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    N-(2-oxpyrrolidin-1-yl-)acetyl)piperazine derivatives and drug for senile dementia
    6.
    发明授权
    N-(2-oxpyrrolidin-1-yl-)acetyl)piperazine derivatives and drug for senile dementia 失效
    N-（2-氧代吡咯烷-1-基）乙酰基）哌嗪衍生物和老年痴呆药物

    公开(公告)号：US4904663A

    公开(公告)日：1990-02-27

    申请号：US221450

    申请日：1988-07-15

    申请人： Hiromu Matsumura ,  Hiroshi Hashizume ,  Akira Matsushita ,  Masami Eigyo

    发明人： Hiromu Matsumura ,  Hiroshi Hashizume ,  Akira Matsushita ,  Masami Eigyo

    IPC分类号： B43L13/00 ,  A61K31/495 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D409/12 ,  G06F17/50

    CPC分类号： C07D207/27 ,  C07D401/12 ,  C07D409/12

    摘要： A compound of the formula: ##STR1## (wherein R is --SO.sub.2 R.sup.1 or --CONHR.sup.2 ; R.sup.1 is C.sub.1 -C.sub.5 alkyl, C.sub.8 -C.sub.12 phenylalkenyl, amino, dimethylamino, optionally substituted C.sub.8 -C.sub.12 aryl, or 5- or 6-membered heterocyclic group including at least one hetero atom selected from the group consisting of N, S, and O; R.sup.2 is amino, C.sub.1 -C.sub.8 alkylamino, C.sub.1 -C.sub.8 alkyl, or optionally substituted C.sub.8 -C.sub.12 aryl) or its pharmaceutically acceptable acid-addition salt, being useful as a drug for senile dementia, psychotropic, or antiamnesia agent is provided through several routes.

    摘要翻译： 下式化合物：其中R为-SO 2 R 1或-CONHR 2; R 1为C 1 -C 5烷基，C 8 -C 12苯基链烯基，氨基，二甲基氨基，任选取代的C 6 -C 12芳基 或包含至少一个选自N，S和O的杂原子的5-或6-元杂环基; R 2是氨基，C 1 -C 5烷基氨基，C 1 -C 5烷基或任选取代的C 6 -C 12芳基）或其药学上可接受的酸加成盐，可用作老年痴呆，精神药物或抗遗忘因子药物。

    COMPOUNDS HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY
    8.
    发明申请
    COMPOUNDS HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY 失效
    具有NPY Y5受体拮抗活性的化合物

    公开(公告)号：US20120130070A1

    公开(公告)日：2012-05-24

    申请号：US13354881

    申请日：2012-01-20

    申请人： Masahiro SAKAGAMI ,  Hiroshi Hashizume ,  Satoru Tanaka

    发明人： Masahiro SAKAGAMI ,  Hiroshi Hashizume ,  Satoru Tanaka

    IPC分类号： C07D471/04

    CPC分类号： C07D231/12 ,  C07D231/14 ,  C07D233/64 ,  C07D249/08 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D407/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04

    摘要： This invention provides a compound of the formula (I): a pharmaceutically acceptable salt or solvate thereof, wherein R1 is substituted or unsubstituted alkyl or the like, R2 is hydrogen or substituted or unsubstituted alkyl, Ring A is monocyclic or bicyclic aromatic heterocycle, R3 is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocycle, R4 is halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl or the like, m is an integer between 0 and 2, n is an integer between 0 and 5, R is halogen, oxo, cyano, nitro, substituted or unsubstituted alkyl or the like, and p is an integer between 0 and 2 as novel compounds having NPY Y5 antagonistic activity.

    摘要翻译： 本发明提供式（I）化合物：其药学上可接受的盐或溶剂合物，其中R 1为取代或未取代的烷基等，R 2为氢或取代或未取代的烷基，环A为单环或双环芳族杂环，R 3 取代或未取代的芳基，取代或未取代的杂芳基或取代或未取代的杂环，R4为卤素，氰基，取代或未取代的烷基，取代或未取代的环烷基等，m为0至2之间的整数，n为0 和5，R是卤素，氧代，氰基，硝基，取代或未取代的烷基等，p是0和2之间的整数，作为具有NPY Y5拮抗活性的新化合物。