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    Aminomethyl-substituted thiazolobenzimidazole compounds
    1.
    发明授权
    Aminomethyl-substituted thiazolobenzimidazole compounds 失效
    氨基甲基取代的噻唑并噻唑化合物

    公开(公告)号：US07250429B2

    公开(公告)日：2007-07-31

    申请号：US10508329

    申请日：2003-03-19

    申请人： Hirotsune Itahana ,  Jiro Fujiyasu ,  Satoshi Hayashibe ,  Toshihiro Watanabe ,  Masamichi Okada ,  Takashi Toya

    发明人： Hirotsune Itahana ,  Jiro Fujiyasu ,  Satoshi Hayashibe ,  Toshihiro Watanabe ,  Masamichi Okada ,  Takashi Toya

    IPC分类号： A61K31/429 ,  C07D513/04

    CPC分类号： A61K31/429 ,  A61K31/5377 ,  C07D513/04

    摘要： This invention relates to the provision of novel aminomethyl-substituted thiazolobenzimidazole derivatives represented by the following general formula (I) or a salt thereof.The aforementioned derivative or a salt thereof has a metabotropic glutamate receptor action and excellent oral activity and is therefore useful as a medicament. (In the formula, R1: an oxygen-containing saturated hetero ring or the like, Alk1: a lower alkylene, m: 0 or 1, Alk2: a lower alkylene which may be substituted with oxo group, n: 0 or 1, X: a bond, O, S or NR5, R3: H or the like, and R2, R4, R5, R6 and R7: the same or different from one another and each represents H or the like. Provided that R3 does not represent a lower alkyl or a halogeno-lower alkyl when X is a bond and n is 1. Also, R4 represents a group other than Me when m is 1, R1 is OH or OMe and Alk1 is a C1-3 alkylene, and further 1) when X is a bond, n is 1 and R3 is H, or 2) when X is a bond, n is 0 and R3 is cyclohexane.)

    摘要翻译： 本发明涉及提供由以下通式（I）表示的新型氨基甲基取代的噻唑并苯并咪唑衍生物或其盐。 上述衍生物或其盐具有代谢型谷氨酸受体作用和优异的口服活性，因此可用作药物。 （式中，R 1：含氧饱和杂环等，Alk 1：低级亚烷基，m：0或1，Alk， 2：可以被氧代基取代的低级亚烷基，n：0或1，X：键，O，S或NR 5，R 3 O >：H等，R 2，R 4，R 5，R 6和R 6， 其中R 3彼此相同或不同，并且各自表示H等，条件是R 3不表示低级烷基或卤代低级烷基，当X为 键，n为1.另外，当m为1时，R 4表示除Me以外的基团，R 1是OH或OMe，Alk 1 是C 1-3亚烷基，进一步1）当X为键时，n为1且R 3为H，或2）当X为键时 ，n为0，R 3为环己烷）

    Aminomethyl-substituted thiazolobenzimidazole derivative
    2.
    发明申请
    Aminomethyl-substituted thiazolobenzimidazole derivative 失效
    氨基甲基取代的噻唑并噻唑衍生物

    公开(公告)号：US20050148642A1

    公开(公告)日：2005-07-07

    申请号：US10508329

    申请日：2003-03-19

    申请人： Hirotsune Itahana ,  Jiro Fujiyasu ,  Satoshi Hayashibe ,  Toshihiro Watanabe ,  Masamichi Okada ,  Takashi Toya

    发明人： Hirotsune Itahana ,  Jiro Fujiyasu ,  Satoshi Hayashibe ,  Toshihiro Watanabe ,  Masamichi Okada ,  Takashi Toya

    IPC分类号： A61K31/429 ,  A61K31/5377 ,  A61P9/10 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/28 ,  A61P43/00 ,  C07D513/04 ,  A61K31/43 ,  C07D498/04

    CPC分类号： A61K31/429 ,  A61K31/5377 ,  C07D513/04

    摘要： This invention relates to the provision of novel aminomethyl-substituted thiazolobenzimidazole derivatives represented by the following general formula (I) or a salt thereof. The aforementioned derivative or a salt thereof has a metabotropic glutamate receptor action and excellent oral activity and is therefore useful as a medicament. (In the formula, R1: an oxygen-containing saturated hetero ring or the like, Alk1: a lower alkylene, m: 0 or 1, Alk2: a lower alkylene which may be substituted with oxo group, n: 0 or 1, X: a bond, O, S or NR5, R3: H or the like, and R2, R4, R5, R6 and R7: the same or different from one another and each represents H or the like. Provided that R3 does not represent a lower alkyl or a halogeno-lower alkyl when X is a bond and n is 1. Also, R4 represents a group other than Me when m is 1, R1 is OH or OMe and Alk1 is a C1-3 alkylene, and further 1) when X is a bond, n is 1 and R3 is H, or 2) when X is a bond, n is 0 and R3 is cyclohexane.)

    摘要翻译： 本发明涉及提供由以下通式（I）表示的新型氨基甲基取代的噻唑并苯并咪唑衍生物或其盐。 上述衍生物或其盐具有代谢型谷氨酸受体作用和优异的口服活性，因此可用作药物。 （式中，R 1：含氧饱和杂环等，Alk 1：低级亚烷基，m：0或1，Alk， 2：可以被氧代基取代的低级亚烷基，n：0或1，X：键，O，S或NR 5，R 3 O >：H等，R 2，R 4，R 5，R 6和R 6， 其中R 3彼此相同或不同，并且各自表示H等，条件是R 3不表示低级烷基或卤代低级烷基，当X为 键，n为1.另外，当m为1时，R 4表示除Me以外的基团，R 1是OH或OMe，Alk 1 是C 1-3亚烷基，进一步1）当X为键时，n为1且R 3为H，或2）当X为键时 ，n为0，R 3为环己烷）

    SKILL ESTIMATION METHOD IN MACHINE-HUMAN HYBRID CROWDSOURCING
    6.
    发明申请
    SKILL ESTIMATION METHOD IN MACHINE-HUMAN HYBRID CROWDSOURCING 有权
    机器人混合运动中的技巧估计方法

    公开(公告)号：US20160132815A1

    公开(公告)日：2016-05-12

    申请号：US14869308

    申请日：2015-09-29

    申请人： Toshinari Itoko ,  Masatomo Kobayashi ,  Shin Saito ,  Toshihiro Watanabe

    发明人： Toshinari Itoko ,  Masatomo Kobayashi ,  Shin Saito ,  Toshihiro Watanabe

    IPC分类号： G06Q10/06 ,  G06Q50/00

    CPC分类号： G06Q10/06398 ,  G06Q10/0639 ,  G06Q50/01

    摘要： In one embodiment, a computer-implemented method for estimating an ability of a worker in a process for integrating work results of multiple workers for the same task includes acquiring, for each of one or more tasks, a work result of a preceding-stage worker and a work result of a succeeding-stage worker that works based on the work result of the preceding-stage worker. The method also includes estimating multiple parameters of a probability model in which an ability of the succeeding-stage worker conditioned by a quality of the work result of the preceding-stage worker is introduced as a conditioned ability parameter, based on the multiple work results obtained for each of the one or more tasks.

    摘要翻译： 在一个实施例中，用于估计工作人员在用于为同一任务整合多个工人的工作结果的过程中的能力的计算机实现的方法包括为一个或多个任务中的每一个获取前一阶段工作者的工作结果 以及根据前期工作人员的工作成果开展工作的后期工作者的工作成果。 该方法还包括基于获得的多个工作结果来估计其中引入了由前级工作人员的工作结果的质量调节的后级工作人员的能力作为条件能力参数的概率模型的多个参数 对于每个一个或多个任务。

    Prophylactic Antimigraine Agents
    7.
    发明申请
    Prophylactic Antimigraine Agents 审中-公开
    预防性抗偏头痛药

    公开(公告)号：US20080161419A1

    公开(公告)日：2008-07-03

    申请号：US10589892

    申请日：2005-02-17

    申请人： Shinobu Akuzawa ,  Toshihiro Watanabe

    发明人： Shinobu Akuzawa ,  Toshihiro Watanabe

    IPC分类号： A61K45/00 ,  A61P25/06

    CPC分类号： A61K31/166 ,  A61K31/454 ,  A61K31/505 ,  C07D339/06

    摘要： The present invention relates to prophylactic antimigraine agents comprising as an active ingredient a dual antagonist for the 5-HT2B and 5-HT7 receptors, the antagonist having a binding affinity selective for the 5-HT2B and 5-HT7 receptors.Since these prophylactic antimigraine agents show an excellent pharmacological effect in comparison with the cases in which a 5-HT2B receptor antagonist having a selective binding affinity to the 5-HT2B receptor or a 5-HT7 receptor antagonist having a selective binding affinity to the 5-HT7 receptor is used alone, they are useful as drugs which are excellent in prophylaxis of migraine and in which the side effects found in the existing prophylactic antimigraine agents are reduced.

    摘要翻译： 本发明涉及含有5-HT 2B和5-HT 7受体的双重拮抗剂作为活性成分的预防性抗偏头痛药，所述拮抗剂具有结合亲和选择性 对于5-HT 2B和5-HT 7受体。 由于与对5-HT 2B受体具有选择性结合亲和力的5-HT 2B受体拮抗剂相比，这些预防性抗偏头痛药物显示出优异的药理作用 或对5-HT 7受体具有选择性结合亲和力的5-HT 7受体拮抗剂单独使用，它们可用作预防偏头痛的药物 并且其中在现有的预防性抗偏头痛药中发现的副作用减少。

    SMTP server, POP server, mail server, mail processing system and web server
    9.
    发明授权
    SMTP server, POP server, mail server, mail processing system and web server 有权
    SMTP服务器，POP服务器，邮件服务器，邮件处理系统和Web服务器

    公开(公告)号：US07035901B1

    公开(公告)日：2006-04-25

    申请号：US09466813

    申请日：1999-12-20

    申请人： Masatoshi Kumagai ,  Toshihiro Watanabe ,  Kenichiro Osada ,  Nobuhiro Miyatake

    发明人： Masatoshi Kumagai ,  Toshihiro Watanabe ,  Kenichiro Osada ,  Nobuhiro Miyatake

    IPC分类号： G06F15/16

    CPC分类号： G06Q30/0277 ,  G06Q10/107 ,  G06Q30/02 ,  G06Q30/0256 ,  G06Q30/0271 ,  H04L51/063

    摘要： According to the present invention, an SMTP server sending a mail having a predetermined mail address as a recipient to a server that receives and manages the mail having the predetermined mail address, includes: an advertisement information memory operable to store advertisement information to be added to the mail; an advertisement information detector operable to detect the advertisement information to be added to the mail from the advertisement information memory based on at least one of user information about a user having the mail address of the recipient of the mail, user information about a user having a mail address of a sender of the mail and a sentence included in the mail; an advertisement information adding portion operable to add the advertisement information to the mail; and a sending portion operable to send the mail to the server.

    摘要翻译： 根据本发明，向接收和管理具有预定邮件地址的邮件的服务器发送具有预定邮件地址的邮件作为收件人的SMTP服务器包括：广告信息存储器，用于存储要添加到的广告信息 邮件; 广告信息检测器，用于基于关于具有所述邮件的接收者的邮件地址的用户的用户信息中的至少一个来检测从所述广告信息存储器添加到所述邮件的广告信息，所述用户信息关于具有所述邮件的用户的用户信息 邮件的发件人的邮件地址和邮件中包含的句子; 广告信息添加部分，用于将广告信息添加到邮件中; 以及可操作以将邮件发送到服务器的发送部分。