公开(公告)号：US10585089B2

公开(公告)日：2020-03-10

申请号：US15320406

申请日：2015-06-17

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Makoto Nogami ,  Shinya Ito ,  Tadao Yabuhara

IPC: G01N35/02 ,  G01N33/543 ,  G01N15/12 ,  G01N30/72 ,  G01N33/82 ,  G01N35/08 ,  G01N35/10 ,  G01N15/00

Abstract: When using an immunological analysis method wherein antigen-antibody reactions are used to form complexes of microparticles and a substance being measured, purifying, then measuring by spectroscopy, and a mass spectrometry method wherein antigen-antibody reactions are used to form complexes of microparticles and a substance being measured, purifying, then measuring with a mass spectrometer, the amount of the complex flowing in the flow path for immunological analysis and the amount of the complex flowing in the flow path for mass spectrometry are unknown, so the substance being measured cannot be accurately quantified even when merging information obtained from immunological analysis and information obtained from mass spectrometry. The invention provides a mechanism for quantifying the complexes after formation of the complexes, on the flow path for mass spectrometry and the flow path for immunological analysis.

公开(公告)号：US09885732B2

公开(公告)日：2018-02-06

申请号：US14911406

申请日：2014-06-24

Applicant: Hitachi High-Technologies Corporation

Inventor： Makoto Nogami ,  Shinya Ito ,  Tadao Yabuhara

IPC: G01N35/02 ,  G01N33/543 ,  G01N35/10 ,  G01N35/00 ,  G01N1/28 ,  G01N35/04

CPC classification number: G01N35/025 ,  G01N33/54366 ,  G01N35/00871 ,  G01N35/1065 ,  G01N2001/2826 ,  G01N2035/0458

Abstract: An analysis device is provided with a first disk on which a sample container and disposable container can be disposed, a second disk on which a solid-phase extraction cartridge and disposable container can be disposed, a first probe capable of transferring a sample of the sample container disposed on the first disk or a solution of the disposable container disposed on the first disk to the solid-phase extraction cartridge or disposable container disposed on the second disk, and a second probe capable of transferring a reagent of a reagent container to the sample container or disposable container disposed on the first disk and the solid-phase extraction cartridge or disposable container disposed on the second disk. Sample preprocessing before solid-phase extraction processing takes place on the first disk.

公开(公告)号：US11385208B2

公开(公告)日：2022-07-12

申请号：US16083308

申请日：2016-03-07

Applicant: Hitachi High-Technologies Corporation

Inventor： Makoto Nogami ,  Shinya Ito

IPC: G01N30/20 ,  G01N30/38 ,  G01N30/14 ,  G01N30/28 ,  G01N30/72 ,  G01N30/32

Abstract: An analysis device of the present invention is provided with a sample introduction unit that introduces a sample into a mass spectroscope; a sample condensation unit that treats the sample introduced into the device; a detection unit that analyzes the sample treated by a treatment unit; and a control unit that controls the sample introduction unit, the sample condensation unit, and the detection unit. The sample introduction unit includes a sample introduction valve, and the sample condensation unit includes an elution valve and a cleaning valve, and the cleaning valve is disposed between the sample introduction valve and the elution valve.

公开(公告)号：US08604425B2

公开(公告)日：2013-12-10

申请号：US13680630

申请日：2012-11-19

Applicant: Hitachi High-Technologies Corporation

Inventor： Katsuhiro Kanda ,  Makoto Nogami ,  Izumi Waki

IPC: G01N1/10 ,  G01N1/28 ,  G01N1/02 ,  G01N33/48 ,  H01J49/26

CPC classification number: G01N1/4077 ,  G01N1/405 ,  G01N30/82 ,  G01N2030/009 ,  H01J49/0431 ,  H01J49/26

Abstract: The present invention relates to a pretreatment apparatus that performs concentration and separation of a sample, and in particular, in order to provide a sample pretreatment apparatus using a solid-phase extraction column, and a mass spectrometer using the same, which is particularly suitable for clinical analysis in which qualitative/quantitative analysis of a biological sample such as blood is performed, according to each operational step for a solid-phase extraction treatment, for example, a collection device serving as flow passages or containers for collection of waste liquid or extracted matter is installed on a bottom face of the solid-phase extraction column, and the extracted matter is separately collected without being mixed with waste liquid by switching the positions of the collection device.

Abstract translation: 本发明涉及一种进行样品浓缩分离的预处理装置，特别是为了提供使用固相萃取柱的样品预处理装置和使用其的质谱仪，特别适用于 根据固相萃取处理的每个操作步骤，例如用作流动通道的收集装置或用于收集废液或提取的容器的容器，进行诸如血液的生物样品的定性/定量分析的临床分析 物质被安装在固相萃取塔的底面上，并且通过切换收集装置的位置而分离地收集提取物而不与废液混合。