公开(公告)号：US20060194251A1

公开(公告)日：2006-08-31

申请号：US10551809

申请日：2004-03-25

申请人： Hiroyuki Osada ,  Naoki Kanch

发明人： Hiroyuki Osada ,  Naoki Kanch

IPC分类号： G01N33/53 ,  B05D3/02

CPC分类号： G03F7/165 ,  B05D1/185 ,  B05D3/06 ,  B82Y30/00 ,  B82Y40/00 ,  G03F7/008 ,  G03F7/016 ,  G03F7/0755

摘要： A method of fixing a low-molecular compound to a solid-phase support, which comprises a step in which a solution containing a low-molecular compound is brought into contact with a solid-phase support having a photoreactive compound bonded to the surface, a step in which the solution containing a low-molecular compound is evaporated to dryness in the state of being in contact with the solid-phase support, and a step in which the solid-phase support is irradiated with light to form a covalent bond between the photoreactive compound and the low-molecular compound. This fixing method enables a low-molecular compound to be fixed to a solid-phase support without the aid of a functional group.

摘要翻译： 一种将低分子化合物固定在固相载体上的方法，其包括使含有低分子化合物的溶液与具有与表面结合的光反应性化合物的固相载体接触的步骤， 在与固相载体接触的状态下将含有低分子化合物的溶液蒸发至干的步骤，以及固相支持体在光照射下形成共价键的步骤 光反应性化合物和低分子化合物。 这种固色方法能够使低分子化合物固定在固相载体上而无需官能团的帮助。

公开(公告)号：US09324889B2

公开(公告)日：2016-04-26

申请号：US14003452

申请日：2012-03-07

申请人： Minoru Hanaya ,  Kenji Kakiage ,  Masafumi Unno ,  Yohei Aoyama ,  Toru Yano ,  Daisuke Sawamoto ,  Hiroyuki Osada

发明人： Minoru Hanaya ,  Kenji Kakiage ,  Masafumi Unno ,  Yohei Aoyama ,  Toru Yano ,  Daisuke Sawamoto ,  Hiroyuki Osada

IPC分类号： C07F7/18 ,  H01L31/0256 ,  H01L51/00 ,  C07F17/02 ,  H01G9/20

CPC分类号： H01G9/2059 ,  C07F7/1804 ,  C07F17/02 ,  C09B1/16 ,  C09B23/0075 ,  C09B23/14 ,  C09B23/145 ,  C09B23/164 ,  C09B29/0808 ,  C09B57/00 ,  H01G9/2031 ,  H01L31/0256 ,  H01L51/005 ,  H01L51/0052 ,  H01L51/0055 ,  H01L51/006 ,  H01L51/0061 ,  H01L51/0065 ,  H01L51/0068 ,  H01L51/007 ,  H01L51/0071 ,  H01L51/0072 ,  H01L51/0073 ,  H01L51/0083 ,  H01L51/0094 ,  Y02E10/542

摘要： Disclosed is a novel compound represented by formula (1) below. In the formula, A represents an optionally substituted aromatic hydrocarbon ring or aromatic heterocyclic group, B represents a group including a chain of one to four pieces of one or more groups selected from groups represented by specific formulae (B-1) to (B-13) (such as —C═C— or —N═N—, specifically see the description), R1 to R3 each represent an optionally substituted hydrocarbon or hydrocarbonoxy group, at least one of R1 to R3 represents an optionally substituted hydrocarbonoxy group, R4 and R5 each represent an optionally substituted hydrocarbon group, R4 and R5 may be linked together to form a ring, and R4 and R5 may be each independently linked with A to form a ring.

摘要翻译： 公开了由下式（1）表示的新化合物。 式中，A表示可以具有取代基的芳香族烃环或芳香族杂环基，B表示含有1〜4个选自特定式（B-1）〜（B- 13）（例如-C≡C-或-N = N-，具体参见描述），R 1至R 3各自表示任选取代的烃或烃氧基，R 1至R 3中的至少一个表示任选取代的烃氧基， R 4和R 5各自表示任选取代的烃基，R 4和R 5可以连接在一起形成环，并且R 4和R 5可以各自独立地与A形成环。

公开(公告)号：US20080124809A1

公开(公告)日：2008-05-29

申请号：US11665636

申请日：2005-10-13

申请人： Naoki Kanoh ,  Hiroyuki Osada ,  Motoki Kyo

发明人： Naoki Kanoh ,  Hiroyuki Osada ,  Motoki Kyo

IPC分类号： G01N33/00 ,  G01N21/00

CPC分类号： G01N33/553 ,  G01N33/54353

摘要： A method of label-free observing of any interaction between biomolecule and substance immobilized on a metal substrate, characterized in that the substance is immobilized on the metal substrate by a covalent bond through photoreaction.

摘要翻译： 固定在金属基材上的生物分子与物质之间任何相互作用的无标记观察方法，其特征在于通过光反应通过共价键将该物质固定在金属基底上。

公开(公告)号：US06670187B2

公开(公告)日：2003-12-30

申请号：US09866590

申请日：2001-05-30

申请人： Hiroyuki Osada ,  Siro Simizu

发明人： Hiroyuki Osada ,  Siro Simizu

IPC分类号： C12N1587

CPC分类号： C12N9/12

摘要： A mutant Plk protein having a mutation in C-terminal domain thereof specified by amino acid residues of from 439 to 603 of amino acid sequence of wild-type Plk protein wherein said mutation decreases affinity with Hsp90 protein, and a gene encoding said mutant Plk protein are provided. A method for detecting an abnormal cell which comprises the step of detecting the mutant Plk protein or the gene encoding the protein is also provided.

公开(公告)号：US6094556A

公开(公告)日：2000-07-25

申请号：US239021

申请日：1999-01-29

申请人： Atsushi Tanaka ,  Minoru Shimojo ,  Akira Shimada ,  Hiroyuki Osada ,  Tsunenori Ashibe ,  Hidekazu Matsuda

发明人： Atsushi Tanaka ,  Minoru Shimojo ,  Akira Shimada ,  Hiroyuki Osada ,  Tsunenori Ashibe ,  Hidekazu Matsuda

IPC分类号： G03G15/16 ,  G03G15/01

CPC分类号： G03G15/162 ,  G03G15/161 ,  G03G2215/0119 ,  G03G2215/0177

摘要： An intermediate transfer member for receiving a toner image formed on a first image-bearing member and transferring the toner image onto a second image-bearing member has a surface coated with at least one of a nitrate ion adsorbent and a compound having a layer structure, whereby a scattering of toner particles during a successive image formation is effectively suppressed for a long period.

摘要翻译： 用于接收形成在第一图像承载部件上并将调色剂图像转印到第二图像承载部件上的调色剂图像的中间转印部件具有涂覆有硝酸根离子吸附剂和具有层结构的化合物中的至少一种的表面， 从而在连续成像期间的调色剂颗粒的散射被长时间有效地抑制。

公开(公告)号：US09530571B2

公开(公告)日：2016-12-27

申请号：US14350171

申请日：2012-08-21

申请人： Yohei Aoyama ,  Kazuyuki Noda ,  Hiroyuki Osada

发明人： Yohei Aoyama ,  Kazuyuki Noda ,  Hiroyuki Osada

IPC分类号： C07F7/10 ,  H01G9/20 ,  C09B69/00 ,  C07F15/00 ,  C07F7/18 ,  H01L51/00

CPC分类号： H01G9/2059 ,  C07F7/1804 ,  C07F15/0053 ,  C09B69/008 ,  H01G9/2031 ,  H01G9/204 ,  H01L51/006 ,  H01L51/0061 ,  H01L51/0068 ,  H01L51/0069 ,  H01L51/0072 ,  H01L51/0086 ,  H01L51/0094 ,  Y02E10/542

摘要： A novel compound represented by general formula (1), a support supporting this novel compound, and a photoelectric transduction element using this support. (In the formula, Y is an optionally substituted hydrocarbon group having 1-20 carbon atoms having —CO—NR4- or —SO2—NR4- in the group; Z is a group of a conjugated system; R1, R2, and R3 represent optionally substituted hydrocarbon groups or optionally substituted hydrocarbon-oxy groups; at least one of R1, R2, and R3 is an optionally substituted hydrocarbon-oxy group; R4 represents a hydrogen atom or an optionally substituted hydrocarbon group having 1-20 carbon atoms; R4 and Z may join together to form a ring. However, Y excludes groups represented by partial structural formulas (Y-11) and (Y-12).)

摘要翻译： 公开了由通式（1）表示的新化合物，载有新化合物的载体材料和使用该载体材料制备的光电转换装置，其中Y为任选取代的具有1至20个碳原子的烃基且具有-CO -NR 4 - 或-SO 2 -NR 4 - ，Z是共轭基团，R 1，R 2和R 3各自表示任选取代的烃基或任选取代的烃氧基，R 1，R 2和R 3中的至少一个 表示任选取代的烃氧基，R 4表示氢原子或具有1至20个碳原子的任选取代的烃基，并且R 4和Z可以连接在一起形成环，条件是Y不包括由部分结构式（ Y-11）和（Y-12）。

公开(公告)号：US08980587B2

公开(公告)日：2015-03-17

申请号：US13819959

申请日：2011-08-30

申请人： Hiroyuki Osada ,  Shunji Takahashi ,  Makoto Kawatani ,  Yoshiyuki Sakaki ,  Atsushi Toyoda

发明人： Hiroyuki Osada ,  Shunji Takahashi ,  Makoto Kawatani ,  Yoshiyuki Sakaki ,  Atsushi Toyoda

IPC分类号： C12N1/21 ,  C12P17/06 ,  C12P17/16 ,  C07K14/36 ,  C07D493/10 ,  C12N15/52 ,  C12P17/18 ,  C12N1/20 ,  A61K31/351

CPC分类号： C07D493/10 ,  A61K31/351 ,  C07K14/36 ,  C12N1/20 ,  C12N15/52 ,  C12P17/06 ,  C12P17/181

摘要： A bacterium belonging to the genus Streptomyces having an ability to produce reveromycin A or a synthetic intermediate thereof, the bacterium being modified so as to increase expression of revQ gene coding for the amino acid sequence of SEQ ID NO: 36 or an amino acid sequence having an identity of not less than 80% to SEQ ID NO: 36 as compared with a parent strain, thereby the above-mentioned production ability is increased as compared with the parent strain.

摘要翻译： 属于属于链霉菌属的细菌，其具有产生还原霉素A或其合成中间体的能力，所述细菌被修饰以增加编码SEQ ID NO：36的氨基酸序列的revQ基因的表达或具有SEQ ID NO：36的氨基酸序列的表达， 与亲本菌株相比，与SEQ ID NO：36不小于80％的身份，因此与亲本菌株相比上述生产能力增加。

公开(公告)号：US07713706B2

公开(公告)日：2010-05-11

申请号：US10551809

申请日：2004-03-25

申请人： Hiroyuki Osada ,  Naoki Kanoh

发明人： Hiroyuki Osada ,  Naoki Kanoh

IPC分类号： G01N33/53

CPC分类号： G03F7/165 ,  B05D1/185 ,  B05D3/06 ,  B82Y30/00 ,  B82Y40/00 ,  G03F7/008 ,  G03F7/016 ,  G03F7/0755

摘要： A method of fixing a low-molecular compound to a solid-phase support, by bringing a solution containing a low-molecular compound into contact with a solid-phase support having a photoreactive compound bonded to the surface, evaporating the solution containing a low-molecular compound to dryness, in the state of being in contact with the solid-phase support, and irradiating the solid-phase support with light to form a covalent bond between the photoreactive compound and the low-molecular compound. This fixing method enables a low-molecular compound to be fixed to a solid-phase support without the aid of a functional group.

摘要翻译： 通过使含有低分子化合物的溶液与具有键合到表面的光反应性化合物的固相载体接触来蒸发含有低分子化合物的低分子化合物的溶液， 分子化合物在与固相载体接触的状态下干燥，并用光照射固相载体以在光反应性化合物和低分子化合物之间形成共价键。 这种固色方法能够使低分子化合物固定在固相载体上而无需官能团的帮助。

公开(公告)号：US07612213B2

公开(公告)日：2009-11-03

申请号：US10516743

申请日：2003-06-06

申请人： Hiroyuki Osada ,  Hideaki Kakeya ,  Yujiro Hayashi

发明人： Hiroyuki Osada ,  Hideaki Kakeya ,  Yujiro Hayashi

IPC分类号： C07D207/00 ,  C07D209/32 ,  C07D303/38 ,  C07D491/02

CPC分类号： C07D491/04 ,  A61K31/407

摘要： A compound represented by the general formula (I): (I) wherein R represents linear, branched, or cyclic alkyl or aryl; a process for producing the compound; and an antitumor agent containing the compound as an active ingredient.

摘要翻译： 由通式（I）表示的化合物：（I）其中R表示直链，支链或环状的烷基或芳基; 一种制备该化合物的方法; 和含有该化合物作为活性成分的抗肿瘤剂。

公开(公告)号：US08901044B2

公开(公告)日：2014-12-02

申请号：US12777562

申请日：2010-05-11

申请人： Hiroyuki Osada ,  Kaori Honda ,  Kunihiro Ohta ,  Akiho Murayama

发明人： Hiroyuki Osada ,  Kaori Honda ,  Kunihiro Ohta ,  Akiho Murayama

IPC分类号： C40B30/04 ,  B05D3/06 ,  C40B40/00 ,  G01N33/543 ,  B03C1/01

CPC分类号： G01N33/54326 ,  B03C1/01 ,  B03C2201/18 ,  G01N33/54353

摘要： It is an object of the present invention to provide a method for stably and efficiently binding a compound to magnetic beads. The present invention relates to a method for producing compound-bound magnetic beads, which comprises: allowing a compound to come into contact with magnetic beads, on the surface of each of which a photoreactive compound has bound; extending the magnetic beads together with the compound on a support; and applying light to the magnetic beads to form a covalent bond between the photoreactive compound and the compound.

摘要翻译： 本发明的目的是提供一种稳定且有效地将化合物与磁珠结合的方法。 本发明涉及一种化合物结合磁珠的制造方法，其特征在于：使化合物在光反应性化合物结合的表面上与磁珠接触; 将磁珠与化合物一起在载体上延伸; 并向光磁珠施加光，以在光反应性化合物和化合物之间形成共价键。