comprises a predetermined number of pieces of data selected from the data group, (C) calculating standard deviations of the plurality of extracted data groups to obtain a standard deviation group, and (D) referencing each standard deviation included in the standard deviation group and selecting the signal of interest.

    摘要翻译： 一种用于从至少一个对象产生的信号中提取感兴趣的信号的方法，包括以下步骤：（A）获得从被摄体产生的时间序列信号作为由多条数据组成的数据组（B ）从所述数据组中获取多个提取的数据组，其中每个提取的数据组包括从所述数据组中选择的预定数量的数据，（C）计算所述多个提取的数据组的标准偏差以获得标准偏差 组和（D）参考包括在标准偏差组中的每个标准偏差并选择感兴趣的信号。

    Method for measuring physiocochemical properties of tissues of cells, method for examining chemicals, and apparatus therefor
    5.
    发明授权
    Method for measuring physiocochemical properties of tissues of cells, method for examining chemicals, and apparatus therefor 失效
    用于测量细胞组织的生理化学性质的方法，用于检查化学品的方法及其装置

    公开(公告)号：US06890762B1

    公开(公告)日：2005-05-10

    申请号：US08913811

    申请日：1997-01-24

    申请人： Hirokazu Sugihara ,  Yasushi Kobayashi ,  Hiroaki Oka ,  Ryuta Ogawa ,  Makoto Taketani

    发明人： Hirokazu Sugihara ,  Yasushi Kobayashi ,  Hiroaki Oka ,  Ryuta Ogawa ,  Makoto Taketani

    IPC分类号： C12Q1/02 ,  G01N33/50 ,  G01N33/567 ,  C12Q1/04 ,  G01N33/48 ,  G01N33/53 ,  C12N27/00

    CPC分类号： G01N33/5005 ,  C12Q1/02 ,  Y10S436/806 ,  Y10S436/807

    摘要： A method of measuring the physical and chemical properties of tissue or cells and a device for the same is provided, with which the physical and chemical environment of the tissue or cells can be changed arbitrarily corresponding to experimental necessities. The device comprises a system 40 for keeping the physical and chemical environment surrounding the biological tissue or cells constant, a system 50 for arbitrarily changing the physical and chemical environment, observation systems 10 and 20 for observing the physical and chemical properties of the tissue or cells, and a system 30 for comparing the change of the physical and chemical properties of the tissue or cells before and after changing the physical and chemical environment. The observation system 10 is a potential measurement device for measuring the electrophysiological properties of the tissue or cells. This device comprises an integrated cell placement device 1 provided with a plurality of microelectrodes 11 on a substrate, a cell placement portion 6 for placing the tissue or cells on the microelectrodes 11, and a wiring pattern 12 for applying an electrical signal to the microelectrodes 11 and extracting an electrical signal from the microelectrodes 11.

    摘要翻译： 提供了一种测量组织或细胞的物理和化学性质的方法及其装置，通过该方法可以根据实验需要任意改变组织或细胞的物理和化学环境。 该装置包括用于保持生物组织或细胞周围的物理和化学环境恒定的系统40，用于任意改变物理和化学环境的系统50，用于观察组织或细胞的物理化学性质的观察系统10和20 以及用于比较在改变物理和化学环境之前和之后组织或细胞的物理和化学性质的变化的系统30。 观察系统10是用于测量组织或细胞的电生理特性的电位测量装置。 该装置包括在基板上设置有多个微电极11的集成电池放置装置1，用于将组织或电池放置在微电极11上的电池放置部分6以及用于向微电极11施加电信号的布线图案12 以及从微电极11提取电信号。

    Cell potential measuring electrode and measuring apparatus using the same
    7.
    再颁专利
    Cell potential measuring electrode and measuring apparatus using the same 有权
    电池电位测量电极及使用其的测量装置

    公开(公告)号：USRE37977E1

    公开(公告)日：2003-02-04

    申请号：US09953412

    申请日：2001-09-11

    申请人： Hirokazu Sugihara ,  Hiroaki Oka ,  Ken Shimono ,  Ryuta Ogawa ,  Makoto Taketani

    发明人： Hirokazu Sugihara ,  Hiroaki Oka ,  Ken Shimono ,  Ryuta Ogawa ,  Makoto Taketani

    IPC分类号： G01N2700

    CPC分类号： G01N33/4836 ,  C12M41/46

    摘要： This invention relates to a low impedance cell potential measuring electrode assembly typically having a number of microelectrodes on an insulating substrate and having a wall enclosing the region including the microelectrodes. The device is capable of measuring electrophysiological activities of a monitored sample using the microelectrodes while cultivating those cells or tissues in the in the region of the microelectrodes. The invention utilizes independent reference electrodes to lower the impedance of the overall system and to therefore lower the noise often inherent in the measured data. Optimally the microelectrodes are enclosed by a physical wall used for controlling the atmosphere around the monitored sample.

    摘要翻译： 本发明涉及一种低阻抗电池电位测量电极组件，通常在绝缘衬底上具有许多微电极，并且具有围绕包括微电极的区域的壁。 该装置能够在微电极区域中培养那些细胞或组织的同时使用微电极测量被监测样品的电生理活性。 本发明利用独立的参考电极来降低整个系统的阻抗并因此降低测量数据中常常固有的噪声。 最佳地，微电极由用于控制被监测样品周围大气的物理壁包围。