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    PROCESS FOR PRODUCTION OF SURFACE-COATED INORGANIC PARTICLES
    3.
    发明申请
    PROCESS FOR PRODUCTION OF SURFACE-COATED INORGANIC PARTICLES 有权
    生产表面涂层无机颗粒的方法

    公开(公告)号：US20100254908A1

    公开(公告)日：2010-10-07

    申请号：US12670807

    申请日：2008-07-25

    申请人： Hiroshi Handa ,  Mamoru Hatakeyama ,  Masanori Abe ,  Satoshi Sakamoto ,  Yuka Masaike ,  Kosuke Nishio ,  Yoshinori Kita ,  Hiroshi Kishi

    发明人： Hiroshi Handa ,  Mamoru Hatakeyama ,  Masanori Abe ,  Satoshi Sakamoto ,  Yuka Masaike ,  Kosuke Nishio ,  Yoshinori Kita ,  Hiroshi Kishi

    IPC分类号： A61K49/06 ,  B05D7/00 ,  H01F1/00

    CPC分类号： H01F1/0045 ,  A61K41/0052 ,  A61K49/183 ,  A61K49/1833 ,  A61K49/1836 ,  A61K49/1851 ,  A61K49/1854 ,  B22F1/0022 ,  B22F1/0062 ,  B82Y25/00 ,  B82Y30/00 ,  C01G49/00 ,  C01P2006/42 ,  C09C1/24 ,  C09C3/08 ,  C09C3/10 ,  C09C3/12 ,  G01N33/53 ,  G01N33/54393 ,  H01F1/0054

    摘要： Nano-sized inorganic particles having uniform particle sizes and precisely controlled particle diameters have already been produced by synthesis in an organic solvent, but these nano-sized inorganic particles are hindered from dispersing in a polar solvent because of the adsorption of a long-chain fatty acid on the surfaces of the particles. Further, it was difficult to form nano-sized inorganic particles dispersible in a polar solvent by replacing the long-chain fatty acid coats. According to the invention, various surface-coated inorganic particles dispersible in polar solvents can be produced from fatty acid-coated inorganic particles by adding a temporary coating substance such as thiomalic acid to a nonpolar solvent containing fatty acid-coated inorganic particles dispersed therein to replace the fatty acid coats by the temporary coating substance, dispersing the inorganic particles coated with the temporary coating substance in a polar solvent, and then adding a coating substance dispersible in a polar solvent, e.g., citric acid to the obtained dispersion to replace the temporary coating substance coats covering the inorganic particles by the coating substance dispersible in a polar solvent.

    摘要翻译： 通过在有机溶剂中合成已经制备了具有均匀粒度和精确控制的粒径的纳米尺寸的无机颗粒，但是这些纳米尺寸的无机颗粒由于吸附长链脂肪而被阻挡在极性溶剂中 酸在颗粒的表面上。 此外，通过代替长链脂肪酸涂层，难以形成分散在极性溶剂中的纳米级无机颗粒。 根据本发明，分散在极性溶剂中的各种表面涂覆的无机颗粒可以通过向包含分散在其中的含脂肪酸涂覆的无机颗粒的非极性溶剂中添加诸如硫代酸的临时涂层物质，由脂肪酸包覆的无机颗粒制备，以代替 通过临时涂布物质将脂肪酸涂布，将涂覆有临时涂层物质的无机颗粒分散在极性溶剂中，然后将分散在极性溶剂如柠檬酸中的涂覆物质加入到所得分散体中以替代临时涂层 通过可分散在极性溶剂中的涂层物质覆盖无机颗粒的物质外套。

    BIOSENSING METHOD USING COATED MAGNETIC FINE PARTICLES AND BIOSENSING APPARATUS FOR BIOSENSING METHOD
    4.
    发明申请
    BIOSENSING METHOD USING COATED MAGNETIC FINE PARTICLES AND BIOSENSING APPARATUS FOR BIOSENSING METHOD 审中-公开
    使用包覆磁性细粒的生物传感方法和生物传感方法的生物传感装置

    公开(公告)号：US20100323457A1

    公开(公告)日：2010-12-23

    申请号：US12745619

    申请日：2008-12-01

    申请人： Hiroshi Handa ,  Masanori Abe ,  Mamoru Hatakeyama ,  Satoshi Sakamoto ,  Kosuke Nishio ,  Yusuke Mochizuki

    发明人： Hiroshi Handa ,  Masanori Abe ,  Mamoru Hatakeyama ,  Satoshi Sakamoto ,  Kosuke Nishio ,  Yusuke Mochizuki

    IPC分类号： G01N33/553

    CPC分类号： G01N33/54333 ,  G01N21/553

    摘要： An object of the present invention is to provide a novel biosensing method as the novel application development of the magnetic particles in the biosensing. In an affinity reaction of biosensing, ligands are immobilized to magnetic fine particles and the magnetic fine particles are forced to reaction fields of the affinity reaction by magnetic guiding so as to bring the affinity reaction, which is the velocity controlling factor in the sensing, to high rates. According to the present invention, coated magnetic fine particles with having both of the high dispersion performance and high magnetic responsibility as the above described magnetic fine particles and the affinity reaction occurs quickly and in high density such that the present invention makes it possible to obtain relatively large signals within significantly short time duration when compared to the conventional art.

    摘要翻译： 本发明的目的是提供一种新型的生物传感方法作为生物传感中的磁性颗粒的新应用开发。 在生物感应的亲和反应中，将配体固定在磁性细颗粒上，并通过磁性引导将磁性微粒强制为亲和反应的反应场，从而将作为感测中的速度控制因子的亲和反应带入 高利率。 根据本发明，具有上述磁性细颗粒的高分散性和高磁性作用两者的涂覆磁性微粒快速且高密度地发生，从而本发明使得可以获得相对的 与传统技术相比，在显着短的持续时间内的大信号。

    Polymer particle containing fluorescent molecule and method for producing the same
    7.
    发明授权
    Polymer particle containing fluorescent molecule and method for producing the same 有权
    含有荧光分子的聚合物粒子及其制造方法

    公开(公告)号：US09494580B2

    公开(公告)日：2016-11-15

    申请号：US13060882

    申请日：2009-09-10

    申请人： Hiroshi Handa ,  Mamoru Hatakeyama ,  Satoshi Sakamoto ,  Yusuke Mochizuki ,  Shintaro Kawada

    发明人： Hiroshi Handa ,  Mamoru Hatakeyama ,  Satoshi Sakamoto ,  Yusuke Mochizuki ,  Shintaro Kawada

    IPC分类号： G01N33/553 ,  G01N33/533 ,  C08J3/12 ,  G01N33/543 ,  H01F1/06 ,  H01F1/09

    CPC分类号： G01N33/533 ,  C08J3/12 ,  C08J3/128 ,  C08J2327/12 ,  G01N33/54326 ,  H01F1/06 ,  H01F1/09

    摘要： Polymer particles are provided which contain fluorescent molecules with high presence ratio in a polymer layer thereof and a method for preparing thereof. Polymer particles are swelled in a non-aqueous solution excluding exclusively water preferably promotes selling of the polymer layer and transfer of the fluorescent molecules to the polymer layer could not protected by water molecules such that much more fluorescent molecule may be introduced into inside of the polymer layer. Furthermore, since the water is added to the reaction system prior to evaporation removal of the non-aqueous solvent, dry-up of the polymer particles is prevented by the water remained in the reaction system and the polymer particles including fluorescent molecules with high presence ratio of the fluorescent molecules preferably keep high dispersibility using the above described procedures.

    摘要翻译： 提供聚合物颗粒，其聚合物层中含有高存在比例的荧光分子及其制备方法。 聚合物颗粒在除水之外的非水溶液中膨胀，优选促进聚合物层的销售并且荧光分子转移到聚合物层不能被水分子保护，使得可以将更多的荧光分子引入聚合物内部 层。 此外，由于在蒸发除去非水溶剂之前将水加入到反应体系中，聚合物颗粒的干燥可以通过反应体系中残留的水来防止，聚合物颗粒包括具有高存在比的荧光分子 的荧光分子优选使用上述方法保持高分散性。

    POLYMER PARTICLE CONTAINING FLUORESCENT MOLECULE AND METHOD FOR PRODUCING THE SAME
    8.
    发明申请
    POLYMER PARTICLE CONTAINING FLUORESCENT MOLECULE AND METHOD FOR PRODUCING THE SAME 有权
    含有荧光分子的聚合物颗粒及其制造方法

    公开(公告)号：US20110183355A1

    公开(公告)日：2011-07-28

    申请号：US13060882

    申请日：2009-09-10

    申请人： Hiroshi Handa ,  Mamoru Hatakeyama ,  Satoshi Sakamoto ,  Yusuke Mochizuki ,  Shintaro Kawada

    发明人： Hiroshi Handa ,  Mamoru Hatakeyama ,  Satoshi Sakamoto ,  Yusuke Mochizuki ,  Shintaro Kawada

    IPC分类号： G01N33/53

    CPC分类号： G01N33/533 ,  C08J3/12 ,  C08J3/128 ,  C08J2327/12 ,  G01N33/54326 ,  H01F1/06 ,  H01F1/09

    摘要： Polymer particles are provided which contain fluorescent molecules with high presence ratio in a polymer layer thereof and a method for preparing thereof. Polymer particles are swelled in a non-aqueous solution excluding exclusively water preferably promotes selling of the polymer layer and transfer of the fluorescent molecules to the polymer layer could not protected by water molecules such that much more fluorescent molecule may be introduced into inside of the polymer layer. Furthermore, since the water is added to the reaction system prior to evaporation removal of the non-aqueous solvent, dry-up of the polymer particles is prevented by the water remained in the reaction system and the polymer particles including fluorescent molecules with high presence ratio of the fluorescent molecules preferably keep high dispersibility using the above described procedures.

    摘要翻译： 提供聚合物颗粒，其聚合物层中含有高存在比例的荧光分子及其制备方法。 聚合物颗粒在除水之外的非水溶液中膨胀，优选促进聚合物层的销售并且荧光分子转移到聚合物层不能被水分子保护，使得可以将更多的荧光分子引入聚合物内部 层。 此外，由于在蒸发除去非水溶剂之前将水加入到反应体系中，聚合物颗粒的干燥可以通过反应体系中残留的水来防止，聚合物颗粒包括具有高存在比的荧光分子 的荧光分子优选使用上述方法保持高分散性。