摘要:
The present invention relates to a substituted thiazolo[3,2-a] azepine derivative having inhibitory activity against angiotensin I converting enzyme and neutral endpeptidase and is represented by the following general formula (I): ##STR1##
摘要:
The present invention relates to a substituted thiazolo�3,2-a!azepine derivative having inhibitory activity against angiotensin I converting enzyme and neutral endpeptidase. The above substituted thiazolo�3,2-a!azepine derivative is represented by the following general formula (I): ##STR1## (wherein R1 represents a hydrogen atom or a protecting group of a thiol group; R2 represents a hydrogen atom, a lower alkyl group, an aryl group which may have a substituent, a hetroaryl group which may have a substituent, a lower alkoxyl group or a lower alkylthio group; R3, R4 and R5 may be the same or different from one another and represent each a hydrogen atom, a lower alkyl group, a lower alkoxyl group, a lower alkylthio group or the like, with the proviso that the case wherein all of R3, R4 and R5 are hydrogen atoms are excepted; R6 and R7 may be the same or different from each other and represent each a hydrogen atom or a lower alkyl group; R8 represents a hydrogen atom or a protecting group of a carboxyl group; and m and m are each independently 0 or, 1 or 2).
摘要:
The present invention relates to an amino acid derivative having an angiotensin I-converting enzyme inhibition activity, a vasopressin antagonism and an atrial natriuretic peptide hydrolase inhibition activity. This amino acid derivative is represented by the following general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or an acyl group; R.sup.2 represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, an ary group which may have a substituent, a heteroaryl group which may have a substituent, an arylalkyl group which may have a substituent or a heteroarylalkyl group which may have a substituent; m and n represent each independently an integer of 0, 1 or 2 and J represents a cyclic group having an angiotensin I-converting enzyme inhibition activity.
摘要翻译:本发明涉及具有血管紧张素I-转化酶抑制活性,加压素拮抗作用和心房利尿钠肽水解酶抑制活性的氨基酸衍生物。 该氨基酸衍生物由以下通式(I)表示:其中R 1表示氢原子或酰基; R 2表示氢原子,低级烷基,环烷基,可以具有取代基的芳基,可以具有取代基的杂芳基,可以具有取代基的芳烷基或可以具有取代基的杂芳基烷基 ; m和n各自独立地表示0,1或2的整数,J表示具有血管紧张素I-转化酶抑制活性的环状基团。
摘要:
A pyrrolidine compound having the following formula and a pharmacologically acceptable salt thereof is disclosed. It is useful in the pharmaceutical field. ##STR1## in which X is hydrogen, a halogen, or a lower alkyl, Y is --(CH2)n--, n being zero, 1 or 2, --S(O)p--, p being zero, 1 or 2, --O--, or --NH-- and R is phenyl, a substituent-having phenyl, naphtyl, a substituent-having naphthyl, a heteroaryl or a substituent-having heteroaryl.
摘要:
To provide a less expensive and high-efficient free-piston Stirling cycle machine with an outer diameter of entire machine being relatively small. In a Stirling cycle cooler as a free-piston Stirling cycle machine including a cylinder 7, a piston 18 which is reciprocable inside said cylinder 7 and an electromagnetic driving mechanism 19 for reciprocating said piston 18, said electromagnetic driving mechanism 19 is comprised of a mover 20 and a stator 35, said piston 18 and said mover 20 formed by disposing a permanent magnets 24 outside an inner yoke 23 made of magnetic flux conducting material are disposed in an axial alignment, and said stator 35 and said cylinder 7 are disposed in an axial alignment. By this disposition, the outer diameter Rm of said mover 20 of said electromagnetic driving mechanism 19 can be reduced, and consequently the inner diameter Rs and the outer diameter of said stator 35 provided outside said mover 20, eventually the outer diameter of entire Stirling cycle cooler can also be reduced.
摘要:
A granular stabilizer for chlorine-containing polymers, which is formed by granulating a hardly fusible or infusible powdery stabilizer for chlorine-containing polymers or a mixture of said powdery stabilizer with a powdery stabilizer aid through an organic solid binder or dispersion medium, wherein respective primary particles of said powdery stabilizer or said powdery mixture are surface-treated with the organic solid binder or dispersion medium in an amount of 2 to 15 parts by weight per 100 parts by weight of said powdery stabilizer or said powdery mixture, which is smaller than the critical liquid absorption of said powdery, and said primary particles are granulated into particles having an average particle size of 0.1 to 2 mm by fusion bonding of the surface treatment layers of the organic solid binder or dispersion medium. This granular stabilizer is prominently excellent in the dispersibility in a chlorine-containing polymer, the uniformity of the composition, the scattering resistance, the flowability and the blocking resistance, though the starting powdery stabilizer is granulated with a much reduced amount of the solid binder or dispersion medium.
摘要:
An image processing apparatus including: a scene recognition section recognizing a scene captured by an image; an assigning section selecting a change-target parameter being an adjustment parameter whose parameter value is to be changed from a plurality of adjustment parameters adjusting the image in response to the scene of the image, and assigning the parameter to a specific operation section being a specific operation section out of user-operable operation sections; and a parameter setting section setting a parameter value of the change-target parameter assigned to the specific operation section in response to operation of the specific operation section by a user.
摘要:
Disclosed is a granular stabilizer for chlorine-containing polymers, which comprises porous spherical particles composed of randomly integrated needle crystals of a polybasic sulfuric acid/fatty acid lead salt having a chemical composition of 1 mole of SO.sub.3, 3.7 to 4.5 moles of PbO and 0.06 to 1.27 moles of a higher fatty acid and also having X-ray diffraction peaks at spacings d of 2.95 A and 3.27 A, wherein the fatty acid component is enrolled in the surfaces of the respective needle crystals without substantial phase separation in the surfaces of the spherical particles.
摘要:
A novel lead monoxide having a true density of 8.3 to 9.2 g/cc, a primary particle size not larger than 0.2 .mu., an infrared absorption peak at a wave number of 1400 to 1410 cm.sup.-1 and a chromic anhydride reactivity of at least 94%.This lead monoxide is of the ultrafine particulate form excellent in light resistance, hue stability and reactivity and is substantially free of metallic lead. Chrome yellow, tribasic lead sulfate, lead silicate, white lead and the like lead salts can be prepared from this lead monoxide without performing a particular washing operation or using a catalyst.
摘要:
To provide a less expensive and high-efficient free-piston Stirling cycle machine with an outer diameter of entire machine being relatively small. In a Stirling cycle cooler as a free-piston Stirling cycle machine including a cylinder 7, a piston 18 which is reciprocable inside said cylinder 7 and an electromagnetic driving mechanism 19 for reciprocating said piston 18, said electromagnetic driving mechanism 19 is comprised of a mover 20 and a stator 35, said piston 18 and said mover 20 formed by disposing a permanent magnets 24 outside an inner yoke 23 made of magnetic flux conducting material are disposed in an axial alignment, and said stator 35 and said cylinder 7 are disposed in an axial alignment. By this disposition, the outer diameter Rm of said mover 20 of said electromagnetic driving mechanism 19 can be reduced, and consequently the inner diameter Rs and the outer diameter of said stator 35 provided outside said mover 20, eventually the outer diameter of entire Stirling cycle cooler can also be reduced.